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The Role of Non-coding RNAs in Cerebellar Development

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Development of the Cerebellum from Molecular Aspects to Diseases

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

Since the sequencing of the human and various mammalian genomes, it is clear that there are far too few protein-coding genes to specify and coordinate the complex series of developmental events that results in a mature brain. Non-coding RNAs (ncRNAs) are seen as a fount of transcriptional richness that can regulate gene expression in time and space. Together, protein-coding RNAs and ncRNAs can reproducibly replicate a formed and functioning brain. In this chapter, we focus on the roles of three dominant species of ncRNAs – enhancers, long non-coding RNAs, and microRNAs – in driving the development and function in the mouse cerebellum.

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Author notes

  1. Authors Maryam Rahimi-Balaei, Miguel Ramirez, and Ishita Gupta have equally contributed to this chapter.

Authors and Affiliations

  1. Centre for Molecular Medicine and Therapeutics, BC Children’s Hospital Research Institute, Vancouver, BC, Canada

    Maryam Rahimi-Balaei, Miguel Ramirez, Ishita Gupta & Daniel Goldowitz

  2. Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada

    Maryam Rahimi-Balaei, Miguel Ramirez, Ishita Gupta & Daniel Goldowitz

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  1. Maryam Rahimi-Balaei
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  2. Miguel Ramirez
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  3. Ishita Gupta
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  4. Daniel Goldowitz
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Correspondence to Daniel Goldowitz .

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Editors and Affiliations

  1. Department of Human Anatomy and Cell Science The Children’s Hospital Research Institute of Manitoba (CHRIM) Max Rady College of Medicine Rady Faculty of Health Science, University of Manitoba, Winnipeg, MB, Canada

    Hassan Marzban

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Rahimi-Balaei, M., Ramirez, M., Gupta, I., Goldowitz, D. (2023). The Role of Non-coding RNAs in Cerebellar Development. In: Marzban, H. (eds) Development of the Cerebellum from Molecular Aspects to Diseases. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-031-23104-9_6

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