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Inhibitory effects of selected antiepileptics on spontaneous motility of isolated human oviducts

  • Pharmacodynamics
  • Published:
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Abstract

Objective

Spontaneous motility of the human oviduct is an important factor in the regulation of fertility that can be influenced by a variety of substances. In this study we examined the effects of several antiepileptic drugs on spontaneous contractions of isolated human oviducts.

Methods

The isolated ampullar and isthmic segments of Fallopian tubes, taken from 34 patients with extensive uterine fibroids, were exposed to carbamazepine, lamotrigine, valproic acid, phenobarbital, diazepam and lorazepam.

Results

Carbamazepine and lamotrigine produced concentration-dependent inhibition of spontaneous contractions of both ampullar and isthmic isolated preparations, while the other investigated substances did not exhibit any effect. The effective concentrations of carbamazepine and lamotrigine fall within the range of their therapeutic serum concentrations.

Conclusion

When choosing antiepileptics for women of reproductive age, the effects of the drug on motility of the Fallopian tubes should also be considered.

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Acknowledgement

This study was partially financed by a grant from the Serbian Ministry of Science and Ecology, No 145005.

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Authors and Affiliations

  1. Pharmacology Department, Medical Faculty, University of Kragujevac, Ul. Svetozara Markovica 69, 34000, Kragujevac, Serbia, Yugoslavia

    Slobodan M. Jankovic, Snezana V. Jankovic, Jelena Kostic, Irena Kostic & Mihajlo Jakovljevic

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  1. Slobodan M. Jankovic
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  2. Snezana V. Jankovic
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  3. Jelena Kostic
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  4. Irena Kostic
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  5. Mihajlo Jakovljevic
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Correspondence to Slobodan M. Jankovic.

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Jankovic, S.M., Jankovic, S.V., Kostic, J. et al. Inhibitory effects of selected antiepileptics on spontaneous motility of isolated human oviducts. Eur J Clin Pharmacol 62, 707–712 (2006). https://doi.org/10.1007/s00228-006-0172-5

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  • DOI: https://doi.org/10.1007/s00228-006-0172-5

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