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Genome scans for asthma

  • Chapter
The Hereditary Basis of Allergic Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

In 1989 highly variable DNA repeats were described as short tandem repeats of a few base pairs (bps) [1]. The repeated elements are usually di-, tri-, or tetranucleotide sequences ([CA]n, [CAG]n, or [AGAT]n). The number of elements in these blocks is variable and ranges between 10 and 100. The evolutionary reasons for these microsatellites, as they have been immediately termed, are not fully understood. They are probably a side-effect of DNA replication, wherein a gap by polymerase slippage is filled by additional bases. The term “microsatellite DNA” derives from the initial observation of these repeats as side or satellite bands by ultracentrifugation over a CsCI density gradient. Even though there are no known biological functions, two distinct features make the microsatellites interesting. First, they are more or less evenly distributed over the whole human genome. The most common microsatellite is the dinucleotide [CAL, repeat, which comprises

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Author information

Authors and Affiliations

  1. Gruppe Molekulare Epidemiologie, Institut für Epidemiologie, GSF — Forschungszentrum für Umwelt und Gesundheit, Ingolstädter Landstrasse 1, D-85758, Neuherberg/Munich, Germany

    Matthias Wjst

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  1. Matthias Wjst
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Editor information

Editors and Affiliations

  1. School of Medicine IIR (Respiratory Cell and Molecular Biology) Division Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK

    Stephen T. Holgate

  2. School of Medicine Human Genetics and IIR (Respiratory Cell and Molecular Biology) Divisions, University of Southampton, Southampton, SO16 6YD, UK

    John W. Holloway

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© 2002 Springer Basel AG

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Wjst, M. (2002). Genome scans for asthma. In: Holgate, S.T., Holloway, J.W. (eds) The Hereditary Basis of Allergic Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8137-1_2

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  • DOI: https://doi.org/10.1007/978-3-0348-8137-1_2

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9452-4

  • Online ISBN: 978-3-0348-8137-1

  • eBook Packages: Springer Book Archive

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