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Roles of Substance P in Gastrointestinal Functions and Neuroimmune Interactions

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Neuro-Immuno-Gastroenterology

Abstract

Substance P (SP), a member of the tachykinin (TK) peptide family, is ubiquitously expressed from invertebrates to mammals with a role in different organ systems and a number of functions also in the gastrointestinal (GI) tract. In the current chapter, the roles of SP and other TKs in the GI tract with wider implications and its role in intersystem communication are emphasized. Roles for SP and different neurokinin receptors in the enteric nervous system and neuroimmune modulation are covered. In disease, SP roles in autoimmune and other inflammatory and infectious conditions are summarized.

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Abbreviations

ACh:

Acetylcholine

CD:

Crohn’s disease

CGRP:

Calcitonin-gene-related peptide

ChAT:

Choline acetyltransferase

CNS:

Central nervous system

EKA:

Endokinin A

EKB:

Endokinin B

EKC:

Endokinin C

ENS:

Enteric nervous system

ERK1/2:

Extracellular signal-regulated kinases 1 and 2

GI tract:

Gastrointestinal tract

HK-1:

Hemokinin-1

IBD:

Inflammatory bowel disease

ICC:

Interstitial cell of Cajal

IPAN:

Intrinsic primary afferent neuron

mRNA:

Messenger ribonucleic acid

NFκB:

Nuclear factor-κB

NK1R:

Neurokinin-1 receptor

NK1R-T:

Truncated neurokinin-1 receptor

NKA:

Neurokinin A

NKB:

Neurokinin B

NPK:

Neuropeptide K

NPγ:

Neuropeptide-γ

SP:

Substance P

TKs:

Tachykinins

UC:

Ulcerative colitis

VIP:

Vasoactive intestinal peptide

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Authors and Affiliations

  1. Department of Neurology, Tartu University Hospital, Tartu, Estonia

    Janek Vilisaar MD, DM

  2. Atlantic Digestive Health Institute, Director, Atlantic Inflammatory Bowel Disease Center, Morristown, NJ, USA

    Razvan I. Arsenescu MD, PhD (Chief)

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  1. Janek Vilisaar MD, DM
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  2. Razvan I. Arsenescu MD, PhD
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Correspondence to Razvan I. Arsenescu MD, PhD .

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  1. Neurology, C Floor South Block, University of Nottingham, Nottingham, United Kingdom

    Cris Constantinescu

  2. Atlantic Digestive Health Institute, Morristown Medical Center, Columbus, Ohio, USA

    Razvan Arsenescu

  3. Armedica LLC, Columbus, Ohio, USA

    Violeta Arsenescu

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Vilisaar, J., Arsenescu, R.I. (2016). Roles of Substance P in Gastrointestinal Functions and Neuroimmune Interactions. In: Constantinescu, C., Arsenescu, R., Arsenescu, V. (eds) Neuro-Immuno-Gastroenterology. Springer, Cham. https://doi.org/10.1007/978-3-319-28609-9_4

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