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Current and Future Engineering Strategies for ECMO Therapy

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Engineering Translational Models of Lung Homeostasis and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1413))

Abstract

Extracorporeal membrane oxygenation (ECMO) is a last resort therapy for patients with respiratory failure where the gas exchange capacity of the lung is compromised. Venous blood is pumped through an oxygenation unit outside of the body where oxygen diffusion into the blood takes place in parallel to carbon dioxide removal. ECMO is an expensive therapy which requires special expertise to perform. Since its inception, ECMO technologies have been evolving to improve its success and minimize the complications associated with it. These approaches aim for a more compatible circuit design capable of maximum gas exchange with minimal need for anticoagulants. This chapter summarizes the basic principles of ECMO therapy with the latest advancements and experimental strategies aiming for more efficient future designs.

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Author information

Authors and Affiliations

  1. Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden

    Deniz A. Bölükbas & Sinem Tas

  2. Lund Stem Cell Center, Lund University, Lund, Sweden

    Deniz A. Bölükbas & Sinem Tas

  3. Department of Clinical Sciences, Lund University, Lund, Sweden

    Deniz A. Bölükbas & Sinem Tas

  4. Department of Cardiothoracic Surgery and Transplantation, Skåne University Hospital, Lund, Sweden

    Deniz A. Bölükbas & Sinem Tas

Authors
  1. Deniz A. Bölükbas
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  2. Sinem Tas
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Editors and Affiliations

  1. University of Colorado, Denver | Anschutz Medical Campus, Aurora, CO, USA

    Chelsea M. Magin

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Bölükbas, D.A., Tas, S. (2023). Current and Future Engineering Strategies for ECMO Therapy. In: Magin, C.M. (eds) Engineering Translational Models of Lung Homeostasis and Disease. Advances in Experimental Medicine and Biology, vol 1413. Springer, Cham. https://doi.org/10.1007/978-3-031-26625-6_16

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