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Genome scans for asthma

  • Matthias Wjst
Chapter
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Part of the Progress in Inflammation Research book series (PIR)

Abstract

In 1989 highly variable DNA repeats were described as short tandem repeats of a few base pairs (bps) [1]. The repeated elements are usually di-, tri-, or tetranucleotide sequences ([CA]n, [CAG]n, or [AGAT]n). The number of elements in these blocks is variable and ranges between 10 and 100. The evolutionary reasons for these microsatellites, as they have been immediately termed, are not fully understood. They are probably a side-effect of DNA replication, wherein a gap by polymerase slippage is filled by additional bases. The term “microsatellite DNA” derives from the initial observation of these repeats as side or satellite bands by ultracentrifugation over a CsCI density gradient. Even though there are no known biological functions, two distinct features make the microsatellites interesting. First, they are more or less evenly distributed over the whole human genome. The most common microsatellite is the dinucleotide [CAL, repeat, which comprises

Keywords

Duchenne Muscular Dystrophy Genome Scan Bronchial Hyperreactivity Phenotype Asthma Asthma Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Weber JL, May PE (1989) Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am J Hum Genet 44: 388–396PubMedGoogle Scholar
  2. 2.
    Collins FS (1992) Positional cloning: let’s not call it reverse anymore. Nature Genetics 1: 3–6PubMedCrossRefGoogle Scholar
  3. 3.
    Botstein D, White RL, Skolnick M, Davis RW (1980) Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet 32:314–331PubMedGoogle Scholar
  4. 4.
    Ott J (1991) Analysis of human genetic linkage. Johns Hopkins University Press, Balti-more, MDGoogle Scholar
  5. 5.
    Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for inter-preting and reporting linkage results. Nature Genetics 11: 241–247PubMedCrossRefGoogle Scholar
  6. 6.
    Morton NE (1998) Significance levels in complex inheritance. Am J Hum Genet 62:690–697 (Published erratum in Am J Hum Genet (1998) 63: 1252)Google Scholar
  7. 7.
    Eiberg H, Lind P, Mohr J, Nielsen LS (1985) Linkage relationship between the human immunoglobulin-E polymorphism and marker. Cytogen Cell Genet 40: 622Google Scholar
  8. 8.
    Cookson WOCM, Sharp PA, Faux JA, Hopkin JM (1989) Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. Lancet 1: 1292–1295Google Scholar
  9. 9.
    Sandford A, Weir T, Pare P (1996) The genetics of asthma. Am J Respir Crit Care Med 153: 1749–1765CrossRefGoogle Scholar
  10. 10.
    Holloway JW, Beghé B, Holgate ST (1999) The genetic basis of atopic asthma. Clin Exp Allergy 29: 1023–1032PubMedCrossRefGoogle Scholar
  11. 11.
    Weissenbach J, Gyapay G, Dib C, Vignal A, Morissette J, Millasseau P, Vaysseix G, Lathrop M (1992) A second-generation linkage map of the human genome. Nature 359: 794–801PubMedCrossRefGoogle Scholar
  12. 12.
    Zamel N (1995) In search of the genes of asthma on the island of Tristan da Cunha. Can Respir J 2: 18–22Google Scholar
  13. 13.
    Holgate ST (1997) Asthma genetics: waiting to exhale. Nature Genetics 15: 227–229PubMedCrossRefGoogle Scholar
  14. 14.
    Vogel G (1997) A scientific result without the science. Science 276: 1327PubMedCrossRefGoogle Scholar
  15. 15.
    Daniels SE, Bhattacharrya S, James A, Leaves NI, Young A, Hill MR, Faux JA, Ryan GF, de LeSoeuf PN, Lathrop GM et al. (1996) A genome-wide search for quantitative trait loci underlying asthma. Nature 383: 247–250PubMedCrossRefGoogle Scholar
  16. 16.
    CSGA. The Collaborative Study on the Genetics of Asthma (1997) A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nature Genetics 15: 389–392CrossRefGoogle Scholar
  17. 17.
    Hizawa N, Freidhoff LR, Chiu YF, Ehrlich E, Luehr CA, Anderson JL, Duffy DL, Dunston GM, Weber JL, Huang SK et al (1998) Genetic regulation of Dermatophagoides pteronyssinus-specific IgE responsiveness: a genome-wide multipoint linkage analysis in families recruited through 2 asthmatic sibs. Collaborative Study on the Genetics of Asthma (CSGA). J Allergy Clin Immunol 102: 436–442PubMedCrossRefGoogle Scholar
  18. 18.
    Hizawa N, Freidhoff LR, Ehrlich E, Chiu YF, Duffy DL, Schou C, Dunston GM, Beaty TH, Marsh DG, Barnes KC et al (1998) Genetic influences of chromosomes 5q31—q33 and 11q13 ors specific IgE responsiveness to common inhaled allergens among African American families. Collaborative Study on the Genetics of Asthma (CSGA). J Allergy Clin Immunol 102: 436–442PubMedCrossRefGoogle Scholar
  19. 19.
    Ober C, Cox NJ, Abney M, di Rienzo A, Lander AS, Changyaleket B, Gidley H, Kurtz B, Lee J, Nance M et al (1998) Genome-wide search for asthma susceptibility loci in a founder population. Hum Mol Gen 7: 1393–1398PubMedCrossRefGoogle Scholar
  20. 20.
    Wjst M, Fischer G, Immervoll T, Jung M, Saar K, Rueschendorf F, Reis A, Ulbrecht M, Gomolka M, Weiss EH et al (1999) A genome-wide search for linkage to asthma. Genomics 58: 1–8PubMedCrossRefGoogle Scholar
  21. 21.
    Wjst M for the German Asthma Genetics Group (1999) Specific IgE — One gene fits all? Clin Exp Allergy 29 (Suppl 4): 5–10Google Scholar
  22. 22.
    Dizier MH, Matran R, Meunier F, Neukirch F, Pacheco Y, Parent V, Paty E, Pin I, Pison C, Scheinmann P et al (1999) Genome screen for asthma and related phenotypes in the French EGEA study. Am Rev Respir Grit Care Med 159 (Suppl): A649Google Scholar
  23. 23.
    Koppleman GH, Stine OC, Howard TD et al (1998). Genome screen for asthma susceptibility loci in a restricted Dutch population (abstract). Am J Hum Gen 63 (Suppl): 1705Google Scholar
  24. 24.
    Rioux JD, Stone VA, Daly MJ, Cargill M, Green T, Nguyen H, Nutman T, Zimmerman PA, Tucker MA, Hudson T et al (1998) Familial eosinophilia maps to the cytokine gene cluster on human chromosomal region 5q31—q33. Am J Hum Genet 63: 1086–1094PubMedCrossRefGoogle Scholar
  25. 25.
    de Sanctis G, Merchant M, Beier DR, Dredge RD, Grobholz JK, Martin TR, Lander Es, Drazen JM (1995) Quantitative locus analysis of airway hyperresponsivenes in A/J and C57BL/6J mice. Nature Genetics 11: 150–154PubMedCrossRefGoogle Scholar
  26. 26.
    Zhang Y, Lefort J, Kearsley V, Lapa e Silva JR, Cookson WOCM, Vargafting BB (1999) A genome wide search for asthma associated quantitative trait loci in a mouse model of allergic asthma. Hum Mol Genet 8: 601–605PubMedCrossRefGoogle Scholar
  27. 27.
    Roberts SB, MacLean CJ, Neale MC, Eaves LJ, Kendler KS (1999) Replication of linkage studies of complex traits: An examination of variation in location estimates. Am J Hum Gen 65: 876–884CrossRefGoogle Scholar
  28. 28.
    Todd JA (1999) Interpretation of results from genetic studies of multifactorial diseases. Lancet 354 (Suppl 1): 15–16CrossRefGoogle Scholar
  29. 29.
    Cookson WOCM (1999). The alliance of genes and environment in asthma and allergy. Nature 402 (Suppl): B5—B11Google Scholar
  30. 30.
    Wjst M, Immervoll T (1998) An internet linkage and mutation database for the complex phenotype asthma. Bioinformatics 14: 827–828PubMedCrossRefGoogle Scholar

Copyright information

© Springer Basel AG 2002

Authors and Affiliations

  • Matthias Wjst
    • 1
  1. 1.Gruppe Molekulare EpidemiologieInstitut für Epidemiologie, GSF — Forschungszentrum für Umwelt und GesundheitNeuherberg/MunichGermany

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