Antiepileptic Drugs and Becoming Pregnant
There is published evidence that intake of antiepileptic drugs may affect the possibility of a woman becoming pregnant. Use of the drugs in her male partner may tend to decrease his libido and sexual activity, thus diminishing the chances of pregnancy occurring. A similar effect on libido may occur in the woman being treated with antiepileptic drugs, and the treatment may be responsible for circulating sex hormone concentration alterations that result in menstrual disturbances, this combination of effects tending to lessen fertility. Taking antiepileptic drugs in the non-pregnant state, particularly the older agents that induce formation of enzymes that catalyse the metabolism of steroidal sex hormones, also tends to decrease the circulating concentrations of steroidal hormones used for contraceptive purposes. This effect may increase the chances of undesired pregnancies occurring.
KeywordsAntiepileptic Drug Polycystic Ovary Premature Ovarian Failure Ethinyl Oestradiol Male Control Subject
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