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Nutrition, Macrobiotics, and the Brain’s Neuroinflammatory Response

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Neuro-Immuno-Gastroenterology

Abstract

Environmental factors play an important role in the development of chronic brain inflammatory and neurodegenerative conditions. Diet-derived bioactive molecules can modulate the blood-brain barrier and immune cell traffic to the brain. Alteration in the brain cytokine milieu results in microglial polarization that dictates the outcome of inflammatory process. Preclinical and clinical studies have revealed the anti-inflammatory properties of plant-derived compounds, such as polyphenols and polyunsaturated fatty acids. Nevertheless, no specific diets have been adopted in patients with multiple sclerosis (MS) or Alzheimer’s or Parkinson’s diseases.

The aim of this review was to provide a framework for nutritional interventions in patients with chronic brain inflammatory and neurodegenerative conditions. The effects of diet are analyzed in the context of complex interaction with gut microbiota and preexistent gut barrier defects as seen in patients with inflammatory bowel disease.

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Authors and Affiliations

  1. Section of Medical Nutrition Consulting, ARMEDICA LLC, Basking Ridge, NJ, USA

    Violeta Arsenescu MD, PhD (Director)

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  1. Violeta Arsenescu MD, PhD
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Correspondence to Violeta Arsenescu MD, PhD .

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Editors and Affiliations

  1. Neurology, C Floor South Block, University of Nottingham, Nottingham, United Kingdom

    Cris Constantinescu

  2. Atlantic Digestive Health Institute, Morristown Medical Center, Columbus, Ohio, USA

    Razvan Arsenescu

  3. Armedica LLC, Columbus, Ohio, USA

    Violeta Arsenescu

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Arsenescu, V. (2016). Nutrition, Macrobiotics, and the Brain’s Neuroinflammatory Response. In: Constantinescu, C., Arsenescu, R., Arsenescu, V. (eds) Neuro-Immuno-Gastroenterology. Springer, Cham. https://doi.org/10.1007/978-3-319-28609-9_8

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  • DOI: https://doi.org/10.1007/978-3-319-28609-9_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28607-5

  • Online ISBN: 978-3-319-28609-9

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