Abstract
For more clinical applications of deep learning models for medical image segmentation, high demands on labeled data and computational resources must be addressed. This study proposes a coarse-to-fine framework with two teacher models and a student model that combines knowledge distillation and cross teaching, a consistency regularization based on pseudo-labels, for efficient semi-supervised learning. The proposed method is demonstrated on the abdominal multi-organ segmentation task in CT images under the MICCAI FLARE 2022 challenge, with mean Dice scores of 0.8429 and 0.8520 in the validation and test sets, respectively. The code is available at https://github.com/jwc-rad/MISLight.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Alalwan, N., Abozeid, A., ElHabshy, A.A., Alzahrani, A.: Efficient 3d deep learning model for medical image semantic segmentation. Alex. Eng. J. 60(1), 1231–1239 (2021)
Bilic, P., et al.: The liver tumor segmentation benchmark (LITS). arXiv preprint arXiv:1901.04056 (2019)
Chen, L.C., Papandreou, G., Kokkinos, I., Murphy, K., Yuille, A.L.: DeepLab: Semantic image segmentation with deep convolutional nets, Atrous convolution, and fully connected CRFs. IEEE Trans. Pattern Anal. Mach. Intell. 40(4), 834–848 (2017)
Chen, X., Yuan, Y., Zeng, G., Wang, J.: Semi-supervised semantic segmentation with cross pseudo supervision. In: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition, pp. 2613–2622 (2021)
Çiçek, Ö., Abdulkadir, A., Lienkamp, S.S., Brox, T., Ronneberger, O.: 3D U-net: learning dense volumetric segmentation from sparse annotation. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9901, pp. 424–432. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46723-8_49
Clark, K., et al.: The cancer imaging archive (TCIA): maintaining and operating a public information repository. J. Digit. Imaging 26(6), 1045–1057 (2013)
Gou, J., Yu, B., Maybank, S.J., Tao, D.: Knowledge distillation: a survey. Int. J. Comput. Vision 129(6), 1789–1819 (2021)
Heller, N., et al.: The state of the art in kidney and kidney tumor segmentation in contrast-enhanced CT imaging: results of the kits19 challenge. Med. Image Anal. 67, 101821 (2021)
Heller, N., et al.: An international challenge to use artificial intelligence to define the state-of-the-art in kidney and kidney tumor segmentation in ct imaging. Proc. Am. Soc. Clin. Oncol. 38(6), 626–626 (2020)
Hinton, G., Vinyals, O., Dean, J., et al.: Distilling the knowledge in a neural network. arXiv preprint arXiv:1503.02531 2(7) (2015)
Howard, A.G., et al.: Mobilenets: Efficient convolutional neural networks for mobile vision applications. arXiv preprint arXiv:1704.04861 (2017)
Hu, J., Shen, L., Sun, G.: Squeeze-and-excitation networks. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 7132–7141 (2018)
Isensee, F., Jaeger, P.F., Kohl, S.A., Petersen, J., Maier-Hein, K.H.: NNU-net: a self-configuring method for deep learning-based biomedical image segmentation. Nat. Methods 18(2), 203–211 (2021)
Isensee, F., Maier-Hein, K.H.: An attempt at beating the 3d u-net. arXiv preprint arXiv:1908.02182 (2019)
Kavur, A.E., et al.: Chaos challenge-combined (CT-MR) healthy abdominal organ segmentation. Med. Image Anal. 69, 101950 (2021)
Lin, T.Y., Goyal, P., Girshick, R., He, K., Dollár, P.: Focal loss for dense object detection. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 2980–2988 (2017)
Liu, Y., Chen, K., Liu, C., Qin, Z., Luo, Z., Wang, J.: Structured knowledge distillation for semantic segmentation. In: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition, pp. 2604–2613 (2019)
Luo, X., Chen, J., Song, T., Wang, G.: Semi-supervised medical image segmentation through dual-task consistency. In: Proceedings of the AAAI Conference on Artificial Intelligence, vol. 35, pp. 8801–8809 (2021)
Luo, X., Hu, M., Song, T., Wang, G., Zhang, S.: Semi-supervised medical image segmentation via cross teaching between cnn and transformer. arXiv preprint arXiv:2112.04894 (2021)
Luo, X., et al.: Efficient semi-supervised gross target volume of nasopharyngeal carcinoma segmentation via uncertainty rectified pyramid consistency. In: de Bruijne, M., et al. (eds.) MICCAI 2021. LNCS, vol. 12902, pp. 318–329. Springer, Cham (2021). https://doi.org/10.1007/978-3-030-87196-3_30
Ma, J., et al.: Loss odyssey in medical image segmentation. Med. Image Anal. 71, 102035 (2021)
Ma, J., et al.: Fast and low-GPU-memory abdomen CT organ segmentation: the flare challenge. Med. Image Anal. 82, 102616 (2022). https://doi.org/10.1016/j.media.2022.102616
Ma, J., et al.: Abdomenct-1k: is abdominal organ segmentation a solved problem? IEEE Trans. Pattern Anal. Mach. Intell. 44(10), 6695–6714 (2022)
Mehta, S., Rastegari, M., Caspi, A., Shapiro, L., Hajishirzi, H.: ESPNet: efficient spatial pyramid of dilated convolutions for semantic segmentation. In: Ferrari, V., Hebert, M., Sminchisescu, C., Weiss, Y. (eds.) ECCV 2018. LNCS, vol. 11214, pp. 561–580. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-01249-6_34
Milletari, F., Navab, N., Ahmadi, S.A.: V-net: Fully convolutional neural networks for volumetric medical image segmentation. In: 2016 Fourth International Conference on 3D Vision (3DV), pp. 565–571. IEEE (2016)
Qin, D., et al.: Efficient medical image segmentation based on knowledge distillation. IEEE Trans. Med. Imaging 40(12), 3820–3831 (2021)
Rundo, L., et al.: Use-net: incorporating squeeze-and-excitation blocks into u-net for prostate zonal segmentation of multi-institutional mri datasets. Neurocomputing 365, 31–43 (2019)
Simpson, A.L., et al.: A large annotated medical image dataset for the development and evaluation of segmentation algorithms. arXiv preprint arXiv:1902.09063 (2019)
Soffer, S., Ben-Cohen, A., Shimon, O., Amitai, M.M., Greenspan, H., Klang, E.: Convolutional neural networks for radiologic images: a radiologist’s guide. Radiology 290(3), 590–606 (2019)
Taha, A.A., Hanbury, A.: Metrics for evaluating 3d medical image segmentation: analysis, selection, and tool. BMC Med. Imaging 15(1), 1–28 (2015)
Thaler, F., Payer, C., Bischof, H., Stern, D.: Efficient multi-organ segmentation using spatial configuration-net with low GPU memory requirements. arXiv preprint arXiv:2111.13630 (2021)
Wang, L., Yoon, K.J.: Knowledge distillation and student-teacher learning for visual intelligence: a review and new outlooks. IEEE Trans. Pattern Anal. Mach. Intell. 44, 3048–3068 (2021)
Wu, Y., Xu, M., Ge, Z., Cai, J., Zhang, L.: Semi-supervised left atrium segmentation with mutual consistency training. In: de Bruijne, M., et al. (eds.) MICCAI 2021. LNCS, vol. 12902, pp. 297–306. Springer, Cham (2021). https://doi.org/10.1007/978-3-030-87196-3_28
Yu, L., Wang, S., Li, X., Fu, C.-W., Heng, P.-A.: Uncertainty-aware self-ensembling model for semi-supervised 3d left atrium segmentation. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11765, pp. 605–613. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32245-8_67
Zhang, F., Wang, Y., Yang, H.: Efficient context-aware network for abdominal multi-organ segmentation. arXiv preprint arXiv:2109.10601 (2021)
Acknowledgements
The author of this paper declares that the segmentation method implemented for participation in the FLARE 2022 challenge has not used any pre-trained models or additional datasets other than those provided by the organizers. Also, the proposed solution is fully automatic without any manual intervention.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Choi, J.W. (2022). Knowledge Distillation from Cross Teaching Teachers for Efficient Semi-supervised Abdominal Organ Segmentation in CT. In: Ma, J., Wang, B. (eds) Fast and Low-Resource Semi-supervised Abdominal Organ Segmentation. FLARE 2022. Lecture Notes in Computer Science, vol 13816. Springer, Cham. https://doi.org/10.1007/978-3-031-23911-3_10
Download citation
DOI: https://doi.org/10.1007/978-3-031-23911-3_10
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-23910-6
Online ISBN: 978-3-031-23911-3
eBook Packages: Computer ScienceComputer Science (R0)