Skip to main content

Nahrungsmittelallergien und -UnvertrÄglichkeiten

  • Chapter
Klinische Ernährungsmedizin

Zusammenfassung

Unverträglichkeitsreaktionen auf Nahrungsmittel können prinzipiell immunologisch oder nicht immunologisch bedingt sein (siehe Abb. 1). Zu den nicht immunologischen Reaktionen zählen toxische Ereignisse (z. B. Nahrungsmittelvergiftung), Enzymdefekte wie bei Laktoseintoleranz, Transportdefekte wie bei der Fruktosemalabsorption, psychische Aversionen, aber auch so genannte pseudoallergische Reaktionen, zu denen etwa die Histaminintoleranz oder eine Überempfindlichkeit auf andere biogene Amine wie Glutamat („China-Restaurant-Syndrom“) zählen. Diese zuletzt genannten Krankheitsbilder sind klinisch mitunter von echten immunologischen Reaktionen, also Allergien, nicht zu unterscheiden, da in beiden Fällen Histamin den zentralen Mediator darstellt. Aus der Symptomatik allein können daher kaum Rückschlüsse auf den Pathomechanismus gezogen werden. Der Unterschied zu echten Allergien liegt darin, dass bei diesen antikörperve rmittelte und antigenspezifische Reaktionen vorliegen.

Klassifizierung von Nahrungsmittelunverträglichkeiten. Nur immunologisch mediierte Reaktionen werden als „allergisch” bezeichnet.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literaturverzeichnis

  • Burks W (2008) Diagnostic tools for food allergy. UpToDate online 16.2 (28. 08. 2008), www. uptodate. com

    Google Scholar 

  • Henzgen M, Vieths S, Reese I, Erdmann S, Fuchs T, Jäger L, Kleine-Tebbe J, Lepp U, Niggemann B, Saloga J, Vieluf I, Zuberbier T, Werfel T (2005) Nahrungsmittelallergien durch immunologische Kreuzreaktionen. Leitlinie der Arbeitsgruppe Nahrungsmittelallergie der Deutschen Gesellschaft für Allergologie und Klinische Immunologie (DGAI) und des Ärzteverbandes Deutscher Allergologen (ÄDA). Allergo J 14: 48–59

    Google Scholar 

  • Jäger L, Wüthrich B (1998) Nahrungsmittelallergien und-intoleranzen. Gustav Fischer Verlag, Ulm Stuttgart Jena Lübeck

    Google Scholar 

  • Lepp U, Ehlers I, Erdmann S, Fuchs T, Henzgen M, Kleine-Tebbe J, Niggemann B, Saloga J, Vieluf I, Vieths S, Zuberbier T, Werfel T (2002) Therapiemöglichkeiten bei der IgE-vermittelten Nahrungsmittelallergie. Positionspapier der Arbeitsgruppe Nahrungsmittelallergie der Deutschen Gesellschaft für Allergologie und Klinische Immunologie (DGAI) und des Ärzteverbandes Deutscher Allergologen (ÄDA). Allergo J 11: 156–162

    Google Scholar 

  • Stapel SO, Asero R, Ballmer-Weber BK, Knol EF, Strobel S, Vieths S, Kleine-Tebbe J (2008) Testing for IgG4 against foods is not recommended as a diagnostic tool: EAACI Task Force. Allergy 63: 793–796

    Article  PubMed  CAS  Google Scholar 

Literaturverzeichnis

  • Bergmann RL, Bergmann KE, Lau-Schadensdorf S, Luck W, Dannemann A, Bauer CP, Dorsch W, Forster J, Schmidt E, Schulz J, et al. (1994) Atopic diseases in infancy. The German multicenter atopy study (MAS-90). Pediatr Allergy Immunol 5:19–25

    Article  PubMed  CAS  Google Scholar 

  • Gore C, Custovic A (2004) Can we prevent allergy? Allergy 59:151–161

    Article  PubMed  CAS  Google Scholar 

  • Johansson SG, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF, Motala C, Ortega Martell JA, Platts-Mills TA, Ring J, Thien F, Van Cauwenberge P, Williams HC (2003) Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization. J Allergy Clin Immunol 113: 832–836

    Article  Google Scholar 

  • Niggemann B (2003) Diagnostik und Therapie der Nahrungsmittelallergie im Kindesalter. Monatsschr Kinderheilkd 151: S39–S46

    Article  Google Scholar 

  • Beyer K, Niggemann B (2005) Nahrungsmittelallergien. In: Wahn U, Seger R, Wahn V (Hrsg) Pädiatrische Allergologie und Immunologie. Urban & Fischer, S 423–428

    Google Scholar 

  • Osborn DA, Sinn J (2006) Soy formula for prevention of allergy and food intolerance in infants. Cochrane Database Syst Rev 18(4):CD003741

    Google Scholar 

  • Sicherer SH, Sampson HA (2006) Food allergy. J Allergy Clin Immunol 117: S470–S475

    Article  PubMed  CAS  Google Scholar 

  • Sicherer SH, Teuber S (2004) Adverse Reactions to Foods Committee. Current approach to the diagnosis and management of adverse reactions to foods. J Allergy Clin Immunol 114: 1146–1150

    Article  PubMed  Google Scholar 

  • Thong BY, Hourihane JO (2004) Monitoring of IgE-mediated food allergy in childhood. Acta Paediatr 93: 759–764

    Article  PubMed  CAS  Google Scholar 

  • Von Berg A, Berdel D (2006) Hypoallergene Säuglingsnahrung zur Allergieprävention. Monatsschr Kinderheilkd 154: 417–423

    Article  Google Scholar 

  • von Mutius E (2007) Allergies, infections and the hygiene hypothesis-the epidemiological evidence. Immunobiology 212: 433–439

    Article  CAS  Google Scholar 

  • Wahn U (2000) What drives the allergic march? Allergy 55: 591–599

    Article  PubMed  CAS  Google Scholar 

Literaturverzeichnis

  • Bogucki A (1990) Studies on nitroglycerin and histamine provoke cluster headache attacks. Cephalalgia 10: 71–75

    Article  PubMed  CAS  Google Scholar 

  • Jarisch R, Wantke F (1996) Wines and Headache. A Mini-Review. Int Arch Allergy Immunol 110: 7–12

    Article  PubMed  CAS  Google Scholar 

  • Jarisch R, Beringer K, Hemmer W (1999a) Role of food allergy and food intolerance in recurrent urticaria. In: Wüthrich B (ed) The Atopy Syndrome in the Third Millenium. Curr Probl Dermatol 28: 64–73

    Google Scholar 

  • Jarisch R, Hemmer W (1999b) Biogene Amine als Ursache von Unverträglichkeitsreaktionen. In: Plewig G, Wolff H (Hrsg) Fortschritte der praktischen Dermatologie und Venerologie 1998. Springer, Berlin, S 211–219

    Google Scholar 

  • Jarisch R, Wöhrl S, Focke M, Hemmer W (2001) Anaphylaktische Reaktion bei spezifischer Immuntherapie durch Diaminoxidasehemmung nach Acetylcystein-Therapie. Allergologie 24: 112–115

    Google Scholar 

  • Jarisch R, Hemmer W (2001) Nahrungsmittelallergien und-intoleranzen (State of the Art). Österr. Ärztezeitung 17: 30–36

    Google Scholar 

  • Jarisch R (2004) Histamin-Intoleranz, Histamin und Seekrankheit, Thieme, Stuttgart, S 177

    Google Scholar 

  • Jarisch R (2008) Histamin Intoleranz. Allergopinion 03/2008

    Google Scholar 

  • Ku M, Silverman B, Prifti N, Ying W, Persaud Y, Schneider A (2006) Prevalence of migraine headaches in patients with allergic rhinitis. Ann Allergy Asthma Immunol 97: 226–230

    Article  PubMed  Google Scholar 

  • Lassen LH, Heinig JH, Oestergaard S, Olesen J (1996) Histamin inhalation is a specific but intensive laboratory test for migraine. Cephalalgia 16: 550–553

    Article  PubMed  CAS  Google Scholar 

  • Maintz L, Bieber T, Novak N (2006) Die verschiedenen Gesichter der Histamin-Intoleranz. Dtsch Ärztebl 103: A3477–A3483

    Google Scholar 

  • Maintz L, Benfadal S, Allam JP, Hagemann T, Fimmers R, Novak N(2006) Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema. J Allergy Clin Immunol 117: 1106–1112

    Article  PubMed  CAS  Google Scholar 

  • Mayer I, Missbichler A, Wantke F, Focke M, Reichl H, Winter M, Jarisch R (2005) Optimierter Radioextraktionsassay zur quantitativen Bestimmung der Aktivität von Diaminooxidase (DAO) in humanem Serum und Plasma. Allergologie 28: 1–8

    Google Scholar 

  • Steinbrecher I, Jarisch R (2005) Histamin und Kopfschmerz. Allergologie 28: 85–91

    Google Scholar 

  • Togha M, Ashrafian H, Tajik P (2006) Open-label trial of cinnarizine in migraine prophylaxis. Headache 46: 498–502

    Article  PubMed  Google Scholar 

  • Wantke F, Götz M, Jarisch R (1993) Histamine free diet: treatment of choice for histamine induced food intolerance and supporting treatment for chronical headaches. Clin Exp Allergy 23: 982–985

    Article  PubMed  CAS  Google Scholar 

  • Wantke F, Hemmer W, Haglmüller T, Götz M, Jarisch R (1996) Histamine in wine: bronchoconstriction after a double blind placebo controlled provocation test. A case report. Int Arch Allergy Immunol 110: 397–400

    Article  PubMed  CAS  Google Scholar 

  • Wöhrl S, Hemmer W, Focke M, Rappersberger K, Jarisch R (2004) Histamine intolerance-like symptoms in healthy volunteers by oral prococation with liquid histamine. Allergy Asthma Proc 25: 305–311

    PubMed  Google Scholar 

  • Wu SF, Chen W (2003) An outbreak of scombroid fish poisoning in a kindergarden. Acta Paediatr Taiwan 44: 297–299

    PubMed  Google Scholar 

Literaturverzeichnis

  • Arya S (1984) Rotaviral infection and intestinal lactase level. J Infect Dis 150(5): 791

    PubMed  CAS  Google Scholar 

  • Bethge R (2002) Isolierung des humanen Lactasegens und seine Expression in der Hefe Pichia pastoris. Dissertation, Institut für Technische Biochemie der Universität Stuttgart

    Google Scholar 

  • Boudreau F, Rings EH, Van Wering HM, Kim RK, Swain GP, Krasinski SD, Moffett J, Grand RJ, Suh ER, Traber PG (2002) Hepatocyte-nuclear-factor-1alpha (HNF-1alpha), GATA-4 and caudal-related homeodomain protein Cdx 2 functionally interact to modulate intestinal gene transcription: implication for the developmental regulation of the sucrase-isomaltase gene. J Biol Chem 277: 31909–31917

    Article  PubMed  CAS  Google Scholar 

  • Boudreau F, Zhu Y, Traber PG (2001) Sucrase-isomaltase gene transcription requires the hepatocyte nuclear factor-1 (hnf-1) regulatory element and its regulated by the ratio of hnf-1 alpha to hnf-1beta. J Biol Chem 276: 32122–32128

    Article  PubMed  CAS  Google Scholar 

  • Buller H, Kothe MJC, Goldman DA, Grubman SA, Sasak WV, Matusdaira PT, Montgomery RK, Grand RJ (1990) Coordinate expression of lactase-phlorizin hydrolase mRNA and enzyme levels in rat intestine during development. J Biol Chem 265: 6978–6983

    PubMed  CAS  Google Scholar 

  • Buller H, Montgomery RK, Sasak WV, Grand RJ (1987) Biosynthesis, glycosylation and intracellular transport of intestinal lactase-phlorizin hydrolase in rat. J Biol Chem 262(35): 17206–17211

    PubMed  CAS  Google Scholar 

  • Buning C, Genschel J, Jurga J Fiedler T, Voderholzer W, Fiedler EM, Weltrich R, Lochs H, Schmidt H, Ockenga J (2005) Introducing genetic testing for adult-type hypolactasia. Digestion 71(4): 245–250

    Article  PubMed  Google Scholar 

  • Dahlqvist A, Hammond JD, Crane RK, Dunphy JV, Littman A (1963) Intestinal lactase deficiency and lactose intertolerance in adults: preliminary report. Gastroenterology 45: 488–491

    PubMed  CAS  Google Scholar 

  • Danielsen E, Cowell GM (1984) Biosynthesis of intestinal microvillar proteins. Further characterization of the intracellular processing and transport. FEBS Lett 166(1): 28–32

    Article  PubMed  CAS  Google Scholar 

  • Divine J, Staloch LJ, Haveri H, Jacobsen CM, Wilson DB, Heikinheimo M, Simon TC (2004) GATA-4, GATA-5 and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1 (alpha). Am J Phy-Physiol Gastrointest Liver Physiol 287: 1086–1099

    Article  CAS  Google Scholar 

  • Durand P (1958) Lactosuria idiopathica in una paziente con diarrea ad acidi. Minerva Pediat 10: 706–711

    PubMed  CAS  Google Scholar 

  • Enattah N, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Jarvela I (2002) Identification of a variant associated with adult-type hypolactasia. Nat Genet 30(2): 233–237

    Article  PubMed  CAS  Google Scholar 

  • Escaffit F, Boudreau F, Beaulieu JF (2004) Differential expression of claudin-2 along the human intestine: implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. J Cell Physiol: 11–16

    Google Scholar 

  • Escher J, de Koning ND, van Engen CG, Arora S, Buller HA, Montgomery RK, Grand RJ (1992) Moleculs basis of lactase levels in adult humans. J Clin Invest 89(2): 480–483

    Article  PubMed  CAS  Google Scholar 

  • Fang R, Olds LC, Santiago NA, Sibley E (2001) GATA family transcription factors activate lactase gene promoter in intestinal Caco-2 cells. Am J Physiol Gastrointest Liver Physiol 280: 58–67

    Google Scholar 

  • Fernandez-Banares F, Gassull MA (1994) Accuracy of breath H2 criteria to detect carbohydrate malabsorption. Gastroenterology 107(1): 323–324

    PubMed  CAS  Google Scholar 

  • Freeman T, Collins AJ, Heavens RP, Tivey DR (1993) Genetic regulation of enterocyte function; a quantitative in situ hybridisation study of lactase-phlorizin hydro-lase Na(+)-glucose co transporter mRNAs in rabbit small intestine. Pflugers Arch 422: 570–576

    Article  PubMed  CAS  Google Scholar 

  • Freund J, Jost B, Duluc I, Morel G (1995) Ultrastructural stuy of intestinal lactase expression. Biol Cell 83: 211–217

    Article  PubMed  CAS  Google Scholar 

  • Grabnitz F, Seiss M, Rucknagel KP, Staudenbauer WL (1991) Structure of the beta-glucosidase gene bglA of Clostridium thermocellum. Sequence analysis reveals a superfamily of cellulases and beta-gylcosidases including human lactase/phlorizin hydrolase. Eur J Biochem 200(2): 301–309

    Article  PubMed  CAS  Google Scholar 

  • Greenberger N, Isselbacher KJ (1998) Disorders of absorption. In: Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL (eds) Harrison’s Principles of Internal Medicine. McGraw-Hill, New York, pp 1630–631

    Google Scholar 

  • Gregory P, Lewinsky RH, Gardner-Stephen DA, Mackenzie PI (2004) Coordinate regulation of the human UDP-glucuronosyltransferase 1A8, 1A9 and 1A10 genes by hepatocyte nuclear factor 1 (alpha) and the caudal-related homeodomain protein 2. Mol Pharmacol 65: 953–963

    Article  PubMed  CAS  Google Scholar 

  • Gudmand-Hoyer E, Skovbjerg H (1996) Disaccharide digestion and maldigestion. Scand J Gastroenterol 216: 111–121

    Article  CAS  Google Scholar 

  • Hammer HF FK, Santa Ana CA, Porter JL, Schiller LR, Fordtran JS (1990) Carbohydrate malaborption: Its measurement and its contribution to diarrhea. J Clin Invest 86: 1936–1944

    Article  PubMed  CAS  Google Scholar 

  • Harvey CB, Fox MF, Jeggo PA, Mantei N, Povey S, Swallow DM (1993) Regional localization of the lactase-phlorizin hydrolase gene, LCT, to chromosome 2q21. Ann Hum Genet 57: 179–185

    Article  PubMed  CAS  Google Scholar 

  • Hauri H, Sterchi EE, Bienz D, Fransen JA, Marxer A (1985) Expression and intracellular transport of microvillus membrane hydrolases in human intestinal epithelial cells. J Cell Biol 101(3): 838–851

    Article  PubMed  CAS  Google Scholar 

  • Heitlinger L, Lebenthal E (1988) Disorders of carbohydrate digestion and absorption. Pediatr Clin North Am 35(2): 239–255

    PubMed  CAS  Google Scholar 

  • Jarvela I, Enattah NS, Kokkonen J, Varilo T, Savilahti E, Peltonen L (1998) Assignment of the locus for congential lactase deficiency to 2q21, in the vicinity of but separate from the lactase-phlorizin hydrolase gene. Am J Hum Genet 63(4): 1078–1085

    Article  PubMed  CAS  Google Scholar 

  • Johnson JD, Simoons FJ, Hurwitz R, Grange A, Mitchell CH, Sinatra FR, Sunshine P, Robertson WV, Bennett PH, Kretchmer N (1977) Lactose malabsorption among Pima indians of Arizona. Gastroenterology 73: 1299–1304

    PubMed  CAS  Google Scholar 

  • Keller P, Zwicker E, Mantei N, Semenza G (1992) The levels of lactase and of sucrase-isomaltase along the rabbit small intestine are regulated both at the mRNA level and post-translationally. FEBS Lett 313: 265–269

    Article  PubMed  CAS  Google Scholar 

  • Krasinski S, Van Wering HM, Tannemaat MR, Grand RJ (2001) Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha. Am J Physiol Gastrointest Liver Physiol 281: 69–84

    Google Scholar 

  • Kruse T, Bolund L, Grzeschuj KH, Ropers HH, Sjostrom H, Noren O, Mantei N, Semenza G (1988) The human lactase-phlorizin hydrolase gene is located on chromosome 2. FEBS Lett 240(1–2): 123–126

    Article  PubMed  CAS  Google Scholar 

  • Kuokkanen M, Enattah NS, Oksanen A, Savilahti E, Orpana A, Jarvela I (2003) Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia. GUT 52(2): 647–652

    Article  PubMed  CAS  Google Scholar 

  • Ledochowski M, Sperner-Unterweger B, Fuchs D (1998) Lactose malabsorption is associated with early signs of mental depresssion in females. Dig Dis Sci 43: 2513–2517

    Article  PubMed  CAS  Google Scholar 

  • Ledochowski M, Widner B, Sperner-Unterweger B, Propst T, Vogel W, Fuchs D (2000) Carbohydrate malabsorption syndromes and early signs of mental depression in females. Dig Dis Sci 45: 1255–1259

    Article  PubMed  CAS  Google Scholar 

  • Lembcke B (1996) Current role of breath tests in gastroenterology. Gastroenterol (Suppl): 46–53

    Google Scholar 

  • Lin L, See M, Wang NK (1990) Breath hydrogen test for assessment of lactose malabsorption following rotavirus gastroenteritits. J Formos Med Assoc 89(12): 1072–1076

    PubMed  CAS  Google Scholar 

  • Lloyd M, Mevissen G, Fischer M, Olsen W, Goodspeed D, Genini M, Boll W, Semenza G, Mantei N (1992) Regulation of intestinal lactase in adult hypolactasia. J Clin Invest 89(2): 524–529

    Article  PubMed  CAS  Google Scholar 

  • Mantei N, Villa M, Enzler T; Wacker H, Boll W, James P, Hunziker W, Semenza G (1988) Complete primary structure of human and rabbit lactase-phlorizin hydrolase: implications for biosynthesis, membrane anchoring and evolution of the enzyme. EMBO J 7(9): 2705–2713

    PubMed  CAS  Google Scholar 

  • Marsh M, Riley SA (1998) Digestion and absorption of nutrients and vitamins. Saunders Corp, Philadelphia

    Google Scholar 

  • Mitchelmore C, Troelsen JT, Sjostrom H, Noren O (1998) The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1alpha-dependent transcription. Biochem J 273: 13297–13306

    CAS  Google Scholar 

  • Naim H, Lentze MJ (1992) Impact of O-glycosylation on the function of human intestinal lactase-phlorizin hydrolase. Characterization of glycoforms varying in enzyme activity and localization of O-glycoside addition. J Biol Chem 267(35): 25494–25504

    PubMed  CAS  Google Scholar 

  • Naim H, Sterchi EE, Lentze MJ (1987) Biosynthesis and maturation of lactase-phlorizin hydrolase in the human small intestinal epithelial cells. Biochem J 241(2): 427–434

    PubMed  CAS  Google Scholar 

  • Oberholzer T, Mantei N, Semenza G (1993) The pro sequence of lactase-phlorizin hydrolase is required for the enzyme to reach tha plasma membrane. An intramolecular chaperone? FEBS Lett 333(1–2): 127–131

    Article  PubMed  CAS  Google Scholar 

  • Olds L, Sibley E (2003) Lactase persistence DNA variant enhances lactase promotor activity in vitro. Functional role as a cis regulatory element. Hum Mol Genet 12(18): 2333–2340

    Article  PubMed  CAS  Google Scholar 

  • Olsen J, Laustsen L, Troelsen JT (1994) HNF1-alpha activates the amino-peptidase N promoter in intestinal (Caco-2) cells. FEBS Lett 342: 325–328

    Article  PubMed  CAS  Google Scholar 

  • Payne D, Welsh JD, Claypool PL (1983) Breath hydrogen (H2) response to carbohydrate malabsorption after exercise. J Lab Clin Med 102: 147–150

    PubMed  CAS  Google Scholar 

  • Potter J, Ho MW, Bolton H, Furth AJ, Swallow DM, Griffiths B (1985) Human lactase and the molecular basis of lactase persistence. Biochem Genet 23: 423–439

    Article  PubMed  CAS  Google Scholar 

  • Rings E, Krasinski SD, van Beers EH, Moormann AF, Dekker J, Grand RJ, Buller HA (1994) Restriction of lactase gene expression along the proximal-to-distal axis of rat small intestine occurs during postnatal development. Gastoenterology 106: 1223–1232

    CAS  Google Scholar 

  • Rosenkranz W, Hadorn B, Muller W, Heinz-Erian P, Hensen C, Flatz G (1982) Distribution of human adult lactose phentotypes in the population of Austria. Hum Genet 62(2): 158–161

    Article  PubMed  CAS  Google Scholar 

  • Rosenthal A, Solomons NW (1983) Time-course of cigarette smoke contamination of clinical hydrogen breath-analysis tests. Clin Chem 29: 1980–1981

    PubMed  CAS  Google Scholar 

  • Rusynyk R, Still CD (2001) Lactose Intolerance. J Am Osteopath Assoc 101(4 Suppl Pt 1): 10–12

    Google Scholar 

  • Saavedra J, Perman JA (1989) Current concepts in lactose malabsorption and intolerance. Annu Rev Nutr 9: 475–502

    Article  PubMed  CAS  Google Scholar 

  • Sahi T (1994) Genetics and epidemiology of adult-type hypolactasia. Scand J Gastroenterol 202(Suppl): 7–20

    Article  CAS  Google Scholar 

  • Skovbjerg H, Danielsen EM, Noren O, Sjostrom H (1984) Evidence for biosynthesis of lactase-phlorizin hydrolase as a single-chain high-molecular weight precursor. Biochim Biophys Acta 798(2): 247–251

    PubMed  CAS  Google Scholar 

  • Souci S, Fachmann W, Kraut H (2000) Food Composition and Nutrition Tables. med-pharm Verlag, Stuttgart

    Google Scholar 

  • Swagerty DJ, Walling AD, Klein RM (2002) Lactose intolerance. Am Fam Physican 65(9): 1845–1850

    Google Scholar 

  • Taylor J, Boll W, Levy T, Suh E, Siang S, Mantei N, Traber PG (1997) Comparison of intestinal phospholipase A/lysophospholipase and sucrase-isomaltase genes suggest a common structure for enterocyte-specific promoters. DNA Cell Biol 16: 1419–1428

    Article  PubMed  CAS  Google Scholar 

  • Thompson D, Binfield P, De Belder A, O’Brien J, Warren S, Wilsan M (1985) Extra intestinal influences on exhaled breath hydrogen measurements during the investigation of gastrointestinal disease. GUT 26(2): 1349–1352

    Article  PubMed  CAS  Google Scholar 

  • Torp N, Rossi M, Troelsen JT, Olsen J, Danielsen EM (1993) Lactase-phlorizin hydrolase and aminopeptidase N are differentially regulated in the small intestine of the pig. Biochem J 295: 177–182

    PubMed  CAS  Google Scholar 

  • Troelsen J, Mitchelmore C, Spodsberg N, Jensen AM, Noren O, Sjostrom H (1997) Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homeodomain protein Cdx-2. Biochem J 322: 833–838

    PubMed  CAS  Google Scholar 

  • Van Wering H, Bosse T, Musters A, de Jong E, de Jong N, Hogen-Esch CE, Boudreau F, Swain GP, Dowling LN, Montgomery RK, Grand RJ, Krasinski SD (2004) Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4. Am J Physiol Gastrointest Liver Physiol 287: 899–909

    Article  Google Scholar 

  • Van Wering H, Huibregtse IL, Van der Zwan SM, De Bie MS, Dowling LN, Grand RJ, Krasinski SD (2002a) Physical interaction between GATA-5 and HNF-1 alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter. J Biol Chem 277: 27659–27667

    Article  PubMed  CAS  Google Scholar 

  • Van Wering H, Moyer L, Grand RJ, Krasinski SD (2002b) Novel interaction at the Cdx-2 binding sites of the lactase-phlorizin hydrolase promotor. Biochem Biophys Res Commun 299: 587–593

    Article  PubMed  CAS  Google Scholar 

  • Verhave M, Krasinski SD, Christian SI, Van Schaik S, Van Den Brink GR, Doting EM, Maas SM, Wolthers KC, Grand RJ, Montgomery RK (2004) Regulatory regions in the rat lactase-phlorizin hydrolase gene that control cell-specific expression. J Pediatr Gastroenterol Nutr 39: 275–285

    Article  PubMed  CAS  Google Scholar 

  • Vesa T, Marteau P, Korpela R (2000) Lactose intolerance. J Am Coll Nutr 19(2): 165–175

    Google Scholar 

  • Villa M, Brunschwiler D, Gächter T, Boll W, Semenza G, Mantei N (1993) Region-specific expression of multiple lactase-phlorizin hydrolase genes in intestine of rabbit. FEBS 336(1): 70–74

    Article  CAS  Google Scholar 

  • Villako K, Maaroos H (1994) Clinical picture of hypolactasia and lactose intolerance. Scand J Gastroenterol 202(Suppl): 36–54

    Article  CAS  Google Scholar 

  • Wacker H, Keller P, Falchetto R, Legler G, Semenza G (1992) Location of the two catalyric sites in intestinal lactase-phlorizin hydrolase. Comparison with sucrase-isomaltase and with other glycosidases, the membrane anchor of lactase-phlorizin hydrolase. J Biol Chem 267(26): 18744–18752

    PubMed  CAS  Google Scholar 

  • Wu G, Chen L, Forslund K, Traber PG (1994) Hepatocyte nuclear factor-1 alpha (HNF-1 alpha) and HNF-1 beta regulate transcription via two elements in an intestine-specific promoter. J Biol Chem 269: 17080–17085

    PubMed  CAS  Google Scholar 

Literaturverzeichnis

  • Archer S, Meng S, Wu J, Johnson J, Tang R, Hodin R (1998) Butyrate inhibits colon carcinoma cell growth through two distinct pathways. Surgery 124: 248–253

    PubMed  CAS  Google Scholar 

  • BGVV — Bundesinstitut für gesundheitlichen Verbraucherschutz und Veterinärmedizin (1999) Bundeslebensmittelschlüssel (BLS), version II.3. Bundesinstitut für gesundheitlichen Verbraucherschutz und Veterinärmedizin, Berlin

    Google Scholar 

  • Born P, Vierling T, Barina W (1991) Fructose malabsorption and the irritable bowel syndrome. Gastroenterology 101: 1454

    PubMed  CAS  Google Scholar 

  • Born P, Zech J, Lehn H, Classen M, Lorenz R (1995) Colonic bacterial activity determines the symptoms in people with fructose-malabsorption. Hepatogastroenterology 42: 778–785

    PubMed  CAS  Google Scholar 

  • Born P, Zech J, Stark M, Classen M, Lorenz R (1994) [Carbohydrate substitutes: comparative study of intestinal absorption of fructose, sorbitol and xylitol]. Med Klin (Munich) 89: 575–578

    CAS  Google Scholar 

  • Camilo E, Zimmerman J, Mason JB, Golner B, Russell R, Selhub J, Rosenberg IH (1996) Folate synthesized by bacteria in the human upper small intestine is assimilated by the host. Gastroenterology 110: 991–998

    Article  PubMed  CAS  Google Scholar 

  • Choi YK, Johlin FC, Jr., Summers RW, Jackson M, Rao SS (2003) Fructose intolerance: an under-recognized problem. Am J Gastroenterol 98: 1348–1353

    Article  PubMed  CAS  Google Scholar 

  • Cox TM (1988) Hereditary fructose intolerance. Q J Med 68: 585–594

    PubMed  CAS  Google Scholar 

  • Dainese R, Galliani EA, De Lazzari F, Di Leo V, Naccarato R (1999) Discrepancies between reported food intolerance and sensitization test findings in irritable bowel syndrome patients. Am J Gastroenterol 94: 1892–1897

    Article  PubMed  CAS  Google Scholar 

  • Dills WL, Jr. (1993) Protein fructosylation: fructose and the Maillard reaction. Am J Clin Nutr 58: 779S–787S

    PubMed  CAS  Google Scholar 

  • Ferraris RP (2001) Dietary and developmental regulation of intestinal sugar transport. Biochem J 360: 265–276

    Article  PubMed  CAS  Google Scholar 

  • Florent C, L’Hirondel C, Desmazures C, Aymes C, Bernier JJ (1981) Intestinal clearance of alpha 1-antitrypsin. A sensitive method for the detection of protein-losing enteropathy. Gastroenterology 81: 777–780

    PubMed  CAS  Google Scholar 

  • Fujisawa T, Mulligan K, Wada L, Schumacher L, Riby J, Kretchmer N (1993) The effect of exercise on fructose absorption. Am J Clin Nutr 58: 75–79

    PubMed  CAS  Google Scholar 

  • Gitzelmann R, Baerlocher K (1973) Vorteile und Nachteile der Fructose in der Nahrung. Pädiat Fortbildung Praxis 37: 40

    CAS  Google Scholar 

  • Hill MJ (1995) Role of gut bacteria in human toxicology and pharmacology, 1 edn. Taylor and Francis, London

    Google Scholar 

  • Hill MJ (1997) Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 6Suppl 1: S43–S45

    Article  PubMed  Google Scholar 

  • Hungin AP, Whorwell PJ, Tack J, Mearin F (2003) The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40,000 subjects. Aliment Pharmacol Ther 17: 643–650

    Article  PubMed  CAS  Google Scholar 

  • Ledochowski M, Sperner-Unterweger B, Widner B, Fuchs D (1998) Fructose malabsorption is associated with early signs of mental depression. Eur J Med Res 3: 295–298

    PubMed  CAS  Google Scholar 

  • Ledochowski M, Uberall F, Propst T, Fuchs D (1999) Fructose malabsorption is associated with lower plasma folic acid concentrations in middle-aged subjects. Clin Chem 45: 2013–2014

    PubMed  CAS  Google Scholar 

  • Ledochowski M, Widner B, Murr C, Fuchs D (2001a) Decreased serum zinc in fructose malabsorbers. Clin Chem Lab Med 47: 745–747

    CAS  Google Scholar 

  • Ledochowski M, Widner B, Murr C, Sperner-Unterweger B, Fuchs D (2001b) Fructose malabsorption is associated with decreased plasma tryptophan. Scand J Gastroenterol 36: 367–371

    Article  PubMed  CAS  Google Scholar 

  • Ledochowski M, Widner B, Sperner-Unterweger B, Propst T, Vogel W, Fuchs D (2000) Carbohydrate malabsorption syndromes and early signs of mental depression in females. Dig Dis Sci 45: 1255–1259

    Article  PubMed  CAS  Google Scholar 

  • Ledochowski M (2008) H2-Atemteste. Akademie f. Ernährungsmedizin GmbH-Verlag, Innsbruck

    Google Scholar 

  • Mearin F, Roset M, Badia X, Balboa A, Baro E, Ponce J, Diaz-Rubio M, Caldwell E, Cucala M, Fueyo A, Talley NJ (2004) Splitting irritable bowel syndrome: from original Rome to Rome II criteria. Am J Gastroenterol 99: 122–130

    Article  PubMed  Google Scholar 

  • Rumessen JJ (1992) Fructose and related food carbohydrates. Sources, intake, absorption, and clinical implications. Scand J Gastroenterol 27: 819–828

    Article  PubMed  CAS  Google Scholar 

  • Rumessen JJ, Gudmand-Hoyer E (1988) Functional bowel disease: malabsorption and abdominal distress after ingestion of fructose, sorbitol, and fructose-sorbitol mixtures. Gastroenterology 95: 694–700

    PubMed  CAS  Google Scholar 

  • Saito YA, Locke GR, Talley NJ, Zinsmeister AR, Fett SL, Melton LJ, III (2000) A comparison of the Rome and Manning criteria for case identification in epidemiological investigations of irritable bowel syndrome. Am J Gastroenterol 95: 2816–2824

    Article  PubMed  CAS  Google Scholar 

  • Scheppach W, Sommer H, Kirchner T, Paganelli GM, Bartram P, Christl S, Richter F, Dusel G, Kasper H (1992) Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis. Gastroenterology 103: 51–56

    PubMed  CAS  Google Scholar 

  • Souci SW, Fachmann W, Kraut H (2005) Die Zusammensetzung der Lebensmittel. Nährwerttabellen. Medpharm Scientific Publishers, Stuttgart

    Google Scholar 

  • Veligati LN, Treem WR, Sullivan B, Burke G, Hyams JS (1994) Delta 10 ppm versus delta 20 ppm: a reappraisal of diagnostic criteria for breath hydrogen testing in children. Am J Gastroenterol 89: 758–761

    PubMed  CAS  Google Scholar 

  • Wantke F, Gotz M, Jarisch R (1993) Histamine-free diet: treatment of choice for histamine-induced food intolerance and supporting treatment for chronic headaches. Clin Exp Allergy 23: 982–985

    Article  PubMed  CAS  Google Scholar 

  • Wasserman D, Hoekstra JH, Tolia V, Taylor CJ, Kirschner BS, Takeda J, Bell GI, Taub R, Rand EB (1996) Molecular analysis of the fructose transporter gene (GLUT5) in isolated fructose malabsorption. J Clin Invest 98: 2398–2402

    Article  PubMed  CAS  Google Scholar 

  • Wood IS, Trayhurn P (2003) Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr 89: 3–9

    Article  PubMed  CAS  Google Scholar 

  • Wuthrich B (1998) Food-induced cutaneous adverse reactions. Allergy 53: 131–135

    Article  PubMed  CAS  Google Scholar 

Literaturverzeichnis

  • Castle L (2007) Chemical migration into food: an overview. In: Karen, Barnes, Sinclair, Watson (eds) Chemical Migration and Food Contact Materials. Woodhead Publishing Ltd, Cambridge, pp. 1–13

    Google Scholar 

  • Dekant W, Vamvakas S (2005) Spektrum Lehrbuch: Toxikologie Eine Einführung für Chemiker, Biologen und Pharamzeuten. Elsevier Spektrum Akademischer Verlag, Heidelberg Berlin Oxford

    Google Scholar 

  • EG (2002) Verordnung (EG) Nr. 178/2002 des Europäischen Parlamentes und des Rates vom 28. Januar 2002 zur Festlegung der allgemeinen Grundsätze und Anforderungen des Lebensmittelrechts, zur Errichtung der Europäischen Behörde für Lebensmittelsicherheit und zur Festlegung von Verfahren zur Lebensmittelsicherheit, Amtsblatt der Europäischen Union vom 1. 2. 2002, L31/1–24

    Google Scholar 

  • EG (2004) Verordnung (EG) Nr. 1935/2004 des Europäischen Parlamentes und des Rates vom 27. Oktober 2004 über Materialien und Gegenstände, die dazu bestimmt sind, mit Lebensmitteln in Berührung zu kommen und zur Aufhebung der Richtlinien 80/590/EWG und 89/109/EWG, Amtsblatt der Europäischen Union vom 13. 11. 2004, L338/4–17

    Google Scholar 

  • EG (2007) Richtlinie 2007/19/EG der Kommission vom 30. März 2007 zur Änderung der Richtlinie 2002/72/EG über Materialien und Gegenstände aus Kunststoff, die dazu bestimmt sind, mit Lebensmitteln in Berührung zu kommen, und der Richtlinie 85/572/EWG des Rates über die Liste der Simulanzlösemittel für die Migrationsuntersuchungen von Materialien und Gegenständen aus Kunststoff, die dazu bestimmt sind, mit Lebensmitteln in Berührung zu kommen. Amtsblatt der Europäischen Union vom 31. März 2007, L91/17–36

    Google Scholar 

  • EFSA — European Food Safety Authority (2005) Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to 2-Isopropyl thioxanthone (ITX) and 2-ethylhexyl-4-dimethylaminobenzoate (EHDAB) in food contact materials. The EFSA Journal 293, 1–15

    Google Scholar 

  • EFSA European Food Safety Authority (2006) Food Contact Materials: Note for Guidance http://www.efsa.europa.eu/EFSA/Scientific_Document/afc_noteforguidancefcm_en1,0.pdf

    Google Scholar 

  • Franz R, Störmer A (2008) Migration of Plastics Constituents. In: Piringer O, Baner AL (eds) Plastic Packaging — Interactions with Foods and Pharmaceuticals. Wiley — VCH, Weinheim, pp 349–416

    Google Scholar 

  • Franz R (2005) Migration modelling from food contact plastics into foodstuffs as a new tool for consumer exposure estimation. Food Additiv Contam 22: 920–937

    Article  CAS  Google Scholar 

  • Löser E, Wölfle D (2007) Stoffe aus Materialien im Kontakt mit Lebensmitteln. In: Dunkelberg H, Giebel T, Hartwig A (Hrsg) Handbuch der Lebensmitteltoxikologie. Wiley-VCH Verlag, Weinheim

    Google Scholar 

  • Madle S, Broschinski L, Mosbach-Schulz O, Schöning G, Schulte A (2003) Zur aktuellen Risikobewertung von Acrylamid in Lebensmitteln. Bundesgesundheitsbl-Gesundheitsforsch-Gesundheitsschutz 46: 405–415

    Article  Google Scholar 

  • Paseiro P, Simoneau C, Franz R (eds) (2006) Compilation of analytical methods for model migrants in foodstuffs: Collection of method descriptions. European Report EUR 22232 EN, ISSN 1018-5593. European Commission — Joint Research Centre

    Google Scholar 

  • Piringer O, Baner AL (eds) (2008) Packaging — Interactions with Foods and Pharmaceuticals. Wiley-VCH, Weinheim

    Google Scholar 

  • Sanches-Silva A, Cruz Freire JM, Franz R, Paseiro-Losada P (2008) Time-temperature study of the kinetics of migration of diphenylbutadiene from polyethylene films into aqueous foodstuffs. Food Research International 41: 138–144

    Article  CAS  Google Scholar 

  • Schäfer A (2007) Regulation of food contact materials in the EU. In: Karen, Barnes, Sinclair, Watson (eds) Chemical Migration and Food Contact Materials. Woodhead Publishing Ltd, Cambridge, pp 43–63

    Google Scholar 

  • Sendón García R, Sanches Silva A, Cooper I, Franz R, Paseiro Losada P (2006) Revision of analytical strategies to evaluate different migrants from food packaging materials. Trends in Food Science & Technology 17: 354–366

    Article  CAS  Google Scholar 

  • Welle F (2007) Alltäglich und doch unscheinbar: Lebensmittelverpackungen. Chemie in unserer Zeit 41: 96–106

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag/Wien

About this chapter

Cite this chapter

Reider, N. et al. (2010). Nahrungsmittelallergien und -UnvertrÄglichkeiten. In: Ledochowski, M. (eds) Klinische Ernährungsmedizin. Springer, Vienna. https://doi.org/10.1007/978-3-211-88900-8_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-211-88900-8_15

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-88899-5

  • Online ISBN: 978-3-211-88900-8

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics