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Role of Abnormal Calcium Signaling and Liver Tissue Structure in Glucose and Lipid Metabolism: Mathematical Modeling

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Mathematical Modeling and Supercomputer Technologies (MMST 2022)

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 1750))

Abstract

One of the main components of glucose and lipid metabolism in hepatocytes that provide liver’s metabolic flexibility is the cell ability to temporarily store glucose in the form of glycogen. The glycogen storage and release processes are regulated by hormones insulin and glucagon and by intracellular calcium signaling. Correct calcium signaling strongly depends on proper intracellular structure, in particular on adequate functioning of mitochondria-associated membranes (MAMs). MAMs defects were shown to affect calcium signaling and expected to alter glucose metabolism and storage. Using mathematical modeling we research the role of both abnormal MAMs functioning and calcium release from endoplasmic reticulum in hepatocyte glucose and lipid metabolism. Also we estimate the consequences of decreased amount of hormones, that reach pericentral liver zone in comparison to periportal zone, for the amount of stored glycogen, TAG and glucose released by hepatocyte in the glycogenolytic mode.

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Authors and Affiliations

  1. Sarov Physics and Technology Institute, National Research Nuclear University MEPhI, Sarov, Nizhniy Novgorod, 607186, Russian Federation

    Arina V. Martyshina & Irina V. Dokukina

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  1. Arina V. Martyshina
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  2. Irina V. Dokukina
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Correspondence to Irina V. Dokukina .

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Editors and Affiliations

  1. Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia

    Dmitry Balandin

  2. Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia

    Konstantin Barkalov

  3. Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia

    Iosif Meyerov

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Martyshina, A.V., Dokukina, I.V. (2022). Role of Abnormal Calcium Signaling and Liver Tissue Structure in Glucose and Lipid Metabolism: Mathematical Modeling. In: Balandin, D., Barkalov, K., Meyerov, I. (eds) Mathematical Modeling and Supercomputer Technologies. MMST 2022. Communications in Computer and Information Science, vol 1750. Springer, Cham. https://doi.org/10.1007/978-3-031-24145-1_10

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  • DOI: https://doi.org/10.1007/978-3-031-24145-1_10

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