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Circadian Rhythm Disorders in Children and Adults

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Sleep Medicine

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Abstract

The sleep timekeeping system also called the intrinsic circadian rhythm promotes consolidation of sleep and wake and is vital for sleep health as well as the proper function of other bodily systems. Lack of proper synchrony between the internal circadian system and the desired sleep-wake periods causes one or more of the six main types of circadian rhythm disorders. Different circadian rhythm sleep disorders are more common in certain age groups than others. For example, among adolescents, delayed sleep phase sleep disorders can be seen more commonly. Among the elderly, advanced sleep phase disorders are seen. As one transitions between different stages of life, the changes in the intrinsic circadian system along with lifestyle conditions lead to changes in sleep wake cycles. This chapter provides a succinct review of the physiopathology, clinical findings, diagnostic criteria, as well as treatment options of the common circadian rhythm disorders in children, adolescents, and adults.

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References

  1. Rosenwasser AM, Turek FW. Neurobiology of circadian rhythm regulation. Sleep Med Clin. 2015;10(4):403–12.

    Article  PubMed  Google Scholar 

  2. Cornelissen G, Otsuka K. Chronobiology of aging: a mini-review. Gerontology. 2017;63(2):118–28.

    Article  CAS  PubMed  Google Scholar 

  3. Reiter RJ, Tan DX, Korkmaz A, Rosales-Corral SA. Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology. Hum Reprod Update. 2014;20(2):293–307.

    Article  CAS  PubMed  Google Scholar 

  4. Logan RW, McClung CA. Rhythms of life: circadian disruption and brain disorders across the lifespan. Nat Rev Neurosci. 2019;20(1):49–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Reppert SM. Interaction between the circadian clocks of mother and fetus. Ciba Found Symp. 1995;183:198–207. Discussion −11.

    CAS  PubMed  Google Scholar 

  6. Garcia J, Rosen G, Mahowald M. Circadian rhythms and circadian rhythm disorders in children and adolescents. Semin Pediatr Neurol. 2001;8(4):229–40.

    Article  CAS  PubMed  Google Scholar 

  7. Rivkees SA. Mechanisms and clinical significance of circadian rhythms in children. Curr Opin Pediatr. 2001;13(4):352–7.

    Article  CAS  PubMed  Google Scholar 

  8. Weinert D, Sitka U, Minors DS, Waterhouse JM. The development of circadian rhythmicity in neonates. Early Hum Dev. 1994;36(2):117–26.

    Article  CAS  PubMed  Google Scholar 

  9. Roenneberg T, Kuehnle T, Pramstaller PP, Ricken J, Havel M, Guth A, et al. A marker for the end of adolescence. Curr Biol. 2004;14(24):R1038–9.

    Article  CAS  PubMed  Google Scholar 

  10. Carskadon MA, Vieira C, Acebo C. Association between puberty and delayed phase preference. Sleep. 1993;16(3):258–62.

    Article  CAS  PubMed  Google Scholar 

  11. Crowley SJ, Cain SW, Burns AC, Acebo C, Carskadon MA. Increased sensitivity of the circadian system to light in early/mid-puberty. J Clin Endocrinol Metab. 2015;100(11):4067–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Duarte LL, Menna-Barreto L, Miguel MA, Louzada F, Araujo J, Alam M, et al. Chronotype ontogeny related to gender. Braz J Med Biol Res. 2014;47(4):316–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. James SM, Honn KA, Gaddameedhi S, Van Dongen HPA. Shift work: disrupted circadian rhythms and sleep-implications for health and well-being. Curr Sleep Med Rep. 2017;3(2):104–12.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Czeisler CA, Dumont M, Duffy JF, Steinberg JD, Richardson GS, Brown EN, et al. Association of sleep-wake habits in older people with changes in output of circadian pacemaker. Lancet. 1992;340(8825):933–6.

    Article  CAS  PubMed  Google Scholar 

  15. American Academy of Sleep Medicine. International classification of sleep disorders. Darien, IL: American Academy of Sleep Medicine; 2014.

    Google Scholar 

  16. Saxvig IW, Pallesen S, Wilhelmsen-Langeland A, Molde H, Bjorvatn B. Prevalence and correlates of delayed sleep phase in high school students. Sleep Med. 2012;13(2):193–9.

    Article  PubMed  Google Scholar 

  17. Wolfson AR, Carskadon MA. Sleep schedules and daytime functioning in adolescents. Child Dev. 1998;69(4):875–87.

    Article  CAS  PubMed  Google Scholar 

  18. Herman JH. Circadian rhythm disorders in pediatrics. Pediatr Ann. 2008;37(7):488–95.

    PubMed  Google Scholar 

  19. Coogan AN, McGowan NM. A systematic review of circadian function, chronotype and chronotherapy in attention deficit hyperactivity disorder. Atten Defic Hyperact Disord. 2017;9(3):129–47.

    Article  PubMed  Google Scholar 

  20. Baird AL, Coogan AN, Siddiqui A, Donev RM, Thome J. Adult attention-deficit hyperactivity disorder is associated with alterations in circadian rhythms at the behavioural, endocrine and molecular levels. Mol Psychiatry. 2012;17(10):988–95.

    Article  CAS  PubMed  Google Scholar 

  21. Nir I, Meir D, Zilber N, Knobler H, Hadjez J, Lerner Y. Brief report: circadian melatonin, thyroid-stimulating hormone, prolactin, and cortisol levels in serum of young adults with autism. J Autism Dev Disord. 1995;25(6):641–54.

    Article  CAS  PubMed  Google Scholar 

  22. Gringras P, Nir T, Breddy J, Frydman-Marom A, Findling RL. Efficacy and safety of pediatric prolonged-release melatonin for insomnia in children with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 2017;56(11):948–57 e4.

    Article  PubMed  Google Scholar 

  23. Videnovic A, Lazar AS, Barker RA, Overeem S. The clocks that time us—circadian rhythms in neurodegenerative disorders. Nat Rev Neurol. 2014;10(12):683–93.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Volicer L, Harper DG, Manning BC, Goldstein R, Satlin A. Sundowning and circadian rhythms in Alzheimer's disease. Am J Psychiatry. 2001;158(5):704–11.

    Article  CAS  PubMed  Google Scholar 

  25. Smith MT, McCrae CS, Cheung J, Martin JL, Harrod CG, Heald JL, et al. Use of Actigraphy for the evaluation of sleep disorders and circadian rhythm sleep-wake disorders: an American Academy of sleep medicine systematic review, meta-analysis, and GRADE assessment. J Clin Sleep Med. 2018;14(7):1209–30.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Shanahan TL, Czeisler CA. Physiological effects of light on the human circadian pacemaker. Semin Perinatol. 2000;24(4):299–320.

    Article  CAS  PubMed  Google Scholar 

  27. Amaral FGD, Cipolla-Neto J. A brief review about melatonin, a pineal hormone. Arch Endocrinol Metab. 2018;62(4):472–9.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Claustrat B, Leston J. Melatonin: physiological effects in humans. Neurochirurgie. 2015;61(2–3):77–84.

    Article  CAS  PubMed  Google Scholar 

  29. Zhdanova IV, Wurtman RJ. Efficacy of melatonin as a sleep-promoting agent. J Biol Rhythm. 1997;12(6):644–50.

    Article  CAS  Google Scholar 

  30. Esposito S, Laino D, D'Alonzo R, Mencarelli A, Di Genova L, Fattorusso A, et al. Pediatric sleep disturbances and treatment with melatonin. J Transl Med. 2019;17(1):77.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Cole RJ, Smith JS, Alcala YC, Elliott JA, Kripke DF. Bright-light mask treatment of delayed sleep phase syndrome. J Biol Rhythm. 2002;17(1):89–101.

    Article  Google Scholar 

  32. Auger RR, Burgess HJ, Emens JS, Deriy LV, Thomas SM, Sharkey KM. Clinical practice guideline for the treatment of intrinsic circadian rhythm sleep-wake disorders: advanced sleep-wake phase disorder (ASWPD), delayed sleep-wake phase disorder (DSWPD), Non-24-hour sleep-wake rhythm disorder (N24SWD), and irregular sleep-wake rhythm disorder (ISWRD). An update for 2015: an American Academy of sleep medicine clinical practice guideline. J Clin Sleep Med. 2015;11(10):1199–236.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Morgenthaler TI, Lee-Chiong T, Alessi C, Friedman L, Aurora RN, Boehlecke B, et al. Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. An American Academy of sleep medicine report. Sleep. 2007;30(11):1445–59.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Siebler M, Steinmetz H, Freund HJ. Therapeutic entrainment of circadian rhythm disorder by melatonin in a non-blind patient. J Neurol. 1998;245(6–7):327–8.

    Article  CAS  PubMed  Google Scholar 

  35. Sack RL, Brandes RW, Kendall AR, Lewy AJ. Entrainment of free-running circadian rhythms by melatonin in blind people. N Engl J Med. 2000;343(15):1070–7.

    Article  CAS  PubMed  Google Scholar 

  36. Nishimon S, Nishimon M, Nishino S. Tasimelteon for treating non-24-h sleep-wake rhythm disorder. Expert Opin Pharmacother. 2019;20(9):1065–73.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Pulmonary, Critical Care and Sleep Section, Department of Medicine, Michael E. DeBakey VA Medical Centre, Houston, TX, USA

    Kanta Velamuri, Supriya Singh, Ritwick Agrawal & Shahram Moghtader

  2. Department of Medicine, Baylor College of Medicine, Houston, TX, USA

    Amir Sharafkhaneh

Authors
  1. Kanta Velamuri
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  2. Supriya Singh
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  3. Ritwick Agrawal
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  4. Shahram Moghtader
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  5. Amir Sharafkhaneh
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Correspondence to Kanta Velamuri .

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Editors and Affiliations

  1. Department of Medicine, Baylor College of Medicine, Houston, TX, USA

    Amir Sharafkhaneh

  2. University of Missouri School of Medicine, Department of Child Health and the Child Health Research Institute, Columbia, MO, USA

    David Gozal

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© 2023 This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply

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Velamuri, K., Singh, S., Agrawal, R., Moghtader, S., Sharafkhaneh, A. (2023). Circadian Rhythm Disorders in Children and Adults. In: Sharafkhaneh, A., Gozal, D. (eds) Sleep Medicine. Springer, Cham. https://doi.org/10.1007/978-3-031-30010-3_12

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  • DOI: https://doi.org/10.1007/978-3-031-30010-3_12

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-30009-7

  • Online ISBN: 978-3-031-30010-3

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