Function and Regulation of Cellular Systems

  • Andreas Deutsch
  • Jonathon Howard
  • Martin Falcke
  • Walter Zimmermann

Part of the Mathematics and Biosciences in Interaction book series (MBI)

Table of contents

  1. Front Matter
    Pages i-x
  2. Metabolic Networks and Engineering

    1. Front Matter
      Pages 1-1
    2. Reinhart Heinrich, Thomas Höfer
      Pages 3-5
    3. Finn Hynne, Sune Danø, Preben G. Sørensen
      Pages 7-18
    4. Jochen Förster, Mats Åkesson, Jens Nielsen
      Pages 47-58
  3. Intracellular Signal Transduction

    1. Front Matter
      Pages 59-59
    2. Thomas Höfer, Reinhart Heinrich
      Pages 61-62
    3. Michael Meyer-Hermann, Frido Erler, Gerhard Soff
      Pages 63-71
    4. Birgit Schöberl, Martin Ginkel, Ernst D. Gilles, Gertrud Müller
      Pages 73-87
    5. Paramita Ghosh, Debasish Bose, Subhendu Ghosh
      Pages 89-97
    6. Antonio Politi, Thomas Höfer
      Pages 99-110
  4. Cellular Materials: Mechanics and Motility

    1. Front Matter
      Pages 133-133
    2. Erwin Frey, Wolfgang Alt
      Pages 135-137
    3. Chris H. Wiggins, Loïc Le Goff
      Pages 139-150
    4. Andrea Parmeggiani, Christoph F. Schmidt
      Pages 151-176
    5. Wolfgang Pompe, Katharina Flade, Michael Gelinsky, Birgit Knepper-Nicolai, Antje Reinstorf
      Pages 177-183
    6. Ralf Kemkemer, Hans Gruler, Dieter Kaufmann, Joachim P. Spatz
      Pages 185-197
    7. Peter Dieterich, Jochen Seebach, Hans-J. Schnittler
      Pages 199-207
  5. Complex Network Dynamics in Biological Cells

    1. Front Matter
      Pages 209-209
    2. Alexander S. Mikhailov
      Pages 211-212
    3. Hans-Philipp Lerch, Pedro Stange, Benno Hess
      Pages 225-232
    4. Mads Ipsen
      Pages 241-249
    5. Rengaswamy Maithreye, Somdatta Sinha
      Pages 251-257
    6. Jan T. Kim, Thomas Martinetz, Daniel Polani
      Pages 259-264
  6. Interacting Cell Systems

    1. Front Matter
      Pages 265-265
    2. Dirk Drasdo, Angela Stevens
      Pages 267-268
    3. Gabor Forgacs, Ramsey A. Foty
      Pages 269-277
    4. Uwe Börner, Andreas Deutsch, Markus Bär
      Pages 295-301
  7. How Cells Construct an Organism: Experiments and Modeling

    1. Front Matter
      Pages 303-303
    2. Markus Kirkilionis
      Pages 305-308
    3. Ulrich Technau, Bert Hobmayer, Fabian Rentzsch, Thomas W. Holstein
      Pages 309-321
    4. Markus Kirkilionis
      Pages 347-359
  8. Tumors, Diseases and the Immune System

    1. Front Matter
      Pages 361-361
    2. Michal Or-Guil, Angela Stevens, Dirk Drasdo
      Pages 363-365
    3. Dirk Drasdo, Sabine Dormann, Stefan Hoehme, Andreas Deutsch
      Pages 367-378
    4. Alexander R. A. Anderson
      Pages 379-389
    5. Ulrich Behn, Markus Brede, Jan Richter
      Pages 399-410
    6. Susanne Schreiber, Kai Ludwig, Hermann-Georg Holzhütter, Andreas Herrmann
      Pages 411-420
    7. Markus A. Dahlem, Thomas Mair, Stefan C. Müller
      Pages 421-434

About this book


Current biological research demands more and more the extensive use of sophisticated mathematical methods and computer-aided analysis of experiments and data. Mathematical analysis reveals similarities and differences in organization principles of metabolic, signaling and cellular interaction networks.
This highly interdisciplinary book focuses on structural, dynamical and functional aspects of cellular systems and presents corresponding experiments and mathematical models. It may serve as an introduction for biologists, mathematicians and physicists to key questions in cellular systems which can be studied with mathematical models. Recent model approaches are presented with applications in cellular metabolism, intra- and intercellular signaling, cellular mechanics, network dynamics and pattern formation. In addition, applied issues as tumor cell growth, dynamics of the immune system and biotechnology are included. The book is based on selected peer-reviewed contributions and discussions at the "1. International MTBio workshop on function and regulation of cellular systems: experiments and models" (Dresden, June 24-30, 2001). The international competence and information network MTBio (Modeling and Theory in the Biosciences, has been recently founded to improve communication between experimentalists and theoreticians sharing interests in the application of mathematical models.


Computerassistierte Detektion Dynamics Gap Hydra Immune System In silico Radiologieinformationssystem migration model modeling nonlinear dynamics regulation simulation system

Editors and affiliations

  • Andreas Deutsch
    • 1
  • Jonathon Howard
    • 2
  • Martin Falcke
    • 3
  • Walter Zimmermann
    • 4
  1. 1.Zentrum für HochleistungsrechnenTechnische Universität DresdenDresdenGermany
  2. 2.Max Planck Institute of Molecular Cell Biology and GeneticsDresdenGermany
  3. 3.Department Theory (SF5)Hahn-Meitner-Institut BerlinBerlinGermany
  4. 4.Theoretische PhysikUniversität des SaarlandesSaarbrückenGermany

Bibliographic information