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Discovery and Characterization of Linear Motif Mediated Protein-Protein Complexes

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Advanced Technologies for Protein Complex Production and Characterization

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1453))

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Abstract

There are myriads of protein-protein complexes that form within the cell. In addition to classical binding events between globular domains, many protein-protein interactions involve short disordered protein regions. The latter contain so-called linear motifs binding specifically to ordered protein domain surfaces. Linear binding motifs are classified based on their consensus sequence, where only a few amino acids are conserved. In this chapter we will review experimental and in silico techniques that can be used for the discovery and characterization of linear motif mediated protein-protein complexes involved in cellular signaling, protein level and gene expression regulation.

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Acknowledgements

This work was supported by grants from the National Research, Development and Innovation Office, Hungary (OTKA NN 114309, OTKA PD120973 and KKP_17 126963).

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Authors and Affiliations

  1. Institute of Organic Chemistry, HUN-REN Research Center for Natural Sciences, Budapest, Hungary

    András Zeke, Anita Alexa & Attila Reményi

Authors
  1. András Zeke
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  2. Anita Alexa
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  3. Attila Reményi
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Correspondence to Attila Reményi .

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Editors and Affiliations

  1. Centro de Investigaciones Biologicas Margarita Salas (CIB-CSIC), Madrid, Spain

    M. Cristina Vega

  2. Abvance Biotech SL, Madrid, Spain

    Francisco J. Fernández

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Zeke, A., Alexa, A., Reményi, A. (2024). Discovery and Characterization of Linear Motif Mediated Protein-Protein Complexes. In: Vega, M.C., Fernández, F.J. (eds) Advanced Technologies for Protein Complex Production and Characterization. Advances in Experimental Medicine and Biology, vol 1453. Springer, Cham. https://doi.org/10.1007/978-3-031-52193-5_5

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