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Cell Cycle Regulators and Mechanisms of Growth Control Evasion in Lung Cancer

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Clinical and Biological Basis of Lung Cancer Prevention

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

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Abstract

The last several years have seen an explosion in our understanding of the components and mechanisms involved in regulation of the eukaryotic cell cycle. The explosion began with the discovery of cyclins and the identification of Xenopus maturation promoting factor as a complex of cyclin B and a cdc2-related protein kinase [1]. Since then cyclins and the cyclindependent kinases (CDKs) have been identified as the key mediators of cell cycle progression, and the cast of known players has expanded to include cyclins A, B1, B2, C, D1-3, E, F, G, H, and I and CDKs 1–7, as well as inhibitors and mediators of CDK activity [2-5].

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References

  1. Minshull J (1993) Cyclin synthesis: who needs it? BioEssays 15: 149–155.

    Article  PubMed  CAS  Google Scholar 

  2. Grana X, Reddy EP (1995) Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 11: 211–219.

    PubMed  CAS  Google Scholar 

  3. Nigg EA (1995) Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. Bio Essays 17: 471–480.

    CAS  Google Scholar 

  4. Pines J (1993) Cyclins and cyclin-dependent kinases: take your partners. Trends Biochem Sci 18: 195–197.

    Article  PubMed  CAS  Google Scholar 

  5. Sherr CJ (1993) Mammalian G1 cyclins. Cell 73: 1059–1065.

    Article  PubMed  CAS  Google Scholar 

  6. Morgan DO (1995) Principles of CDK regulation. Nature 374: 131–134.

    Article  PubMed  CAS  Google Scholar 

  7. Kato JY, Sherr CJ (1993) Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1. Proc Natl Acad Sci USA 90: 11513–11517.

    Article  PubMed  CAS  Google Scholar 

  8. Baldin V, Lukas J, Marcote MJ, Pagano M, Draetta G (1993) Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes and Dev 7: 812–821.

    Article  PubMed  CAS  Google Scholar 

  9. Tarn SW, Theodoras AM, Shay JW, Draetta GF, Pagano M (1994) Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression. Oncogene 9: 2663–2674.

    Google Scholar 

  10. Bartkova J, Lukas J, Müller H, Lützhoft D, Strauss M, Bartek J (1994) Cyclin D1 protein expression and function in human breast cancer. Int J Cancer 57: 353–361.

    Article  PubMed  CAS  Google Scholar 

  11. Sherr CJ (1994) G1 phase progression: cycling on cue. Cell 79: 551–555.

    Article  PubMed  CAS  Google Scholar 

  12. Böhmer R-M, Scharf E, Assoian RK (1996) Cytoskeletal Integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1. Molec Biol Cell 7:101–111.

    PubMed  Google Scholar 

  13. Marx J (1994) How cells cycle towards cancer. Science 263: 319–321.

    Article  PubMed  CAS  Google Scholar 

  14. Motokura T, Arnold A (1993) Cyclin D and oncogenesis. Curr Opin in Genet Devel 3:5–10.

    Article  CAS  Google Scholar 

  15. Hunter T, Pines J (1994) Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell 79: 573–582.

    Article  PubMed  CAS  Google Scholar 

  16. Lew DJ, Dulic V, Reed SI (1991) Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell 66: 1197–1206.

    Article  PubMed  CAS  Google Scholar 

  17. Xiong Y, Connolly T, Futcher B, Beach D (1991) Human D-type cyclin. Cell 65: 691–699.

    Article  PubMed  CAS  Google Scholar 

  18. Withers DA, Harvey RC, Faust JB, Melnyk O, Carey K, Meeker TC (1991) Characterization of a candidate bcl-1 gene. Molec Cell Biol 11: 4846–4853.

    PubMed  CAS  Google Scholar 

  19. Rosenberg CL, Wong E, Petty EM, Bale AE, Tsujimoto Y, Harris NL, Arnold A (1991) PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma. Proc Natl Acad Sci USA 88: 9638–9642.

    Article  PubMed  CAS  Google Scholar 

  20. Ando K, Ajchenbaum-Cymbalista F, Griffin JD (1993) Regulation of G1/S transition by cyclins D2 and D3 in hematopoietic cells. Proc NatlAcad Sci USA 90: 9571–9575.

    Article  CAS  Google Scholar 

  21. Ohtsubo M, Roberts JM (1993) Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science 259: 1908–191

    Article  PubMed  CAS  Google Scholar 

  22. Quelle DE, Ashmun RA, Shurtleff SA, Kato J-Y, Bar-Sagi D, Roussel MF, Sherr CJ (1993) Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes and Devi: 1559-1571.

    Google Scholar 

  23. Resnitzky D, Gossen M, Bujard H, Reed SI (1994) Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Molec Cell Biol 14: 1669–1679.

    PubMed  CAS  Google Scholar 

  24. Hinds PW, Dowdy SF, Eaton EN, Arnold A, Weinberg RA (1994) Function of a human cyclin gene as an oncogene. Proc Natl Acad Sci USA 91: 709–713.

    Article  PubMed  CAS  Google Scholar 

  25. Lovec H, Sewing A, Lucibello FC, Muller R, Moroy T (1994) Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: link between cell cycle control and malignant transformation. Oncogene 9: 323–326.

    PubMed  CAS  Google Scholar 

  26. Lovec H, Grzeschiczek A, Kowalski MB, Moroy T (1994) Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice. Embo J 13:3487–3495.

    PubMed  CAS  Google Scholar 

  27. Jung JU, Stager M, Desrosiers RC (1994) Virus-encoded cyclin. Molec Cell Biol 14: 7235–7244.

    PubMed  CAS  Google Scholar 

  28. Harper JW, Elledge SJ (1996) Cdk inhibitors in development and cancer. Curr Opin Genet Dev 6: 56–64.

    Article  PubMed  CAS  Google Scholar 

  29. Sherr CJ, Roberts JM (1995) Inhibitors of mammalian G1 cyclin-dependent kinases. Genes and Devel 9: 1149–1163.

    Article  CAS  Google Scholar 

  30. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Mercer WE, Kinzler KW, Vogelstein B (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817–825.

    Article  PubMed  CAS  Google Scholar 

  31. Shiohara M, El-Diery WS, Wada M, Nakamaki T, Takeuchi S, Yang R, Chen DL, Vögelstein B, Koeffler HP (1994) Absence of WAF1 mutations in a variety of human malignancies. Blood 84: 3781–3784.

    PubMed  CAS  Google Scholar 

  32. Deng C, Zhang P, Harper JW, Elledge SJ, Leder PJ (1995) Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82: 675–684.

    Article  PubMed  CAS  Google Scholar 

  33. Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, Stockert E, Day RFI, Johnson BE, Skelnick MH (1994) A cell cycle regulator potentially involved in genesis of many tumor types. Science 264: 436–440.

    Article  PubMed  CAS  Google Scholar 

  34. Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D (1995) 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nature Med 1: 686–692.

    Article  PubMed  CAS  Google Scholar 

  35. Mao L, Merlo A, Bedi G, Shapiro GI, Edwards CD, Rollins BJ, Sidransky D (1995) A novel p16INK4a transcript. Cancer Res 55: 2995–2997.

    PubMed  CAS  Google Scholar 

  36. Stone S, Jiang P, Dayanath P, Tavtigian SV, Katcher H, Parry D, Peters G, Kamb A (1995) Complex structure and regulation of the p16 (MTS1) locus. Cancer Res 55: 2988–2994.

    PubMed  CAS  Google Scholar 

  37. Ewen ME (1994) The cell cycle and the retinoblastoma protein family. Cancer Metastasis Rev 13: 45–66.

    Article  PubMed  CAS  Google Scholar 

  38. Hollingsworth RE, Jr, Chen PL, Lee WH (1993) Integration of cell cycle control with transcriptional regulation by the retinoblastoma protein. Curr Opin Cell Biol 5: 194–200.

    Article  PubMed  CAS  Google Scholar 

  39. Lukas J, Bartkova J, Rohde M, Strauss M, Bartek J (1995) Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Molec Cell Biol 15:2600–2611.

    PubMed  CAS  Google Scholar 

  40. Horowitz JM, Park S-H, Bogenmann E, Cheng J-C, Yandell DW, Kaye FJ, Minna JD, Dryja TP, Weinberg RA (1990) Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells. Proc Natl Acad Sci USA 87: 2775–2779.

    Article  PubMed  CAS  Google Scholar 

  41. Hensel CH, Hsieh C-L, Gazdar AF, Johnson BE, Sakaguchi AY, Naylor SL, Lee W-H, Lee EY-HP (1990) Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer. Cancer Res 50: 3067–3072.

    PubMed  CAS  Google Scholar 

  42. Harbour JW, Lai S-L, Whang-Penn J, Gazdar AF, Minna JD, Kaye FJ (1988) Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 241: 353–357.

    Article  PubMed  CAS  Google Scholar 

  43. Sclafani RA, Schauer IE (1996) Cell cycle control and cancer: lessons from lung cancer. J Invest Dermatol 106: 1S–5S.

    Article  Google Scholar 

  44. Schauer IE, Siriwardana S, Langan TA, Sclafani RA (1994) Cyclin D1 overexpression vs. Rb inactivation: Alternate mechanisms of growth control evasion in non-small cell and small cell lung cancer. Proc Natl Acad Sci USA 91: 7827–7831.

    Article  PubMed  CAS  Google Scholar 

  45. Buckley MF, Sweeney KJE, Hamilton JA, Sini RL, Manning DL, Nicholson RI, deFazio A, Watts CKW, Musgrove EA, Sutherland RL (1993) Expression and amplification of cyclin genes in human breast cancer. Oncogene 8: 2127–2133.

    PubMed  CAS  Google Scholar 

  46. Müller H, Lukas J, Schneider A, Warthoe P, Bartek J, Eilers M, Strauss M (1994) Cyclin D1 expression is regulated by the retinoblastoma protein. Proc Natl Acad Sci USA 91: 2945–2949.

    Article  PubMed  Google Scholar 

  47. Shapiro GI, Park JE, Edwards CD, Mao L, Merlo A, Sidransky D, Ewen ME, Rollins BJ (1995) Multiple mechanism of p16INK4A inactivation in non-small cell lung cancer cell lines. Cancer Res 55: 6200–6209.

    PubMed  CAS  Google Scholar 

  48. Linardopoulos S, Gonos ES, Spandidos DA (1993) Abnormalities of retinoblastoma gene structure in human lung tumors. Cancer Lett 71: 61–74.

    Article  Google Scholar 

  49. Bartkova J, Lukas J, Müller H, Strauss M, Gusterson B, Bartek J (1995) Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer. Cancer Res 55: 949–956.

    PubMed  CAS  Google Scholar 

  50. Bartkova J, Lukas J, Strauss M, Bartek J (1995) Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis. Oncogene 10: 775–778.

    PubMed  CAS  Google Scholar 

  51. Gillett C, Fantl V, Smith R, Fisher C, Bartek J, Dickson C, Barnes D, Peters G (1994) Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistoche-mical staining. Cancer Res 54: 1812–1817.

    PubMed  CAS  Google Scholar 

  52. Jiang W, Zhang Y-J, Kahn SM, Hollstein MC, Santella RM, Lu S-H, Harris C, Montesano R, Weinstein IB (1993) Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc Natl Acad Sci USA 90: 9026–9030.

    Article  PubMed  CAS  Google Scholar 

  53. Reissmann PT, Koga H, Takahashi R, Figlin RA, Hohnes EC, Piantadosi S, Cordan-Cardo C, Slamon DJ, Group LCS (1993) Inactivation of the retinoblastoma susceptibility gene in non small cell lung cancer. Oncogene 8: 1913–1919.

    PubMed  CAS  Google Scholar 

  54. Yokota J, Akiyama T, Fung Y-KT, Benedict WF, Namba Y, Hanaoka M, Wada M, Terasaki T, Shimosato Y, Sugimura T, Terada M (1988) Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung. Oncogene 3: 471–475.

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biochemistry, Biophysics and Genetics, University of Colorado Health Sciences Center, Denver, Colorado, USA

    Irene E. Schauer & Robert A. Sclafani

Authors
  1. Irene E. Schauer
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  2. Robert A. Sclafani
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Editor information

Editors and Affiliations

  1. Hôpital de Brabois Service de Pneumologie A, Centre Hospitalier Universitaire de Nancy, 54511, Vandoeuvre-lès-Nancy, France

    Yves Martinet

  2. The Finsen Center Department of Oncology 5074, Copenhagen University Hospital Rigshospitalet, DK-2100, Copenhagen, Denmark

    Fred R. Hirsch

  3. Unité de Recherche de Physipathologie Respiratoire, INSERM U14, C.O. No 10, 54511, Vandoeuvre-lès-Nancy, France

    Nadine Martinet

  4. Service d’Anatomie Pathologique, Centre Hospitalier Universitaire de Nancy Hôpital Central, 54035, Nancy, France

    Jean-Michel Vignaud

  5. National Cancer Institute / National Institutes of Health, Division of Clinical Sciences / Medicine Branch Cell and Cancer Biology Department, Rockville, MD, 20850-3300, USA

    James L. Mulshine

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© 1998 Springer Basel AG

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Schauer, I.E., Sclafani, R.A. (1998). Cell Cycle Regulators and Mechanisms of Growth Control Evasion in Lung Cancer. In: Martinet, Y., Hirsch, F.R., Martinet, N., Vignaud, JM., Mulshine, J.L. (eds) Clinical and Biological Basis of Lung Cancer Prevention. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8924-7_9

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  • DOI: https://doi.org/10.1007/978-3-0348-8924-7_9

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9829-4

  • Online ISBN: 978-3-0348-8924-7

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