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Glioma Extent of Resection and Ultra-Low-Field iMRI: Interim Analysis of a Prospective Randomized Trial

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Intraoperative Imaging

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 109))

Abstract

Aiming at providing high-class evidence regarding the use of intraoperative MRI (ioMRI), we are conducting a prospective randomized controlled trial. Adult patients with contrast enhancing lesions suspicious of malignant gliomas scheduled to undergo radiologically complete tumor resection are eligible to enter this trial. After giving their informed consent, patients are randomized to undergo either ioMRI-guided or conventional microneurosurgical tumor resection. To assess the extent of resection, pre- and early postoperative high-field MR images are obtained to perform volumetric analyses. Primary endpoint of the study is the rate of radiologically complete tumor resections. After the inclusion of 35 patients, we performed an interim analysis. In six patients, histopathological examination revealed metastases, so they were excluded from further analyses. Thus, data from 29 patients with gliomas could be analyzed. There were no significant differences in patient age (P=0.28) or preoperative tumor sizes (P=0.40) between the two treatment groups. We observed a trend towards a higher rate of complete tumor resections in the ioMRI-group compared to the control group (P=0.07). Postoperative tumor volumes were significantly lower in the ioMRI-group than in the control group (P<0.05). The use of ioMRI appears to be associated with a higher rate of radiographically complete as well as near total tumor resections compared to conventional microneurosurgery.

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Authors and Affiliations

  1. Department of Neurosurgery, Johann-Wolfgang-Goethe-University, Schleusenweg 2-16, 60528, Frankfurt, Germany

    Christian Senft, Michael Heckelmann, Thomas Gasser & Volker Seifert

  2. Department of Neuroradiology, Johann-Wolfgang-Goethe-University, Frankfurt, Germany

    Andrea Bink

  3. Department of Neurosurgery, University of Essen, Essen, Germany

    Thomas Gasser

Authors
  1. Christian Senft
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  2. Andrea Bink
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  3. Michael Heckelmann
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  4. Thomas Gasser
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  5. Volker Seifert
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Corresponding author

Correspondence to Christian Senft .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Acibadem Hospital Kozyatagi, Inönü Cad Okur Sok 20, Kozytagi, Istanbul, 34742, Turkey

    M. Necmettin Pamir

  2. Zentrum Neurologie und, Neurochirurgie, Univ.Klinikum Frankfurt, Schleusenweg 2-16, Frankfurt, 60528, Germany

    Volker Seifert

  3. School of Medicine, Dept. Neurosurgery, University of Istanbul, Capa, Istanbul, 34390, Turkey

    Talat Kiris

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© 2011 Springer-Verlag/Wien

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Senft, C., Bink, A., Heckelmann, M., Gasser, T., Seifert, V. (2011). Glioma Extent of Resection and Ultra-Low-Field iMRI: Interim Analysis of a Prospective Randomized Trial. In: Pamir, M., Seifert, V., Kiris, T. (eds) Intraoperative Imaging. Acta Neurochirurgica Supplementum, vol 109. Springer, Vienna. https://doi.org/10.1007/978-3-211-99651-5_8

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  • DOI: https://doi.org/10.1007/978-3-211-99651-5_8

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-99650-8

  • Online ISBN: 978-3-211-99651-5

  • eBook Packages: MedicineMedicine (R0)

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