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Non-Adrenergic Non-Cholinergic Neurotransmission in the Airways: Role of Nitric Oxide

  • Chapter
Nitric Oxide in Pulmonary Processes

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

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Abstract

Autonomic nerves regulate several aspects of airway function [1]. However, for the purposes of this chapter, we will focus on the role of nitric oxide (NO)-containing nerves in the control of airway smooth muscle function. Neural control of airway smooth muscle is very complex since in addition to cholinergic and adrenergic innervation there is a non-adrenergic non-cholinergic (NANC) innervation. The existence of a NANC nervous system in the gastrointestinal tract, which controls gut motility, sphincters and secretions had previously been established in vertebrates from fish to humans [2]. The airways develop embryologically from the foregut and so the existence of NANC nerves in the respiratory tract was not an unexpected finding.

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Authors and Affiliations

  1. Pharmacology Department, Rhône-Poulenc Rorer Research and Development, Rainham Road South, Dagenham Essex, RM10 7XS, UK

    Maria G. Belvisi

  2. Pharmacology Group, Biomedical Sciences Division, King’s College London, Manresa Road, Chelsea, London, SW3 6LX, UK

    Alan Gibson

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  1. Maria G. Belvisi
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  1. Pharmacology Department, Rhône-Poulenc Rorer Research & Development, Rainham Road South, Dagenham, Essex, RM 10 7XS, UK

    Maria G. Belvisi

  2. Unit of Critical Care Medicine Imperial College Medical School, Royal Brompton Hospital, Sidney Street, London, SW3 6NP, UK

    Jane A. Mitchell

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Belvisi, M.G., Gibson, A. (2000). Non-Adrenergic Non-Cholinergic Neurotransmission in the Airways: Role of Nitric Oxide. In: Belvisi, M.G., Mitchell, J.A. (eds) Nitric Oxide in Pulmonary Processes. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8474-7_3

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  • DOI: https://doi.org/10.1007/978-3-0348-8474-7_3

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