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Tissue Energy Metabolism and Mitochondrial Function

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Mitochondrial Function In Vivo Evaluated by NADH Fluorescence

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Abstract

The functional capacity of any tissue is dependent on its ability to perform work. It is possible to assess this ability through the knowledge of changes in the oxygen balance, that is, the ratio of oxygen supply to oxygen demand by the tissue. Monitoring of mitochondrial NADH redox state is sensitive to changes in oxygen supply as well as oxygen balance. The addition of microcirculatory blood flow and hemoglobin oxygenation to the real-time monitoring of NADH has significant value in understanding the development of tissue pathophysiology. The same approach could be applied as a practical clinical tool or device in patient monitoring.

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  1. Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel

    Avraham Mayevsky

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Mayevsky, A. (2015). Tissue Energy Metabolism and Mitochondrial Function. In: Mitochondrial Function In Vivo Evaluated by NADH Fluorescence. Springer, Cham. https://doi.org/10.1007/978-3-319-16682-7_2

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