Skip to main content
SpringerLink
Log in

Hepatoblastoma imaging with gadoxetate disodium-enhanced MRI—typical, atypical, pre- and post-treatment evaluation

  • Pictorial Essay
  • Published:
Pediatric Radiology Aims and scope Submit manuscript

Abstract

Gadoxetate disodium (Gd-EOB-DTPA) is a hepatobiliary MRI contrast agent widely used in adults for characterization of liver tumors and increasingly used in children. Hepatoblastoma is the most common primary hepatic malignancy of childhood. In this review, we describe our experience with this agent both before and after initiating therapy in children with hepatoblastoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9

Similar content being viewed by others

References

  1. Ringe KI, Husarik DB, Sirlin CB et al (2010) Gadoxetate disodium-enhanced MRI of the liver: part 1, protocol optimization and lesion appearance in the noncirrhotic liver. AJR 195:13–28

    Article  PubMed  Google Scholar 

  2. Cruite I, Schroeder M, Merkle EM et al (2010) Gadoxetate disodium-enhanced MRI of the liver: part 2, protocol optimization and lesion appearance in the cirrhotic liver. AJR 195:29–41

    Article  PubMed  Google Scholar 

  3. Meyers AM, Towbin AJ, Serai A et al (2011) Characterization of pediatric liver lesions with gadoxetate disodium. Pediatr Radiol 41:1183–1197

    Article  PubMed  Google Scholar 

  4. Zech CJ, Herrmann KA, Reiser MF et al (2007) MR imaging in patients with suspected liver metastases: value of liver-specific contrast agent Gd-EOB-DTPA. Magn Reson Med Sci 6:43–52

    Article  PubMed  Google Scholar 

  5. Choi JY, Kim MJ, Park YM et al (2011) Gadoxetate disodium-enhanced hepatobiliary phase MRI of hepatocellular carcinoma: correlation with histological characteristics. AJR 197:399–405

    Article  PubMed  Google Scholar 

  6. Goodwin MD, Dobson JE, Sirlin CB et al (2011) Diagnostic challenges and pitfalls in MR imaging with hepatocyte-specific contrast agents. Radiographics 31:1547–1568

    Article  Google Scholar 

  7. Vasanawala S (2010) MRI of the liver—how to do it. Pediatr Radiol 40:431–437

    Article  PubMed  Google Scholar 

  8. Marrone G, Maggiore G, Carollo V et al (2011) Biliary cystadenoma with bile duct communication depicted on liver-specific contrast agent-enhanced MRI in a child. Pediatr Radiol 41:121–124

    Article  PubMed  Google Scholar 

  9. Tamrazi A, Vasanawala SS (2011) Functional hepatobiliary MR imaging in children. Pediatr Radiol 22:1250–1258

    Article  Google Scholar 

  10. Das CJ, Dhingra S, Gupta AK et al (2009) Imaging of paediatric liver tumours with pathological correlation. Clin Radiol 64:1015–1025

    Article  PubMed  CAS  Google Scholar 

  11. Imbach P (2006) Hepatic tumors. In: Imbach P, Kuhne T, Arceci RJ (eds) Pediatric oncology: a comprehensive guide. Springer, New York, pp 187–191

    Chapter  Google Scholar 

  12. Chung EM, Lattin GE, Cube R et al (2011) Pediatric liver masses: radiologic-pathologic correlation part 2. Malignant tumors. Radiographics 31:483–507

    Article  PubMed  Google Scholar 

  13. Roebuck DJ, Aronson D, Clapuyt P et al (2005) PRETEXT: a revised staging system for primary malignant liver tumours of childhood developed by the SIOPEL group. Pediatr Radiol 37:123–132

    Article  Google Scholar 

  14. Vogel TJ, Kummel S, Hammerstingl R et al (1996) Liver tumors: comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA. Radiology 200:59–67

    Google Scholar 

  15. Reimer P, Rummeny EJ, Shamsi K et al (1996) Phase II clinical evaluation of Gd-EOB-DTPA: dose, safety aspects, and pulse sequence. Radiology 199:177–183

    PubMed  CAS  Google Scholar 

  16. Towbin AJ, Luo GG, Yin H et al (2010) Focal nodular hyperplasia in children, adolescents, and young adults. Pediatr Radiol 41:341–349

    Article  PubMed  Google Scholar 

  17. Asbach P, Klessen C, Koch M et al (2007) Magnetic resonance imaging findings of atypical focal nodular hyperplasia of the liver. Clin Imaging 31:244–252

    Article  PubMed  Google Scholar 

  18. Christison-Lagay ER, Burrows PE, Alomari A et al (2007) Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry. J Pediatr Surg 42:62–67

    Article  PubMed  Google Scholar 

  19. Goshima S, Kanematsu M, Watanabe H et al (2010) Hepatic hemangioma and metastasis: differentiation with gadoxetate disodium-enhanced 3-T MRI. AJR 195:941–946

    Article  PubMed  Google Scholar 

  20. Prokurat A, Kluge P, Kosciesza A et al (2002) Transitional liver cell tumors (TLCT) in older children and adolescents: a novel group of aggressive hepatic tumors expressing beta-catenin. Med Pediatr Oncol 39:510–518

    Article  PubMed  Google Scholar 

Download references

Author information

Author notes

  1. Arthur B. Meyers

    Present address: Department of Pediatric Imaging, Children’s Hospital of Wisconsin, 9000 W. Wisconsin Ave., Milwaukee, WI, 53226, USA

Authors and Affiliations

  1. Department of Radiology, Cincinnati Children’s Hospital Medical Center, 3333 Burnett Ave., Cincinnati, OH, 45219, USA

    Arthur B. Meyers, Alexander J. Towbin & Daniel J. Podberesky

  2. Department of Hematology/Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    James I. Geller

  3. Department of Radiology, Medical College of Wisconsin, Milwaukee, WI, USA

    Arthur B. Meyers

Authors
  1. Arthur B. Meyers
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alexander J. Towbin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. James I. Geller
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Daniel J. Podberesky
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Arthur B. Meyers.

Additional information

CME activity

This article has been selected as the CME activity for the current month. Please visit the SPR Web site at www.pedrad.org on the Education page and follow the instructions to complete this CME activity.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Meyers, A.B., Towbin, A.J., Geller, J.I. et al. Hepatoblastoma imaging with gadoxetate disodium-enhanced MRI—typical, atypical, pre- and post-treatment evaluation. Pediatr Radiol 42, 859–866 (2012). https://doi.org/10.1007/s00247-012-2366-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00247-012-2366-6

Keywords

Search

Navigation