Abstract
Skeletal muscle converts the thermodynamic force of the non-equilibrium ATP/ADP concentration ratio in the cytosol into mechanical force during contrac-tion1 [1]. As such, skeletal muscle function can be described using engineering concepts as a chemo-mechano transducer (Fig. 1). The molecular machinery in-volved in this conversion consists, amongst others, of filaments of actin and the motor protein myosin ATPase, and the calcium (Ca2+)-activated switch protein troponin [1]. The non-equilibrium cytosolic ATP/ADP concentration potential is thermodynamically buffered by the cellular pool of mitochondria via oxidative ADP phosphorylation. Kinetically, this cytosolic potential is buffered on a fast (i.e. (sub)second) time scale by creatine kinase (CK) and glycolysis, and on a slow (i.e. minutes) timescale by oxidative phosphorylation [2]. Muscle contraction and the associated conversion of thermodynamic ATP energy force is under voluntary, neural control [1]. It is initiated at the cellular level by action potential-gated re-lease of Ca2+ions from the sarcoplasmic reticulum (SR) stores into the myoplasm2.
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References
L.C. Rome and S.L. Lindstedt,Mechanical and Metabolic design of the vertebrate muscular system, in: W.H. Dantzler, Ed. Handbook of Physiology. Section13, Comparative Physiology (Oxford University Press) (1997), 1587–1651.
M.J. Kushmerick Energy balance in muscle activity: simulations of ATPase coupled to oxidative phos-phorylation and to creatine kinase. Comp Biochem Physiol B Biochem Mol Biol. 120 (1998), 109–123.
H. Westerblad, D.G. Allen, J.D. Bruton, F.H. Andrade and J. Lannergren Mechanisms underlying the reduction of isometric force in skeletal muscle fatigue, Acta Physiol Scand. 162 (1998), 253–260.
R. Heinrich, S.M. Rapoport and T.A. Rapoport Metabolic regulation and mathematical models, Prog. Biophys. Molec. Biol. 32 (1977), 1–82.
J.A.L. Jeneson, H.V. Westerhoff and M.J. Kushmerick. A metabolic control analysis of kinetic controls in ATP free energy metabolism in contracting skeletal muscle, Am. J. Physiol. (Cell Physiol.) 279 (2000), C813–C832.
G.J. Stienen, R. Zaremba, and G. Elzinga ATP utilization for calcium uptake and force production in skinned muscle fibres of Xenopus laevis, J. Physiol. 482 (1995), 109–122.
J.A.L. Jeneson, R.W. Wiseman, H.V. Westerhoff, and M.J. Kushmerick The signal transduction function for oxidative phosphorylation is at least second order in ADP, J. Biol. Chem. 271 (1996), 27995–27998.
J. Sakamoto and Y. Tonomura Order of release of ADP and Pi from phosphoenzyme with bound ADP of Ca2+-dependent ATPase from sarcoplasmic reticulum and of Na+/K+-dependent ATPase studied by ADP-inhibition patterns, J. Biochem. 87 (1980), 1721–1727.
R. Cooke and E. Pate The effect of ADP and phosphate on the contraction of muscle fibers, Biophys J 48 (1985), 789–798.
E.E. Burmeister Getz and S.L. Lehman Calcium removal kinetics of the sarcoplasmic reticulum ATPase in skeletal muscle, Am. J. Physiol. (Cell Physiol.) 272 (1997), C1087–C1098.
M.L. Blei, K.E. Conley, and M.J. Kusmerick Separate measures of ATP utilization and recovery in human skeletal muscle, J. Physiol. 465 (1993), 203–222.
J.A.L. Jeneson, R.W. Wiseman, and M.J. Kushmerick Non-invasive quantitative 31P MRS assay of mitochondrial function in skeletal muscle in situ, Mol. Cell. Biochem. 174 (1997), 17–22.
R.C. Harris, E. Hultman, and L.-O. Nordesjo Glycogen glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest, Scand. J. Clin. Lab. Invest. 33 (1974), 109–120.
D.J. Taylor, P.J. Bore, P. Styles, D.G. Gadian, and G.K. Radda Bioenergetics of intact human muscle: a 31P NMR study, Mol. Biol. Med. 1 (1983), 77–94.
J.G. McCormack, A.P. Halestrap and R.M. Denton Role of calcium ions in regulation of mammalian intramitochondrial metabolism, Physiol Rev. 70 (1990), 391–425.
M.J. Kushmerick, R.A. Meyer and T.R. Brown Regulation of oxygen consumption in fast-and slow-twitch muscle, Am J Physiol. 263 (1992), C598–606.
D. Fell Understanding the control of metabolism, Portland Press, London, 1997.
J.-H.S. Hofmeyr and A. Cornish-Bowden Regulating the cellular economy of supply and demand, FEBS Lett. 476 (2000), 47–51.
R.P. Hafner, G.C. Brown and M.D. Brand Analysis of the control of respiration rate phosphorylation rate proton leak rate and protonmotive force in isolated mitochondria using the ‘top-down’ approach of metabolic control theory, Eur J Biochem. 188 (1990), 313–319.
K. Steeghs, A. Benders, F. Oerlemans, A. de Haan, A. A. Heerschap, W. Ruitenbeek, C. Jost, J. van Deursen, B. Perryman, D. Pette, M Bruckwilder, J. Koudijs, P. Jap, J. Veerkamp and B. Wieringa, Altered Ca2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies, Cell 89 (1997), 93–103.
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Jeneson, J.A.L., Westerhoff, H.V., Kushmerick, M.J. (2004). Metabolic Control Analysis of the ATPase Network in Contracting Muscle: Regulation of Contractile Function and ATP Free Energy Potential. In: Deutsch, A., Howard, J., Falcke, M., Zimmermann, W. (eds) Function and Regulation of Cellular Systems. Mathematics and Biosciences in Interaction. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7895-1_4
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