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Drugs affecting the renin-angiotensin system

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Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

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Abstract

Hypertension is the leading risk factor in cardiovascular disease and renal disorders resulting in premature illness and death. Essential (primary) hypertension accounts for 80% of all hypertensive cases. The term ‘essential hypertension’ is used to designate a disorder for which no well- defined etiologic process has been elucidated. It is often asymptomatic and manifested only by increased arterial blood pressure.

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Abbreviations

ACE:

Angiotensin-converting enzyme

AI:

Angoitensin I

AII:

Angoitensin II

BP:

Blood pressure

FDA:

Food and Drug Administration

PRA:

Plasma renin activity

References

  1. G. deStevens and M. Wilhelm: Prog. Drug Res., vol.20, p. 197. Ed. E. Jucker. Birkhäuser Verlag, Basel.

    Google Scholar 

  2. Veterans Administration Cooperative Study Group on Antihypertensive Agents: JAMA 202, 1028 (1967); 213, 1143 (1970).

    Article  Google Scholar 

  3. D.T. Pals, F.D. Masucei, F. Sipos and G.S. Denning, Jr.: Circ. Res. 29, 664 (1971).

    Google Scholar 

  4. J.H. Laragh, L. Baer, H.R. Brunner, F.R. Bühler, J.E. Sealey and E.D. Vaughan: Am. J. Med. 52, 633 (1972).

    Article  Google Scholar 

  5. H.R. Brunner, H. Gavras and J.H. Laragh: Circ. Res. 34 suppl. 1, 35 (1974).

    Google Scholar 

  6. D.H.P. Streeten, G.H. Anderson, J.M. Freiberg and T.H. Dalakos: New Engl. J. Med. 292, 657 (1975).

    Article  Google Scholar 

  7. D.B. Case, J.M. Wallace, H.J. Keim, M.A. Weber, J.M. Drayer, R.P. White, J.E. Sealey and J.H. Laragh: Am. J. Med. 61, 790 (1976).

    Article  Google Scholar 

  8. H. Gavras, A. Ribiero, H.R. Brunner and I. Gavras: New Engl. J. Med. 295, 1278 (1976).

    Google Scholar 

  9. D.B. Case, J.M. Wallace, H.J. Keim, M.A. Weber, J.E. Sealey and J.H. Laragh: New Engl. J. Med. 296, 641 (1977).

    Article  Google Scholar 

  10. J.H. Laragh and J.E. Sealey: Cardiovasc. Med. 2, 1053 (1977).

    Google Scholar 

  11. J.H. Laragh: Prog. Cardiovasc. Dis. 21, 159 (1978).

    Article  Google Scholar 

  12. J.H. Laragh, R.L. Letcher and T.G. Pickering: JAMA 241, 151 (1979).

    Google Scholar 

  13. F. Gross: Klin. Wschr. 36, 193 (1958).

    Article  Google Scholar 

  14. R. Schwyzer, B. Iselin, H. Kappeler, B. Riniker, W. Rittel and H. Zuber: Helv. Chim. Acta 41, 1287 (1958).

    Article  Google Scholar 

  15. J. Genest, W. Nowaczynski, E. Koiw, T. Sandor and P. Biron. In: K.D. Bock and P.R. Cottier (eds.): Essential Hypertension. Springer, Heidelberg 1960.

    Google Scholar 

  16. J.H. Laragh, M. Angers, W.G. Kelly and S. Liebermann: JAMA 174, 234 (1960).

    Google Scholar 

  17. J.H. Laragh: JAMA 174, 293 (1960).

    Article  Google Scholar 

  18. J.O. Davis and R.H. Freeman: Physiol. Rev. 56, 1 (1976).

    Google Scholar 

  19. N.K. Hollenberg: Ann. Rev. Pharmac. Toxic. 19, 559 (1979).

    Article  Google Scholar 

  20. J.H. Laragh and J.E. Sealey, in: J. Orloff and R.W. Berliner (eds.): Handbook of Physiology, section 8, Renal Physiology, Am. Phys. Soc. Washington, D.C., 1973.

    Google Scholar 

  21. M. J. Peach: Physiol. Rev. 57, 313 (1977).

    Google Scholar 

  22. P. Vecsei, E. Hackenthal and D. Ganten: Klin. Wschr. 56, suppl. 1, 5 (1978).

    Article  Google Scholar 

  23. T. Inagami and K. Murakami: J. Biol. Chem. 252, 2978 (1977).

    Google Scholar 

  24. R. L. Hauger, G. Aguilera and K. J. Catt: Nature 271, 176 (1978).

    Article  Google Scholar 

  25. F.E. Cole, E.D. Fröhlich and A.A. Macphee: Brain Res. 154, 178 (1978).

    Google Scholar 

  26. N.E. Sirett, S.N. Thornton and J.I. Hubbard: Clin. Sei. 56, 607 (1979).

    Google Scholar 

  27. E.G. Erdös, in: Bradykinin, Kallidin and Kallikrein. Handbook of Experimental Pharmacology, suppl., vol. 25. Springer-Verlag. Heidelberg 1979.

    Google Scholar 

  28. H.O.J. Collier: Proc. R. Soc. Med. 64, 1 (1971).

    Google Scholar 

  29. J.C. McGiff, N.A. Terragno, K.U. Malik and A.J. Lonigro: Circ. Res. 31, 36 (1972).

    Google Scholar 

  30. A.L. Blumberg, S.E. Denny, G.R. Marshall and P. Needleman: Am. J. Physiol. 232, 305 (1977).

    Google Scholar 

  31. O.A. Carretero and A.G. Scicli: Klin. Wschr. 56, suppl. 1, 113 (1978).

    Article  Google Scholar 

  32. E.G. Erdös: Biochem. Pharmac. 25, 1563 (1976); Am. J. Med. 60, 749 (1976).

    Google Scholar 

  33. N.G. Levinsky: Circ. Res. 44, 441 (1979).

    Article  Google Scholar 

  34. O.A. Carretero, S. Miyazaki and A. G. Scicli: Hypertension 3, 18 (1981).

    Article  Google Scholar 

  35. F.R. Bühler, J.H. Laragh, L. Baer, E.D. Vaughan, Jr., and H.R. Brunner: New Engl. J. Med. 287, 1209 (1972).

    Google Scholar 

  36. S. Muhammed, A.F. Fasola, P.J. Privitera, R.J. Lipicky, B.L. Martz and T.E. Gaffney: Circ. Res. 25, 543 (1969).

    Article  Google Scholar 

  37. G. Onesti, A.B. Schwartz, K.E. Kim, V. Pazmarti and C. Swartz: Circ. Res. 38, suppl. II, 53 (1971).

    Google Scholar 

  38. R.P. Alhquist: Prog. Drug Res. 20, 27 (1976).

    Google Scholar 

  39. B.N.C. Prichard and P.M. S. Gillam: Br. J. Med. 2, 725 (1964).

    Article  Google Scholar 

  40. G. Schröder and L. Werkö: Clin. Pharmac. Ther. 5, 159 (1964).

    Google Scholar 

  41. L. Hansson, R. Malmerona, R. Olander, A. Rosenhall, A. Westerlund, H. Arberg and B. Hood: Klin. Wschr. 50, 364 (1972).

    Article  Google Scholar 

  42. H.J. Waal-Manning: New Z. J. Med. 71, 383 (1970).

    Google Scholar 

  43. F.J. Zacharias, K.J. Cowen, J. Prestt, J. Vickers and B.G. Wall: Am. Heart J. 83, 755 (1972).

    Article  Google Scholar 

  44. C. Wilhelmsson, J.A. Vedin, L. Wilhelmsen, G. Tiblin and L. Werkö: Lancet J., 1157(1974).

    Google Scholar 

  45. M. Meier, J. Orwin, H. Rogg and H. Brunner, in: A. Scriabine (ed): Pharmacology of Antihypertensive Drugs. Raven Press, New York 1980.

    Google Scholar 

  46. A.M. Michelakis and R.G. McAllister: J. Clin. Endocr. 34, 386 (1972).

    Article  Google Scholar 

  47. N. Winer, D.S. Chokshi, M.S. Yoon and A.D. Freedman: J. Clin. Endocr. 29, 1168 (1969).

    Google Scholar 

  48. N. Winer, D.S. Chokshi and W.G. Walkenhorst: Circ. Res. 29, 239 (1971).

    Article  Google Scholar 

  49. J.-M. Alexandre, J. Menard, C Chevillard and H. Schmitt: Eur. J. Pharmac. 12, 111 (1970).

    Google Scholar 

  50. T.A. Assaykeen, P.L. Clayton, A. Goldfien and W.F. Ganong: Endocrinology, 1318(1970).

    Google Scholar 

  51. F.R. Bühler, J.H. Laragh, E.D. Vaughan, Jr., H.R. Brunner, H. Gavras and L. Baer: Am. J. Cardiol. 32, 511 (1973).

    Article  Google Scholar 

  52. J.I.M. Drayer, P.W.C. Kloppenborg, J. Festen, A. van’t Laar and T.J. Benraad: Am. J. Cardiol. 36, 716 (1975).

    Google Scholar 

  53. B.-G. Hansson, J.-F. Dymling, H. Hedeland and U.L. Hulthen: Eur. J. Clin. Pharmac. 11, 239 (1977).

    Article  Google Scholar 

  54. B.E. Karlberg, B. Kagedal, L. Tegler and K. Tolagen: Br. Med. J. I, 251 (1976).

    Google Scholar 

  55. K.O. Stumpe, H. Vetter, V. Hessenbruch, R. Düsing, R. Kolloch and F. Krück: Klin. Wschr. 53, 907 (1975).

    Article  Google Scholar 

  56. W. Vetter, K. Zäruba, H. Armbruster, R. Beckerhoff, H. Vetter, J. Nussberger, U. Schmied, G. Reck, A. Fontana and W. Siegenthaler: Klin. Wschr. 53, 709 (1975).

    Article  Google Scholar 

  57. F.R. Bühler, G. Marbet, U. Patel and F. Burkhart: Clin. Sei. Mol. Med. 48, 61s (1975).

    Google Scholar 

  58. F.R. Bühler, F. Burkhart, B.E. Lütold, M. Küng, G. Marbet and M. Pfisterer: Am. J. Cardiol. 36, 653 (1975).

    Article  Google Scholar 

  59. E.L. Bravo, R.C. Tarazi and H.P. Dustan: J. Lab. Clin. Med. 83, 119 (1974); New Engl. J. Med. 292, 66 (1975).

    Google Scholar 

  60. T. G. Pickering: New York State Med. J. Dec., 2054 (1979).

    Google Scholar 

  61. T.O. Morgan, R. Roberts, S.L. Carney, W.J. Louis and A.E. Doyle: Br. J. Clin. Pharmac. 2, 159 (1975).

    Article  Google Scholar 

  62. E.B. Pedersen and H. J. Kornerup: Eur. J. Clin. Pharmac. 12, 93 (1977).

    Article  Google Scholar 

  63. G.S. Stokes, M.A. Weber and I.R. Thornell Br. Med. J. I, 60 (1974).

    Article  Google Scholar 

  64. G. Leonetti, G. Mayer, A. Morganti, L. Terzoli, A, Zanchetti, G. Bianchet- ti, E. DiSalle, P.L. Monselli and C.A. Chidsey: Clin. Sci. Mol. Med. 48, 491 (1975).

    Google Scholar 

  65. F.W. Hong Tai Eng, M. Huber-Smith and D.S. McCann: Hypertension 2, 14 (1980).

    Google Scholar 

  66. E.K. Jackson and W.B. Campbell: Hypertension 3, 23 (1981); 2, 90 (1980).

    Google Scholar 

  67. P. Lewis: Am. J. Med. 60, 837 (1976).

    Article  Google Scholar 

  68. J.W. Hollifield, K. Sheeman, R.V. Zwagg and D.G. Shand: New Engl. J. Med. 295, 68 (1976).

    Article  Google Scholar 

  69. G. E. Walkerin: Circulation 17, 653 (1958).

    Article  Google Scholar 

  70. S. Sen, R.R. Smeby, F.M. Bumpus: Biochemistry 6, 1572 (1967); Am. J. Physiol. 214, 337 (1968).

    Google Scholar 

  71. T.A. Kotehin: J. Clin. Endoer. Metab. 39, 530 (1974).

    Article  Google Scholar 

  72. K. Poulsen, J. Burton and E. Haber: Biochemistry 12, 3877 (1973).

    Article  Google Scholar 

  73. J. Burton, K. Poulsen and E. Haber: Biochemistry 14, 3892 (1975).

    Google Scholar 

  74. T. Haber and J. Burton: Fed. Proc. 38, 2768 (1979),

    Google Scholar 

  75. T. Paiva, G. Goissis, L. Juliano, M. Miyamoto and A. Paiva: J. Med. Chem. 17, 238 (1974).

    Article  Google Scholar 

  76. E. Jörgensen, I. Kiraly-Olah, T. Lee and G. Windridge: J. Med. Chem. 17, 323 (1974).

    Article  Google Scholar 

  77. M. Khosla, M. Hall, R. Smeby and F. Bumpus: J. Med. Chem. 17, 431, 1156 (1974).

    Google Scholar 

  78. T. Paiva, A. Paiva, R.J. Freer and J.M. Stewart: J. Med. Chem. 15, 6 (1972).

    Article  Google Scholar 

  79. D. Regoli, W.K. Park, F. Rioux and C.S. Chan: Revue Can. Biol, 30, 319 (1971).

    Google Scholar 

  80. E.H.F. Escher, T. Mai Dung Nguyen, G. Gillemette and D.C. Regoli: Nature 275, 145 (1978).

    Google Scholar 

  81. P.A. Khairallah, A. Toth and F.M. Bumpus: J. Med. Chem. 13, 181 (1970).

    Article  Google Scholar 

  82. D.H.P. Streeten, G.H. Anderson, J.M. Freiberg and T.G. Dalakos: New Engl. J. Med. 292, 659 (1975).

    Google Scholar 

  83. D.B. Case, J.M. Wallace, H.G. Keim, J.E. Sealey and J.H. Laragh: Am. J. Med. 60, 825 (1976). 8Í G.R. Marshall: Fed. Proc. 35, 2494 (1976).

    Google Scholar 

  84. L.S. Marks, M.H. Maxwell and J.J. Kaufman: Ann. Int. Med. 87, 176 (1977).

    Article  Google Scholar 

  85. L. Baer, J.Z. Parra-Carrillo, I. Radichevich and G.S. Williams: Ann. Int. med. 87, 257 (1977).

    Article  Google Scholar 

  86. G. A. MacGregor and P. M. Dawes: Aust. N.Z. J. Med. 6, 53 (1976).

    Article  Google Scholar 

  87. N.K. Hollenberg, G.H. Williams, B. Burger, I. Ishikawa and D.F. Adams: J. Clin. Invest. 57, 39 (1976).

    Article  Google Scholar 

  88. E.D. Vaughan and M.J. Peach (eds.): Kidney Int. 15, suppl.9 (1979).

    Google Scholar 

  89. N.K. Hollenberg: Proceedings of the VII International Meeting of Congressional Nephrologists, Montreal 1978.

    Google Scholar 

  90. L.J. Greene, J.M. Stewart and S.H. Ferreira: Pharmac. Res. Commun. 1, 159 (1969).

    Google Scholar 

  91. S.H. Ferreira, D.C. Bartlett and L.J. Greene: Biochemistry 9, 2583 (1970). 89a S.H. Ferreira, L.J. Greene, V.A. Alabaster, Y.S. Bakhle and J.R. Vane: Nature 225, 379 (1970).

    Google Scholar 

  92. M.A. Ondetti, N.J. Williams, E.F. Sabo, J. Pluscec, E.R. Weaver and O. Kocy: Biochemistry 10, 4033 (1971).

    Google Scholar 

  93. H. Kato and T. Suzuki: Experientia 25, 694 (1969); Proc. Jap. Acad. 46, 176 (1969); Experientia 26, 1205 (1970); Biochemistry 10, 972 (1971).

    Google Scholar 

  94. D.W.J. Cushman, J. Pluscec, N.J. Williams, E.R. Weaver, E.F. Sabo, O. Kocy, H.S. Cheung and M. A. Ondetti: Experientia 29, 1032 (1973).

    Article  Google Scholar 

  95. S.L. Engel, T.R. Schaeffer, M.H. Waugh and B. Rubin: Proc. Soc. exp. Biol. Med. 143, 483 (1973).

    Article  Google Scholar 

  96. E.M. Krieger, H.C. Salgado, C.J. Assan, L.J. Greene and S.H. Ferreira: Lancet/, 269(1971).

    Google Scholar 

  97. E.D. Miller, Jr., A.L. Samuels, E. Haber and A.C. Barger: Am. J. Physiol. 228, 448 (1975).

    Google Scholar 

  98. C.R. Ayers, E.D. Vaughan, Jr., M.R. Yancey, K.T. Bing, C.C. Johnson and C.L. Morton: Circ. Res. 34, suppl., 1 - 27 (1974).

    Google Scholar 

  99. A.I. Samuels, E.D. Miller, Jr., J.C.S. Fray, E. Haber and A.C. Barger: Fed. Proc. 32, 380 (1973).

    Google Scholar 

  100. S. Oparil, T. Koerner and J.K. O’Donoghue: Hypertension 1, 13 (1979).

    Google Scholar 

  101. G.H. Williams and N.K. Hollenberg: New Engl. J. Med. 297, 184 (1977).

    Article  Google Scholar 

  102. J. Sancho, R. Re and J. Burton: Circulation 53, 400 (1976).

    Article  Google Scholar 

  103. H. Gavras, H.R. Brunner, J.H. Laragh, J.E. Sealey, I. Gavras and R.A. Vukovich: New Engl. J. Med. 291, 817 (1974).

    Article  Google Scholar 

  104. H. Gavras, H.R. Brunner, J.H. Laragh, I. Gavras and R.A. Vukovich: Clin. Sei. Mol. Med. 48, 57s (1975).

    Google Scholar 

  105. R. Re, R. Novelline, M.-T. Escourrou, C. Athanasoulis, J. Burton and E. Haber: New Engl. J. Med. 298, 582 (1978).

    Article  Google Scholar 

  106. D.W. Cushman, H.S. Cheung, E.F. Sabo, B. Rubin and M.A. Ondetti: Fed. Proc. 38, 2778 (1979).

    Google Scholar 

  107. B. Rubin and M. J. Antonaccio, in: A. Scriabine (ed.): Pharmacology of Antihypertensive Drugs. Raven Press, New York 1980.

    Google Scholar 

  108. R.C. Heel, R.N. Brogden, T.M. Speight and G.S. Avery: Drugs 20, 409 (1980).

    Google Scholar 

  109. A. R. Christlieb and R. B. Hickler: Endocrinology 91, 1064 (1972).

    Article  Google Scholar 

  110. D.T. Pals, F.D. Masucci, G.S. Denning, Jr., F. Sipos and D.C. Fessler: Circ. Res. 29, 673 (1971).

    Google Scholar 

  111. A. Mimran, R. Targhetta and B. Laroche: Hypertension 2, 732 (1980).

    Google Scholar 

  112. F.R. Crantz, S.L. Swartz, N.K. Hollenberg, T.J. Moore, R.G. Dluhy and G. H. Williams: Hypertension 2, 604 (1980).

    Article  Google Scholar 

  113. C.M. Huang, F. del Greco, A. Quintanilla and A. Molteni: JAMA 245, 478 (1981).

    Google Scholar 

  114. A.A. Patchett, E. Harris, E.W. Tristram, M.J. Wyvratt, M.T. Wu, D. Taub, E.R. Peterson, T.J. Ikeler, J. ten Broeke, L.G. Payne, D.L. Ondeyka, E.D. Thorsett, W.J. Greenlee, N.S. Lohr, R.D. Hoffsommer,

    Google Scholar 

  115. H. Joshua, W.V. Ruyle, J.W. Rothrock, S.D. Aster, A.L. Maycock, F. M. Robinson, R. Hirschmann, C.S. Sweet, E.H. Ulm, D.M. Gross, T.C. Vassil and C. A. Stone: Nature 288, 280 (1980).

    Article  Google Scholar 

  116. European Pat. Appl. 0, 012, 401 (1979).

    Google Scholar 

  117. D.M. Gross, C.S. Sweet, E.H. Ulm, E.P. Backlund, A.A. Morris, D. Weitz, D.L. Bohn, H.C. Wenger, T.C. Vassil and C.A. Stone: J. Pharmac. Exp. Ther. 216, 552 (1981).

    Google Scholar 

  118. C.S. Sweet, D.M. Gross, P.T. Arbegast, S.L. Gaul, P.M. Britt, C.T. Ludden, D. Weitz and C.A. Stone: J. Pharmac. Exp. Ther. 216, 558 (1981).

    Google Scholar 

  119. J. Biollaz, M. Burnier, G.A. Turini, D.B. Brunner, M. Porchet, H.J. Gomez, K.H. Jones, F. Ferber, W.B. Abrams, H. Gavras and H.R. Brunner: Clin. Pharmac. Ther. 29, 665 (1981).

    Article  Google Scholar 

  120. a H. Gavras, J. Biollaz, B. Waeber, H.R. Brunner, J. Gavras and R.O.

    Google Scholar 

  121. D.B. Brunner, G. Desponds, J. Biollaz, I. Keller, F. Ferber, H. Gavras, H.R. Brunner and J.L. Schelling: Brit. J. clin. Pharmac. II, 461 (1981).

    Google Scholar 

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  1. Pharmaceuticals Division, Ciba-Geigy Corporation, Summit, New Jersey, USA

    Robert W. Ashworth

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    Ernst Jucker

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Ashworth, R.W. (1982). Drugs affecting the renin-angiotensin system. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 26. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7111-2_6

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