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Disorders of Spermatogenesis and Spermiogenesis

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Andrology

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Abstract

Male infertility is often caused by congenital or acquired disorders of spermatogenesis and spermiogenesis; with impaired semen quality ranging from oligo- or oligoasthenoteratozoospermia (OAT) to non-obstructive azoospermia (NOA). While the etiology of OAT remains unclear in many cases, correlation of histopathological findings with cyto- or molecular genetic alterations allows an increasingly accurate differential diagnosis of NOA. Next-generation sequencing techniques have already identified more than 200 genes associated with disorders of spermatogenesis such as spermatogenic arrest or Sertoli cell-only phenotype. Monogenic causes can also be identified for specific structural sperm defects, which reflect disorders of spermiogenesis and can usually be identified by light microscopy. Causal therapeutic options do not exist for genetic disorders of spermatogenesis or spermiogenesis.

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Authors and Affiliations

  1. Section of Conservative Andrology, Department of Urology, Pediatric Urology and Andrology, University Hospital Giessen and Marburg GmbH, Justus Liebig University Giessen, Giessen, Germany

    Hans-Christian Schuppe

  2. Institute of Reproductive Genetics, University of Münster, Münster, Germany

    Margot J. Wyrwoll & Frank Tüttelmann

  3. Institute of Veterinary Anatomy, Histology and Embryology, Justus Liebig University Giessen, Giessen, Germany

    Daniela Fietz

Authors
  1. Hans-Christian Schuppe
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  2. Margot J. Wyrwoll
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  3. Daniela Fietz
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  4. Frank Tüttelmann
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Corresponding author

Correspondence to Hans-Christian Schuppe .

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Editors and Affiliations

  1. Center for Reproductive Medicine and Andrology, University Hospital Münster, Münster, Germany

    Eberhard Nieschlag

  2. Center for Reproductive Medicine and Andrology, University Hospital Halle (Saale), Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

    Hermann M. Behre

  3. Center for Reproductive Medicine and Andrology, University Hospital Münster, Münster, Germany

    Sabine Kliesch

  4. Center for Reproductive Medicine and Andrology, University Hospital Münster, Münster, Germany

    Susan Nieschlag

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Schuppe, HC., Wyrwoll, M.J., Fietz, D., Tüttelmann, F. (2023). Disorders of Spermatogenesis and Spermiogenesis. In: Nieschlag, E., Behre, H.M., Kliesch, S., Nieschlag, S. (eds) Andrology. Springer, Cham. https://doi.org/10.1007/978-3-031-31574-9_20

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