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Genetic, Epigenetics, and Cell Adhesion in Acute Kidney Injury

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Organ Crosstalk in Acute Kidney Injury

Abstract

The structural, functional, and dynamic coupling of the different systems of the human body means that an alteration in a specific organ might have diverse etiologies and heterogeneous local and systemic effects such as acute kidney injury (AKI). The interrelationship between genome, epigenome, and phenotypic characteristics is also modulated and has organic consequences. AKI is a syndrome with renal function impairment, in which variations in genetic information, as well as the dynamics of its expression in specific contexts, induce cellular programs interrelated among themselves and with the tissue microenvironment that through complex interactions can trigger and perpetuate AKI. In this section, the experimental and clinical evidence implicating genetic, epigenetic mechanisms and phenotypic characteristics that contribute to the emergence of AKI will be presented.

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Authors and Affiliations

  1. Life Sciences Research Centre, Universidad Simon Bolivar, Barranquilla, Colombia

    Eloina Del Carmen Zarate-Peñata & Jaime Luna-Carrascal

  2. Faculty of Basic and Biomedical Sciences, Universidad Simon Bolivar, Barranquilla, Colombia

    Eloina Del Carmen Zarate-Peñata & Jaime Luna-Carrascal

  3. Life Sciences Research Centre, Universidad Simon Bolivar, Barranquilla, Colombia

    Estefania Zapata, Ornella Fiorillo-Moreno, Yezit Bello & Milton Quintana-Sosa

  4. Centro de Investigaciones clinicas, Clinica de la costa, Barranquilla, Colombia

    Lorena Gómez-Escorcia

  5. Life Sciences Research Centre, Universidad Simon Bolivar, Barranquilla, Colombia

    Roberto Navarro-Quiroz & Elkin Navarro-Quiroz

  6. Faculty of Basic and Biomedical Sciences, Universidad Simon Bolivar, Barranquilla, Colombia

    Roberto Navarro-Quiroz & Elkin Navarro-Quiroz

  7. Fundación Universidad San Martin, School of medicine, Puerto Colombia, Colombia

    Roberto Navarro-Quiroz & Elkin Navarro-Quiroz

  8. School of Medicine, Universidad Simon Bolivar, Barranquilla, Colombia

    Katherine Zarate

  9. School of Medicine, Universidad Rafael Nuñez, Cartagena, Colombia

    Marlon Múnera

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  1. Eloina Del Carmen Zarate-Peñata
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Correspondence to Elkin Navarro-Quiroz .

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Editors and Affiliations

  1. Nephrology Division, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Carlos Guido Musso

  2. Grigore T. Popa University of Medicine, Iasi, Romania

    Adrian Covic

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Zarate-Peñata, E.D.C. et al. (2023). Genetic, Epigenetics, and Cell Adhesion in Acute Kidney Injury. In: Musso, C.G., Covic, A. (eds) Organ Crosstalk in Acute Kidney Injury. Springer, Cham. https://doi.org/10.1007/978-3-031-36789-2_6

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  • DOI: https://doi.org/10.1007/978-3-031-36789-2_6

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