Genome scans for asthma

  • Matthias Wjst
Part of the Progress in Inflammation Research book series (PIR)


In 1989 highly variable DNA repeats were described as short tandem repeats of a few base pairs (bps) [1]. The repeated elements are usually di-, tri-, or tetranucleotide sequences ([CA]n, [CAG]n, or [AGAT]n). The number of elements in these blocks is variable and ranges between 10 and 100. The evolutionary reasons for these microsatellites, as they have been immediately termed, are not fully understood. They are probably a side-effect of DNA replication, wherein a gap by polymerase slippage is filled by additional bases. The term “microsatellite DNA” derives from the initial observation of these repeats as side or satellite bands by ultracentrifugation over a CsCI density gradient. Even though there are no known biological functions, two distinct features make the microsatellites interesting. First, they are more or less evenly distributed over the whole human genome. The most common microsatellite is the dinucleotide [CAL, repeat, which comprises


Duchenne Muscular Dystrophy Genome Scan Bronchial Hyperreactivity Phenotype Asthma Asthma Gene 
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Copyright information

© Springer Basel AG 2002

Authors and Affiliations

  • Matthias Wjst
    • 1
  1. 1.Gruppe Molekulare EpidemiologieInstitut für Epidemiologie, GSF — Forschungszentrum für Umwelt und GesundheitNeuherberg/MunichGermany

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