Skip to main content
SpringerLink
Log in

Fertility/Sexual Function

  • Chapter
Crohn’s Disease

  • 2085 Accesses

Abstract

Advances in the surgical and medical management of Crohn’s disease (CD) continue to improve clinical control highlighting the need for an increased focus on patient quality of life and functional outcomes. Patients with CD are often diagnosed in their late adolescence or early adulthood when sexual function and fertility are of particular concern. Symptoms and treatment related factors of CD have a significant effect on both physiologic and psychosocial aspects of sexuality and fertility. However, many patients feel uncomfortable addressing these issues with their health care providers. It is therefore imperative that all health care professionals caring for patients with CD understand the impact of the disease on sexual function, sexuality, and fertility and create a supportive environment in which to discuss these issues.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Muller KR, Prosser R, Brampton P, Mountifield R, Andrews JM. Female gender and surgery impair relationships, body image, and sexuality in inflammatory bowel disease: patient perceptions. Inflamm Bowel Dis. 2010;16(4):657–63.

    Article  PubMed  Google Scholar 

  2. Timmer A, Bauer A, Dignass A, Rogler G. Sexual function in persons with inflammatory bowel disease: a survey with matched controls. Clin Gastroenterol Hepatol. 2007;5(1):87–94.

    Article  PubMed  Google Scholar 

  3. Timmer A, Bauer A, Kemptner D, Furst A, Rogler G. Determinants of male sexualfunction in inflammatory bowel disease: a survey based cross-sectional analysis in 280 men. Inflamm Bowel Dis. 2007;13(10):1236–43.

    Article  PubMed  Google Scholar 

  4. Gazzard BG, Price HL, Libby GW, Dawson AM. The social toll of Crohn’s disease. Br Med J. 1978;2:1117–9.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Moody G, Probert CSJ, Strivastava EM, RHodes J, Mayberry JF. Sexual dysfunction amongst women with Crohn’s disease: a hidden problem. Digestion. 1992;52:179–83.

    Article  CAS  PubMed  Google Scholar 

  6. Marin L, Manosa M, Garcia-Planella E, Gordillo J, Zabana Y, Cabre E, Domenech E. Sexual function and patients’ perceptions in inflammatory bowel disease: a case control survey. J Gastroenterol. 2013;48:713–20.

    Article  PubMed  Google Scholar 

  7. Timmer A, Kemptner D, Bauer A, Takses A, Ott C, Furst A. Determinants of female sexual function in inflammatory bowel disease: a survey based cross-sectional analysis. BMC Gastroenterol. 2008;8:45.

    Article  PubMed Central  PubMed  Google Scholar 

  8. Blackburn Jr WD, Alarcon GS. Impotence in three rheumatoid arthritis patients treated with methotrexate. Arthritis Rheum. 1989;32:1341–2.

    Article  PubMed  Google Scholar 

  9. Ireland A, Jewell DP. Sulfasalazine-induced impotence: a beneficial resolution with olsalazine? J Clin Gastroenterol. 1989;11:711.

    CAS  PubMed  Google Scholar 

  10. Riba N, Moreno F, Costa J, Olive A. Appearance of impotence in relation to the use of methotrexate. Med Clin (Barc). 1996;106(14):558.

    CAS  Google Scholar 

  11. Thomas E, Koumouvi K, Blotman E. Impotence in a patient with rheumatoid arthritis treated with methotrexate. J Rheumatol. 2000;27:1821–2.

    CAS  PubMed  Google Scholar 

  12. Feagins LA, Kane SV. Sexual and reproductive issues for men with inflammatory bowel disease. Am J Gastroenterol. 2009;104:768–73.

    Article  PubMed  Google Scholar 

  13. Bauer JJ, Gelernt IM, Salky B, Kreel I. Sexual dysfunction following proctocolectomy for benign disease of the colon and rectum. Ann Surg. 1983;197:363–7.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. Farouk R, Pemberton JH, Wolff BG, Dozois RR, Browning S, Larson D. Functional outcomes after ileal pouch-anal anastomosis for chronic ulcerative colitis. Ann Surg. 2000;231:919–26.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. Lindsey I, George BD, Kettlewell MG, Mortensen NJ. Impotence after mesorectal and close rectal dissection for inflammatory bowel disease. Dis Colon Rectum. 2001;44(6):831–5.

    Article  CAS  PubMed  Google Scholar 

  16. Hueting WE, Buskens E, van der Tweel I. Results and complications after ileal pouch anal anastomosis: a meta-analysis of 43 observational studies compromising 9,317 patients. Dig Surg. 2005;22:69–79.

    Article  PubMed  Google Scholar 

  17. Bambrick M, Fazio VW, Hull TL, Pucel G. Sexual function following restorative proctocolectomy in women. Dis Colon Rectum. 1996;39:610–4.

    Article  CAS  PubMed  Google Scholar 

  18. Hueting WE, Gooszen HG, van Laarhoven CJ. Sexual function and continence after ileo pouch anal anastomosis: a comparison between a meta-analysis and a questionnaire survey. Int J Colorectal Dis. 2004;19:215–8.

    Article  CAS  PubMed  Google Scholar 

  19. Scaglia M, Delaini GG, Hulten L. Sexual dysfunctions after conventional proctectomy. Chir Ital. 1992;44:230–42.

    CAS  PubMed  Google Scholar 

  20. Ogilvie JW, Goetz L, Baxter NN, Park J, Minami S, Madoff RD. Female sexual function after ileal pouch-anal anastomosis. Br J Surg. 2008;95:887–92.

    Article  PubMed  Google Scholar 

  21. Metcalf AM, Dozois RR, Kelly KA. Sexual function in women after proctocolectomy. Ann Surg. 1986;204(6):624–7.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  22. Damgaard B, Wettergren A, Kirkegaard P. Social and sexual function following ileal pouch-anal anastomosis. Dis Colon Rectum. 1995;38:286–9.

    Article  CAS  PubMed  Google Scholar 

  23. Gorgun E, Remzi FH, Montague DK, Connor JT, O’Brien K, Loparo B, Fazio VW. Male sexual function improves after ileal pouch anal anastomosis. Colorectal Dis. 2005;7(6):545–50.

    Article  CAS  PubMed  Google Scholar 

  24. Wang JY, Hart SL, Wilkowski KSY, Lee JW, Delmotte EC, del Rosario KM, del Rosario AS, Varma MG. Gender-specific difference in pelvic organ function after proctectomy for inflammatory bowel disease. Dis Colon Rectum. 2011;54:66–76.

    Article  PubMed  Google Scholar 

  25. Moser G, Tillinger W, Sachs G, Genser D, Maier-Dobersberger T, Spiess K, Wyatt J, Vogelsang H, Lochs H, Gangl A. Disease-related worries and concerns: a study on out-patients with inflammatory bowel disease. Eur J Gastroenterol Hepatol. 1995;7:853–8.

    CAS  PubMed  Google Scholar 

  26. Fielding JF. Pregnancy and inflammatory bowel disease. Ir J Med Sci. 1982;151:194–202.

    Article  CAS  PubMed  Google Scholar 

  27. Mayberry JF, Weterman IT. European survey of fertility and pregnancy in women with Crohn’s disease: a case control study by European collaborative group. Gut. 1986;27:821–5.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  28. Burnell D, Mayberry J, Calcraft BJ, Morris JS, Rhodes J. Male fertility in Crohn’s disease. Postgrad Med J. 1986;62:269–72.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  29. Narendranathan M, Sandler RS, Suchindran CM, Savitz DA. Male infertility in inflammatory bowel disease. J Clin Gastroenterol. 1989;11:403–6.

    Article  CAS  PubMed  Google Scholar 

  30. Hudson M, Flett G, Sinclair TS, Brunt PW, Templeton A, Mowat NA. Fertility and pregnancy in inflammatory bowel disease. Int J Gynaecol Obstet. 1997;58(2):229–37.

    Article  CAS  PubMed  Google Scholar 

  31. Mañosa M, Navarro-Llavat M, Marín L, Zabana Y, Cabré E, Domènech E. Fecundity, pregnancy outcomes, and breastfeeding in patients with inflammatory bowel disease: a large cohort survey. Scand J Gastroenterol. 2013;48(4):427–32.

    Article  PubMed  Google Scholar 

  32. Marri SR, Ahn C, Buchman AL. Voluntary childlessness is increased in women with inflammatory bowel disease. Inflamm Bowel Dis. 2007;13(5):591–9.

    Article  PubMed  Google Scholar 

  33. Mountifield R, Bampton P, Prosser R, Muller K, Andrews JM. Fear and fertility in inflammatory bowel disease: a mismatch of perception and reality affects family planning decisions. Inflamm Bowel Dis. 2009;15(5):720–5.

    Article  PubMed  Google Scholar 

  34. Alonso V, Linares V, Belles M, Albina ML, Sirvent JJ, Domingo JL, Sanchez DJ. Sulfasalazine induced oxidative stress: a possible mechanism of male infertility. Reprod Toxicol. 2009;27(1):35–40.

    Article  CAS  PubMed  Google Scholar 

  35. Heetun ZS, Byrnes C, Neary P, O’Marain C. Review article: reproduction in the patient with inflammatory bowel disease. Aliment Pharmacol Ther. 2007;26(4):513–33.

    Article  CAS  PubMed  Google Scholar 

  36. Mahadevan U. Fertility and pregnancy in the patient with inflammatory bowel disease. Gut. 2006;55(8):1198–206.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  37. Wikland M, Jansson I, Asztély M, Palselius I, Svaninger G, Magnusson O, Hultén L. Gynaecological problems related to anatomical changes after conventional proctocolectomy and ileostomy. Int J Colorectal Dis. 1990;5(1):49–52.

    Article  CAS  PubMed  Google Scholar 

  38. Oresland T, Palmblad S, Ellström M, Berndtsson I, Crona N, Hultén L. Gynaecological and sexual function related to anatomical changes in the female pelvis after restorative proctocolectomy. Int J Colorectal Dis. 1994;9(2):77–81.

    Article  CAS  PubMed  Google Scholar 

  39. Tiainen J, Matikainen M, Hiltunen KM. Ileal J-pouch-anal anastomosis, sexual dysfunction, and fertility. Scand J Gastroenterol. 1999;34(2):185–8.

    Article  CAS  PubMed  Google Scholar 

  40. Gorgun E, Remzi FH, Goldberg JM, Thornton J, Bast J, Hull TL, Loparo B, Fazio VW. Fertility is reduced after restorative proctocolectomy with ileal pouch anal anastomosis: a study of 300 patients. Surgery. 2004;136(4):795–803.

    Article  PubMed  Google Scholar 

  41. Rajaratnam SG, Eglinton TW, Hider P, Fearnhead NS. Impact of ileal pouch-anal anastomosis on female fertility: meta-analysis and systematic review. Int J Colorectal Dis. 2011;26(11):1365–74.

    Article  PubMed  Google Scholar 

  42. Johnson P, Richard C, Ravid A, Spencer L, Pinto E, Hanna M, Cohen Z, McLeod R. Female infertility after ileal pouch-anal anastomosis for ulcerative colitis. Dis Colon Rectum. 2004;47(7):1119–26.

    Article  PubMed  Google Scholar 

  43. Waljee A, Walljee J, Morris AM, Higgins PD. Threefold increased risk of fertility: a meta-analysis of infertility after ileal pouch anal anastomosis in ulcerative colitis. Gut. 2006;55(11):1575–80.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  44. Bartels SA, D’Hoore A, Cuesta MA, Bensdorp AJ, Lucas C, Bemelman WA. Significantly increased pregnancy rates after laparoscopic restorative proctocolectomy: a cross-sectional study. Ann Surg. 2012;256(6):1045–8.

    Article  PubMed  Google Scholar 

  45. Beyer-Berjot L, Maggiori L, Birnbaum D, Lefevre JH, Berdah S, Panis Y. A total laparoscopic approach reduces the infertility rate after ileal pouch-anal anastomosis: a 2-center study. Ann Surg. 2013;258(2):275–8.

    Article  PubMed  Google Scholar 

  46. Borum ML, Igiehon E, Shafa S. Physicians may inadequately address sexuality in women with inflammatory bowel disease. Inflamm Bowel Dis. 2007;13(10):1236–43.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, 60637, USA

    Julia Berian MD

  2. Department of Surgery, University of Washington School of Medicine, 1959 NE Pacific Street, Box 356410, Seattle, WA, 98195-6410, USA

    Mukta K. Krane MD

Authors
  1. Julia Berian MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mukta K. Krane MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mukta K. Krane MD .

Editor information

Editors and Affiliations

  1. Department of Surgery, University of Washington Medical Center, Seattle, Washington, USA

    Alessandro Fichera

  2. Department of Surgery, University of Washington Medical Center, Seattle, Washington, USA

    Mukta K. Krane

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Berian, J., Krane, M.K. (2015). Fertility/Sexual Function. In: Fichera, A., Krane, M. (eds) Crohn’s Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-14181-7_22

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-14181-7_22

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-14180-0

  • Online ISBN: 978-3-319-14181-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation