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Clinical Genomics in Oncology

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Molecular Genetic Pathology

Abstract

Clinical genomics can be described as the application of large-scale, high-throughput genomic technologies in clinical settings, such as clinical trials or primary care of patients. The field of clinical genomics has grown enormously by the elucidation of the full sequence of the human genome as well as the ability of large-scale surveys of gene expression, single-nucleotide polymorphisms, DNA copy number changes, and high-throughput sequencing technologies. In this chapter, we will describe methodologies and applications of clinical genomics, primarily focusing on DNA microarrays and high-throughput sequencing in breast cancer, hematological malignancies, prostate cancer, and gastrointestinal tumors.

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Authors and Affiliations

  1. Academic Medical Center, Amsterdam, The Netherlands

    Hugo M. Horlings MD, PhD (Pathologist)

  2. Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY, USA

    Thalia A. Farazi MD, PhD (Instructor in Clinical investigation, Howard Hughes Medical Institute)

  3. Head, Division of Diagnostic Oncology, NKI, Amsterdam

    Marc J. van de Vijver MD, PhD

  4. Head, Department of Pathology, NKI, Amsterdam

    Marc J. van de Vijver MD, PhD

  5. Pathologist, Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

    Marc J. van de Vijver MD, PhD

  6. Professor of Pathology, Department of Pathology, Leiden, The Netherlands

    Marc J. van de Vijver MD, PhD

  7. Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Marc J. van de Vijver MD, PhD

Authors
  1. Hugo M. Horlings MD, PhD
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  2. Thalia A. Farazi MD, PhD
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  3. Marc J. van de Vijver MD, PhD
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Editor information

Editors and Affiliations

  1. School of Medicine, Dept. Pathology, Indiana University, N. University Blvd. 550, Indianapolis, 46202, Indiana, USA

    Liang Cheng

  2. Dept. Pathology, Mount Sinai School of Medicine, Gustave L. Levy Place 1, New York, 10029, New York, USA

    David Y. Zhang

  3. School of Medicine, Department of Pathology and, Indiana University, 635 Barnhill Drive, Indianapolis, 46202, Indiana, USA

    John N. Eble

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Horlings, H.M., Farazi, T.A., van de Vijver, M.J. (2013). Clinical Genomics in Oncology. In: Cheng, L., Zhang, D., Eble, J. (eds) Molecular Genetic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4800-6_11

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