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Biomaterials and 3D Printing Techniques for Neural Tissue Regeneration

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Neural Engineering

Abstract

Nerve regeneration involves a series of complex physiological phenomena. Larger peripheral nerve injuries must be surgically treated, typically with autografts harvested from elsewhere in the body. Central nervous injuries and diseases are more complicated, as there are inhibitive factors resulting in less than ideal repair. Currently, many researches in peripheral nerve regeneration are focused on developing alternatives to the autograft, while efforts for treating central nervous injuries and diseases are devoted to creating a permissive microenvironment for neural regeneration and therapeutic delivery. In recent years, neural tissue engineering has emerged as one of the very promising strategies for treating various nervous system injuries and diseases. Particularly, advancement in both biomaterials and 3D biomimetic scaffolds fabrication techniques such as 3D printing has inspired this field into a new era. This book chapter will focus on the two key pillars and discuss their current progress for improving neural regeneration.

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Acknowledgments

This work is supported by March of Dimes Foundation’s Gene Discovery and Translational Research Grant and NIH Director’s New Innovator Award 1DP2EB020549-01.

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Authors and Affiliations

  1. Department of Mechanical and Aerospace Engineering, The George Washington University, 3590 Science and Engineering Hall, 800 22nd Street NW, Washington, DC, 20052, USA

    Se-Jun Lee, Wei Zhu, Nathan Castro & Lijie Grace Zhang

  2. Department of Biomedical Engineering, The George Washington University, 3590 Science and Engineering Hall, 800 22nd Street NW, Washington, DC, 20052, USA

    Lijie Grace Zhang

  3. Department of Medicine, The George Washington University, 3590 Science and Engineering Hall, 800 22nd Street NW, Washington, DC, 20052, USA

    Lijie Grace Zhang

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Correspondence to Lijie Grace Zhang .

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  1. & Aero Eng., Biomed.Eng & Medicine, The George Washington Univ.,Dept of Mech, Washington, District of Columbia, USA

    Lijie Grace Zhang

  2. Dept of Biomedical Engineering, Tufts University,Stern Family Prof., Medford, Massachusetts, USA

    David L. Kaplan

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© 2016 Springer International Publishing Switzerland

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Lee, SJ., Zhu, W., Castro, N., Zhang, L.G. (2016). Biomaterials and 3D Printing Techniques for Neural Tissue Regeneration. In: Zhang, L., Kaplan, D. (eds) Neural Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-31433-4_1

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  • DOI: https://doi.org/10.1007/978-3-319-31433-4_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-31431-0

  • Online ISBN: 978-3-319-31433-4

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