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Ischemic Stroke

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Handbook of Cerebrovascular Disease and Neurointerventional Technique

Part of the book series: Contemporary Medical Imaging ((CMI))

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Abstract

This chapter focuses on acute ischemic stroke: initial evaluation and management, treatment, epidemiology, outcomes, pathophysiology, risk factors, and stroke syndromes. Endovascular treatment of stroke and the clinical evidence behind thrombectomy for large vessel occlusions are discussed in Chap. 8. Ischemic stroke in pediatric patients is discussed separately in an appendix.

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References

  1. Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2019;50:e344–418.

    Article  PubMed  Google Scholar 

  2. Gorelick PB. Primary and comprehensive stroke centers: history, value and certification criteria. J Stroke. 2013;15:78–89.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Rudd M, Buck D, Ford GA, Price CI. A systematic review of stroke recognition instruments in hospital and prehospital settings. Emerg Med J. 2016;33:818–22.

    Article  PubMed  Google Scholar 

  4. Jovin TG, Chamorro A, Cobo E, et al. Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med. 2015;372:2296–306.

    Article  CAS  PubMed  Google Scholar 

  5. Desai SM, Leslie-Mazwi TM, Hirsch JA, Jadhav AP. Optimal transfer paradigm for emergent large vessel occlusion strokes: recognition to recanalization in the RACECAT trial. J Neurointerv Surg. 2021;13:97–9.

    Article  PubMed  Google Scholar 

  6. Johnston SC, Gress DR, Browner WS, Sidney S. Short-term prognosis after emergency department diagnosis of TIA. JAMA. 2000;284:2901–6.

    Article  CAS  PubMed  Google Scholar 

  7. Johnston SC, Rothwell PM, Nguyen-Huynh MN, et al. Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet. 2007;369:283–92.

    Article  PubMed  Google Scholar 

  8. Wardlaw JM, Brazzelli M, Chappell FM, et al. ABCD2 score and secondary stroke prevention: meta-analysis and effect per 1,000 patients triaged. Neurology. 2015;85:373–80.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Adams HP Jr, del Zoppo G, Alberts MJ, et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke. 2007;38:1655–711.

    Article  PubMed  Google Scholar 

  10. Feldmann E, Wilterdink JL, Kosinski A, et al. The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) trial. Neurology. 2007;68:2099–106.

    Article  CAS  PubMed  Google Scholar 

  11. Pearson AC, Labovitz AJ, Tatineni S, Gomez CR. Superiority of transesophageal echocardiography in detecting cardiac source of embolism in patients with cerebral ischemia of uncertain etiology. J Am Coll Cardiol. 1991;17:66–72.

    Article  CAS  PubMed  Google Scholar 

  12. Rauh R, Fischereder M, Spengel FA. Transesophageal echocardiography in patients with focal cerebral ischemia of unknown cause. Stroke. 1996;27:691–4.

    Article  CAS  PubMed  Google Scholar 

  13. McNamara RL, Lima JA, Whelton PK, Powe NR. Echocardiographic identification of cardiovascular sources of emboli to guide clinical management of stroke: a cost-effectiveness analysis. Ann Intern Med. 1997;127:775–87.

    Article  CAS  PubMed  Google Scholar 

  14. Angeli S, Del Sette M, Beelke M, Anzola GP, Zanette E. Transcranial Doppler in the diagnosis of cardiac patent foramen ovale. Neurol Sci. 2001;22:353–6.

    Article  CAS  PubMed  Google Scholar 

  15. Del Sette M, Dinia L, Rizzi D, Sugo A, Albano B, Gandolfo C. Diagnosis of right-to-left shunt with transcranial Doppler and vertebrobasilar recording. Stroke. 2007;38:2254–6.

    Article  PubMed  Google Scholar 

  16. Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359:1317–29.

    Article  CAS  PubMed  Google Scholar 

  17. Del Zoppo GJ, Saver JL, Jauch EC, Adams HP Jr. Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator: a science advisory from the American Heart Association/American Stroke Association. Stroke. 2009;40:2945–8.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Lansberg MG, Schrooten M, Bluhmki E, Thijs VN, Saver JL. Treatment time-specific number needed to treat estimates for tissue plasminogen activator therapy in acute stroke based on shifts over the entire range of the modified Rankin Scale. Stroke. 2009;40:2079–84.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Campbell BCV, Mitchell PJ, Churilov L, et al. Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke. N Engl J Med. 2018;378:1573–82.

    Article  CAS  PubMed  Google Scholar 

  20. Warach SJ, Dula AN, Milling TJ Jr. Tenecteplase thrombolysis for acute ischemic stroke. Stroke. 2020;51:3440–51.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Campbell BC, Mitchell PJ, Kleinig TJ, et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med. 2015;372:1009–18.

    Article  CAS  PubMed  Google Scholar 

  22. Saver JL, Goyal M, Bonafe A, et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med. 2015;372:2285–95.

    Article  CAS  PubMed  Google Scholar 

  23. Goyal M, Demchuk AM, Menon BK, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015;372:1019–30.

    Article  CAS  PubMed  Google Scholar 

  24. Berkhemer OA, Fransen PS, Beumer D, et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med. 2015;372:11–20.

    Article  PubMed  Google Scholar 

  25. Powers WJ, Derdeyn CP, Biller J, et al. 2015 American Heart Association/American Stroke Association focused update of the 2013 guidelines for the early management of patients with acute ischemic stroke regarding endovascular treatment: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2015;46:3020–35.

    Article  CAS  PubMed  Google Scholar 

  26. Goyal M, Menon BK, van Zwam WH, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet. 2016;387:1723–31.

    Article  PubMed  Google Scholar 

  27. Albers GW, Marks MP, Kemp S, et al. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med. 2018;378:708–18.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct. N Engl J Med. 2018;378:11–21.

    Article  PubMed  Google Scholar 

  29. Yoshimura S, Sakai N, Yamagami H, et al. Endovascular therapy for acute stroke with a large ischemic region. N Engl J Med. 2022.

    Google Scholar 

  30. Schwarz S, Georgiadis D, Aschoff A, Schwab S. Effects of body position on intracranial pressure and cerebral perfusion in patients with large hemispheric stroke. Stroke. 2002;33:497–501.

    Article  PubMed  Google Scholar 

  31. Olavarria VV, Arima H, Anderson CS, et al. Head position and cerebral blood flow velocity in acute ischemic stroke: a systematic review and meta-analysis. Cerebrovasc Dis. 2014;37:401–8.

    Article  PubMed  Google Scholar 

  32. Anderson CS, Arima H, Lavados P, et al. Cluster-randomized, crossover trial of head positioning in acute stroke. N Engl J Med. 2017;376:2437–47.

    Article  PubMed  Google Scholar 

  33. Anadani M, Orabi MY, Alawieh A, et al. Blood pressure and outcome after mechanical thrombectomy with successful revascularization. Stroke. 2019;50:2448–54.

    Article  PubMed  Google Scholar 

  34. Ovbiagele B, Saver JL, Starkman S, et al. Statin enhancement of collateralization in acute stroke. Neurology. 2007;68:2129–31.

    Article  CAS  PubMed  Google Scholar 

  35. Caplan LR. Resolved: heparin may be useful in selected patients with brain ischemia. Stroke. 2003;34:230–1.

    Article  PubMed  Google Scholar 

  36. Chimowitz MI, Lynn MJ, Derdeyn CP, et al. Stenting versus aggressive medical therapy for intracranial arterial stenosis. N Engl J Med. 2011;365:993–1003.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Wang Y, Wang Y, Zhao X, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med. 2013;369:11–9.

    Article  CAS  PubMed  Google Scholar 

  38. Johnston SC, Easton JD, Farrant M, et al. Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA. N Engl J Med. 2018;379:215–25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Thiers FA, Sinskey AJ, Berndt ER. Trends in the globalization of clinical trials. Nat Rev. 2008;7:13–4.

    CAS  Google Scholar 

  40. Politis-Virk KI. China’s clinical trial boom. Pharma® Focus Asia; 2010.

    Google Scholar 

  41. Faden AI, Stoica B. Neuroprotection: challenges and opportunities. Arch Neurol. 2007;64:794–800.

    Article  PubMed  Google Scholar 

  42. Lampl Y, Boaz M, Gilad R, et al. Minocycline treatment in acute stroke: an open-label, evaluator-blinded study. Neurology. 2007;69:1404–10.

    Article  CAS  PubMed  Google Scholar 

  43. Garg R, Chaudhuri A, Munschauer F, Dandona P. Hyperglycemia, insulin, and acute ischemic stroke: a mechanistic justification for a trial of insulin infusion therapy. Stroke. 2006;37:267–73.

    Article  CAS  PubMed  Google Scholar 

  44. Yong M, Kaste M. Dynamic of hyperglycemia as a predictor of stroke outcome in the ECASS-II trial. Stroke. 2008;39:2749–55.

    Article  PubMed  Google Scholar 

  45. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001;345:1359–67.

    Article  PubMed  Google Scholar 

  46. Van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354:449–61.

    Article  PubMed  Google Scholar 

  47. Qaseem A, Humphrey LL, Chou R, Snow V, Shekelle P. Use of intensive insulin therapy for the management of glycemic control in hospitalized patients: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2011;154:260–7.

    Article  PubMed  Google Scholar 

  48. Gray CS, Hildreth AJ, Sandercock PA, et al. Glucose-potassium-insulin infusions in the management of post-stroke hyperglycaemia: the UK Glucose Insulin in Stroke Trial (GIST-UK). Lancet Neurol. 2007;6:397–406.

    Article  CAS  PubMed  Google Scholar 

  49. Johnston KC, Hall CE, Kissela BM, Bleck TP, Conaway MR. Glucose Regulation in Acute Stroke Patients (GRASP) trial: a randomized pilot trial. Stroke. 2009;40:3804–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. AHA Heart Disease and Stroke Statistics-2004 Update. 2004.

    Google Scholar 

  51. Godoy DA, Di Napoli M, Rabinstein AA. Treating hyperglycemia in neurocritical patients: benefits and perils. Neurocrit Care. 2010;13:425–38.

    Article  PubMed  Google Scholar 

  52. Umpierrez GE, Palacio A, Smiley D. Sliding scale insulin use: myth or insanity? Am J Med. 2007;120:563–7.

    Article  PubMed  Google Scholar 

  53. Zaremba J. Hyperthermia in ischemic stroke. Med Sci Monit. 2004;10:RA148–53.

    PubMed  Google Scholar 

  54. Fernandez A, Schmidt JM, Claassen J, et al. Fever after subarachnoid hemorrhage: risk factors and impact on outcome. Neurology. 2007;68:1013–9.

    Article  CAS  PubMed  Google Scholar 

  55. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346:549–56.

    Google Scholar 

  56. Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346:557–63.

    Article  PubMed  Google Scholar 

  57. Nielsen N, Wetterslev J, Cronberg T, et al. Targeted temperature management at 33 degrees C versus 36 degrees C after cardiac arrest. N Engl J Med. 2013;369:2197–206.

    Article  CAS  PubMed  Google Scholar 

  58. Bhardwaj A, Mirski M, Ulatowski J. Handbook of neurocritical care. Totowa, NJ: Humana Press; 2004.

    Book  Google Scholar 

  59. Nguyen T, Koroshetz WJ. Intensive care management of ischemic stroke. Curr Neurol Neurosci Rep. 2003;3:32–9.

    Article  PubMed  Google Scholar 

  60. Ali LK, Saver JL. The ischemic stroke patient who worsens: new assessment and management approaches. Rev Neurol Dis. 2007;4:85–91.

    PubMed  Google Scholar 

  61. Karepov VG, Gur AY, Bova I, Aronovich BD, Bornstein NM. Stroke-in-evolution: infarct-inherent mechanisms versus systemic causes. Cerebrovasc Dis. 2006;21:42–6.

    Article  PubMed  Google Scholar 

  62. Dostovic Z, Dostovic E, Smajlovic D, Ibrahimagic OC, Avdic L. Brain edema after ischaemic stroke. Med Arch. 2016;70:339–41.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Davenport A. The management of renal failure in patients at risk of cerebral edema/hypoxia. New Horiz. 1995;3:717–24.

    CAS  PubMed  Google Scholar 

  64. Qureshi AI, Geocadin RG, Suarez JI, Ulatowski JA. Long-term outcome after medical reversal of transtentorial herniation in patients with supratentorial mass lesions. Crit Care Med. 2000;28:1556–64.

    Article  CAS  PubMed  Google Scholar 

  65. Vahedi K, Hofmeijer J, Juettler E, et al. Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurol. 2007;6:215–22.

    Article  PubMed  Google Scholar 

  66. Wijdicks EF, Sheth KN, Carter BS, et al. Recommendations for the management of cerebral and cerebellar infarction with swelling: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45:1222–38.

    Article  PubMed  Google Scholar 

  67. Berges S, Moulin T, Berger E, et al. Seizures and epilepsy following strokes: recurrence factors. Eur Neurol. 2000;43:3–8.

    Article  CAS  PubMed  Google Scholar 

  68. Camilo O, Goldstein LB. Seizures and epilepsy after ischemic stroke. Stroke. 2004;35:1769–75.

    Article  PubMed  Google Scholar 

  69. McCarthy ST, Turner J. Low-dose subcutaneous heparin in the prevention of deep-vein thrombosis and pulmonary emboli following acute stroke. Age Ageing. 1986;15:84–8.

    Article  CAS  PubMed  Google Scholar 

  70. Sherman DG, Albers GW, Bladin C, et al. The efficacy and safety of enoxaparin versus unfractionated heparin for the prevention of venous thromboembolism after acute ischaemic stroke (PREVAIL Study): an open-label randomised comparison. Lancet. 2007;369:1347–55.

    Article  CAS  PubMed  Google Scholar 

  71. Epstein NE. A review of the risks and benefits of differing prophylaxis regimens for the treatment of deep venous thrombosis and pulmonary embolism in neurosurgery. Surg Neurol. 2005;64:295–301; discussion 2.

    Article  PubMed  Google Scholar 

  72. Kamran SI, Downey D, Ruff RL. Pneumatic sequential compression reduces the risk of deep vein thrombosis in stroke patients. Neurology. 1998;50:1683–8.

    Article  CAS  PubMed  Google Scholar 

  73. Reddy M, Gill SS, Rochon PA. Preventing pressure ulcers: a systematic review. JAMA. 2006;296:974–84.

    Article  CAS  PubMed  Google Scholar 

  74. Martin B. Prevention of gastrointestinal complications in the critically ill patient. AACN Adv Crit Care. 2007;18:158–66.

    PubMed  Google Scholar 

  75. Loo VG, Bourgault AM, Poirier L, et al. Host and pathogen factors for Clostridium difficile infection and colonization. N Engl J Med. 2011;365:1693–703.

    Article  CAS  PubMed  Google Scholar 

  76. Chemerinski E, Levine SR. Neuropsychiatric disorders following vascular brain injury. Mt Sinai J Med. 2006;73:1006–14.

    PubMed  Google Scholar 

  77. Ferro JM, Caeiro L, Verdelho A. Delirium in acute stroke. Curr Opin Neurol. 2002;15:51–5.

    Article  PubMed  Google Scholar 

  78. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ. 2002;324:71–86.

    Google Scholar 

  79. Furie KL, Kasner SE, Adams RJ, et al. Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the american heart association/american stroke association. Stroke. 2011;42:227–76.

    Article  PubMed  Google Scholar 

  80. Adams RJ, Albers G, Alberts MJ, et al. Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack. Stroke. 2008;39:1647–52.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Ishida K, Messe SR. Antiplatelet strategies for secondary prevention of stroke and TIA. Curr Atheroscler Rep. 2014;16:449.

    Article  PubMed  Google Scholar 

  82. Sharma M, Pearce LA, Benavente OR, et al. Predictors of mortality in patients with lacunar stroke in the secondary prevention of small subcortical strokes trial. Stroke. 2014;45:2989–94.

    Article  PubMed  PubMed Central  Google Scholar 

  83. Hao Q, Tampi M, O’Donnell M, Foroutan F, Siemieniuk RA, Guyatt G. Clopidogrel plus aspirin versus aspirin alone for acute minor ischaemic stroke or high risk transient ischaemic attack: systematic review and meta-analysis. BMJ. 2018;363:k5108.

    Article  PubMed  PubMed Central  Google Scholar 

  84. Johnston SC, Amarenco P, Albers GW, et al. Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack. N Engl J Med. 2016;375:35–43.

    Article  CAS  PubMed  Google Scholar 

  85. Gengo FM, Rainka M, Robson M, et al. Prevalence of platelet nonresponsiveness to aspirin in patients treated for secondary stroke prophylaxis and in patients with recurrent ischemic events. J Clin Pharmacol. 2008;48:335–43.

    Article  CAS  PubMed  Google Scholar 

  86. Chen WH, Cheng X, Lee PY, et al. Aspirin resistance and adverse clinical events in patients with coronary artery disease. Am J Med. 2007;120:631–5.

    Article  CAS  PubMed  Google Scholar 

  87. Lyerly MJ, Bartlett K, Albright KC. Role of CYP2C19 alleles in the management of recurrent ischemic stroke. Neurol Clin Pract. 2019;9:140–4.

    Article  PubMed  PubMed Central  Google Scholar 

  88. Sandercock PA, Counsell C, Kane EJ. Anticoagulants for acute ischaemic stroke. Cochrane Database Syst Rev. 2015:CD000024.

    Google Scholar 

  89. Proietti M, Romanazzi I, Romiti GF, Farcomeni A, Lip GYH. Real-world use of apixaban for stroke prevention in atrial fibrillation: a systematic review and meta-analysis. Stroke. 2018;49:98–106.

    Article  CAS  PubMed  Google Scholar 

  90. Granger CB, Alexander JH, McMurray JJ, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365:981–92.

    Article  CAS  PubMed  Google Scholar 

  91. Amarenco P, Bogousslavsky J, Callahan A 3rd, et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med. 2006;355:549–59.

    Article  CAS  PubMed  Google Scholar 

  92. Kleindorfer DO, Towfighi A, Chaturvedi S, et al. 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association/American Stroke Association. Stroke. 2021;52:e364–467.

    Article  PubMed  Google Scholar 

  93. Jin HM. Clinical uses and studies of the mechanism of Dan Shen. J Chin Med. 1978;3:180–3.

    Google Scholar 

  94. Wu B, Liu M, Liu H, et al. Meta-analysis of traditional Chinese patent medicine for ischemic stroke. Stroke. 2007;38:1973–9.

    Article  PubMed  Google Scholar 

  95. Kreisel SH, Hennerici MG, Bazner H. Pathophysiology of stroke rehabilitation: the natural course of clinical recovery, use-dependent plasticity and rehabilitative outcome. Cerebrovasc Dis. 2007;23:243–55.

    Article  PubMed  Google Scholar 

  96. Mark VW, Taub E, Morris DM. Neuroplasticity and constraint-induced movement therapy. Eura Medicophys. 2006;42:269–84.

    CAS  PubMed  Google Scholar 

  97. O’Malley MK, Ro T, Levin HS. Assessing and inducing neuroplasticity with transcranial magnetic stimulation and robotics for motor function. Arch Phys Med Rehabil. 2006;87:S59–66.

    Article  PubMed  Google Scholar 

  98. Hogan N, Krebs HI, Rohrer B, et al. Motions or muscles? Some behavioral factors underlying robotic assistance of motor recovery. J Rehabil Res Dev. 2006;43:605–18.

    Article  PubMed  Google Scholar 

  99. Sheffler LR, Chae J. Neuromuscular electrical stimulation in neurorehabilitation. Muscle Nerve. 2007;35:562–90.

    Article  PubMed  Google Scholar 

  100. Phillips JP, Devier DJ, Feeney DM. Rehabilitation pharmacology: bridging laboratory work to clinical application. J Head Trauma Rehabil. 2003;18:342–56.

    Article  PubMed  Google Scholar 

  101. Dobkin BH. Behavioral, temporal, and spatial targets for cellular transplants as adjuncts to rehabilitation for stroke. Stroke. 2007;38:832–9.

    Article  PubMed  Google Scholar 

  102. Chen J, Chopp M. Neurorestorative treatment of stroke: cell and pharmacological approaches. NeuroRx. 2006;3:466–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  103. Collaborators GBDS. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 2021;20:795–820.

    Article  Google Scholar 

  104. Mao L, Jin H, Wang M, et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. 2020;77:683–90.

    Article  PubMed  Google Scholar 

  105. Leading Causes of Death. 2017. https://www.cdc.gov/nchs/fastats/leading-causes-of-death.htm.

  106. Meschia JF, Bushnell C, Boden-Albala B, et al. Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45:3754–832.

    Article  PubMed  PubMed Central  Google Scholar 

  107. Kissela B, Schneider A, Kleindorfer D, et al. Stroke in a biracial population: the excess burden of stroke among blacks. Stroke. 2004;35:426–31.

    Article  PubMed  Google Scholar 

  108. Niewada M, Kobayashi A, Sandercock PA, Kaminski B, Czlonkowska A. Influence of gender on baseline features and clinical outcomes among 17,370 patients with confirmed ischaemic stroke in the international stroke trial. Neuroepidemiology. 2005;24:123–8.

    Article  PubMed  Google Scholar 

  109. Bushnell C, McCullough LD, Awad IA, et al. Guidelines for the prevention of stroke in women: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45:1545–88.

    Article  PubMed  PubMed Central  Google Scholar 

  110. Goldstein LB, Bushnell CD, Adams RJ, et al. Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42:517–84.

    Article  PubMed  Google Scholar 

  111. White H, Boden-Albala B, Wang C, et al. Ischemic stroke subtype incidence among whites, blacks, and Hispanics: the Northern Manhattan Study. Circulation. 2005;111:1327–31.

    Article  PubMed  Google Scholar 

  112. Fukutake T. Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL): from discovery to gene identification. J Stroke Cerebrovasc Dis. 2011;20:85–93.

    Article  PubMed  Google Scholar 

  113. Donohue MM, Tirschwell DL. Implications of pharmacogenetic testing for patients taking warfarin or clopidogrel. Curr Neurol Neurosci Rep. 2011;11:52–60.

    Article  CAS  PubMed  Google Scholar 

  114. Chobanian AV, Bakris GL, Black HR, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42:1206–52.

    Article  CAS  PubMed  Google Scholar 

  115. Rashid P, Leonardi-Bee J, Bath P. Blood pressure reduction and secondary prevention of stroke and other vascular events: a systematic review. Stroke. 2003;34:2741–8.

    Article  PubMed  Google Scholar 

  116. Sacco RL, Adams R, Albers G, et al. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline. Stroke. 2006;37:577–617.

    Article  PubMed  Google Scholar 

  117. Sandset EC, Bath PM, Boysen G, et al. The angiotensin-receptor blocker candesartan for treatment of acute stroke (SCAST): a randomised, placebo-controlled, double-blind trial. Lancet. 2011;377:741–50.

    Article  CAS  PubMed  Google Scholar 

  118. Ahmed N, Wahlgren N, Brainin M, et al. Relationship of blood pressure, antihypertensive therapy, and outcome in ischemic stroke treated with intravenous thrombolysis. Stroke. 2009;40:2442–9.

    Article  PubMed  Google Scholar 

  119. Prevention CfDCa. National diabetes statistics report. In: Services USDoHaH, ed. Atlanta, GA; 2020.

    Google Scholar 

  120. Goldstein LB, Adams R, Alberts MJ, et al. Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group: the American Academy of Neurology affirms the value of this guideline. Stroke. 2006;37:1583–633.

    Article  PubMed  Google Scholar 

  121. Bonora E, Kiechl S, Willeit J, et al. Insulin resistance as estimated by homeostasis model assessment predicts incident symptomatic cardiovascular disease in caucasian subjects from the general population: the Bruneck study. Diabetes Care. 2007;30:318–24.

    Article  PubMed  Google Scholar 

  122. Blanco M, Nombela F, Castellanos M, et al. Statin treatment withdrawal in ischemic stroke: a controlled randomized study. Neurology. 2007;69:904–10.

    Article  CAS  PubMed  Google Scholar 

  123. Goldstein LB. Low LDL cholesterol, statins, and brain hemorrhage: should we worry? Neurology. 2007;68:719–20.

    Article  PubMed  Google Scholar 

  124. Stone NJ, Robinson JG, Lichtenstein AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129:S1–45.

    Article  PubMed  Google Scholar 

  125. Cimino M, Gelosa P, Gianella A, Nobili E, Tremoli E, Sironi L. Statins: multiple mechanisms of action in the ischemic brain. Neuroscientist. 2007;13:208–13.

    Article  CAS  PubMed  Google Scholar 

  126. National Health and Nutrition Examination Survey. 2009. https://wwwn.cdc.gov/nchs/nhanes/ContinuousNhanes/Default.aspx?BeginYear=2009.

  127. Bang OY. Intracranial atherosclerotic stroke: specific focus on the metabolic syndrome and inflammation. Curr Atheroscler Rep. 2006;8:330–6.

    Article  CAS  PubMed  Google Scholar 

  128. Collop N. The effect of obstructive sleep apnea on chronic medical disorders. Cleve Clin J Med. 2007;74:72–8.

    Article  PubMed  Google Scholar 

  129. Yaggi H, Mohsenin V. Obstructive sleep apnoea and stroke. Lancet Neurol. 2004;3:333–42.

    Article  PubMed  Google Scholar 

  130. Elkind MS, Cole JW. Do common infections cause stroke? Semin Neurol. 2006;26:88–99.

    Article  PubMed  Google Scholar 

  131. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  132. Hess DC, Eldahshan W, Rutkowski E. COVID-19-related stroke. Transl Stroke Res. 2020;11:322–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  133. Yaghi S, Ishida K, Torres J, et al. SARS-CoV-2 and stroke in a New York Healthcare System. Stroke. 2020;51:2002–11.

    Article  CAS  PubMed  Google Scholar 

  134. Merkler AE, Parikh NS, Mir S, et al. Risk of ischemic stroke in patients with coronavirus disease 2019 (COVID-19) vs patients with influenza. JAMA Neurol. 2020.

    Google Scholar 

  135. Knight R, Walker V, Ip S, et al. Association of COVID-19 with major arterial and venous thrombotic diseases: a population-wide cohort study of 48 million adults in England and Wales. Circulation. 2022;146:892–906.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  136. Siegler JE, Heslin ME, Thau L, Smith A, Jovin TG. Falling stroke rates during COVID-19 pandemic at a comprehensive stroke center. J Stroke Cerebrovasc Dis. 2020;29:104953.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  137. Kim YE, Huh K, Park YJ, Peck KR, Jung J. Association between vaccination and acute myocardial infarction and ischemic stroke after COVID-19 infection. JAMA. 2022;328:887–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  138. Marzolini C, Kuritzkes DR, Marra F, et al. Recommendations for the management of drug-drug interactions between the COVID-19 antiviral nirmatrelvir/ritonavir (paxlovid) and comedications. Clin Pharmacol Ther. 2022;112:1191–200.

    Article  CAS  PubMed  Google Scholar 

  139. Elkind MS. Inflammation, atherosclerosis, and stroke. Neurologist. 2006;12:140–8.

    Article  PubMed  Google Scholar 

  140. Everett BM, Glynn RJ, MacFadyen JG, Ridker PM. Rosuvastatin in the prevention of stroke among men and women with elevated levels of C-reactive protein: justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER). Circulation. 2010;121:143–50.

    Article  CAS  PubMed  Google Scholar 

  141. Suzuki S, Brown CM, Wise PM. Mechanisms of neuroprotection by estrogen. Endocrine. 2006;29:209–15.

    Article  CAS  PubMed  Google Scholar 

  142. Bushnell CD. Oestrogen and stroke in women: assessment of risk. Lancet Neurol. 2005;4:743–51.

    Article  CAS  PubMed  Google Scholar 

  143. Simon JA, Hsia J, Cauley JA, et al. Postmenopausal hormone therapy and risk of stroke: the Heart and Estrogen-progestin Replacement Study (HERS). Circulation. 2001;103:638–42.

    Article  CAS  PubMed  Google Scholar 

  144. Viscoli CM, Brass LM, Kernan WN, Sarrel PM, Suissa S, Horwitz RI. A clinical trial of estrogen-replacement therapy after ischemic stroke. N Engl J Med. 2001;345:1243–9.

    Article  CAS  PubMed  Google Scholar 

  145. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA. 2002;288:321–33.

    Article  CAS  PubMed  Google Scholar 

  146. Hormone therapy for the prevention of chronic conditions in postmenopausal women: recommendations from the U.S. Preventive Services Task Force. Ann Intern Med. 2005;142:855–60.

    Google Scholar 

  147. Executive summary. Hormone therapy. Obstet Gynecol. 2004;104:1S–4S.

    Google Scholar 

  148. Helms A, Ajayi O, Kittner S. Investigating the link between oral contraceptives and stroke. Pract Neurol. 2007;35–41.

    Google Scholar 

  149. Arnett DK, Blumenthal RS, Albert MA, et al. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;140:e563–e95.

    PubMed  PubMed Central  Google Scholar 

  150. Billinger SA, Arena R, Bernhardt J, et al. Physical activity and exercise recommendations for stroke survivors: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45:2532–53.

    Article  PubMed  Google Scholar 

  151. Hackam DG. Cannabis and stroke: systematic appraisal of case reports. Stroke. 2015;46:852–6.

    Article  CAS  PubMed  Google Scholar 

  152. Dutta T, Ryan KA, Thompson O, et al. Marijuana use and the risk of early ischemic stroke: the stroke prevention in young adults study. Stroke. 2021;52:3184–90.

    Article  PubMed  PubMed Central  Google Scholar 

  153. Cahill K, Stead LF, Lancaster T. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev. 2007:CD006103.

    Google Scholar 

  154. Williams KE, Reeves KR, Billing CB Jr, Pennington AM, Gong J. A double-blind study evaluating the long-term safety of varenicline for smoking cessation. Curr Med Res Opin. 2007;23:793–801.

    Article  CAS  PubMed  Google Scholar 

  155. Moore TJ, Furberg CD, Glenmullen J, Maltsberger JT, Singh S. Suicidal behavior and depression in smoking cessation treatments. PLoS One. 2011;6:e27016.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  156. Haggstram FM, Chatkin JM, Sussenbach-Vaz E, Cesari DH, Fam CF, Fritscher CC. A controlled trial of nortriptyline, sustained-release bupropion and placebo for smoking cessation: preliminary results. Pulm Pharmacol Ther. 2006.

    Google Scholar 

  157. Administration USFaD. FDA approves novel medication for smoking cessation. Report No. 2006. http://www.fda.gov/bbs/topics/NEWS/2006/NEW01370.html.

  158. Khurshid I, Downie GH. Pulmonary arteriovenous malformation. Postgrad Med J. 2002;78:191–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  159. White RI Jr, Lynch-Nyhan A, Terry P, et al. Pulmonary arteriovenous malformations: techniques and long-term outcome of embolotherapy. Radiology. 1988;169:663–9.

    Article  PubMed  Google Scholar 

  160. Jauss M, Zanette E. Detection of right-to-left shunt with ultrasound contrast agent and transcranial Doppler sonography. Cerebrovasc Dis. 2000;10:490–6.

    Article  CAS  PubMed  Google Scholar 

  161. Cottin V, Dupuis-Girod S, Lesca G, Cordier JF. Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (rendu-osler disease). Respiration. 2007;74:361–78.

    Article  CAS  PubMed  Google Scholar 

  162. Amarenco P. Cryptogenic stroke, aortic arch atheroma, patent foramen ovale, and the risk of stroke. Cerebrovasc Dis. 2005;20(Suppl 2):68–74.

    Article  PubMed  Google Scholar 

  163. Handke M, Harloff A, Olschewski M, Hetzel A, Geibel A. Patent foramen ovale and cryptogenic stroke in older patients. N Engl J Med. 2007;357:2262–8.

    Article  CAS  PubMed  Google Scholar 

  164. Mas JL, Arquizan C, Lamy C, et al. Recurrent cerebrovascular events associated with patent foramen ovale, atrial septal aneurysm, or both. N Engl J Med. 2001;345:1740–6.

    Article  CAS  PubMed  Google Scholar 

  165. Dalen JE, Alpert JS. Cryptogenic strokes and patent foramen ovales: what’s the right treatment? Am J Med. 2016;129:1159–62.

    Article  PubMed  Google Scholar 

  166. Messe SR, Gronseth G, Kent DM, et al. Practice advisory: recurrent stroke with patent foramen ovale (update of practice parameter): report of the guideline development, dissemination, and implementation subcommittee of the American Academy of Neurology. Neurology. 2016;87:815–21.

    Article  PubMed  PubMed Central  Google Scholar 

  167. Mas JL, Derumeaux G, Guillon B, et al. patent foramen ovale closure or anticoagulation vs. antiplatelets after stroke. N Engl J Med. 2017;377:1011–21.

    Article  CAS  PubMed  Google Scholar 

  168. Sondergaard L, Kasner SE, Rhodes JF, et al. patent foramen ovale closure or antiplatelet therapy for cryptogenic stroke. N Engl J Med. 2017;377:1033–42.

    Article  PubMed  Google Scholar 

  169. Lee PH, Song JK, Kim JS, et al. Cryptogenic stroke and high-risk patent foramen ovale: the DEFENSE-PFO trial. J Am Coll Cardiol. 2018;71:2335–42.

    Article  PubMed  Google Scholar 

  170. Messe SR, Gronseth GS, Kent DM, et al. Practice advisory update summary: patent foramen ovale and secondary stroke prevention: report of the guideline subcommittee of the American Academy of Neurology. Neurology. 2020;94:876–85.

    Article  PubMed  PubMed Central  Google Scholar 

  171. Wozniak MA, Kittner SJ. Return to work after ischemic stroke: a methodological review. Neuroepidemiology. 2002;21:159–66.

    Article  PubMed  Google Scholar 

  172. Benjamin EJVS, Callaway CW, et al. Heart disease and stroke statistics-2018 update: a report from the American Heart Association. Circulation. 2018;137:e270–308.

    Article  Google Scholar 

  173. Cucchiara B, Elm J, Easton JD, et al. disability after minor stroke and transient ischemic attack in the POINT trial. Stroke. 2020;51:792–9.

    Article  PubMed  PubMed Central  Google Scholar 

  174. Moroney JT, Bagiella E, Paik MC, Sacco RL, Desmond DW. Risk factors for early recurrence after ischemic stroke: the role of stroke syndrome and subtype. Stroke. 1998;29:2118–24.

    Article  CAS  PubMed  Google Scholar 

  175. Gattringer T, Posekany A, Niederkorn K, et al. Predicting early mortality of acute ischemic stroke. Stroke. 2019;50:349–56.

    Article  PubMed  Google Scholar 

  176. Hand PJ, Kwan J, Lindley RI, Dennis MS, Wardlaw JM. Distinguishing between stroke and mimic at the bedside: the brain attack study. Stroke. 2006;37:769–75.

    Article  PubMed  Google Scholar 

  177. Foster JW, Hart RG. Hypoglycemic hemiplegia: two cases and a clinical review. Stroke. 1987;18:944–6.

    Article  CAS  PubMed  Google Scholar 

  178. Bladin CF, Alexandrov AV, Bellavance A, et al. Seizures after stroke: a prospective multicenter study. Arch Neurol. 2000;57:1617–22.

    Article  CAS  PubMed  Google Scholar 

  179. Sylaja PN, Dzialowski I, Krol A, Roy J, Federico P, Demchuk AM. Role of CT angiography in thrombolysis decision-making for patients with presumed seizure at stroke onset. Stroke. 2006;37:915–7.

    Article  CAS  PubMed  Google Scholar 

  180. Selim M, Kumar S, Fink J, Schlaug G, Caplan LR, Linfante I. Seizure at stroke onset: should it be an absolute contraindication to thrombolysis? Cerebrovasc Dis. 2002;14:54–7.

    Article  PubMed  Google Scholar 

  181. Benditt DG, van Dijk JG, Sutton R, et al. Syncope. Curr Probl Cardiol. 2004;29:152–229.

    Article  PubMed  Google Scholar 

  182. Arboix A, Massons J, Oliveres M, Arribas MP, Titus F. Headache in acute cerebrovascular disease: a prospective clinical study in 240 patients. Cephalalgia. 1994;14:37–40.

    Article  CAS  PubMed  Google Scholar 

  183. Ng YS, Stein J, Ning M, Black-Schaffer RM. Comparison of clinical characteristics and functional outcomes of ischemic stroke in different vascular territories. Stroke. 2007;38:2309–14.

    Article  PubMed  Google Scholar 

  184. Caplan LR. Transient ischemic attack with abnormal diffusion-weighted imaging results: what’s in a name? Arch Neurol. 2007;64:1080–2.

    Article  PubMed  Google Scholar 

  185. Kidwell CS, Warach S. Acute ischemic cerebrovascular syndrome: diagnostic criteria. Stroke. 2003;34:2995–8.

    Article  PubMed  Google Scholar 

  186. A CLASSIFICATION and outline of cerebrovascular diseases. Neurology 1958;8:395–434.

    Google Scholar 

  187. Quinette P, Guillery-Girard B, Dayan J, et al. What does transient global amnesia really mean? Review of the literature and thorough study of 142 cases. Brain. 2006;129:1640–58.

    Article  PubMed  Google Scholar 

  188. Bettermann K. Transient global amnesia: the continuing quest for a source. Arch Neurol. 2006;63:1336–8.

    Article  PubMed  Google Scholar 

  189. Roach ES. Transient global amnesia: look at mechanisms not causes. Arch Neurol. 2006;63:1338–9.

    Article  CAS  PubMed  Google Scholar 

  190. Menendez Gonzalez M, Rivera MM. Transient global amnesia: increasing evidence of a venous etiology. Arch Neurol. 2006;63:1334–6.

    Article  PubMed  Google Scholar 

  191. Brazis PW, Masdeau JC, Biller J. Localization in clinical neurology. Philadelphia: Lippincott, Williams & Wilkins; 2007.

    Google Scholar 

  192. Ali S, Khan MA, Khealani B. Limb-shaking Transient Ischemic Attacks: case report and review of literature. BMC Neurol. 2006;6:5.

    Article  PubMed  PubMed Central  Google Scholar 

  193. Murie JA, Sheldon CD, Quin RO. Carotid artery bruit: association with internal carotid stenosis and intraluminal turbulence. Br J Surg. 1984;71:50–2.

    Article  CAS  PubMed  Google Scholar 

  194. Shorr RI, Johnson KC, Wan JY, et al. The prognostic significance of asymptomatic carotid bruits in the elderly. J Gen Intern Med. 1998;13:86–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  195. Hillis AE. Aphasia: progress in the last quarter of a century. Neurology. 2007;69:200–13.

    Article  PubMed  Google Scholar 

  196. Chambers BR, Brooder RJ, Donnan GA. Proximal posterior cerebral artery occlusion simulating middle cerebral artery occlusion. Neurology. 1991;41:385–90.

    Article  CAS  PubMed  Google Scholar 

  197. Maulaz AB, Bezerra DC, Bogousslavsky J. Posterior cerebral artery infarction from middle cerebral artery infarction. Arch Neurol. 2005;62:938–41.

    Article  PubMed  Google Scholar 

  198. Hommel M, Besson G, Pollak P, Kahane P, Le Bas JF, Perret J. Hemiplegia in posterior cerebral artery occlusion. Neurology. 1990;40:1496–9.

    Article  CAS  PubMed  Google Scholar 

  199. Sorensen BF. Bow hunter’s stroke. Neurosurgery. 1978;2:259–61.

    Article  CAS  PubMed  Google Scholar 

  200. Gregoire SM, Charidimou A, Gadapa N, et al. Acute ischaemic brain lesions in intracerebral haemorrhage: multicentre cross-sectional magnetic resonance imaging study. Brain. 2011;134:2376–86.

    Article  PubMed  Google Scholar 

  201. Petrone L, Nannoni S, Del Bene A, Palumbo V, Inzitari D. Branch atheromatous disease: a clinically meaningful, yet unproven concept. Cerebrovasc Dis. 2016;41:87–95.

    Article  PubMed  Google Scholar 

  202. Bamford J, Sandercock P, Dennis M, Burn J, Warlow C. Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet. 1991;337:1521–6.

    Article  CAS  PubMed  Google Scholar 

  203. Adams HP Jr, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24:35–41.

    Article  PubMed  Google Scholar 

  204. Kolominsky-Rabas PL, Weber M, Gefeller O, Neundoerfer B, Heuschmann PU. Epidemiology of ischemic stroke subtypes according to TOAST criteria: incidence, recurrence, and long-term survival in ischemic stroke subtypes: a population-based study. Stroke. 2001;32:2735–40.

    Article  CAS  PubMed  Google Scholar 

  205. Di Tullio MR, Russo C, Jin Z, Sacco RL, Mohr JP, Homma S. Aortic arch plaques and risk of recurrent stroke and death. Circulation. 2009;119:2376–82.

    Article  PubMed  PubMed Central  Google Scholar 

  206. Molisse TA, Tunick PA, Kronzon I. Complications of aortic atherosclerosis: atheroemboli and thromboemboli. Curr Treat Options Cardiovasc Med. 2007;9:137–47.

    Article  PubMed  Google Scholar 

  207. Dressler FA, Craig WR, Castello R, Labovitz AJ. Mobile aortic atheroma and systemic emboli: efficacy of anticoagulation and influence of plaque morphology on recurrent stroke. J Am Coll Cardiol. 1998;31:134–8.

    Article  CAS  PubMed  Google Scholar 

  208. Ferrari E, Vidal R, Chevallier T, Baudouy M. Atherosclerosis of the thoracic aorta and aortic debris as a marker of poor prognosis: benefit of oral anticoagulants. J Am Coll Cardiol. 1999;33:1317–22.

    Article  CAS  PubMed  Google Scholar 

  209. Amarenco P, Davis S, Jones EF, et al. Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques. Stroke. 2014;45:1248–57.

    Article  CAS  PubMed  Google Scholar 

  210. Lutsep HL. MATCH results: implications for the internist. Am J Med. 2006;119(526):e1–7.

    Google Scholar 

  211. Medi C, Hankey GJ, Freedman SB. Atrial fibrillation. Med J Aust. 2007;186:197–202.

    Article  PubMed  Google Scholar 

  212. Fang MC, Chen J, Rich MW. Atrial fibrillation in the elderly. Am J Med. 2007;120:481–7.

    Article  PubMed  Google Scholar 

  213. Tsivgoulis G, Katsanos AH, Kohrmann M, et al. Duration of implantable cardiac monitoring and detection of atrial fibrillation in ischemic stroke patients: a systematic review and meta-analysis. J Stroke. 2019;21:302–11.

    Article  PubMed  PubMed Central  Google Scholar 

  214. Skrebelyte-Strom L, Ronning OM, Dahl FA, Steine K, Kjekshus H. Prediction of occult atrial fibrillation in patients after cryptogenic stroke and transient ischaemic attack: PROACTIA. Europace. 2022;24:1881–8.

    Article  PubMed  PubMed Central  Google Scholar 

  215. Gage BF, Waterman AD, Shannon W, Boechler M, Rich MW, Radford MJ. Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation. JAMA. 2001;285:2864–70.

    Article  CAS  PubMed  Google Scholar 

  216. Hart RG, Benavente O, McBride R, Pearce LA. Antithrombotic therapy to prevent stroke in patients with atrial fibrillation: a meta-analysis. Ann Intern Med. 1999;131:492–501.

    Article  CAS  PubMed  Google Scholar 

  217. January CT, Wann LS, Alpert JS, et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation. 2014;130:2071–104.

    Article  PubMed  Google Scholar 

  218. Pollack CV Jr, Reilly PA, Eikelboom J, et al. Idarucizumab for dabigatran reversal. N Engl J Med. 2015;373:511–20.

    Article  CAS  PubMed  Google Scholar 

  219. Connolly SJ, Crowther M, Eikelboom JW, et al. Full study report of andexanet alfa for bleeding associated with factor xa inhibitors. N Engl J Med. 2019;380:1326–35.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  220. Lip GY, Nieuwlaat R, Pisters R, Lane DA, Crijns HJ. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation. Chest. 2010;137:263–72.

    Article  PubMed  Google Scholar 

  221. Gazova A, Leddy JJ, Rexova M, Hlivak P, Hatala R, Kyselovic J. Predictive value of CHA2DS2-VASc scores regarding the risk of stroke and all-cause mortality in patients with atrial fibrillation (CONSORT compliant). Medicine (Baltimore). 2019;98:e16560.

    Article  CAS  PubMed  Google Scholar 

  222. Orencia AJ, Hammill SC, Whisnant JP. Sinus node dysfunction and ischemic stroke. Heart Dis Stroke. 1994;3:91–4.

    CAS  PubMed  Google Scholar 

  223. Scholten MF, Thornton AS, Mekel JM, Koudstaal PJ, Jordaens LJ. Anticoagulation in atrial fibrillation and flutter. Europace. 2005;7:492–9.

    Article  CAS  PubMed  Google Scholar 

  224. Hart RG, Pearce LA, Rothbart RM, McAnulty JH, Asinger RW, Halperin JL. Stroke with intermittent atrial fibrillation: incidence and predictors during aspirin therapy. Stroke Prevention in Atrial Fibrillation Investigators. J Am Coll Cardiol. 2000;35:183–7.

    Article  CAS  PubMed  Google Scholar 

  225. Merkler AE, Alakbarli J, Gialdini G, et al. Short-term risk of ischemic stroke after detection of left ventricular thrombus on cardiac magnetic resonance imaging. J Stroke Cerebrovasc Dis. 2019;28:1027–31.

    Article  PubMed  PubMed Central  Google Scholar 

  226. Kernan WN, Ovbiagele B, Black HR, et al. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45:2160–236.

    Article  PubMed  Google Scholar 

  227. Lattuca B, Bouziri N, Kerneis M, et al. Antithrombotic therapy for patients with left ventricular mural thrombus. J Am Coll Cardiol. 2020;75:1676–85.

    Article  CAS  PubMed  Google Scholar 

  228. Loh E, Sutton MS, Wun CC, et al. Ventricular dysfunction and the risk of stroke after myocardial infarction. N Engl J Med. 1997;336:251–7.

    Article  CAS  PubMed  Google Scholar 

  229. Bashore TM, Cabell C, Fowler V Jr. Update on infective endocarditis. Curr Probl Cardiol. 2006;31:274–352.

    Article  PubMed  Google Scholar 

  230. el-Shami K, Griffiths E, Streiff M. Nonbacterial thrombotic endocarditis in cancer patients: pathogenesis, diagnosis, and treatment. Oncologist. 2007;12:518–23.

    Article  PubMed  Google Scholar 

  231. Mohananey D, Mohadjer A, Pettersson G, et al. Association of vegetation size with embolic risk in patients with infective endocarditis: a systematic review and meta-analysis. JAMA Intern Med. 2018;178:502–10.

    Article  PubMed  PubMed Central  Google Scholar 

  232. Lopez JA, Ross RS, Fishbein MC, Siegel RJ. Nonbacterial thrombotic endocarditis: a review. Am Heart J. 1987;113:773–84.

    Article  CAS  PubMed  Google Scholar 

  233. Rabinstein AA, Giovanelli C, Romano JG, Koch S, Forteza AM, Ricci M. Surgical treatment of nonbacterial thrombotic endocarditis presenting with stroke. J Neurol. 2005;252:352–5.

    Article  CAS  PubMed  Google Scholar 

  234. Mercadante N. Management of patients with prosthetic heart valves: potential impact of valve site, clinical characteristics, and comorbidity. J Thromb Thrombolysis. 2000;10:29–34.

    Article  CAS  PubMed  Google Scholar 

  235. Hardman SM, Cowie MR. Fortnightly review: anticoagulation in heart disease. BMJ. 1999;318:238–44.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  236. Ekinci EI, Donnan GA. Neurological manifestations of cardiac myxoma: a review of the literature and report of cases. Intern Med J. 2004;34:243–9.

    Article  CAS  PubMed  Google Scholar 

  237. Lee VH, Connolly HM, Brown RD Jr. Central nervous system manifestations of cardiac myxoma. Arch Neurol. 2007;64:1115–20.

    Article  PubMed  Google Scholar 

  238. Kelley RE. CNS vasculitis. Front Biosci. 2004;9:946–55.

    Article  CAS  PubMed  Google Scholar 

  239. Younger DS. Vasculitis of the nervous system. Curr Opin Neurol. 2004;17:317–36.

    Article  PubMed  Google Scholar 

  240. Jennette JC, Falk RJ. Nosology of primary vasculitis. Curr Opin Rheumatol. 2007;19:10–6.

    Article  PubMed  Google Scholar 

  241. Kuker W. Cerebral vasculitis: imaging signs revisited. Neuroradiology. 2007;49:471–9.

    Article  PubMed  Google Scholar 

  242. Melson MR, Weyand CM, Newman NJ, Biousse V. The diagnosis of giant cell arteritis. Rev Neurol Dis. 2007;4:128–42.

    PubMed  Google Scholar 

  243. van der Geest KSM, Sandovici M, Brouwer E, Mackie SL. Diagnostic accuracy of symptoms, physical signs, and laboratory tests for giant cell arteritis: a systematic review and meta-analysis. JAMA Intern Med. 2020;180:1295–304.

    Article  PubMed  PubMed Central  Google Scholar 

  244. Chan FLY, Lester S, Whittle SL, Hill CL. The utility of ESR, CRP and platelets in the diagnosis of GCA. BMC Rheumatol. 2019;3:14.

    Article  PubMed  PubMed Central  Google Scholar 

  245. Lee MS, Smith SD, Galor A, Hoffman GS. Antiplatelet and anticoagulant therapy in patients with giant cell arteritis. Arthritis Rheum. 2006;54:3306–9.

    Article  PubMed  Google Scholar 

  246. Ringleb PA, Strittmatter EI, Loewer M, et al. Cerebrovascular manifestations of Takayasu arteritis in Europe. Rheumatology (Oxford). 2005;44:1012–5.

    Article  CAS  PubMed  Google Scholar 

  247. Arend WP, Michel BA, Bloch DA, et al. The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum. 1990;33:1129–34.

    Article  CAS  PubMed  Google Scholar 

  248. Reichart MD, Bogousslavsky J, Janzer RC. Early lacunar strokes complicating polyarteritis nodosa: thrombotic microangiopathy. Neurology. 2000;54:883–9.

    Article  CAS  PubMed  Google Scholar 

  249. Lightfoot RW Jr, Michel BA, Bloch DA, et al. The American College of Rheumatology 1990 criteria for the classification of polyarteritis nodosa. Arthritis Rheum. 1990;33:1088–93.

    Article  PubMed  Google Scholar 

  250. Jennette JC. Overview of the 2012 revised International Chapel Hill Consensus Conference nomenclature of vasculitides. Clin Exp Nephrol. 2013;17:603–6.

    Article  PubMed  PubMed Central  Google Scholar 

  251. Lamprecht P, Gross WL. Wegener’s granulomatosis. Herz. 2004;29:47–56.

    Article  PubMed  Google Scholar 

  252. Leavitt RY, Fauci AS, Bloch DA, et al. The American College of Rheumatology 1990 criteria for the classification of Wegener’s granulomatosis. Arthritis Rheum. 1990;33:1101–7.

    Article  CAS  PubMed  Google Scholar 

  253. Keogh KA, Specks U. Churg-Strauss syndrome: clinical presentation, antineutrophil cytoplasmic antibodies, and leukotriene receptor antagonists. Am J Med. 2003;115:284–90.

    Article  CAS  PubMed  Google Scholar 

  254. Masi AT, Hunder GG, Lie JT, et al. The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis). Arthritis Rheum. 1990;33:1094–100.

    Article  CAS  PubMed  Google Scholar 

  255. Calabrese LH, Mallek JA. Primary angiitis of the central nervous system. Report of 8 new cases, review of the literature, and proposal for diagnostic criteria. Medicine (Baltimore). 1988;67:20–39.

    Article  CAS  PubMed  Google Scholar 

  256. Moore PM. Vasculitis of the central nervous system. Semin Neurol. 1994;14:307–12.

    Article  CAS  PubMed  Google Scholar 

  257. Gilden DH, Kleinschmidt-DeMasters BK, LaGuardia JJ, Mahalingam R, Cohrs RJ. Neurologic complications of the reactivation of varicella-zoster virus. N Engl J Med. 2000;342:635–45.

    Article  CAS  PubMed  Google Scholar 

  258. Nagel MA, Mahalingam R, Cohrs RJ, Gilden D. Virus vasculopathy and stroke: an under-recognized cause and treatment target. Infect Disord Drug Targets. 2010;10:105–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  259. Lalvani A, Pareek M. Interferon gamma release assays: principles and practice. Enferm Infecc Microbiol Clin. 2010;28:245–52.

    Article  PubMed  Google Scholar 

  260. de Gans J, van de Beek D. Dexamethasone in adults with bacterial meningitis. N Engl J Med. 2002;347:1549–56.

    Article  PubMed  Google Scholar 

  261. Johnson RT, Richardson EP. The neurological manifestations of systemic lupus erythematosus. Medicine (Baltimore). 1968;47:337–69.

    Article  CAS  PubMed  Google Scholar 

  262. Devinsky O, Petito CK, Alonso DR. Clinical and neuropathological findings in systemic lupus erythematosus: the role of vasculitis, heart emboli, and thrombotic thrombocytopenic purpura. Ann Neurol. 1988;23:380–4.

    Article  CAS  PubMed  Google Scholar 

  263. Kitagawa Y, Gotoh F, Koto A, Okayasu H. Stroke in systemic lupus erythematosus. Stroke. 1990;21:1533–9.

    Article  CAS  PubMed  Google Scholar 

  264. Brust JC. Vasculitis owing to substance abuse. Neurol Clin. 1997;15:945–57.

    Article  CAS  PubMed  Google Scholar 

  265. Niehaus L, Meyer BU. Bilateral borderzone brain infarctions in association with heroin abuse. J Neurol Sci. 1998;160:180–2.

    Article  CAS  PubMed  Google Scholar 

  266. Serdaroglu P. Behcet’s disease and the nervous system. J Neurol. 1998;245:197–205.

    Article  CAS  PubMed  Google Scholar 

  267. Call GK, Fleming MC, Sealfon S, Levine H, Kistler JP, Fisher CM. Reversible cerebral segmental vasoconstriction. Stroke. 1988;19:1159–70.

    Article  CAS  PubMed  Google Scholar 

  268. Chen SP, Wang SJ. Pathophysiology of reversible cerebral vasoconstriction syndrome. J Biomed Sci. 2022;29:72.

    Article  PubMed  PubMed Central  Google Scholar 

  269. Ducros A. Reversible cerebral vasoconstriction syndrome. Lancet Neurol. 2012;11:906–17.

    Article  PubMed  Google Scholar 

  270. Hajj-Ali RA, Furlan A, Abou-Chebel A, Calabrese LH. Benign angiopathy of the central nervous system: cohort of 16 patients with clinical course and long-term followup. Arthritis Rheum. 2002;47:662–9.

    Article  PubMed  Google Scholar 

  271. Vinciguerra L, Cantone M, Lanza G, et al. Migrainous infarction and cerebral vasospasm: case report and literature review. J Pain Res. 2019;12:2941–50.

    Article  PubMed  PubMed Central  Google Scholar 

  272. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache Classification Committee of the International Headache Society. Cephalalgia. 1988;8(Suppl 7):1–96.

    Google Scholar 

  273. Etminan M, Takkouche B, Isorna FC, Samii A. Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies. BMJ. 2005;330:63.

    Article  PubMed  PubMed Central  Google Scholar 

  274. Thomas DP, Roberts HR. Hypercoagulability in venous and arterial thrombosis. Ann Intern Med. 1997;126:638–44.

    Article  CAS  PubMed  Google Scholar 

  275. Morris JG, Singh S, Fisher M. Testing for inherited thrombophilias in arterial stroke: can it cause more harm than good? Stroke. 2010;41:2985–90.

    Article  PubMed  Google Scholar 

  276. Bushnell CD, Goldstein LB. Diagnostic testing for coagulopathies in patients with ischemic stroke. Stroke. 2000;31:3067–78.

    Article  CAS  PubMed  Google Scholar 

  277. Hart RG, Kanter MC. Hematologic disorders and ischemic stroke. A selective review. Stroke. 1990;21:1111–21.

    Article  CAS  PubMed  Google Scholar 

  278. Ortel TL. Thrombosis and the antiphospholipid syndrome. Hematology Am Soc Hematol Educ Program. 2005:462–8.

    Google Scholar 

  279. Dufrost V, Risse J, Reshetnyak T, et al. Increased risk of thrombosis in antiphospholipid syndrome patients treated with direct oral anticoagulants. Results from an international patient-level data meta-analysis. Autoimmun Rev. 2018;17:1011–21.

    Article  CAS  PubMed  Google Scholar 

  280. Daneschvar HL, Daw H. Heparin-induced thrombocytopenia (an overview). Int J Clin Pract. 2007;61:130–7.

    Article  CAS  PubMed  Google Scholar 

  281. Arepally GM, Ortel TL. Clinical practice. Heparin-induced thrombocytopenia. N Engl J Med. 2006;355:809–17.

    Article  CAS  PubMed  Google Scholar 

  282. Toole JF, Malinow MR, Chambless LE, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA. 2004;291:565–75.

    Article  CAS  PubMed  Google Scholar 

  283. Spence JD. Homocysteine-lowering therapy: a role in stroke prevention? Lancet Neurol. 2007;6:830–8.

    Article  CAS  PubMed  Google Scholar 

  284. Redding-Lallinger R, Knoll C. Sickle cell disease—pathophysiology and treatment. Curr Probl Pediatr Adolesc Health Care. 2002;36:346–76.

    Article  Google Scholar 

  285. Steen RG, Xiong X, Langston JW, Helton KJ. Brain injury in children with sickle cell disease: prevalence and etiology. Ann Neurol. 2003;54:564–72.

    Article  PubMed  Google Scholar 

  286. Wang WC. The pathophysiology, prevention, and treatment of stroke in sickle cell disease. Curr Opin Hematol. 2007;14:191–7.

    Article  PubMed  Google Scholar 

  287. Adams RJ, Brambilla DJ, Granger S, et al. Stroke and conversion to high risk in children screened with transcranial Doppler ultrasound during the STOP study. Blood. 2004;103:3689–94.

    Article  CAS  PubMed  Google Scholar 

  288. Ware RE, Zimmerman SA, Sylvestre PB, et al. Prevention of secondary stroke and resolution of transfusional iron overload in children with sickle cell anemia using hydroxyurea and phlebotomy. J Pediatr. 2004;145:346–52.

    Article  CAS  PubMed  Google Scholar 

  289. Krishnamurti L. Hematopoietic cell transplantation for sickle cell disease. Front Pediatr. 2020;8:551170.

    Article  PubMed  Google Scholar 

  290. Tsaras G, Owusu-Ansah A, Boateng FO, Amoateng-Adjepong Y. Complications associated with sickle cell trait: a brief narrative review. Am J Med. 2009;122:507–12.

    Article  PubMed  Google Scholar 

  291. Greenberg J, Massey EW. Cerebral infarction in sickle cell trait. Ann Neurol. 1985;18:354–5.

    Article  CAS  PubMed  Google Scholar 

  292. Partington MD, Aronyk KE, Byrd SE. Sickle cell trait and stroke in children. Pediatr Neurosurg. 1994;20:148–51.

    Article  CAS  PubMed  Google Scholar 

  293. Steen RG, Hankins GM, Xiong X, et al. Prospective brain imaging evaluation of children with sickle cell trait: initial observations. Radiology. 2003;228:208–15.

    Article  PubMed  Google Scholar 

  294. Lannuzel A, Salmon V, Mevel G, Malpote E, Rabier R, Caparros-Lefebvre D. Epidemiology of stroke in Guadeloupe and role of sickle cell trait. Rev Neurol (Paris). 1999;155:351–6.

    CAS  PubMed  Google Scholar 

  295. Arboix A, Besses C. Cerebrovascular disease as the initial clinical presentation of haematological disorders. Eur Neurol. 1997;37:207–11.

    Article  CAS  PubMed  Google Scholar 

  296. Buajitti E, Rosella LC, Zabzuni E, Young LT, Andreazza AC. Prevalence and health care costs of mitochondrial disease in Ontario, Canada: a population-based cohort study. PLoS One. 2022;17:e0265744.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  297. Gao Z, Chen Y, Guan MX. Mitochondrial DNA mutations associated with aminoglycoside induced ototoxicity. J Otol. 2017;12:1–8.

    Article  PubMed  PubMed Central  Google Scholar 

  298. Arpa J, Cruz-Martinez A, Campos Y, et al. Prevalence and progression of mitochondrial diseases: a study of 50 patients. Muscle Nerve. 2003;28:690–5.

    Article  PubMed  Google Scholar 

  299. Kinnecom C, Lev MH, Wendell L, et al. Course of cerebral amyloid angiopathy-related inflammation. Neurology. 2007;68:1411–6.

    Article  CAS  PubMed  Google Scholar 

  300. Razvi SS, Bone I. Single gene disorders causing ischaemic stroke. J Neurol. 2006;253:685–700.

    Article  PubMed  Google Scholar 

  301. Moore DF, Kaneski CR, Askari H, Schiffmann R. The cerebral vasculopathy of Fabry disease. J Neurol Sci. 2007;257:258–63.

    Article  PubMed  Google Scholar 

  302. Clarke JT. Narrative review: fabry disease. Ann Intern Med. 2007;146:425–33.

    Article  PubMed  Google Scholar 

  303. Cestari DM, Weine DM, Panageas KS, Segal AZ, DeAngelis LM. Stroke in patients with cancer: incidence and etiology. Neurology. 2004;62:2025–30.

    Article  CAS  PubMed  Google Scholar 

  304. Zaorsky NG, Zhang Y, Tchelebi LT, Mackley HB, Chinchilli VM, Zacharia BE. Stroke among cancer patients. Nat Commun. 2019;10:5172.

    Article  PubMed  PubMed Central  Google Scholar 

  305. Stefan O, Vera N, Otto B, Heinz L, Wolfgang G. Stroke in cancer patients: a risk factor analysis. J Neuro-Oncol. 2009;94:221–6.

    Article  Google Scholar 

  306. Navi BB, Iadecola C. Ischemic stroke in cancer patients: a review of an underappreciated pathology. Ann Neurol. 2018;83:873–83.

    Article  PubMed  PubMed Central  Google Scholar 

  307. Amarenco P. Underlying pathology of stroke of unknown cause (cryptogenic stroke). Cerebrovasc Dis. 2009;27(Suppl 1):97–103.

    Article  PubMed  Google Scholar 

  308. Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med. 2005;353:2034–41.

    Article  CAS  PubMed  Google Scholar 

  309. Gladstone DJ, Spring M, Dorian P, et al. Atrial fibrillation in patients with cryptogenic stroke. N Engl J Med. 2014;370:2467–77.

    Article  CAS  PubMed  Google Scholar 

  310. Sanna T, Diener HC, Passman RS, et al. Cryptogenic stroke and underlying atrial fibrillation. N Engl J Med. 2014;370:2478–86.

    Article  CAS  PubMed  Google Scholar 

  311. Sharp FR, Jickling GC, Stamova B, et al. Molecular markers and mechanisms of stroke: RNA studies of blood in animals and humans. J Cereb Blood Flow Metab. 2011;31:1513–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  312. Amlie-Lefond C, deVeber G, Chan AK, et al. Use of alteplase in childhood arterial ischaemic stroke: a multicentre, observational, cohort study. Lancet Neurol. 2009;8:530–6.

    Article  PubMed  Google Scholar 

  313. Grunwald IQ, Walter S, Fassbender K, et al. Ischemic stroke in children: new aspects of treatment. J Pediatr. 2011;159:366–70.

    Article  PubMed  Google Scholar 

  314. Roach ES, Golomb MR, Adams R, et al. Management of stroke in infants and children: a scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young. Stroke. 2008;39:2644–91.

    Article  PubMed  Google Scholar 

  315. Lloyd-Jones D, Adams RJ, Brown TM, et al. Executive summary: heart disease and stroke statistics—2010 update: a report from the American Heart Association. Circulation. 2011;121:948–54.

    Google Scholar 

  316. Agrawal N, Johnston SC, Wu YW, Sidney S, Fullerton HJ. Imaging data reveal a higher pediatric stroke incidence than prior US estimates. Stroke. 2009;40:3415–21.

    Article  PubMed  PubMed Central  Google Scholar 

  317. Kirton A, Armstrong-Wells J, Chang T, et al. Symptomatic neonatal arterial ischemic stroke: the international pediatric stroke study. Pediatrics. 2011;128:e1402–e10.

    Article  PubMed  Google Scholar 

  318. Srinivasan J, Miller SP, Phan TG, Mackay MT. Delayed recognition of initial stroke in children: need for increased awareness. Pediatrics. 2009;124:e227–34.

    Article  PubMed  Google Scholar 

  319. Abend NS, Beslow LA, Smith SE, et al. Seizures as a presenting symptom of acute arterial ischemic stroke in childhood. J Pediatr. 2011;159:479–83.

    Article  PubMed  PubMed Central  Google Scholar 

  320. Mackay MT, Wiznitzer M, Benedict SL, Lee KJ, Deveber GA, Ganesan V. Arterial ischemic stroke risk factors: the International Pediatric Stroke Study. Ann Neurol. 2011;69:130–40.

    Article  PubMed  Google Scholar 

  321. Amlie-Lefond C, Bernard TJ, Sebire G, et al. Predictors of cerebral arteriopathy in children with arterial ischemic stroke: results of the International Pediatric Stroke Study. Circulation. 2009;119:1417–23.

    Article  PubMed  PubMed Central  Google Scholar 

  322. Steiger HJ, Hanggi D, Assmann B, Turowski B. Cerebral angiopathies as a cause of ischemic stroke in children: differential diagnosis and treatment options. Dtsch Arztebl Int. 2010;107:851–6.

    PubMed  PubMed Central  Google Scholar 

  323. Beslow LA, Jordan LC. Pediatric stroke: the importance of cerebral arteriopathy and vascular malformations. Childs Nerv Syst. 2010;26:1263–73.

    Article  PubMed  PubMed Central  Google Scholar 

  324. Jordan LC, Hillis AE. Challenges in the diagnosis and treatment of pediatric stroke. Nat Rev Neurol. 2011;7:199–208.

    Article  PubMed  PubMed Central  Google Scholar 

  325. Goldenberg NA, Bernard TJ, Fullerton HJ, Gordon A, deVeber G. Antithrombotic treatments, outcomes, and prognostic factors in acute childhood-onset arterial ischaemic stroke: a multicentre, observational, cohort study. Lancet Neurol. 2009;8:1120–7.

    Article  CAS  PubMed  Google Scholar 

  326. Amlie-Lefond C, Gill JC. Pharmacology in childhood arterial ischemic stroke. Semin Pediatr Neurol. 2010;17:237–44.

    Article  PubMed  Google Scholar 

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  1. Departments of Neurosurgery, Neurology and Radiology, University of Alabama at Birmingham, Birmingham, AL, USA

    Mark R. Harrigan

  2. Interventional Neuroradiology, Bayfront.Health Medical Group, Saint Petersburg, FL, USA

    John P. Deveikis

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Harrigan, M.R., Deveikis, J.P. (2023). Ischemic Stroke. In: Handbook of Cerebrovascular Disease and Neurointerventional Technique. Contemporary Medical Imaging. Humana, Cham. https://doi.org/10.1007/978-3-031-45598-8_16

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