Abstract
Coronaviruses belong to Coronaviridae family and Orthocoronavirinae subfamily. Coronaviruses (27–32 kb) are enveloped, positive polarity, spherical RNA viruses with a single-stranded RNA genome. Six strains of coronaviruses were known to cause respiratory diseases in humans. Each human coronaviruses can lead to severe respiratory disease. Although it affects all age groups, it can lead to more serious disease in the elderly and people with multiple comorbidities. A new coronavirus, severe acute respiratory syndrome coronavirus-2, was identified and named in patients presenting with severe pneumonia in late 2019 in Wuhan, China. Later, it was announced by the World Health Organization (WHO) that this situation is a pandemic. Many people in the world have been affected, and millions of people have died by this disease.
The course of COVID-19 can be observed in a wide range, from asymptomatic infection to life-threatening severe disease. Although COVID-19 presents mostly with respiratory symptoms in patients, it has been reported that it can affect most of the organs and systems. An increasing number of neurological symptoms and manifestations have been reported in the present literature. Headache, dizziness, myalgia, loss of smell and taste, altered mental status, confusion, and delirium are the common and essential neurological symptoms of this disease. In this chapter, the characteristics of coronaviruses, the clinical features of COVID-19, and neurological manifestations of great concern such as stroke, cerebral venous thrombosis, seizures, meningoencephalitis, Guillain-Barre syndrome, and acute disseminated encephalomyelitis are discussed in detail.
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References
Mohamadian M, Chiti H, Shoghli A, et al. COVID-19: virology, biology and novel laboratory diagnosis. J Gene Med. 2021;23:1–11.
Tyrrell DA, Bynoe ML. Cultivation of viruses from a high proportion of patients with colds. Lancet. 1966;1:76–7.
Hamre D, Procknow JJ. A new virus isolated from the human respiratory tract. Proc Soc Exp Biol Med. 1966;121:190–3.
Arabacı Ç, Aydın Tutak G, Eroğlu Kesim B, et al. The characteristics of SARS-CoV-2 virus and microbiological diagnosis. Eur Arch Med Res. 2020;36:10–20.
Ogimi C, Kim YJ, Martin ET, et al. What’s new with the old coronaviruses? J Pediatr Infect Dis Soc. 2020;9:210–7.
Guarner J. Three emerging coronaviruses in two decades: the story of SARS, MERS, and now COVID-19. Am J Clin Pathol. 2020;153:420–1.
Zhang AR, Shi WQ, Liu K, et al. Epidemiology and evolution of Middle East respiratory syndrome coronavirus, 2012–2020. Infect Dis Poverty. 2021;10:1–13.
Cui J. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol. 2019;17:181–92.
Jiang F, Deng L, Zhang L, et al. Review of the clinical characteristics of coronavirus disease 2019 (COVID-19). J Gen Intern Med. 2020;35:1545–9.
Machhi J, Herskovitz J, Senan AM, et al. The natural history, pathobiology, and clinical manifestations of SARS-CoV-2 infections. J Neuroimmune Pharmacol. 2020;15:359–86.
Mousavizadeh L, Ghasemi S. Genotype and phenotype of COVID-19: their roles in pathogenesis. J Microbiol Immunol Infect. 2020;54:159–63.
Malik YA. Properties of coronavirus and SARS-CoV-2. Malays J Pathol. 2020;42:3–11.
Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. In: Maier HJ, Brickerton E, Britton P, editors. Coronaviruses methods and protocols, vol. 1. Humana Press; 2015. p. 1–23.
Kirtipal N, Bharadwaj S, Kang SG. From SARS to SARS-CoV-2, insights on structure, pathogenicity and immunity aspects of pandemic human coronaviruses. Infect Genet Evol. 2020;85:104502.
Hasöksüz M, Kiliç S, Saraç F. Coronaviruses and sars-cov-2. Turk J Med Sci. 2020;50:549–56.
Setti L, Passarini F, De Gennaro G, et al. Airborne transmission route of covid-19: why 2 meters/6 feet of inter-personal distance could not be enough. Int J Environ Res Public Health. 2020;17:1–22.
Kadam SB, Sukhramani GS, Bishnoi P, et al. SARS-CoV-2, the pandemic coronavirus: molecular and structural insights. J Basic Microbiol. 2021;61:180–202.
Niazkar M, Niazkar HR. COVID-19 outbreak: application of multi-gene genetic programming to country-based prediction models. Electron J Gen Med. 2020;17(5):247.
Pradhan M, Shah K, Alexander A, et al. COVID-19: clinical presentation and detection methods. J Immunoass Immunochem. 2022;43:1–21.
Chen Z, Boon SS, Wang MH, et al. Genomic and evolutionary comparison between SARS-CoV-2 and other human coronaviruses. J Virol Methods. 2021;289:114032.
Zhang C, Shi L, Wang FS. Liver injury in COVID-19: management and challenges. Lancet Gastroenterol Hepatol. 2020;5:428–30.
Klok FA, Kruip MJHA, van der Meer NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020;191:145–7.
Kayaaslan B, Eser F, Kalem AK, et al. Post-COVID syndrome: a single-center questionnaire study on 1007 participants recovered from COVID-19. J Med Virol. 2021;93:6566–74.
Bobker SM, Robbins MS. COVID-19 and headache: a primer for trainees. Headache. 2020;60:1806–11.
Sharifi-Razavi A, Karimi N, Rouhani N. COVID-19 and intracerebral haemorrhage: causative or coincidental? New Microbes New Infect. 2020;35:1.
Divani A, Andalib S, Di Napoli M, Lattanzi S, Hussain M, Biller J, et al. Coronavirus disease 2019 and stroke: clinical manifestations and pathophysiological insights. J Stroke Cerebrovasc Dis. 2020;29(8):104941.
Silva Andrade B, Siqueira S, de Assis Soares WR, de Souza RF, Santos NO, Dos Santos Freitas A, Ribeiro da Silveira P, Tiwari S, Alzahrani KJ, Góes-Neto A, Azevedo V, Ghosh P, Barh D. Long-COVID and post-COVID health complications: an up-to-date review on clinical conditions and their possible molecular mechanisms. Viruses. 2021;13(4):700.
Giannis D, Ziogas IA, Gianni P. Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past. J Clin Virol. 2020;127:104362.
Wu Y, Xu X, Chen Z, et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020;87:18–22.
Libbey JE, Fujinami RS. Neurotropic viral infections leading to epilepsy: focus on Theiler’s murine encephalomyelitis virus. Future Virol. 2011;6:1339–50.
Roy D, Ghosh R, Dubey S, et al. Neurological and neuropsychiatric impacts of COVID-19 pandemic. Can J Neurol Sci. 2021;48:9–24.
Poyiadji N, Shahin G, Noujaim D, et al. COVID-19-associated acute hemorrhagic necrotizing encephalopathy: imaging features. Radiology. 2020;296:E119–20.
Burks JS, Devald BL, Jankovsky LD, Gerdes JC. Two coronaviruses isolated from central nervous system tissue of two multiple sclerosis patients. Science. 1980;209:933–4.
Mahalakshmi AM, Ray B, Tuladhar S, et al. Does COVID-19 contribute to development of neurological disease? Immun Inflamm Dis. 2021;9:48–58.
Parsons T, Banks S, Bae C, et al. COVID-19-associated acute disseminated encephalomyelitis (ADEM). J Neurol. 2020;267:2799–802.
Giacomelli A, Pezzati L, Conti F, et al. Self-reported olfactory and taste disorders in patients with severe acute respiratory coronavirus 2 infection: a cross-sectional study. Clin Infect Dis. 2020;71:889–90.
Xydakis MS, Dehgani-Mobaraki P, Holbrook EH, et al. Smell and taste dysfunction in patients with COVID-19. Lancet Infect Dis. 2020;20:1015–6.
Dra A, Chancy M, Mendoza A, et al. Priapismo isquémico refractario . Complicación tromboembólica secundaria a la infección severa por SARSCoV-2 ? Reporte de caso y revisión de la literatura. 2021;2021:12890.
Caress JB, Castoro RJ, Simmons Z, et al. COVID-19–associated Guillain-Barré syndrome: the early pandemic experience. Muscle Nerve. 2020;62:485–91.
Assini A, Benedetti L, Di Maio S, et al. Correction to: new clinical manifestation of COVID-19 related Guillain-Barrè syndrome highly responsive to intravenous immunoglobulins: two Italian cases. Neurol Sci. 2020;41:7. (1657-1658)
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Ayhan, M., Coşkun, B., Güner, R. (2023). Clinical Update on the COVID-19 Pandemic. In: Özge, A., Uludüz, D., Bolay, H., Karadaş, Ö. (eds) Headache Disorders in Pandemic Conditions . Headache. Springer, Cham. https://doi.org/10.1007/978-3-031-26309-5_1
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DOI: https://doi.org/10.1007/978-3-031-26309-5_1
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