Abstract
The development of a primary solid tumour (e.g. a carcinoma) begins with a single normal cell becoming transformed as a result of mutations in certain key genes. This transformed cell differs from a normal one in several ways, one of the most notable being its escape from the body’s homeostatic mechanisms, leading to inappropriate proliferation. An individual tumour cell has the potential, over successive divisions, to develop into a cluster (or nodule) of tumour cells. Further growth and proliferation leads to the development of an avascular tumour consisting of approximately 106 cells. This cannot grow any further, owing to its dependence on diffusion as the only means of receiving nutrients and removing waste products. For any further development to occur the tumour must initiate angiogenesis-the recruitment of blood vessels. Once angiogenesis is complete, the blood network can supply the tumour with the nutrients it needs to grow further. There is now also the possibility of tumour cells finding their way into the circulation and being deposited at distant sites in the body, resulting in metastases (secondary tumours).
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References
A. R. A. Anderson and M. A. J. Chaplain, Continuous and Discrete Mathematical Models of Tumour-Induced Angiogenesis Angiogenesis, Bull. Math. Biol., 60 (1998), 857–899.
A. R. A. Anderson, M. A. J. Chaplain, E. L. Newman, R. J. C. Steele and A. M. Thompson, Mathematical Modelling of Tumour Invasion and Metastasis, J. Theoret. Med., 2 (2000), 129–154.
A. R. A. Anderson, A Hybrid Discrete-Continuum Technique for Individual Based Migration Models, in: W. Alt, M. Chaplain, M. Griebel, J. Lenz, Polymer and Cell Dynamics. Multistate Modeling and Numerical Simulations, 2003, Birkhäuser, Basel, 251–259.
D. Bray, Cell Movements, 1992 Garland Publishing, New York.
P. Calabresi and P.S. Schein, editors: Medical Oncology, 2nd ed. 1993 McGraw-Hill, New York.
J. J. Casciari, S. V. Sotirchos and R. M. Sutherland, Variation in tumour cell growth rates and metabolism with oxygen-concentration, glucose-concentration and extracellular pH, J. Cell Physiol., 151 (1992), 386–394.
K. Hotary, E. Allen, A. Punturieri, I. Yana and S. J. Weiss, Regulation of cell invasion and morphogenesis in a 3-dimensional type I collagen matrix by membrane-type metalloproteinases 1, 2 and 3, J. Cell Biol., 149 (2000), 1309–1323.
R. O. Hynes, Integrins: versatility, modulation, and signalling in cell adhesion, Cell, 69 (1992), 11–25.
S. Koochekpour, G.J. Pilkington and A. Merzak, Hyaluronic acid/CD44H interaction induces cell detachment and stimulates migration and invasion of human glioma cells in vitro, Intl. J. Cancer, 63 (1995), 450–454.
D.P. Lane, The regulation of p53 function. Steiner Award Lecture, Int. J. Cancer, 57 (1994), 623–627.
L. Sherwood, Human Physiology: From cells to systems,4th ed., 2001 Brooks/Cole, California.
W.G. Stetler-Stevenson, S. Aznavoorian and L.A. Liotta, Tumor cell interactions with the extracellular matrix during invasion and metastasis, Ann. Rev. Cell Biol., 9 (1993), 541–573.
M. Takeichi, Cadherins in cancer: implications for invasion and metastasis, Curr. Opin. Cell Biol., 5 (1993), 806–811.
V.P. Terranova, R. Diflorio, R.M. Lyall, S. Hic, R. Friesel and T. Maciag, Human endothelial cells are chemotactic to endothelial cell growth factor and heparin, J. Cell Biol., 101 (1985), 2330–2334.
U.P. Thorgeirsson, C.K. Lindsay, D.W. Cottam and Daniel E. Gomez, Tumor invasion, proteolysis, and angiogenesis, J. Neuro-Oncology, 18 (1994), 89–103.
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Anderson, A.R.A. (2004). Solid Tumour Invasion:The Importance of Cell Adhesion. In: Deutsch, A., Howard, J., Falcke, M., Zimmermann, W. (eds) Function and Regulation of Cellular Systems. Mathematics and Biosciences in Interaction. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7895-1_38
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DOI: https://doi.org/10.1007/978-3-0348-7895-1_38
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