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Genetic Implications in Orthodontic Tooth Movement

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Biology of Orthodontic Tooth Movement

Abstract

In orthodontics there is an interest in understanding how orthodontic tooth movement (OTM) may be modified with the use of differential anchorage and decreasing treatment time(s). While the focus of these efforts has been on how various procedures or devices affect OTM (i.e., typically increase OTM), there has been little discussion of how the patient’s genetic background may influence variation in OTM. In this chapter, the clinician will be introduced to basic concepts of clinical genetics to gain insight into various genetic factors that influence bone modeling/remodeling and OTM. We describe how the genetic factors in these important pathways may also influence external apical root resorption (EARR) concurrent with OTM. At the end of the chapter, known genetic factors in two conditions that could secondarily affect OTM as they increase treatment complexity (dental primary failure of eruption and dental agenesis) are reviewed, and a select group of syndromes and other genetic conditions that may affect OTM in patients are also summarized.

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  1. Center for the Biologic Basis of Oral/Systemic Diseases, Hereditary Genetics/Genomics Core, Department of Oral Health Science, University of Kentucky College of Dentistry, 1095 Veterans Administration Drive, 414 Health Science Research Building (HSRB), Lexington, KY, 40536-0305, USA

    James K. Hartsfield Jr. DMD, MS, MMSC, PhD, FACMG, CDABO

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  1. James K. Hartsfield Jr. DMD, MS, MMSC, PhD, FACMG, CDABO
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Correspondence to James K. Hartsfield Jr. DMD, MS, MMSC, PhD, FACMG, CDABO .

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  1. Department of Orthodontics, VCU School of Dentistry, Richmond, Virginia, USA

    Bhavna Shroff

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Hartsfield, J.K., Morford, L.A. (2016). Genetic Implications in Orthodontic Tooth Movement. In: Shroff, B. (eds) Biology of Orthodontic Tooth Movement. Springer, Cham. https://doi.org/10.1007/978-3-319-26609-1_5

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