The Hereditary Basis of Allergic Diseases

  • Stephen T. Holgate
  • John W. Holloway

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Tarja Laitinen
    Pages 1-16
  3. Matthias Wjst
    Pages 17-27
  4. Chaker N. Adra, X.-Q. Mao, A. Yamasaki, P-S. Gao, Xing Yang, T. Shirakawa et al.
    Pages 85-93
  5. Tineke C. T. M. van der Pouw Kraan, John W. Holloway, Lucien A. Aarden, Jaring S. van der Zee
    Pages 95-111
  6. Roy C. Levitt, Michael P McLane, Luigi Grasso, Nicholas C. Nicolaides
    Pages 113-124
  7. Hartmut Grasemann, Jeffrey M. Drazen
    Pages 125-136
  8. I. Sayers, A. P. Sampson
    Pages 137-166
  9. Ladina Joos, Peter D. Paré, Andrew J. Sandford
    Pages 167-176
  10. Back Matter
    Pages 177-181

About this book


Allergic diseases are complex and involve a range of environmental factors interacting with a susceptible genotype. The familial clustering of diseases, such as asthma and hay fever, has been recognised for over two centuries, but identification of the genetic basis to this had to await the molecular biological revolution. Estimates of the contribution that genetic factors make to asthma susceptibility range from 35% to 70%. For the majority of allergic diseases, segregation analysis has not identified a consistent Mendelian pattern of inheritance, which, when combined with multiple phenotypes and environmental interactions, has made identifying candidate genes especially difficult and, at times, controversial. Part of the difficulty has been lack of agreement over phenotype definitions, reduced power of studies to predict linkage and association, and, importantly, lack of true heterogeneity between populations. Despite these difficulties, the last decade has witnessed enormous progress in this field.


Chromosom Genotyp Immunologie Pharmakologie allergy asthma chromosome development evolution genes genetics heredity immunology inflammation pharmacology

Editors and affiliations

  • Stephen T. Holgate
    • 1
  • John W. Holloway
    • 2
  1. 1.School of Medicine IIR (Respiratory Cell and Molecular Biology) Division Southampton General HospitalUniversity of SouthamptonSouthamptonUK
  2. 2.School of Medicine Human Genetics and IIR (Respiratory Cell and Molecular Biology) DivisionsUniversity of SouthamptonSouthamptonUK

Bibliographic information