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Myocardial Pharmacoregeneration

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Regenerative Medicine - from Protocol to Patient

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Abstract

Novel pharmacological approaches addressing the underlying cause of heart failure progression, namely cardiomyocyte loss, are emerging. The main therapeutic aims are to either protect cardiomyocytes from ischemia-associated stressors or to facilitate endogenous regeneration. The latter may be achieved by (1) induction of cardiomyocyte proliferation, (2) activation of resident cardiac progenitor cells, or (3) non-myocyte-to-cardiomyocyte conversion. The development of pharmacological approaches to enhance these under normal circumstances ineffective self-repair mechanisms may enable the regeneration of what we consider today the irreversibly damaged heart. This chapter provides an overview of the current state-of-the-art in myocardial pharmacoregeneration.

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Authors and Affiliations

  1. Institute of Pharmacology and Toxicology, Heart Research Center Goettingen, University Medical Center Goettingen, Georg-August-University Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany

    Laura C. Zelarayán, Maria Patapia Zafiriou & Wolfram-Hubertus Zimmermann M.D.

  2. DZHK (German Center for Cardiovascular Research), Göttingen, Germany

    Laura C. Zelarayán, Maria Patapia Zafiriou & Wolfram-Hubertus Zimmermann M.D.

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  1. Laura C. Zelarayán
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  2. Maria Patapia Zafiriou
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  3. Wolfram-Hubertus Zimmermann M.D.
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Correspondence to Wolfram-Hubertus Zimmermann M.D. .

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  1. Department of Cardiac Surgery and Refere, University of Rostock, Rostock, Mecklenburg-Vorpomm., Germany

    Gustav Steinhoff

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Zelarayán, L.C., Zafiriou, M.P., Zimmermann, WH. (2016). Myocardial Pharmacoregeneration. In: Steinhoff, G. (eds) Regenerative Medicine - from Protocol to Patient. Springer, Cham. https://doi.org/10.1007/978-3-319-28386-9_4

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