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Relaxation of human isolated bronchial smooth muscle

Role of prostacyclin and prostaglandin F2a in muscle tone

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Abstract

The responses of human isolated bronchial smooth muscle to electrical stimulation and to different drugs and substances were studied. Field stimulation produced an initial contraction followed by relaxation. In the presence of muscarinic receptor blockade electrical stimulation resulted primarily in relaxation which was partly due to noradrenaline and partly due to a nonadrenergic substance. Prostacyclin (10−7 to 10−6 M) relaxed and indomethacin enhanced the muscle tone. In addition it was found that indomethacin potentiated the effect of histamine. Prostacyclin was capable of relaxing the tissue which had been previously contracted by histamine or prostaglandin F2a . It is suggested that a defect in the metabolism of prostacyclin could be an underlying cause of bronchospasm in those cases where histamine and/or prostaglandin F2a is involved as a pathogenetic factor.

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Authors and Affiliations

  1. Respiratory Care and Clinical Pharmacological Unit, National Korányi Institute for TBC and Pulmonology, H-1529, Budapest

    I. Hutás & L. Debreczeni

  2. Department of Pharmacodynamics, Semmelweis University of Medicine, H-1089, Budapest

    P. Hadházy

  3. Department of Pharmacology, Semmelweis University of Medicine, H-1089, Budapest, Hungary

    E. S. Vizi

Authors
  1. I. Hutás
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  2. P. Hadházy
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  3. L. Debreczeni
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  4. E. S. Vizi
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Hutás, I., Hadházy, P., Debreczeni, L. et al. Relaxation of human isolated bronchial smooth muscle. Lung 159, 153–161 (1981). https://doi.org/10.1007/BF02713911

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