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Sedation and Analgesia During Non-invasive Ventilation in Intensive Care

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Non-invasive Mechanical Ventilation in Critical Care, Anesthesiology and Palliative Care

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Abstract

Non-invasive ventilation is currently one of the most commonly used support methods in hypoxemic and hypercapnic acute respiratory failure.

Agitation, intolerance, and patient–ventilator asynchrony are factors implicated in NIV failure for which judicious sedation is recommended.

Sedation during NIV should be performed with no/minimal respiratory depression and no/minimal impairment of the upper airway.

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References

  1. Carlucci A, Richard J-C, Wysocki M, Lepage E, Brochard L. Noninvasive versus conventional mechanical ventilation an epidemiologic survey and the SRLF collaborative group on mechanical ventilation. Am J Respir Crit Care Med. 2001;163(4):874–80.

    Article  CAS  PubMed  Google Scholar 

  2. Pisani L, Bianco GL, Pugliesi M, Tramarin J, Gregoretti C. Sedation and analgesia during noninvasive ventilation (NIV). In: Practical trends in anesthesia and intensive care 2017. Springer; 2017. https://doi.org/10.1007/978-3-319-61325-3_9.

    Chapter  Google Scholar 

  3. Nava S, Hill N. Non-invasive ventilation in acute respiratory failure. Lancet. 2009;374(9685):250–9. https://doi.org/10.1016/S0140-6736(09)60496-7.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Muriel A, et al. Impact of sedation and analgesia during noninvasive positive pressure ventilation on outcome: a marginal structural model causal analysis. Intensive Care Med. 2015;41:1586–600. https://doi.org/10.1007/s00134-015-3854-6.

    Article  CAS  PubMed  Google Scholar 

  5. Devlin JW, Nava S, Fong JJ, Bahhady I, Hill NS. Survey of sedation practices during noninvasive positive-pressure ventilation to treat acute respiratory failure. Crit Care Med. 2007;35(10):2298–302. https://doi.org/10.1097/01.CCM.0000284512.21942.F8.

    Article  PubMed  Google Scholar 

  6. Conti G, Hill NS, Nava S. Is sedation safe and beneficial in patients receiving NIV? No. Intensive Care Med. 2015;41:1692–5. https://doi.org/10.1007/s00134-015-3915-x.

    Article  PubMed  Google Scholar 

  7. Longrois D, et al. Sedation in non-invasive ventilation: do we know what to do (and why)? Multidiscip Respir Med. 2014;9:56. https://doi.org/10.1186/2049-6958-9-56.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Devlin JW, et al. Clinical practice guidelines for the prevention and Management of Pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med. 2018;46(9):e825–73. https://doi.org/10.1097/CCM.0000000000003299.

    Article  PubMed  Google Scholar 

  9. Marra A, Ely EW, Pandharipande PP, Patel MB. The ABCDEF bundle in critical care. Crit Care Clin. 2017;33:225–43.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Pandharipande P, et al. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology. 2006;104(1):21–6. https://doi.org/10.1097/00000542-200601000-00005.

    Article  CAS  PubMed  Google Scholar 

  11. Cavaliere F, et al. A low-dose remifentanil infusion is well tolerated for sedation in mechanically ventilated, critically-ill patients. Can J Anesth. 2002;49(10):1088–94. https://doi.org/10.1007/BF03017909.

    Article  PubMed  Google Scholar 

  12. Conti G, et al. Sedation with sufentanil in patients receiving pressure support ventilation has no effects on respiration: a pilot study. Can J Anesth. 2004;51(5):494–9. https://doi.org/10.1007/BF03018315.

    Article  PubMed  Google Scholar 

  13. Costa R, et al. Remifentanil effects on respiratory drive and timing during pressure support ventilation and neurally adjusted ventilatory assist. Respir Physiol Neurobiol. 2017;244:10–6. https://doi.org/10.1016/j.resp.2017.06.007.

    Article  CAS  PubMed  Google Scholar 

  14. Vaschetto R, et al. Effects of propofol on patient-ventilator synchrony and interaction during pressure support ventilation and neurally adjusted ventilatory assist. Crit Care Med. 2014;42(1):74–82. https://doi.org/10.1097/CCM.0b013e31829e53dc.

    Article  CAS  PubMed  Google Scholar 

  15. Clouzeau B, et al. Target-controlled infusion of propofol for sedation in patients with non-invasive ventilation failure due to low tolerance: a preliminary study. Intensive Care Med. 2010;36:1675–80. https://doi.org/10.1007/s00134-010-1904-7.

    Article  CAS  PubMed  Google Scholar 

  16. Senoglu N, et al. Sedation during noninvasive mechanical ventilation with dexmedetomidine or midazolam: a randomized, double-blind, prospective study. Curr Ther Res Clin Exp. 2010;76:3. https://doi.org/10.1016/j.curtheres.2010.06.003.

    Article  CAS  Google Scholar 

  17. Huang Z, Chen Y s, Yang Z l, Liu J y. Dexmedetomidine versus midazolam for the sedation of patients with non-invasive ventilation failure. Intern Med. 2012;51(17):2299–305. https://doi.org/10.2169/internalmedicine.51.7810.

    Article  CAS  PubMed  Google Scholar 

  18. Devlin JW, et al. Efficacy and safety of early dexmedetomidine during noninvasive ventilation for patients with acute respiratory failure: a randomized, double-blind, placebo-controlled pilot study. Chest. 2014;145(6):1204–12. https://doi.org/10.1378/chest.13-1448.

    Article  CAS  PubMed  Google Scholar 

  19. Shutes BL, Gee SW, Sargel CL, Fink KA, Tobias JD. Dexmedetomidine as single continuous sedative during noninvasive ventilation: typical usage, hemodynamic effects, and withdrawal. Pediatr Crit Care Med. 2018;19(4):287–97. https://doi.org/10.1097/PCC.0000000000001451.

    Article  PubMed  Google Scholar 

  20. Venkatraman R, Hungerford JL, Hall MW, Moore-Clingenpeel M, Tobias JD. Dexmedetomidine for sedation during noninvasive ventilation in Pediatric patients∗. Pediatr Crit Care Med. 2017;18(9):831–7. https://doi.org/10.1097/PCC.0000000000001226.

    Article  PubMed  Google Scholar 

  21. Piastra M, et al. Dexmedetomidine is effective and safe during NIV in infants and young children with acute respiratory failure. BMC Pediatr. 2018;18:282. https://doi.org/10.1186/s12887-018-1256-y.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Ni YN, Wang T, Yu H, Liang BM, Liang ZA. The effect of sedation and/or analgesia as rescue treatment during noninvasive positive pressure ventilation in the patients with Interface intolerance after Extubation. BMC Pulm Med. 2017;17:125. https://doi.org/10.1186/s12890-017-0469-4.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Charlesworth M, Elliott MW, Holmes JD. Noninvasive positive pressure ventilation for acute respiratory failure in delirious patients: understudied, underreported, or underappreciated? A systematic review and meta-analysis. Lung. 2012;190:597–603. https://doi.org/10.1007/s00408-012-9403-y.

    Article  PubMed  Google Scholar 

  24. Abdelgalel EF. Dexmedetomidine versus haloperidol for prevention of delirium during non-invasive mechanical ventilation. Egypt J Anaesth. 2016;32:4, 473–81. https://doi.org/10.1016/j.egja.2016.05.008.

    Article  Google Scholar 

  25. Fanfulla F, et al. Effect of sleep on patient/ventilator asynchrony in patients undergoing chronic non-invasive mechanical ventilation. Respir Med. 2007;101(8):1702–7. https://doi.org/10.1016/j.rmed.2007.02.026.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, Naples, Italy

    A. Marra & Giuseppe Servillo

  2. Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University School of Medicine, Nashville, TN, USA

    A. Marra & P. P. Pandharipande

  3. Department of Anesthesiology, Division of Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA

    P. P. Pandharipande

Authors
  1. A. Marra
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  2. P. P. Pandharipande
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  3. Giuseppe Servillo
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Editors and Affiliations

  1. Neurosc, Reprod, Odontostomatol Sc, University of Naples “Federico II”, Naples, Italy

    Giuseppe Servillo

  2. Neurosc, Reprod, Odontostomatol Sc, University of Naples “Federico II”, Naples, Italy

    Maria Vargas

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Marra, A., Pandharipande, P.P., Servillo, G. (2023). Sedation and Analgesia During Non-invasive Ventilation in Intensive Care. In: Servillo, G., Vargas, M. (eds) Non-invasive Mechanical Ventilation in Critical Care, Anesthesiology and Palliative Care. Springer, Cham. https://doi.org/10.1007/978-3-031-36510-2_19

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  • DOI: https://doi.org/10.1007/978-3-031-36510-2_19

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-36509-6

  • Online ISBN: 978-3-031-36510-2

  • eBook Packages: MedicineMedicine (R0)

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