Abstract
High-throughput cancer genomics and bioinformatics are revolutionizing our ability to profile tumor samples. With next-generation sequencing (NGS) and high-performance computing (HPC) platforms, we have developed the infrastructures to determine and characterize tumor genomes and transcriptomes within days. Now, we are integrating these platforms into both cancer immunology and patient therapy decision-making. Here, we briefly describe the technology platforms and highlight several emerging applications: profiling of tumor mutations and gene expression; determination of HLA type and tumor expression, enabling prediction of immunogenic tumor mutations; and identification of viruses present in tumors. These and other concepts will continue to expand the medical impact of NGS.
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Acknowledgment
We warmly thank Christoph Huber for his medical and scientific forethought, advice, guidance, mentorship, and friendship.
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Castle, J.C., Boegel, S., Bukur, T., Boisguerin, V., Loewer, M. (2014). Genomics Meets Cancer Immunotherapy. In: Britten, C., Kreiter, S., Diken, M., Rammensee, HG. (eds) Cancer Immunotherapy Meets Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-05104-8_22
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DOI: https://doi.org/10.1007/978-3-319-05104-8_22
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