Abstract
In order to function as physiological clocks, circadian (and certain ultradian) rhythms contain homeostatic mechanisms which compensate for external temperature variations and other environmental influences. In this paper a theory for temperature-compensation and general homeostasis for physiological clocks is presented and compared with experimental findings. Results obtained from different organisms indicate that circadian pacemakers are based on one or several negative feedback loops where protein products of clock genes act as inhibitors of their own transcription. We have simulated the occurrence of temperature-compensation by using a simple reaction-kinetic model (the so-called Goodwin oscillator) which mimicks the negative feedback loop of a circadian pacemaker. The comparison between simulation calculations and experiments ofNeurospora andDrosophila clock mutants shows that both period length and temperature-compensation appear closely connected through the stability/degradation rate of clock proteins.
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References
L. N. EdmundsCellular and Molecular Bases of Biological ClocksSpringer-Verlag, New York 1988.
J. C. Dunlap Molecular bases for circadian clocks Cell, 96, (1999), 271–290.
L. Rensing, U. Meyer-Grahle and P. Ruoff Biological timing and the clock metaphor: Oscillatory and hourglass mechanisms, Chronobiol. Int., 18 (2001), 329–369.
D. Moore Honey bee circadian clocks: Behavioral control from individual workers to whole-colony rhythms, J. Insect Physiol., 47 (2001), 843–857.
The Q 10 is defined as the ratio between reaction velocities v at (T +10) and T Kelvin, i.e, Q 10 = v(T + 10)/υ(T). Van’t Hoff’s rule states that most chemical reactions increase by a factor of two or more when the temperature is increased by 10 centrigrades.
M. Dixon, E. C. Webb, C. J. R. Thorne and K. F. Tipton Enzymes Longman, London 1979, pp. 175.
C. S. Pittendrigh and P. C. Caldarola General homeostasis of the frequency of circadian oscillations PNAS, 70 (1973), 2697–2701.
P. Ruoff, Ed. Special Issue on, Temperature Compensation of Circadian and Ultradian Rhythms, Chronobiol. Int., 14 (1997), 445–536.
J. J. Loros and J. C. Dunlap Genetic and molecular analysis of circadian rhythms in Neurospora, Annu. Rev. Physiol., 63 (2001), 757–794.
R. M. Noyes Kinetics and Mechanisms of Complex Reactions, in: C. F. Bernasconi, Ed., Investigations of Rates and Mechanisms of Reactions, Vol. 6, Part 1 (John Wiley & Sons, Inc., New York) (1986), 373–423.
R. M. Noyes Mechanisms of some chemical oscillators, J. Phys. Chem., 94 (1990), 4404–4412.
See for example: K. Radhakrishnan and A. C. Hindmarsh Description and Use of LSODE, the Livermore Solver for Ordinary Differential Equations, Lawrence Livermore National Laboratory Report UCRL-ID-113855 and NASA Reference Publication 1327, NASA, Lewis Research Center, 21000 Brookpark Rd., Cleveland,OH 44135–3191, 1993. LSODE and other software tools can freely be downloaded at the LLNL website:http://www.llnl.gov/CASC/download/download_home.html
B. D. Aronson, K. A. Johnson, J. J. Loros and J. C. Dunlap Negative Feedback Defining a Circadian Clock: Autoregulation of the Clock Gene frequency, Science, 263 (1994), 1578–1584.
J. W. Hastings and B. M. Sweeney On the mechanism of temperature independence in a biological clock, PNAS, 43 (1957), 804–811.
H. Franke, Lexikon der Physik, Franckh’sche Verlangshandlung, Stuttgart 1969, pp. 1215.
U. F. Franck Chemical Oscillations, Angew. Chem. Int. Ed., 17 (1978), 1–15.
P. L. Lakin-Thomas, G. G. Coté and S. Brody Circadian rhythms in Neurospora crassa: biochemistry and genetics, Crit. Rev. Microbiol., 17 (1990), 365–416.
B. C. Goodwin Oscillatory behavior in enzymatic control processes, in: G. Weber, Ed., Advances in Enzyme Regulation, Vol. 3 (Pergamon Press, Oxford) (1965), 435–438.
P. Ruoff Introducing temperature-compensation in any reaction kinetic oscillator model, J. Interdiscipl. Cycle Res., 23 (1992), 92–99.
P. Ruoff and L. Rensing The temperature-compensated Goodwin oscillator simulates many circadian clock properties, J. Theor. Biol., 179 (1996), 275–285.
P. Ruoff General homeostasis in period and temperature-compensated chemical clock mutants formed by random selection conditions, Naturwissenschaften, 81 (1994), 456–459.
P. Ruoff, M. Vinsjevik, S. Mohsenzadeh and L. Rensing The Goodwin model: Simulating the effect of cycloheximide and heat shock on the sporulation rhythm of Neurospora crassa, J. Theor. Biol., 196 (1999), 483–494.
“Plurality is not to be assumed without necessity” — William of Ockham, 1285–1349.
P. Ruoff, M. Vinsjevik, C. Monnerjahn and L. Rensing The Goodwin model: Simulating the effect of light pulses on the circadian sporulation rhythm of Neurospora crassa, J. Theor. Biol., 209 (2001), 29–42.
T. Olde Scheper, D. Klinkenberg, C. Pennartz and J. Van Pelt,A mathematical model for the intracellular circadian rhythm generator, J. Neurosci., 19 (1999), 40–47.
P. Ruoff, S. Mohsenzadeh and L. Rensing Circadian rhythms and protein turnover: the effect of temperature on the period lengths of clock mutants simulated by the Goodwin model, Naturwissenschaften, 83 (1996), 514–517.
B. D. Aronson, K. A. Johnson and J. C. Dunlap Circadian clock locus frequency: Protein encoded by a single open reading frame defines period length and temperature compensation, PNAS, 91 (1994), 7683–7687.
N. Y. Garceau, Y. Liu, J. J. Loros and J. C. Dunlap Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein FREQUENCY, Cell, 89 (1997), 469–476.
P. Ruoff, M. Vinsjevik, C. Monnerjahn and L. Rensing The Goodwin oscillator: On the importance of degradation reactions in the circadian clock, J. Biol. Rhythms, 14 (1999), 469–479.
Y. Liu, J. Loros and J. C. Dunlap Phosphorylation of the Neurospora clock protein FREQUENCY determines it degradation rate and strongly influences the period length of the circadian clock, PNAS, 94 (1998), 83–95.
J. L. Price, J. Blau, A. Rothenfluh, M. Abodeely, B. Kloss and Michael W. Young double-time Is a Novel Drosophila Clock gene that regulates PERIOD Protein Accumulation, Cell, 94 (1998), 83–95.
B. Kloss, J. L. Price, L. Saez, J. Blau, A. Rothenfluh, C. S. Wesley and M. W. Young The Drosophila Clock Gene double-time Encodes a Protein Closely Related to Human Casein Kinase Ie, Cell, 94 (1998), 97–107.
P. Ruoff Antagonistic balance in the oregonator: about the possibility of temperature-compensation in the Belousov-Zhabotinsky reaction, Physica D, 84, (1995), 204–211.
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Ruoff, P. (2004). Temperature-Compensation in Biological Clocks: Models and Experiments. In: Deutsch, A., Howard, J., Falcke, M., Zimmermann, W. (eds) Function and Regulation of Cellular Systems. Mathematics and Biosciences in Interaction. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7895-1_3
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DOI: https://doi.org/10.1007/978-3-0348-7895-1_3
Publisher Name: Birkhäuser, Basel
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