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Tissue Regeneration Processing and Mimicking

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Biomaterials and Tissue Engineering

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL,volume 74))

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Abstract

Tissue regeneration has been one of the comprehensive topics that underlie tissue engineering and has been researched over years. The main aim in tissue engineering is to create a tissue microenvironment produced from natural or synthetic biomaterials, to promote tissue regeneration in the injured site, thus mimicking the natural extracellular matrix (ECM) structure as much as possible, to ensure the migration of specific cells to the site, cell proliferation, and cell differentiation. In this context, it is critical to understand the difference between tissue repair and tissue regeneration, the main stages of tissue repair (hemostasis, inflammation, proliferation and remodeling), and the regeneration and repair mechanisms of the four basic tissues (connective, epithelial, muscle, and nerve tissue). Studies on tissue regeneration mainly focus on scaffolds, decellularized tissues, and their combination with cells capable of self-renewal and differentiation, such as stem cells. Herein, it is also presented in detail how to mimic the tissue microenvironment, the essential characteristics of a scaffold and why decellularized tissues are needed.

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Authors and Affiliations

  1. Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Istanbul, 34220, Turkey

    Aysel Oktay, Busra Oktay, Elif Durasi, Hilal Calik, Rabia Yilmaz Ozturk, Ruveyda Aydin & Rabia Cakir Koc

  2. Department of Molecular Biotechnology, Turkish-German University, Istanbul, 34820, Turkey

    Aysel Oktay

  3. Department of Metallurgical and Materials Engineering, Marmara University, Istanbul, 34854, Turkey

    Ilkay Tenim

  4. Department of Metallurgical and Materials Engineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Istanbul, 34220, Turkey

    Tarlan Mahouti & Hakan Yilmazer

  5. Health Institutes of Turkiye (TUSEB), Istanbul, Turkey

    Rabia Cakir Koc

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  1. Aysel Oktay
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Correspondence to Hakan Yilmazer .

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  1. Center for Nanotechnology and Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Türkiye

    Oguzhan Gunduz

  2. Univ Rouen Normandie, INSA Rouen Normandie, CNRS, Normandie Univ Polymères Biopolymères Surfaces (PBS) UMR, Évreux, France

    Christophe Egles

  3. Bioengineering Institute of Technology, International University of Catalonia, Barcelona, Spain

    Román A. Pérez

  4. Polytechnic University of Bucharest, Bucharest, Romania

    Denisa Ficai

  5. Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Istanbul, Türkiye

    Cem Bulent Ustundag

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Oktay, A. et al. (2023). Tissue Regeneration Processing and Mimicking. In: Gunduz, O., Egles, C., Pérez, R.A., Ficai, D., Ustundag, C.B. (eds) Biomaterials and Tissue Engineering. Stem Cell Biology and Regenerative Medicine, vol 74. Springer, Cham. https://doi.org/10.1007/978-3-031-35832-6_2

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