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Neuroendocrine differentiation in hyalinizing trabecular tumor of the thyroid

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Abstract

The presence of neuroendocrine cells is putative in thyroid hyalinizing trabecular tumor (HTT), although this entity requires a differential diagnosis from paraganglioma or medullary carcinoma of the thyroid, due to similarity of the growth pattern of the cells. Here, we present a case of HTT with a mixture of endocrine cells stained positive for somatostatin, chromogranin A and Grimelius’ silver impregnation. The histology and results of other immunostainings were consistent with the features typical for HTT. In the world literature to date, only two cases of HTT with endocrine cells, including the current case, have been reported. Nevertheless, the cases may indicate the diversified differentiation of cells in HTT and may, in part, account for the resemblance of HTT to paraganglioma and medullary carcinoma.

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Acknowledgment

The authors appreciate the excellent technical support of Ms. Kaori Okamoto.

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Authors and Affiliations

  1. Department of Clinical Laboratory, Kuroishi City Hospital, Kuroishi, Aomori, Japan

    Yasuyoshi Shikama

  2. Department of Surgery, Kuroishi City Hospital, Kuroishi, Aomori, Japan

    Tadaharu Osawa & Nobuo Yagihashi

  3. Department of Pathology, Hirosaki University School of Medicine, Hirosaki, Japan

    Yasuyoshi Shikama, Hidekachi Kurotaki & Soroku Yagihashi

  4. Department of Pathology, Hirosaki University School of Medicine, 5 Zaifu-cho, 036-8562, Hirosaki, Japan

    Soroku Yagihashi

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  1. Yasuyoshi Shikama
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  2. Tadaharu Osawa
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  3. Nobuo Yagihashi
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  4. Hidekachi Kurotaki
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  5. Soroku Yagihashi
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Correspondence to Soroku Yagihashi.

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Shikama, Y., Osawa, T., Yagihashi, N. et al. Neuroendocrine differentiation in hyalinizing trabecular tumor of the thyroid. Virchows Arch 443, 792–796 (2003). https://doi.org/10.1007/s00428-003-0901-4

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  • DOI: https://doi.org/10.1007/s00428-003-0901-4

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