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Update in Solid Tumors of Childhood

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Update in Pediatrics

Abstract

Pediatric solid tumors represent a diverse group of malignancies that, despite consistent threads across diagnosis and treatment, require individualized, multidisciplinary care. Over the past two decades, notable progress has been made in the understanding of tumor biology, risk-stratification, and novel therapies intended to mitigate long-term toxicities while retaining or improving outcomes. This chapter provides an overview of the current standards of care while highlighting key advancements in the field. The next generation of therapies will rely further on the evolving field of precision medicine while focusing on the equitable care of all patients with solid tumors.

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References

  • Abramson DH, et al. Familial retinoblastoma: where and when? Acta Ophthalmol Scand. 1998;76(3):334–8.

    Article  CAS  PubMed  Google Scholar 

  • Acord M, Shaikh R. Predictors of diagnostic success in image-guided pediatric soft-tissue biopsies. Pediatr Radiol. 2015;45(10):1529–34.

    Article  PubMed  Google Scholar 

  • Aguado A, et al. Successful use of transarterial radioembolization with yttrium-90 (TARE-Y90) in two children with hepatoblastoma. Pediatr Blood Cancer. 2020;67(9):e28421.

    Article  PubMed  Google Scholar 

  • Alcorn KM, et al. Sentinel lymph node biopsy in pediatric soft tissue sarcoma patients: utility and concordance with imaging. J Pediatr Surg. 2013;48(9):1903–6.

    Article  PubMed  Google Scholar 

  • Allolio B, Fassnacht M. Clinical review: adrenocortical carcinoma: clinical update. J Clin Endocrinol Metab. 2006;91(6):2027–37.

    Article  CAS  PubMed  Google Scholar 

  • Andreou D, et al. The influence of tumor- and treatment-related factors on the development of local recurrence in osteosarcoma after adequate surgery. An analysis of 1355 patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols. Ann Oncol. 2011;22(5):1228–35.

    Article  CAS  PubMed  Google Scholar 

  • Andreou D, et al. Sentinel node biopsy in soft tissue sarcoma subtypes with a high propensity for regional lymphatic spread—results of a large prospective trial. Ann Oncol. 2013;24(5):1400–5.

    Article  CAS  PubMed  Google Scholar 

  • Anninga JK, et al. Chemotherapeutic adjuvant treatment for osteosarcoma: where do we stand? Eur J Cancer. 2011;47(16):2431–45.

    Article  CAS  PubMed  Google Scholar 

  • Aoba T, et al. Relapse of unilateral favorable histology Wilms' tumor: significant clinicopathological factors. J Pediatr Surg. 2012;47(12):2210–5.

    Article  PubMed  Google Scholar 

  • Aronson DC, et al. Predictive value of the pretreatment extent of disease system in hepatoblastoma: results from the International Society of Pediatric Oncology Liver Tumor Study Group SIOPEL-1 study. J Clin Oncol. 2005;23(6):1245–52.

    Article  PubMed  Google Scholar 

  • Asayama Y, et al. Heterogeneity of non-cancerous liver parenchyma on gadoxetic acid-enhanced MRI: an imaging biomarker for hepatocellular carcinoma development in chronic liver disease. Clin Radiol. 2016;71(5):432–7.

    Article  CAS  PubMed  Google Scholar 

  • Bacci G, et al. Prognostic factors in nonmetastatic Ewing's sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli. J Clin Oncol. 2000a;18(1):4–11.

    Article  CAS  PubMed  Google Scholar 

  • Bacci G, et al. Long-term outcome for patients with nonmetastatic osteosarcoma of the extremity treated at the istituto ortopedico rizzoli according to the istituto ortopedico rizzoli/osteosarcoma-2 protocol: an updated report. J Clin Oncol. 2000b;18(24):4016–27.

    Article  CAS  PubMed  Google Scholar 

  • Baker DL, et al. Outcome after reduced chemotherapy for intermediate-risk neuroblastoma. N Engl J Med. 2010;363(14):1313–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bardeesy N, et al. Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations. Nat Genet. 1994;7(1):91–7.

    Article  CAS  PubMed  Google Scholar 

  • Barnett M, et al. Psychosocial outcomes and interventions among cancer survivors diagnosed during adolescence and young adulthood (AYA): a systematic review. J Cancer Surviv. 2016;10(5):814–31.

    Article  PubMed  PubMed Central  Google Scholar 

  • Barr FG, et al. Examination of gene fusion status in archival samples of alveolar rhabdomyosarcoma entered on the Intergroup Rhabdomyosarcoma Study-III trial: a report from the Children's Oncology Group. J Mol Diagn. 2006;8(2):202–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Beckwith JB. Precursor lesions of Wilms tumor: clinical and biological implications. Med Pediatr Oncol. 1993;21(3):158–68.

    Article  CAS  PubMed  Google Scholar 

  • Bhadri VA, et al. Hepatocellular carcinoma in children with Alagille syndrome. J Pediatr Gastroenterol Nutr. 2005;41(5):676–8.

    Article  PubMed  Google Scholar 

  • Biegel JA, et al. Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors. Cancer Res. 1999;59(1):74–9.

    CAS  PubMed  Google Scholar 

  • Blohm ME, et al. Alpha 1-fetoprotein (AFP) reference values in infants up to 2 years of age. Pediatr Hematol Oncol. 1998;15(2):135–42.

    Article  CAS  PubMed  Google Scholar 

  • Bohdiewicz PJ, Gallegos E, Fink-Bennett D. Raccoon eyes and the MIBG super scan: scintigraphic signs of neuroblastoma in a case of suspected child abuse. Pediatr Radiol. 1995;25(Suppl. 1):S90–2.

    Article  PubMed  Google Scholar 

  • Bokemeyer C, et al. Extragonadal germ cell tumors of the mediastinum and retroperitoneum: results from an international analysis. J Clin Oncol. 2002;20(7):1864–73.

    Article  PubMed  Google Scholar 

  • Bourdeaut F, et al. VIP hypersecretion as primary or secondary syndrome in neuroblastoma: a retrospective study by the Societe Francaise des Cancers de l'Enfant (SFCE). Pediatr Blood Cancer. 2009;52(5):585–90.

    Article  PubMed  Google Scholar 

  • Breneman JC, et al. Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma—a report from the Intergroup Rhabdomyosarcoma Study IV. J Clin Oncol. 2003;21(1):78–84.

    Article  PubMed  Google Scholar 

  • Bresler SC, et al. ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma. Cancer Cell. 2014;26(5):682–94.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Breslow NE, et al. End stage renal disease in patients with Wilms tumor: results from the National Wilms Tumor Study Group and the United States Renal Data System. J Urol. 2005;174(5):1972–5.

    Article  PubMed  PubMed Central  Google Scholar 

  • Brock PR, et al. Sodium thiosulfate for protection from cisplatin-induced hearing loss. N Engl J Med. 2018;378(25):2376–85.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brock P, et al. Sodium thiosulfate as cisplatin otoprotectant in children: the challenge of when to use it. Pediatr Blood Cancer. 2023;70(5):e30248.

    Article  PubMed  Google Scholar 

  • Brodeur GM, et al. International criteria for diagnosis, staging, and response to treatment in patients with neuroblastoma. J Clin Oncol. 1988;6(12):1874–81.

    Article  CAS  PubMed  Google Scholar 

  • Brodeur GM, et al. Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. J Clin Oncol. 1993;11(8):1466–77.

    Article  CAS  PubMed  Google Scholar 

  • Brown J, et al. Pretreatment prognostic factors for children with hepatoblastoma—results from the International Society of Paediatric Oncology (SIOP) study SIOPEL 1. Eur J Cancer. 2000;36(11):1418–25.

    Article  CAS  PubMed  Google Scholar 

  • Bruder E, et al. Morphologic and molecular characterization of renal cell carcinoma in children and young adults. Am J Surg Pathol. 2004;28(9):1117–32.

    Article  PubMed  Google Scholar 

  • Byun BH, et al. Comparison of (18)F-FDG PET/CT and (99 m)Tc-MDP bone scintigraphy for detection of bone metastasis in osteosarcoma. Skelet Radiol. 2013;42(12):1673–81.

    Article  Google Scholar 

  • C7R-GD2.CART Cells for Patients with Relapsed or Refractory Neuroblastoma and Other GD2 Positive Cancers (GAIL-N), 2023. Available from: https://clinicaltrials.gov/ct2/show/NCT03635632.

  • Cairo S, et al. Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer. Cancer Cell. 2008;14(6):471–84.

    Article  CAS  PubMed  Google Scholar 

  • Callaghan MU, Wong TE, Federici AB. Treatment of acquired von Willebrand syndrome in childhood. Blood. 2013;122(12):2019–22.

    Article  CAS  PubMed  Google Scholar 

  • Cash T, et al. Comparison of clinical features and outcomes in patients with extraskeletal versus skeletal localized Ewing sarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2016;63(10):1771–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen X, et al. Targeting oxidative stress in embryonal rhabdomyosarcoma. Cancer Cell. 2013;24(6):710–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen X, et al. Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. Cell Rep. 2014;7(1):104–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cohn SL, et al. The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report. J Clin Oncol. 2009;27(2):289–97.

    Article  PubMed  PubMed Central  Google Scholar 

  • Coombs CC, Dickherber T, Crompton BD. Chasing ctDNA in patients with sarcoma. Am Soc Clin Oncol Educ Book. 2020;40:e351–60.

    Article  PubMed  Google Scholar 

  • Crist W, et al. The third intergroup rhabdomyosarcoma study. J Clin Oncol. 1995;13(3):610–30.

    Article  CAS  PubMed  Google Scholar 

  • Crist WM, et al. Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease. J Clin Oncol. 2001;19(12):3091–102.

    Article  CAS  PubMed  Google Scholar 

  • Crompton BD, et al. The genomic landscape of pediatric Ewing sarcoma. Cancer Discov. 2014;4(11):1326–41.

    Article  CAS  PubMed  Google Scholar 

  • Cushing B, et al. Randomized comparison of combination chemotherapy with etoposide, bleomycin, and either high-dose or standard-dose cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup study--Pediatric Oncology Group 9049 and Children's Cancer Group 8882. J Clin Oncol. 2004;22(13):2691–700.

    Article  CAS  PubMed  Google Scholar 

  • Czauderna P, et al. Multicenter retrospective analysis of various primary pediatric malignant hepatic tumors--management in a series of 47 Polish patients (1985–1995). Eur J Pediatr Surg. 2001;11(2):82–5.

    Article  CAS  PubMed  Google Scholar 

  • Czauderna P, et al. Hepatocellular carcinoma in children: results of the first prospective study of the International Society of Pediatric Oncology group. J Clin Oncol. 2002;20(12):2798–804.

    Article  CAS  PubMed  Google Scholar 

  • Czauderna P, et al. The Children's Hepatic tumors International Collaboration (CHIC): novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model. Eur J Cancer. 2016;52:92–101.

    Article  PubMed  Google Scholar 

  • Dark GG, et al. Surveillance policy for stage I ovarian germ cell tumors. J Clin Oncol. 1997;15(2):620–4.

    Article  CAS  PubMed  Google Scholar 

  • Davis LE, et al. randomized double-blind phase II study of regorafenib in patients with metastatic osteosarcoma. J Clin Oncol. 2019;37(16):1424–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • De Bernardi B, et al. Excellent outcome with reduced treatment for infants with disseminated neuroblastoma without MYCN gene amplification. J Clin Oncol. 2009;27(7):1034–40.

    Article  PubMed  Google Scholar 

  • de Wit R, Fizazi K. Controversies in the management of clinical stage I testis cancer. J Clin Oncol. 2006;24(35):5482–92.

    Article  PubMed  Google Scholar 

  • Dehner LP. Gonadal and extragonadal germ cell neoplasia of childhood. Hum Pathol. 1983;14(6):493–511.

    Article  CAS  PubMed  Google Scholar 

  • Del Bufalo F, et al. GD2-CART01 for relapsed or refractory high-risk neuroblastoma. N Engl J Med. 2023;388(14):1284–95.

    Article  PubMed  Google Scholar 

  • Dexeus FH, et al. Genetic abnormalities in men with germ cell tumors. J Urol. 1988;140(1):80–4.

    Article  CAS  PubMed  Google Scholar 

  • Di Giannatale A, et al. Primary cutaneous and subcutaneous Ewing sarcoma. Pediatr Blood Cancer. 2015;62(9):1555–61.

    Article  PubMed  Google Scholar 

  • Diller L, et al. Germline p53 mutations are frequently detected in young children with rhabdomyosarcoma. J Clin Invest. 1995;95(4):1606–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dillon P, et al. A prospective study of nonrhabdomyosarcoma soft tissue sarcomas in the pediatric age group. J Pediatr Surg. 1992;27(2):241–4. discussion 244–5

    Article  CAS  PubMed  Google Scholar 

  • Dirksen U, et al. High-dose chemotherapy compared with standard chemotherapy and lung radiation in Ewing sarcoma with pulmonary metastases: results of the European Ewing Tumour Working Initiative of National Groups, 99 Trial and EWING 2008. J Clin Oncol. 2019;37(34):3192–202.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dix DB, et al. Treatment of stage IV favorable histology Wilms tumor with lung metastases: a report From the Children's Oncology Group AREN0533 study. J Clin Oncol. 2018;36(16):1564–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dix DB, et al. Augmentation of therapy for combined loss of heterozygosity 1p and 16q in favorable histology Wilms tumor: a Children's Oncology Group AREN0532 and AREN0533 Study Report. J Clin Oncol. 2019;37(30):2769–77.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dome JS, et al. Treatment of anaplastic histology Wilms' tumor: results from the fifth National Wilms' Tumor Study. J Clin Oncol. 2006;24(15):2352–8.

    Article  PubMed  Google Scholar 

  • Donaldson SS. Ewing sarcoma: radiation dose and target volume. Pediatr Blood Cancer. 2004;42(5):471–6.

    Article  PubMed  Google Scholar 

  • Donati D, et al. Osteosarcoma of the pelvis. Eur J Surg Oncol. 2004;30(3):332–40.

    Article  CAS  PubMed  Google Scholar 

  • DuBois SG, et al. Comparative evaluation of local control strategies in localized Ewing sarcoma of bone: a report from the Children's Oncology Group. Cancer. 2015;121(3):467–75.

    Article  PubMed  Google Scholar 

  • DuBois SG, et al. Randomized phase II trial of MIBG versus MIBG, vincristine, and irinotecan versus MIBG and vorinostat for patients with relapsed or refractory neuroblastoma: a report from NANT Consortium. J Clin Oncol. 2021;39(31):3506–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • DuBois SG, et al. Randomized phase III trial of ganitumab with interval-compressed chemotherapy for patients with newly diagnosed metastatic ewing sarcoma: a report from the Children's Oncology Group. J Clin Oncol. 2023;41(11):2098–107.

    Article  CAS  PubMed  Google Scholar 

  • Eaton KW, et al. Spectrum of SMARCB1/INI1 mutations in familial and sporadic rhabdoid tumors. Pediatr Blood Cancer. 2011;56(1):7–15.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ehrlich PF, et al. Results of treatment for patients with multicentric or bilaterally predisposed unilateral Wilms tumor (AREN0534): a report from the Children's Oncology Group. Cancer. 2020;126(15):3516–25.

    Article  CAS  PubMed  Google Scholar 

  • Eichenmuller M, et al. The genomic landscape of hepatoblastoma and their progenies with HCC-like features. J Hepatol. 2014;61(6):1312–20.

    Article  PubMed  Google Scholar 

  • El-Khoueiry AB, Melero I, Crocenzi TS, et al. Phase I/II safety and antitumor activity of nivolumab in patients with advanced hepatocellular carcinoma (HCC): CA209-040. J Clin Oncol. 2015;33(18) https://doi.org/10.1200/jco.2015.33.18_suppl.lba101.

  • Eren E, et al. A rare cause of precocious puberty: hepatoblastoma. J Clin Res Pediatr Endocrinol. 2009;1(6):281–3.

    Article  PubMed  Google Scholar 

  • Federico SM, et al. Comparison of PET-CT and conventional imaging in staging pediatric rhabdomyosarcoma. Pediatr Blood Cancer. 2013;60(7):1128–34.

    Article  PubMed  Google Scholar 

  • Federico SM, et al. A pilot induction regimen incorporating dinutuximab and sargramostim for the treatment of newly diagnosed high-risk neuroblastoma: a report from the Children's Oncology Group. J Clin Oncol. 2022;40(Suppl. 16):10003.

    Article  Google Scholar 

  • Federman N. Molecular pathogenesis of desmoid tumor and the role of gamma-secretase inhibition. NPJ Precis Oncol. 2022;6(1):62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Feng W, et al. Myc is a prognostic biomarker and potential therapeutic target in osteosarcoma. Ther Adv Med Oncol. 2020;12:1758835920922055.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ferrari S, et al. Predictive factors of disease-free survival for non-metastatic osteosarcoma of the extremity: an analysis of 300 patients treated at the Rizzoli Institute. Ann Oncol. 2001;12(8):1145–50.

    Article  CAS  PubMed  Google Scholar 

  • Ferrari A, et al. Comparison of the prognostic value of assessing tumor diameter versus tumor volume at diagnosis or in response to initial chemotherapy in rhabdomyosarcoma. J Clin Oncol. 2010;28(8):1322–8.

    Article  PubMed  Google Scholar 

  • Fizazi K, et al. Early predicted time to normalization of tumor markers predicts outcome in poor-prognosis nonseminomatous germ cell tumors. J Clin Oncol. 2004;22(19):3868–76.

    Article  PubMed  Google Scholar 

  • Forrest SJ, et al. Genomic and immunologic characterization of INI1-deficient pediatric cancers. Clin Cancer Res. 2020;26(12):2882–90.

    Article  CAS  PubMed  Google Scholar 

  • Forrest SJ, et al. Phase II study of nivolumab and ipilimumab in children and young adults with INI1-negative cancers. J Clin Oncol. 2021;39(Suppl. 15):TPS10055.

    Article  Google Scholar 

  • Frazier AL, et al. Revised risk classification for pediatric extracranial germ cell tumors based on 25 years of clinical trial data from the United Kingdom and United States. J Clin Oncol. 2015;33(2):195–201.

    Article  CAS  PubMed  Google Scholar 

  • Freyer DR, et al. Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2017;18(1):63–74.

    Article  CAS  PubMed  Google Scholar 

  • Fuchs J, et al. Pretreatment prognostic factors and treatment results in children with hepatoblastoma: a report from the German Cooperative Pediatric Liver Tumor Study HB 94. Cancer. 2002;95(1):172–82.

    Article  PubMed  Google Scholar 

  • Garaventa A, et al. Treatment of advanced neuroblastoma with I-131 meta-iodobenzylguanidine. Cancer. 1991;67(4):922–8.

    Article  CAS  PubMed  Google Scholar 

  • Geller JI, Dome JS. Local lymph node involvement does not predict poor outcome in pediatric renal cell carcinoma. Cancer. 2004;101(7):1575–83.

    Article  PubMed  Google Scholar 

  • Geller JI, et al. Characterization of adolescent and pediatric renal cell carcinoma: a report from the Children's Oncology Group study AREN03B2. Cancer. 2015;121(14):2457–64.

    Article  PubMed  Google Scholar 

  • German J. Bloom's syndrome. XX. The first 100 cancers. Cancer Genet Cytogenet. 1997;93(1):100–6.

    Article  CAS  PubMed  Google Scholar 

  • Gobel U, et al. Teratomas in infancy and childhood. Med Pediatr Oncol. 1998;31(1):8–15.

    Article  CAS  PubMed  Google Scholar 

  • Gobin YP, et al. Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience. Arch Ophthalmol. 2011;129(6):732–7.

    Article  PubMed  Google Scholar 

  • Gounder MM, et al. Sorafenib for advanced and refractory desmoid tumors. N Engl J Med. 2018;379(25):2417–28.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Grant FD, Drubach LA, Treves ST. (18)F-Fluorodeoxyglucose PET and PET/CT in pediatric musculoskeletal malignancies. PET Clin. 2010;5(3):349–61.

    Article  PubMed  Google Scholar 

  • Gratias EJ, et al. Association of chromosome 1q gain with inferior survival in favorable-histology Wilms tumor: a report from the Children's Oncology Group. J Clin Oncol. 2016;34(26):3189–94.

    Article  PubMed  PubMed Central  Google Scholar 

  • Green DM. Diagnosis and management of malignant solid tumors in infants and children. M.N. Publishing; 1985. p. 129–86.

    Google Scholar 

  • Grimer RJ, et al. Osteosarcoma over the age of forty. Eur J Cancer. 2003;39(2):157–63.

    Article  CAS  PubMed  Google Scholar 

  • Grimer RJ, et al. Periosteal osteosarcoma—a European review of outcome. Eur J Cancer. 2005;41(18):2806–11.

    Article  PubMed  Google Scholar 

  • Grundy PE, et al. Loss of heterozygosity for chromosomes 1p and 16q is an adverse prognostic factor in favorable-histology Wilms tumor: a report from the National Wilms Tumor Study Group. J Clin Oncol. 2005;23(29):7312–21.

    Article  CAS  PubMed  Google Scholar 

  • Grundy PE, et al. Clinical significance of pulmonary nodules detected by CT and Not CXR in patients treated for favorable histology Wilms tumor on national Wilms tumor studies-4 and -5: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2012;59(4):631–5.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gupta A, et al. Multifocal hepatic neoplasia in 3 children with APC gene mutation. Am J Surg Pathol. 2013;37(7):1058–66.

    Article  PubMed  Google Scholar 

  • Gurney JG, et al. Incidence of cancer in children in the United States. Sex-, race-, and 1-year age-specific rates by histologic type. Cancer. 1995;75(8):2186–95.

    Article  CAS  PubMed  Google Scholar 

  • Haduong JH, et al. An update on rhabdomyosarcoma risk stratification and the rationale for current and future Children's Oncology Group clinical trials. Pediatr Blood Cancer. 2022;69(4):e29511.

    Article  PubMed  PubMed Central  Google Scholar 

  • Haines K, et al. Characterization of pediatric hepatocellular carcinoma reveals genomic heterogeneity and diverse signaling pathway activation. Pediatr Blood Cancer. 2019;66(7):e27745.

    Article  PubMed  Google Scholar 

  • Hamilton TE, et al. The management of synchronous bilateral Wilms tumor: a report from the National Wilms Tumor Study Group. Ann Surg. 2011;253(5):1004–10.

    Article  PubMed  Google Scholar 

  • Han G, et al. Amputation versus limb-salvage surgery in patients with osteosarcoma: a meta-analysis. World J Surg. 2016;40(8):2016–27.

    Article  PubMed  Google Scholar 

  • Hanks S, et al. Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour. Nat Commun. 2014;5:4398.

    Article  CAS  PubMed  Google Scholar 

  • Harris MB, et al. Treatment of metastatic osteosarcoma at diagnosis: a Pediatric Oncology Group Study. J Clin Oncol. 1998;16(11):3641–8.

    Article  CAS  PubMed  Google Scholar 

  • Heerema-McKenney A, et al. Congenital teratoma: a clinicopathologic study of 22 fetal and neonatal tumors. Am J Surg Pathol. 2005;29(1):29–38.

    Article  PubMed  Google Scholar 

  • Heifetz SA, et al. Immature teratomas in children: pathologic considerations: a report from the combined Pediatric Oncology Group/Children's Cancer Group. Am J Surg Pathol. 1998;22(9):1115–24.

    Article  CAS  PubMed  Google Scholar 

  • Hettmer S, et al. Anaplastic rhabdomyosarcoma in TP53 germline mutation carriers. Cancer. 2014;120(7):1068–75.

    Article  CAS  PubMed  Google Scholar 

  • Honeyman JN, et al. Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma. Science. 2014;343(6174):1010–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Howlader N, Noone AM, Krapcho M, et al. eds., SEER Cancer statistics review, 1975–2009. Bethesda, MD: National Cancer Institute; 2012.

    Google Scholar 

  • Hoyer M, et al. Treatment of hepatoblastoma with drug-eluting bead transarterial chemoembolization in a 13-month-old infant: a case report and review of the literature. J Pediatr Hematol Oncol. 2021;43(1):e123–6.

    Article  PubMed  Google Scholar 

  • Huff V. Wilms tumor genetics. Am J Med Genet. 1998;79(4):260–7.

    Article  CAS  PubMed  Google Scholar 

  • Hurley C, et al. Comparison of (18) F-FDG-PET-CT and bone scintigraphy for evaluation of osseous metastases in newly diagnosed and recurrent osteosarcoma. Pediatr Blood Cancer. 2016;63(8):1381–6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ikeda H, et al. Development of unfavorable hepatoblastoma in children of very low birth weight: results of a surgical and pathologic review. Cancer. 1998;82(9):1789–96.

    Article  CAS  PubMed  Google Scholar 

  • Indolfi P, et al. Renal cell carcinoma in children: a clinicopathologic study. J Clin Oncol. 2003;21(3):530–5.

    Article  PubMed  Google Scholar 

  • Infarinato NR, et al. The ALK/ROS1 inhibitor PF-06463922 overcomes primary resistance to crizotinib in ALK-Driven neuroblastoma. Cancer Discov. 2016;6(1):96–107.

    Article  CAS  PubMed  Google Scholar 

  • Johnson KJ, et al. Paediatric germ cell tumours and congenital abnormalities: a Children's Oncology Group study. Br J Cancer. 2009;101(3):518–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kaatsch P, et al. Pediatric germ cell tumors from 1987 to 2011: incidence rates, time trends, and survival. Pediatrics. 2015;135(1):e136–43.

    Article  PubMed  Google Scholar 

  • Kager L, et al. Skip metastases in osteosarcoma: experience of the Cooperative Osteosarcoma Study Group. J Clin Oncol. 2006;24(10):1535–41.

    Article  PubMed  Google Scholar 

  • Kalish JM, et al. Surveillance recommendations for children with overgrowth syndromes and predisposition to Wilms tumors and hepatoblastoma. Clin Cancer Res. 2017;23(13):e115–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Katzenstein HM, et al. Hepatocellular carcinoma in children and adolescents: results from the Pediatric Oncology Group and the Children's Cancer Group intergroup study. J Clin Oncol. 2002;20(12):2789–97.

    Article  PubMed  Google Scholar 

  • Katzenstein HM, et al. Upfront window vincristine/irinotecan treatment of high-risk hepatoblastoma: a report from the Children's Oncology Group AHEP0731 study committee. Cancer. 2017;123(12):2360–7.

    Article  CAS  PubMed  Google Scholar 

  • Katzenstein HM, et al. Minimal adjuvant chemotherapy for children with hepatoblastoma resected at diagnosis (AHEP0731): a Children's Oncology Group, multicentre, phase 3 trial. Lancet Oncol. 2019;20(5):719–27.

    Article  PubMed  PubMed Central  Google Scholar 

  • Katzenstein HM, et al. Doxorubicin in combination with cisplatin, 5-flourouracil, and vincristine is feasible and effective in unresectable hepatoblastoma: a Children's Oncology Group study. Cancer. 2022;128(5):1057–65.

    Article  CAS  PubMed  Google Scholar 

  • Kayton ML, et al. Experience with 31 sentinel lymph node biopsies for sarcomas and carcinomas in pediatric patients. Cancer. 2008;112(9):2052–9.

    Article  PubMed  Google Scholar 

  • Kim MS, et al. time dependency of prognostic factors in patients with stage II osteosarcomas. Clin Orthop Relat Res. 2007;463:157–65.

    Article  PubMed  Google Scholar 

  • Komura E, et al. Thrombopoietin in patients with hepatoblastoma. Stem Cells. 1998;16(5):329–33.

    Article  CAS  PubMed  Google Scholar 

  • Kopp LM, et al. Utility of bone marrow aspiration and biopsy in initial staging of Ewing sarcoma. Pediatr Blood Cancer. 2015;62(1):12–5.

    Article  PubMed  Google Scholar 

  • Kovar H, et al. Overexpression of the pseudoautosomal gene MIC2 in Ewing's sarcoma and peripheral primitive neuroectodermal tumor. Oncogene. 1990;5(7):1067–70.

    CAS  PubMed  Google Scholar 

  • Labrune P, et al. Hepatocellular adenomas in glycogen storage disease type I and III: a series of 43 patients and review of the literature. J Pediatr Gastroenterol Nutr. 1997;24(3):276–9.

    Article  CAS  PubMed  Google Scholar 

  • Lake CM, et al. Indocyanine green is a sensitive adjunct in the identification and surgical management of local and metastatic hepatoblastoma. Cancer Med. 2021;10(13):4322–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Leavey PJ, et al. Phase III trial adding vincristine-topotecan-cyclophosphamide to the initial treatment of patients with nonmetastatic Ewing sarcoma: A Children's Oncology Group Report. J Clin Oncol. 2021;39(36):4029–38.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lewis EC, et al. A subset analysis of a phase II trial evaluating the use of DFMO as maintenance therapy for high-risk neuroblastoma. Int J Cancer. 2020;147(11):3152–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li FP, Fraumeni JF Jr. Rhabdomyosarcoma in children: epidemiologic study and identification of a familial cancer syndrome. J Natl Cancer Inst. 1969;43(6):1365–73.

    CAS  PubMed  Google Scholar 

  • Liu AK, et al. Local control of metastatic sites with radiation therapy in metastatic Ewing sarcoma and rhabdomyosarcoma. Pediatr Blood Cancer. 2011;57(1):169–71.

    Article  PubMed  Google Scholar 

  • Llovet JM, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359(4):378–90.

    Article  CAS  PubMed  Google Scholar 

  • London WB, et al. Evidence for an age cutoff greater than 365 days for neuroblastoma risk group stratification in the Children's Oncology Group. J Clin Oncol. 2005;23(27):6459–65.

    Article  CAS  PubMed  Google Scholar 

  • Lopez-Terrada D, et al. Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium. Mod Pathol. 2014;27(3):472–91.

    Article  PubMed  Google Scholar 

  • Maas SM, et al. Phenotype, cancer risk, and surveillance in Beckwith-Wiedemann syndrome depending on molecular genetic subgroups. Am J Med Genet A. 2016;170(9):2248–60.

    Article  CAS  PubMed  Google Scholar 

  • Mack JW, Grier HE. The day one talk. J Clin Oncol. 2004;22(3):563–6.

    Article  PubMed  Google Scholar 

  • Madanat-Harjuoja LM, et al. Circulating tumor DNA as a biomarker in patients with stage III and IV Wilms tumor: analysis from a Children's Oncology Group Trial, AREN0533. J Clin Oncol. 2022;40(26):3047–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mahoney NR, et al. Pediatric horner syndrome: etiologies and roles of imaging and urine studies to detect neuroblastoma and other responsible mass lesions. Am J Ophthalmol. 2006;142(4):651–9.

    Article  PubMed  Google Scholar 

  • Maibach R, et al. Prognostic stratification for children with hepatoblastoma: the SIOPEL experience. Eur J Cancer. 2012;48(10):1543–9.

    Article  PubMed  Google Scholar 

  • Malek MM, et al. Review of outcomes of primary liver cancers in children: our institutional experience with resection and transplantation. Surgery. 2010;148(4):778–82. discussion 782–4

    Article  PubMed  Google Scholar 

  • Malempati S, et al. Rhabdomyosarcoma in infants younger than 1 year: a report from the Children's Oncology Group. Cancer. 2011;117(15):3493–501.

    Article  PubMed  Google Scholar 

  • Malogolowkin MH, et al. Germ cell tumors in infancy and childhood: a 45-year experience. Pediatr Pathol. 1990;10(1–2):231–41.

    Article  CAS  PubMed  Google Scholar 

  • Malogolowkin MH, et al. Complete surgical resection is curative for children with hepatoblastoma with pure fetal histology: a report from the Children's Oncology Group. J Clin Oncol. 2011;29(24):3301–6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mann JR, et al. The United Kingdom Children’s Cancer Study Group’s second germ cell tumor study: carboplatin, etoposide, and bleomycin are effective treatment for children with malignant extracranial germ cell tumors, with acceptable toxicity. J Clin Oncol. 2000;18(22):3809–18.

    Article  CAS  PubMed  Google Scholar 

  • Marina NM, et al. Complete surgical excision is effective treatment for children with immature teratomas with or without malignant elements: a Pediatric Oncology Group/Children's Cancer Group Intergroup Study. J Clin Oncol. 1999;17(7):2137–43.

    Article  CAS  PubMed  Google Scholar 

  • Marina N, et al. Prognostic factors in children with extragonadal malignant germ cell tumors: a pediatric intergroup study. J Clin Oncol. 2006;24(16):2544–8.

    Article  PubMed  Google Scholar 

  • Marina NM, et al. Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial. Lancet Oncol. 2016;17(10):1396–408.

    Article  PubMed  PubMed Central  Google Scholar 

  • Maris JM, Matthay KK. Molecular biology of neuroblastoma. J Clin Oncol. 1999;17(7):2264–79.

    Article  CAS  PubMed  Google Scholar 

  • Mascarenhas L, et al. Pilot study of adding vincristine, topotecan, and cyclophosphamide to interval-compressed chemotherapy in newly diagnosed patients with localized ewing sarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2016;63(3):493–8.

    Article  CAS  PubMed  Google Scholar 

  • Matthay KK, et al. Opsoclonus myoclonus syndrome in neuroblastoma a report from a workshop on the dancing eyes syndrome at the advances in neuroblastoma meeting in Genoa, Italy, 2004. Cancer Lett. 2005;228(1–2):275–82.

    Article  CAS  PubMed  Google Scholar 

  • Maurer HM, et al. The intergroup rhabdomyosarcoma study-II. Cancer. 1993;71(5):1904–22.

    Article  CAS  PubMed  Google Scholar 

  • Meyers RL. Tumors of the liver in children. Surg Oncol. 2007;16(3):195–203.

    Article  PubMed  Google Scholar 

  • Meyers RL, et al. Predictive power of pretreatment prognostic factors in children with hepatoblastoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2009;53(6):1016–22.

    Article  PubMed  PubMed Central  Google Scholar 

  • Meyers AB, et al. Hepatoblastoma imaging with gadoxetate disodium-enhanced MRI—typical, atypical, pre- and post-treatment evaluation. Pediatr Radiol. 2012;42(7):859–66.

    Article  PubMed  Google Scholar 

  • Meyers RL, et al. Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration. Lancet Oncol. 2017;18(1):122–31.

    Article  PubMed  Google Scholar 

  • Meza JL, et al. Analysis of prognostic factors in patients with nonmetastatic rhabdomyosarcoma treated on intergroup rhabdomyosarcoma studies III and IV: the Children's Oncology Group. J Clin Oncol. 2006;24(24):3844–51.

    Article  PubMed  Google Scholar 

  • Milano GM, et al. Tumor lysis syndrome and neuroblastoma. Med Pediatr Oncol. 2003;41(6):592.

    Article  PubMed  Google Scholar 

  • Mody R, et al. Irinotecan-temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial. Lancet Oncol. 2017;18(7):946–57.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Moroz V, et al. The prognostic strength of serum LDH and serum ferritin in children with neuroblastoma: a report from the International Neuroblastoma Risk Group (INRG) project. Pediatr Blood Cancer. 2020;67(8):e28359.

    Article  CAS  PubMed  Google Scholar 

  • Mosse YP, et al. Germline PHOX2B mutation in hereditary neuroblastoma. Am J Hum Genet. 2004;75(4):727–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mosse YP, et al. Identification of ALK as a major familial neuroblastoma predisposition gene. Nature. 2008;455(7215):930–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nagae G, et al. Genetic and epigenetic basis of hepatoblastoma diversity. Nat Commun. 2021;12(1):5423.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Narod SA, et al. Congenital anomalies and childhood cancer in Great Britain. Am J Hum Genet. 1997;60(3):474–85.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Newman EN, Jones RL, Hawkins DS. An evaluation of [F-18]-fluorodeoxy-D-glucose positron emission tomography, bone scan, and bone marrow aspiration/biopsy as staging investigations in Ewing sarcoma. Pediatr Blood Cancer. 2013;60(7):1113–7.

    Article  CAS  PubMed  Google Scholar 

  • Norris HJ, Zirkin HJ, Benson WL. Immature (malignant) teratoma of the ovary: a clinical and pathologic study of 58 cases. Cancer. 1976;37(5):2359–72.

    Article  CAS  PubMed  Google Scholar 

  • Nuchtern JG, et al. A prospective study of expectant observation as primary therapy for neuroblastoma in young infants: a Children's Oncology Group study. Ann Surg. 2012;256(4):573–80.

    Article  PubMed  Google Scholar 

  • Ognjanovic S, et al. Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975–2005. Cancer. 2009;115(18):4218–26.

    Article  PubMed  Google Scholar 

  • Ognjanovic S, et al. Birth characteristics and the risk of childhood rhabdomyosarcoma based on histological subtype. Br J Cancer. 2010;102(1):227–31.

    Article  CAS  PubMed  Google Scholar 

  • Ognjanovic S, et al. Sarcomas in TP53 germline mutation carriers: a review of the IARC TP53 database. Cancer. 2012;118(5):1387–96.

    Article  CAS  PubMed  Google Scholar 

  • O'Neill AF, et al. alpha-Fetoprotein as a predictor of outcome for children with germ cell tumors: a report from the Malignant Germ Cell International Consortium. Cancer. 2019;125(20):3649–56.

    Article  CAS  PubMed  Google Scholar 

  • O'Neill AF, et al. Fibrolamellar carcinoma: an entity all its own. Curr Probl Cancer. 2021;45(4):100770.

    Article  PubMed  Google Scholar 

  • Pakos EE, et al. Prognostic factors and outcomes for osteosarcoma: an international collaboration. Eur J Cancer. 2009;45(13):2367–75.

    Article  PubMed  Google Scholar 

  • Palculict TB, et al. Identification of germline DICER1 mutations and loss of heterozygosity in familial Wilms tumour. J Med Genet. 2016;53(6):385–8.

    Article  CAS  PubMed  Google Scholar 

  • Palmerini E, et al. Gemcitabine and docetaxel in relapsed and unresectable high-grade osteosarcoma and spindle cell sarcoma of bone. BMC Cancer. 2016;16:280.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pappo AS, Pratt CB. Soft tissue sarcomas in children. Cancer Treat Res. 1997;91:205–22.

    Article  CAS  PubMed  Google Scholar 

  • Parham DM, Ellison DA. Rhabdomyosarcomas in adults and children: an update. Arch Pathol Lab Med. 2006;130(10):1454–65.

    Article  PubMed  Google Scholar 

  • Parham DM, et al. Nonrhabdomyosarcomatous soft tissue sarcomas of childhood: formulation of a simplified system for grading. Mod Pathol. 1995;8(7):705–10.

    CAS  PubMed  Google Scholar 

  • Patel SS, et al. Milan criteria and UCSF criteria: a preliminary comparative study of liver transplantation outcomes in the United States. Int J Hepatol. 2012;2012:253517.

    Article  PubMed  PubMed Central  Google Scholar 

  • Paulussen M, et al. Localized Ewing tumor of bone: final results of the cooperative Ewing's Sarcoma Study CESS 86. J Clin Oncol. 2001;19(6):1818–29.

    Article  CAS  PubMed  Google Scholar 

  • Pea M, et al. Apparent renal cell carcinomas in tuberous sclerosis are heterogeneous: the identification of malignant epithelioid angiomyolipoma. Am J Surg Pathol. 1998;22(2):180–7.

    Article  CAS  PubMed  Google Scholar 

  • Peifer M, et al. Telomerase activation by genomic rearrangements in high-risk neuroblastoma. Nature. 2015;526(7575):700–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Peinemann F, et al. High-dose chemotherapy followed by autologous stem cell transplantation for metastatic rhabdomyosarcoma—a systematic review. PLoS One. 2011;6(2):e17127.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Perilongo G, et al. Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma. N Engl J Med. 2009;361(17):1662–70.

    Article  CAS  PubMed  Google Scholar 

  • Perlman EJ. Pediatric renal tumors: practical updates for the pathologist. Pediatr Dev Pathol. 2005;8(3):320–38.

    Article  PubMed  Google Scholar 

  • Perlman EJ, et al. Hyperplastic perilobar nephroblastomatosis: long-term survival of 52 patients. Pediatr Blood Cancer. 2006;46(2):203–21.

    Article  PubMed  Google Scholar 

  • Pinto NR, et al. Advances in risk classification and treatment strategies for neuroblastoma. J Clin Oncol. 2015;33(27):3008–17.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Popov SD, et al. Renal tumors in children aged 10-16 Years: a report from the United Kingdom Children's Cancer and Leukaemia Group. Pediatr Dev Pathol. 2011;14(3):189–93.

    Article  PubMed  Google Scholar 

  • Porteus MH, et al. Characteristics and outcome of children with Beckwith-Wiedemann syndrome and Wilms' tumor: a report from the National Wilms Tumor Study Group. J Clin Oncol. 2000;18(10):2026–31.

    Article  CAS  PubMed  Google Scholar 

  • Raney RB, et al. Results of the Intergroup Rhabdomyosarcoma Study Group D9602 protocol, using vincristine and dactinomycin with or without cyclophosphamide and radiation therapy, for newly diagnosed patients with low-risk embryonal rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group. J Clin Oncol. 2011;29(10):1312–8.

    Article  CAS  PubMed  Google Scholar 

  • Rescorla FJ, et al. Surveillance after initial surgery for Stage I pediatric and adolescent boys with malignant testicular germ cell tumors: report from the Children's Oncology Group. J Pediatr Surg. 2015;50(6):1000–3.

    Article  PubMed  Google Scholar 

  • Rodriguez-Galindo C, et al. Analysis of prognostic factors in ewing sarcoma family of tumors: review of St. Jude Children's Research Hospital studies. Cancer. 2007;110(2):375–84.

    Article  PubMed  Google Scholar 

  • Rodriguez-Galindo C, et al. Treatment of pediatric adrenocortical carcinoma with surgery, retroperitoneal lymph node dissection, and chemotherapy: The Children's Oncology Group ARAR0332 Protocol. J Clin Oncol. 2021;39(22):2463–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Roebuck DJ, et al. 2005 PRETEXT: a revised staging system for primary malignant liver tumours of childhood developed by the SIOPEL group. Pediatr Radiol. 2007;37(2):123–32. quiz 249-50

    Article  PubMed  Google Scholar 

  • Rogers PC, et al. Treatment of children and adolescents with stage II testicular and stages I and II ovarian malignant germ cell tumors: a Pediatric Intergroup Study--Pediatric Oncology Group 9048 and Children's Cancer Group 8891. J Clin Oncol. 2004;22(17):3563–9.

    Article  PubMed  Google Scholar 

  • Rudnick E, et al. Opsoclonus-myoclonus-ataxia syndrome in neuroblastoma: clinical outcome and antineuronal antibodies-a report from the Children's Cancer Group Study. Med Pediatr Oncol. 2001;36(6):612–22.

    Article  CAS  PubMed  Google Scholar 

  • Ruteshouser EC, Huff V. Familial Wilms tumor. Am J Med Genet C Semin Med Genet. 2004;129C(1):29–34.

    Article  PubMed  Google Scholar 

  • Ruteshouser EC, Robinson SM, Huff V. Wilms tumor genetics: mutations in WT1, WTX, and CTNNB1 account for only about one-third of tumors. Genes Chromosomes Cancer. 2008;47(6):461–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sankar S, et al. Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma. Oncogene. 2013;32(42):5089–100.

    Article  CAS  PubMed  Google Scholar 

  • Satge D, et al. Abnormal constitutional karyotypes in patients with neuroblastoma: a report of four new cases and review of 47 others in the literature. Cancer Genet Cytogenet. 2003;147(2):89–98.

    Article  CAS  PubMed  Google Scholar 

  • Schilling FH, et al. Neuroblastoma screening at one year of age. N Engl J Med. 2002;346(14):1047–53.

    Article  PubMed  Google Scholar 

  • Schleiermacher G, et al. Segmental chromosomal alterations have prognostic impact in neuroblastoma: a report from the INRG project. Br J Cancer. 2012;107(8):1418–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schmid I, et al. Sorafenib and cisplatin/doxorubicin (PLADO) in pediatric hepatocellular carcinoma. Pediatr Blood Cancer. 2012;58(4):539–44.

    Article  PubMed  Google Scholar 

  • Schultz KA, et al. Ovarian sex cord-stromal tumors, pleuropulmonary blastoma and DICER1 mutations: a report from the International Pleuropulmonary Blastoma Registry. Gynecol Oncol. 2011;122(2):246–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Scott RH, et al. Syndromes and constitutional chromosomal abnormalities associated with Wilms tumour. J Med Genet. 2006;43(9):705–15.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Servaes S, et al. Comparison of diagnostic performance of CT and MRI for abdominal staging of pediatric renal tumors: a report from the Children's Oncology Group. Pediatr Radiol. 2015;45(2):166–72.

    Article  PubMed  Google Scholar 

  • Shaikh F, et al. Paediatric extracranial germ-cell tumours. Lancet Oncol. 2016;17(4):e149–62.

    Article  PubMed  Google Scholar 

  • Shamberger RC, et al. Long-term outcomes for infants with very low risk Wilms tumor treated with surgery alone in National Wilms Tumor Study-5. Ann Surg. 2010;251(3):555–8.

    Article  PubMed  Google Scholar 

  • Sharp SE, et al. 123I-MIBG scintigraphy and 18F-FDG PET in neuroblastoma. J Nucl Med. 2009;50(8):1237–43.

    Article  PubMed  Google Scholar 

  • Shields CL, et al. The International Classification of Retinoblastoma predicts chemoreduction success. Ophthalmology. 2006;113(12):2276–80.

    Article  PubMed  Google Scholar 

  • Shields CL, et al. Intravitreal melphalan for persistent or recurrent retinoblastoma vitreous seeds: preliminary results. JAMA Ophthalmol. 2014;132(3):319–25.

    Article  PubMed  Google Scholar 

  • Shimada H, et al. The International Neuroblastoma Pathology Classification (the Shimada system). Cancer. 1999;86(2):364–72.

    Article  CAS  PubMed  Google Scholar 

  • Shimada H, et al. International neuroblastoma pathology classification for prognostic evaluation of patients with peripheral neuroblastic tumors: a report from the Children's Cancer Group. Cancer. 2001;92(9):2451–61.

    Article  CAS  PubMed  Google Scholar 

  • Shulman DS, et al. Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group. Br J Cancer. 2018;119(5):615–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Siebel NL, Sun J, Anderson JR, et al. Outcome of clear cell sarcoma of the kidney (CCSK) treated on the National Wilms Tumor Study-5 (NWTS). J Clin Oncol. 2006;24(Suppl. 18):9000.

    Article  Google Scholar 

  • Smith SC, et al. CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression. Mod Pathol. 2015;28(1):57–68.

    Article  CAS  PubMed  Google Scholar 

  • Spunt SL, Million L, Anderson JR, et al. Risk-based treatment for nonrhabdomyosarcoma soft tissue sarcomas (MRSTS) in patients under 30 yeras of age: Children’s Oncology Group study ARST0332. J Clin Oncol. 2014;32(Suppl. 15):10008.

    Article  Google Scholar 

  • Strother DR, et al. Outcome after surgery alone or with restricted use of chemotherapy for patients with low-risk neuroblastoma: results of Children's Oncology Group study P9641. J Clin Oncol. 2012;30(15):1842–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Study of CAR T-Cells Targeting the GD2 with IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma or Relapsed/Refractory Osteosarcoma, 2023. Available from: https://clinicaltrials.gov/ct2/show/NCT03721068.

  • Sumazin P, et al. Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups. Hepatology. 2017;65(1):104–21.

    Article  CAS  PubMed  Google Scholar 

  • Sumazin P, et al. Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults. J Hepatol. 2022;77(4):1026–37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sun L, et al. Prognostic value of pathologic fracture in patients with high grade localized osteosarcoma: a systemic review and meta-analysis of cohort studies. J Orthop Res. 2015;33(1):131–9.

    Article  PubMed  Google Scholar 

  • Swartz MA, et al. Renal medullary carcinoma: clinical, pathologic, immunohistochemical, and genetic analysis with pathogenetic implications. Urology. 2002;60(6):1083–9.

    Article  PubMed  Google Scholar 

  • Tajiri H, et al. Reduction of hepatocellular carcinoma in childhood after introduction of selective vaccination against hepatitis B virus for infants born to HBV carrier mothers. Cancer Causes Control. 2011;22(3):523–7.

    Article  PubMed  Google Scholar 

  • Tanaka Y, et al. Gonadal mixed germ cell tumor combined with a large hemangiomatous lesion in a patient with Turner's syndrome and 45,X/46,X, +mar karyotype. Arch Pathol Lab Med. 1994;118(11):1135–8.

    CAS  PubMed  Google Scholar 

  • Tao JJ, et al. ALK fusions in renal cell carcinoma: response to entrectinib. JCO Precis Oncol. 2018;2:1–8.

    Article  PubMed  Google Scholar 

  • Teshiba R, et al. Age-dependent prognostic effect by Mitosis-Karyorrhexis Index in neuroblastoma: a report from the Children's Oncology Group. Pediatr Dev Pathol. 2014;17(6):441–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Tiao GM, et al. The current management of hepatoblastoma: a combination of chemotherapy, conventional resection, and liver transplantation. J Pediatr. 2005;146(2):204–11.

    Article  PubMed  Google Scholar 

  • Tirode F, et al. Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations. Cancer Discov. 2014;4(11):1342–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Trobaugh-Lotrario AD, et al. Small cell undifferentiated variant of hepatoblastoma: adverse clinical and molecular features similar to rhabdoid tumors. Pediatr Blood Cancer. 2009;52(3):328–34.

    Article  PubMed  PubMed Central  Google Scholar 

  • Trobaugh-Lotrario A, et al. Small cell undifferentiated histology does not adversely affect outcome in hepatoblastoma: a report from the Children's Oncology Group (COG) AHEP0731 Study Committee. J Clin Oncol. 2022;40(5):459–67.

    Article  CAS  PubMed  Google Scholar 

  • Twist CJ, et al. Maintaining outstanding outcomes using response- and biology-based therapy for intermediate-risk neuroblastoma: a report from the Children's Oncology Group Study ANBL0531. J Clin Oncol. 2019;37(34):3243–55.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vallance K, et al. Impact of biomarkers on outcome in stage I and II low risk favorable histology Wilms tumor. A report from the Children’s Oncology Group AREN03B2 Protocol. Pediatr Blood Cancer. 2022;69(S5):e29952.

    Google Scholar 

  • van der Beek JN, et al. Characteristics and outcome of children with renal cell carcinoma: a narrative review. Cancers (Basel). 2020;12(7):1776.

    Article  PubMed  Google Scholar 

  • Vasudevan SA, et al. Outcomes of children with well-differentiated fetal hepatoblastoma treated with surgery only: report from Children's Oncology Group Trial, AHEP0731. J Pediatr Surg. 2022;57(10):251–6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wagner AJ, et al. Tivantinib (ARQ 197), a selective inhibitor of MET, in patients with microphthalmia transcription factor-associated tumors: results of a multicenter phase 2 trial. Cancer. 2012;118(23):5894–902.

    Article  CAS  PubMed  Google Scholar 

  • Walker E, et al. Psychosocial interventions for adolescents and young adults diagnosed with cancer during adolescence: a critical review. J Adolesc Young Adult Oncol. 2016;5(4):310–21.

    Article  PubMed  Google Scholar 

  • Walterhouse DO, et al. Shorter-duration therapy using vincristine, dactinomycin, and lower-dose cyclophosphamide with or without radiotherapy for patients with newly diagnosed low-risk rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group. J Clin Oncol. 2014;32(31):3547–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang N, Perkins KL. Involvement of band 3p14 in t(3;8) hereditary renal carcinoma. Cancer Genet Cytogenet. 1984;11(4):479–81.

    Article  CAS  PubMed  Google Scholar 

  • Wang LL, et al. Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome. J Natl Cancer Inst. 2003;95(9):669–74.

    Article  CAS  PubMed  Google Scholar 

  • Wedekind MF, Wagner LM, Cripe TP. Immunotherapy for osteosarcoma: where do we go from here? Pediatr Blood Cancer. 2018;65(9):e27227.

    Article  PubMed  Google Scholar 

  • Wei MY, Zhuang YF, Wang WM. Gemcitabine for the treatment of patients with osteosarcoma. Asian Pac J Cancer Prev. 2014;15(17):7159–62.

    Article  PubMed  Google Scholar 

  • Weiss BD, et al. A safety and feasibility trial of (131) I-MIBG in newly diagnosed high-risk neuroblastoma: a Children's Oncology Group study. Pediatr Blood Cancer. 2021;68(10):e29117.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Weiss AR, et al. Outcomes following preoperative chemoradiation +/− pazopanib in non-rhabdomyosarcoma soft tissue sarcoma (NRSTS): a report from Children's Oncology Group (COG) and NRG Oncology. J Clin Oncol. 2022;40(Suppl. 16):11504.

    Article  Google Scholar 

  • Whelan J, et al. High-dose chemotherapy and blood autologous stem-cell rescue compared with standard chemotherapy in localized high-risk Ewing sarcoma: results of Euro-E.W.I.N.G.99 and Ewing-2008. J Clin Oncol. 2018;36(31):JCO2018782516.

    Article  PubMed  Google Scholar 

  • Wiener ES, et al. Controversies in the management of paratesticular rhabdomyosarcoma: is staging retroperitoneal lymph node dissection necessary for adolescents with resected paratesticular rhabdomyosarcoma? Semin Pediatr Surg. 2001;10(3):146–52.

    Article  CAS  PubMed  Google Scholar 

  • Williams SD, et al. Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N Engl J Med. 1987;316(23):1435–40.

    Article  CAS  PubMed  Google Scholar 

  • Wolden SL, et al. Indications for radiotherapy and chemotherapy after complete resection in rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Studies I to III. J Clin Oncol. 1999;17(11):3468–75.

    Article  CAS  PubMed  Google Scholar 

  • Wong FL, et al. Cancer incidence after retinoblastoma. Radiation dose and sarcoma risk. JAMA. 1997;278(15):1262–7.

    Article  CAS  PubMed  Google Scholar 

  • Woods WG, et al. Screening of infants and mortality due to neuroblastoma. N Engl J Med. 2002;346(14):1041–6.

    Article  PubMed  Google Scholar 

  • Wunder JS, et al. The histological response to chemotherapy as a predictor of the oncological outcome of operative treatment of Ewing sarcoma. J Bone Joint Surg Am. 1998;80(7):1020–33.

    Article  CAS  PubMed  Google Scholar 

  • Yamada Y, et al. Fluorescence-guided surgery for hepatoblastoma with indocyanine green. Cancers (Basel). 2019;11(8):1215.

    Article  CAS  PubMed  Google Scholar 

  • Yanik GA, et al. Semiquantitative mIBG scoring as a prognostic indicator in patients with stage 4 neuroblastoma: a report from the Children's oncology group. J Nucl Med. 2013;54(4):541–8.

    Article  CAS  PubMed  Google Scholar 

  • Yu AL, et al. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N Engl J Med. 2010;363(14):1324–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang J, et al. Noninvasive extendable prosthesis: a new design. Biotechnol Biotechnol Equip. 2020;34(1):447–54.

    Article  Google Scholar 

  • Zsiros J, et al. Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma (SIOPEL-4): a prospective, single-arm, feasibility study. Lancet Oncol. 2013;14(9):834–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Nitin Shrivastava .

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Shrivastava, N., O’Neill, A.F. (2023). Update in Solid Tumors of Childhood. In: Beckwith, S. (eds) Update in Pediatrics. Springer, Cham. https://doi.org/10.1007/978-3-031-41542-5_25

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