Skip to main content
SpringerLink
Log in

Hyalinizing Trabecular Tumor

  • Chapter
  • First Online:
Common Diagnostic Pitfalls in Thyroid Cytopathology

  • 961 Accesses

Abstract

Hyalinizing trabecular tumor of the thyroid gland is a rare neoplasm of follicular origin that is characterized by an encapsulated nodule, a prominent trabecular growth pattern, and stromal hyalinization. This tumor typically behaves in a benign fashion but malignant cases have been reported. Hyalinizing trabecular tumors are usually well circumscribed or encapsulated with variability in color. The possibility that hyalinizing trabecular tumor represents a variant of papillary thyroid carcinoma has been considered given that the tumors frequently coexist and they share similar morphologic and nuclear features. However, on genetic analysis, hyalinizing trabecular tumor has been shown to be a discrete entity from papillary thyroid carcinoma. Hyalinizing trabecular tumors are frequently mistaken for papillary thyroid carcinoma, medullary carcinoma, or paraganglioma, but immunohistochemical stains are helpful in resolving this.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Carney JA, Ryan J, Goellner JR. Hyalinizing trabecular adenoma of the thyroid gland. Am J Surg Pathol. 1987;11:583–91.

    Article  CAS  PubMed  Google Scholar 

  2. Hicks MJ, Batsakis JG. Hyalinizing trabecular adenoma of the thyroid gland. Ann Otol Rhinol Laryngol. 1993;102:239–40.

    Article  CAS  PubMed  Google Scholar 

  3. Chan JK, Tse CC, Chiu HS. Hyalinizing trabecular adenoma-like lesion in multinodular goitre. Histopathology. 1990;16:611–4.

    Article  CAS  PubMed  Google Scholar 

  4. Evenson A, Mowschenson P, Wang H, Connolly J, Mendrinos S, Parangi S, Hasselgren PO. Hyalinizing trabecular adenoma—an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma. Am J Surg. 2007;193:707–12.

    Article  PubMed  Google Scholar 

  5. Molberg K, Albores-Saavedra J. Hyalinizing trabecular carcinoma of the thyroid gland. Hum Pathol. 1994;25:192–7.

    Article  CAS  PubMed  Google Scholar 

  6. McCluggage WG, Sloan JM. Hyalinizing trabecular carcinoma of thyroid gland. Histopathology. 1996;28:357–62.

    Article  CAS  PubMed  Google Scholar 

  7. Galgano MT, Mills SE, Stelow EB. Hyalinizing trabecular adenoma of the thyroid revisited: a histologic and immunohistochemical study of thyroid lesions with prominent trabecular architecture and sclerosis. Am J Surg Pathol. 2006;30:1269–73.

    Article  PubMed  Google Scholar 

  8. DeLellis RA, Lloyd RV, Heitz PU, Eng C. World Health Organization classification of tumours. Pathology and genetics of tumours of endocrine organs. Lyon: IARC Press; 2004.

    Google Scholar 

  9. Salvatore G, Chiappetta G, Nikiforov YE, Decaussin-Petrucci M, Fusco A, Carney JA, Santoro M. Molecular profile of hyalinizing trabecular tumours of the thyroid: high prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutations. Eur J Cancer. 2005;41:816–21.

    Article  CAS  PubMed  Google Scholar 

  10. Gaffney RL, Carney JA, Sebo TJ, Erickson LA, Volante M, Papotti M, Lloyd RV. Galectin-3 expression in hyalinizing trabecular tumors of the thyroid gland. Am J Surg Pathol. 2003;27:494–8.

    Article  PubMed  Google Scholar 

  11. Cheung CC, Boerner SL, MacMillan CM, Ramyar L, Asa SL. Hyalinizing trabecular tumor of the thyroid: a variant of papillary carcinoma proved by molecular genetics. Am J Surg Pathol. 2000;24:1622–6.

    Article  CAS  PubMed  Google Scholar 

  12. Sheu S, Vogel E, Worm K, Grabellus F, Schwertheim S, Schmid KW. Hyalinizing trabecular tumor of the thyroid—differential expression of distinct miRNAs compared with papillary thyroid carcinoma. Histopathology. 2010;56:632–40.

    Article  PubMed  Google Scholar 

  13. Lee S, Hong S, Koo JS. Immunohistochemical subclassification of thyroid tumors with prominent hyalinizing trabecular pattern. APMIS. 2011;119:529–36.

    Article  PubMed  Google Scholar 

  14. Casey MB, Sebo TJ, Carney JA. Hyalinizing trabecular adenoma of the thyroid gland identification through MIB-1 staining of fine-needle aspiration biopsy smears. Am J Clin Pathol. 2004;122:506–10.

    Article  PubMed  Google Scholar 

  15. Howard BE, Gnagi SH, Ocal IT, Hinni ML. Hyalinizing trabecular tumor masquerading as papillary thyroid carcinoma on fine-needle aspiration. ORL J Otorhinolaryngol Relat Spec. 2013;75:309–13.

    Article  PubMed  Google Scholar 

  16. Carney JA, Hirokawa M, Lloyd RV, Papottie M, Sebo TJ. Hyalinizing trabecular tumors of the thyroid gland are almost all benign. Am J Surg Pathol. 2008;32:1877–89.

    Article  PubMed  Google Scholar 

  17. Kini SR. Thyroid cytopathology: an Atlas and text. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins; 2008.

    Google Scholar 

  18. Rothenberg HJ, Goellner JR, Carney JA. Prevalence and incidence of cytoplasmic yellow bodies in thyroid neoplasms. Arch Pathol Lab Med. 2003;127:715–7.

    PubMed  Google Scholar 

  19. Kuma S, Hirokawa M, Miyauchi A, Kakudo K, Katayama S. Cytologic features of hyalinizing trabecular adenoma of the thyroid. Acta Cytol. 2003;47:399–404.

    Article  PubMed  Google Scholar 

  20. Boccato P, Mannara GM, LaRosa F, Rinaldo A, Ferlito A. Hyalinizing trabecular adenoma of the thyroid diagnosed by fine-needle aspiration biopsy. Ann Otol Rhinol Laryngol. 2000;109:235–8.

    Article  CAS  PubMed  Google Scholar 

  21. Bondeson L, Bondeson AG. Clue helping to distinguish hyalinizing trabecular adenoma from carcinoma of the thyroid in fine-needle aspirates. Diagn Cytopathol. 1994;10:25–9.

    Article  CAS  PubMed  Google Scholar 

  22. Katoh R, Kakudo K, Kawaoi A. Accumulated basement membrane material in hyalinizing trabecular tumors of the thyroid. Mod Pathol. 1999;12:1057–61.

    CAS  PubMed  Google Scholar 

  23. Rhoden KJ, Unger K, Salvatore G, et al. RET/papillary thyroid cancer rearrangement in nonneoplastic thyrocytes: follicular cells of Hashimoto’s thyroiditis share low-level recombination events with a subset of papillary carcinoma. J Clin Endocrinol Metab. 2006;91:2414–23.

    Article  CAS  PubMed  Google Scholar 

  24. Trovisco V, Vieira deCastro I, Soares P, et al. BRAF mutations are associated with some histological types of papillary thyroid carcinoma. J Pathol. 2004;202:247–51.

    Article  CAS  PubMed  Google Scholar 

  25. Baloch ZW, Puttaswamy K, Brose M, LiVolsi VA. Lack of BRAF mutations in hyalinizing trabecular neoplasm. Cytojournal. 2006;3:17.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Hirokawa M, Shimizu M, Manabe T, Kuroda M, Mizoguchi Y. Hyalinizing trabecular adenoma of the thyroid: its unusual cytoplasmic immunopositivity for MIB1. Pathol Int. 1995;45:399–401.

    Article  CAS  PubMed  Google Scholar 

  27. Hirokawa M, Carney JA. Cell membrane and cytoplasmic staining for MIB-1 in hyalinizing trabecular adenoma of the thyroid gland. Am J Surg Pathol. 2000;24:575–8.

    Article  CAS  PubMed  Google Scholar 

  28. Shikama Y, Osawa T, Yagihashi N, Kurotaki H, Yagihashi S. Neuroendocrine differentiation in hyalinizing trabecular tumor of the thyroid. Virchows Arch. 2003;443:792–6.

    Article  CAS  PubMed  Google Scholar 

  29. Hirokawa M, Carney JA, Ohtsuki Y. Hyalinizing trabecular adenoma and papillary carcinoma of the thyroid gland express different cytokeratin patterns. Am J Surg Pathol. 2000;24:877–81.

    Article  CAS  PubMed  Google Scholar 

  30. Cerasoli S, Tabarri B, Farabegoli P, Vascotto L, Lanzanova G, Pasquinelli GA, Tison V. Hyalinizing trabecular adenoma of the thyroid. Report of two cases, with cytologic, immunohistochemical and ultrastructural studies. Tumori. 1992;78:274–9.

    CAS  PubMed  Google Scholar 

  31. Katoh R, Jasani B, Williams ED. Hyalinizing trabecular adenoma of the thyroid. A report of three cases with immunohistochemical and ultrastructural studies. Histopathology. 1989;15:211–24.

    Article  CAS  PubMed  Google Scholar 

  32. Huss LJ, Mendelsohn G. Medullary carcinoma of the thyroid gland: an encapsulated variant resembling the hyalinizing trabecular (paraganglioma-like) adenoma of the thyroid. Mod Pathol. 1990;3:581–5.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Yale University School of Medicine, New Haven, CT, USA

    Adebowale J. Adeniran

  2. Department of Pathology, Mount Sinai Health System, New York, NY, USA

    David Chhieng

Authors
  1. Adebowale J. Adeniran
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David Chhieng
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Adeniran, A.J., Chhieng, D. (2016). Hyalinizing Trabecular Tumor. In: Common Diagnostic Pitfalls in Thyroid Cytopathology. Springer, Cham. https://doi.org/10.1007/978-3-319-31602-4_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-31602-4_12

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-31600-0

  • Online ISBN: 978-3-319-31602-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation