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The Putative Role of Measles Virus in the Pathogenesis of Otosclerosis

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Abstract

The main goal of this report is to review our current knowledge about the etiopathogenesis of otosclerotic bone remodeling disorder focusing on measles virus infection. Otosclerosis is a disease of pathologically increased bone turnover of the human otic capsule; however, the etiopathogenesis remained unclear. Persisting measles virus infection, genetic predisposition, disturbed bone metabolism, inflammatory processes, autoimmunity, and hormonal and environmental factors also may play contributing roles in the pathogenesis of otosclerosis. In the future, prospective studies based on comprehensive histopathologic, molecular biologic, and genetic analysis are necessary to get further information about the background of disease in order to clarify the role of measles in the etiopathogenesis and to find the most promising treatment option.

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Authors and Affiliations

  1. Department of Otolaryngology and Head and Neck Surgery, B-A-Z County Hospital and University Hospital, Szentpéteri Kapu 72-76, Miskolc, 3526, Hungary

    Tamás Karosi MD, HSc, PhD

  2. Department of Otolaryngology and Head and Neck Surgery, Clinical Center, University of Debrecen, Debrecen, Hungary

    István Sziklai

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  1. Tamás Karosi MD, HSc, PhD
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Correspondence to Tamás Karosi MD, HSc, PhD .

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  1. Dept. Otorhinolaryngology, University of Debrecen, Debrecen, Hungary

    Istvan Sziklai

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Karosi, T., Sziklai, I. (2016). The Putative Role of Measles Virus in the Pathogenesis of Otosclerosis. In: Sziklai, I. (eds) Surgery of Stapes Fixations. Springer, Cham. https://doi.org/10.1007/978-3-319-28576-4_2

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