Skip to main content

Geriatrics: Traumatic and Non-traumatic Surgical Emergencies

  • Chapter
  • First Online:
Textbook of Emergency General Surgery

Abstract

Elderly patients represent a rapidly growing segment of the world’s population and often experience traumatic and non-traumatic surgical emergencies, which require prompt management. The physiologic decline associated with aging can be better assessed with tools such as frailty, as appropriate risk assessment and resource utilization in treating geriatric patients. Frailty is an entity distinct from age, and gender, affecting outcomes in both trauma and non-trauma emergency general surgery. Trauma-related emergencies such as traumatic brain injury, blunt thoracic trauma, and intra-abdominal hemorrhage are potentially life-threatening pathologies with significant morbidity and mortality. Special population-specific and disease-specific considerations for management can lead to decreasing morbidity and improving both outcomes and quality of life. Both the diagnosis and the management of non-traumatic surgical emergencies such as hollow viscus perforation, cholecystitis, and acute mesenteric ischemia (AMI) are challenging in the elderly. We advocate prompt and timely diagnosis, and patient-centered definitive surgical management in order to improve outcomes and quality of life.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. United States Census Bureau. https://www.census.gov/.

  2. Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci. 2004;59(3):255–63. https://doi.org/10.1093/gerona/59.3.m255.

    Article  PubMed  Google Scholar 

  3. Holliday R. Understanding ageing, vol. 30. New York: Cambridge University Press; 1995.

    Book  Google Scholar 

  4. Olivetti G, Melissari M, Capasso JM, Anversa P. Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circ Res. 1991;68(6):1560–8. https://doi.org/10.1161/01.res.68.6.1560.

    Article  CAS  PubMed  Google Scholar 

  5. Knudson RJ, Lebowitz MD, Holberg CJ, Burrows B. Changes in the normal maximal expiratory flow-volume curve with growth and aging. Am Rev Respir Dis. 1983;127(6):725–34.

    CAS  PubMed  Google Scholar 

  6. Brenner BM, Meyer TW, Hostetter TH. Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med. 1982;307(11):652–9. https://doi.org/10.1056/NEJM198209093071104.

    Article  CAS  PubMed  Google Scholar 

  7. Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–62. https://doi.org/10.1016/S0140-6736(12)62167-9.

    Article  PubMed  Google Scholar 

  8. Dastur DK. Cerebral blood flow and metabolism in normal human aging, pathological aging, and senile dementia. J Cereb Blood Flow Metab. 1985;5(1):1–9. https://doi.org/10.1038/jcbfm.1985.1.

    Article  CAS  PubMed  Google Scholar 

  9. Oresanya LB, Lyons WL, Finlayson E. Preoperative assessment of the older patient: a narrative review. JAMA. 2014;311(20):2110–20. https://doi.org/10.1001/jama.2014.4573.

    Article  CAS  PubMed  Google Scholar 

  10. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.

    Article  CAS  PubMed  Google Scholar 

  11. Theou O, Rockwood K. Should frailty status always be considered when treating the elderly patient? Aging Health. 2012;8(3):261–71.

    Article  CAS  Google Scholar 

  12. de Vries NM, Staal JB, van Ravensberg CD, Hobbelen JSM, Olde Rikkert MGM, Nijhuis-van der Sanden MWG. Outcome instruments to measure frailty: a systematic review. Ageing Res Rev. 2011;10(1):104–14. https://doi.org/10.1016/j.arr.2010.09.001.

    Article  PubMed  Google Scholar 

  13. Rockwood K, Song X, MacKnight C, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005;173(5):489–95. https://doi.org/10.1503/cmaj.050051.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Farhat JS, Velanovich V, Falvo AJ, et al. Are the frail destined to fail? Frailty index as predictor of surgical morbidity and mortality in the elderly. J Trauma Acute Care Surg. 2012;72(6):1526–30; discussion 1530–1531. https://doi.org/10.1097/TA.0b013e3182542fab.

    Article  PubMed  Google Scholar 

  15. Joseph B, Pandit V, Zangbar B, et al. Validating trauma-specific frailty index for geriatric trauma patients: a prospective analysis. J Am Coll Surg. 2014;219(1):10–7.

    Article  PubMed  Google Scholar 

  16. Orouji Jokar T, Ibraheem K, Rhee P, et al. Emergency general surgery specific frailty index: a validation study. J Trauma Acute Care Surg. 2016;81(2):254–60.

    Article  PubMed  Google Scholar 

  17. Latifi R, editor. Surgical decision making in geriatrics. Springer Nature; 2020.

    Google Scholar 

  18. Bonne S, Schuerer DJE. Trauma in the older adult epidemiology and evolving geriatric trauma principles. Clin Geriatr Med. 2013;29(1):137–50. https://doi.org/10.1016/j.cger.2012.10.008.

    Article  PubMed  Google Scholar 

  19. Jacobs DG. Special considerations in geriatric injury. Curr Opin Crit Care. 2003;9(6):535–9. https://doi.org/10.1097/00075198-200312000-00012.

    Article  PubMed  Google Scholar 

  20. Czorlich P, Mader MM-D, Emami P, Westphal M, Lefering R, Hoffmann M. Operative versus non-operative treatment of traumatic brain injuries in patients 80 years of age or older. Neurosurg Rev. 2020;43(5):1305–14. https://doi.org/10.1007/s10143-019-01159-4.

    Article  PubMed  Google Scholar 

  21. Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet. 1974;2:81–4. https://doi.org/10.1016/s0140-6736(74)91639-0.

    Article  CAS  PubMed  Google Scholar 

  22. Kehoe A, Rennie S, Smith JE. Glasgow Coma Scale is unreliable for the prediction of severe head injury in elderly trauma patients. Emerg Med J. 2015;32:613–5. https://doi.org/10.1136/emermed-2013-203488.

    Article  CAS  PubMed  Google Scholar 

  23. Salottolo K, Panchal R, Madayag RM, et al. Incorporating age improves the Glasgow Coma Scale score for predicting mortality from traumatic brain injury. Trauma Surg Acute Care Open. 2021;6(1):e000641.

    Article  PubMed  PubMed Central  Google Scholar 

  24. McIntyre A, Mehta S, Aubut J, Dijkers M, Teasell RW. Mortality among older adults after a traumatic brain injury: a meta-analysis. Brain Inj. 2013;27:31–40.

    Article  PubMed  Google Scholar 

  25. Mosenthal AC, Lavery RF, Addis M, Kaul S, Ross S, Marburger R, Deitch EA, Livingston DH. Isolated traumatic brain injury: age is an independent predictor of mortality and early outcome. J Trauma. 2002;52:907–11.

    PubMed  Google Scholar 

  26. Nishijima DK, Shahlaie K, Sarkar K, Rudisill N, Holmes JF. Risk of unfavorable long-term outcome in older adults with traumatic intracranial hemorrhage and anticoagulant or antiplatelet use. Am J Emerg Med. 2013;31:1244–7.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Scotti P, Seguin C, Lo BWY et al. Antithrombotic agents and traumatic brain injury in the elderly population: hemorrhage patterns and outcomes. J Neurosurg. 2019;1–10.

    Google Scholar 

  28. Feeney JM, Santone E, DiFiori M, et al. Compared to warfarin, direct anticoagulants are associated with lower mortality in patients with blunt traumatic intracranial hemorrhage: a TQIP study. J Trauma Acute Care Surg. 2016;81(5):843–8.

    Article  CAS  PubMed  Google Scholar 

  29. Eibinger N, Halvachizadeh S, Hallmann B, et al. Is the regular intake of anticoagulative agents an independent risk factor for the severity of traumatic brain injuries in geriatric patients? A retrospective analysis of 10,559 patients from the TraumaRegister DGU. Brain Sci. 2020;10(11):842.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, et al.; Brain Trauma Foundation and American Association of Neurological Surgeons. Guidelines for the management of severe traumatic brain injury. J Neurotrauma. 2007;24:S1–S106.

    Google Scholar 

  31. Schupper AJ, Berndtson AE, Smith A, et al. Respect your elders: effects of ageing on intracranial pressure monitor use in traumatic brain injury. Trauma Surg Acute Care Open. 2019;4(1):e000306.

    Article  PubMed  PubMed Central  Google Scholar 

  32. You W, Feng J, Tang Q, et al. Intraventricular intracranial pressure monitoring improves the outcome of older adults with severe traumatic brain injury: an observational, prospective study. BMC Anesthesiol. 2016;16(1):35.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Liveris A, Parsikia A, Melvin J, et al. Is there an age cutoff for intracranial pressure monitoring?: a propensity score matched analysis of the national trauma data bank. Am Surg. 2022;88(6):1163–71. https://doi.org/10.1177/0003134821991985. Online ahead of print.

    Article  PubMed  Google Scholar 

  34. Lukasiewicz A, Grant RA, Basques BA, et al. Patient factors associated with 30-day morbidity, mortality, and length of stay after surgery for subdural hematoma: a study of the American College of Surgeons National Surgical Quality Improvement Program. J Neurosurg. 2016;124(3):760–6.

    Article  PubMed  Google Scholar 

  35. Kerezouids P, Goyal A, Puffer RC. Morbidity and mortality in elderly patients undergoing evacuation of acute traumatic subdural hematoma. Neurosurg Focus. 2020;49(4):E22.

    Article  Google Scholar 

  36. Bulger EM, Arneson MA, Mock CN, et al. Rib fractures in the elderly. J Trauma. 2000;48(6):1040–6.

    Article  CAS  PubMed  Google Scholar 

  37. Battle CE, Hutchings H, Evans PA. Risk factors that predict mortality in patients with blunt chest wall trauma: a systematic review and meta-analysis. Injury. 2012;43(1):8–17.

    Article  PubMed  Google Scholar 

  38. Janssen TL, Hosseinzoi E, Vos DI, et al. The importance of increased awareness for delirium in elderly patients with rib fractures after blunt chest wall trauma: a retrospective cohort study on risk factors and outcomes. BMC Emerg Med. 2018;19:34.

    Article  Google Scholar 

  39. Bulger E, Edwards T, Klotz P, et al. Epidural analgesia improves outcome after multiple rib fractures. Surgery. 2004;136(2):426–30.

    Article  PubMed  Google Scholar 

  40. Flagel BT, Luchette FA, Reed RL, Esposito TJ, Davis KA, Santaniello JM, Gamelli RL. Half-a-dozen ribs: the breakpoint for mortality. Surgery. 2005;138:717–23; discussion 723–5.

    Article  PubMed  Google Scholar 

  41. McKendy KM, Lee LF, Boulva K, et al. Epidural analgesia for traumatic rib fractures is associated with worse outcomes: a matched analysis. J Surg Res. 2017;214:117–23. https://doi.org/10.1016/j.jss.2017.02.057.

    Article  PubMed  Google Scholar 

  42. Griffard J, Daley B, Campbell M, et al. Plate of ribs: a single institution’s matched comparison of patients managed operative and non-operatively for rib fractures. Trauma Surg Acute Care Open. 2020;5(1):e000519.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Zhu RC, de Roulet A, Ogami T, et al. Rib fixation in geriatric trauma: mortality benefits for the most vulnerable patients. J Trauma Acute Care Surg. 2020;89(1):103–10. https://doi.org/10.1097/TA.0000000000002666.

    Article  CAS  Google Scholar 

  44. Sikander N, Ahmad T, Shaikh KA, et al. Analysis of injury patterns and outcomes of blunt thoracic trauma in elderly patients. Cureus. 2020;12(8):e9974. https://doi.org/10.7759/cureus.9974.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Kulvatunyou N, Joseph B, Friese RS, et al. 14 French pigtail catheters placed by surgeons to drain blood on trauma patients: is 14-Fr too small? J Trauma Acute Care Surg. 2012;73(6):1423–7.

    Article  PubMed  Google Scholar 

  46. Lin HL, Huang WY, Yang C, et al. How early should VATS be performed for retained haemothorax in blunt chest trauma? Injury. 2014;45(9):1359–64. https://doi.org/10.1016/j.injury.2014.05.036. Epub 2014 Jun 5.

    Article  PubMed  Google Scholar 

  47. Schweigert M, Beron M, Dubecz A, et al. Video-assisted thoracoscopic surgery for posttraumatic hemothorax in the very elderly. Thorac Cardiovasc Surg. 2012;60(7):474–9. https://doi.org/10.1055/s-0031-1298069. Epub 2012 Jan 20.

    Article  PubMed  Google Scholar 

  48. Huang WY, Lu IY, Yang C, et al. Efficiency analysis of direct video-assisted thoracoscopic surgery in elderly patients with blunt traumatic hemothorax without an initial thoracostomy. Biomed Res Int. 2016;2016:3741426. https://doi.org/10.1155/2016/3741426. Epub 2016 Apr 14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Heffernan DS, Thakkar RK, Monaghan SF, et al. Normal presenting vital signs are unreliable in geriatric blunt trauma victims. J Trauma. 2010;69(4):813–20.

    PubMed  Google Scholar 

  50. Zarzaur BL, Croce MA, Magnotti LJ, et al. Identifying life-threatening shock in the older injured patient: an analysis of the National Trauma Data Bank. J Trauma. 2010;68(5):1134–8.

    PubMed  Google Scholar 

  51. Malhotra AK, Fabian TC, Croce MA, et al. Blunt hepatic injury: a paradigm shift from operative to nonoperative management in the 1990s. Ann Surg. 2000;231(6):804–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Brillantino A, Iacobellis F, Robustelli U, et al. Non operative management of blunt splenic trauma: a prospective evaluation of a standardized treatment protocol. Eur J Trauma Emerg Surg. 2016;42(5):593–8.

    Article  CAS  PubMed  Google Scholar 

  53. Godley CD, Warren RL, Sheridan RL, McCabe CJ. Nonoperative management of blunt splenic injury in adults: age over 55 years as a powerful indicator for failure. J Am Coll Surg. 1996;183:133–9.

    CAS  PubMed  Google Scholar 

  54. Albrecht RM, Schermer CR, Morris A. Nonoperative management of blunt splenic injuries: factors influencing success in age >55 years. Am Surg. 2002;68:227–30.

    Article  PubMed  Google Scholar 

  55. Massarweh NN, Legner VJ, Symons RG, et al. Impact of advancing age on abdominal surgical outcomes. Arch Surg. 2009;144:1108–14.

    Article  PubMed  Google Scholar 

  56. Peitzman AB, Heil B, Rivera L, et al. Blunt splenic injury in adults: multi-institutional study of the Eastern Association for the Surgery of Trauma. J Trauma. 2000;49:177–89.

    Article  CAS  PubMed  Google Scholar 

  57. Al-Refaie WB, Parsons HM, Habermann EB, et al. Operative outcomes beyond 30-day mortality. Ann Surg. 2011;253:947–52.

    Article  PubMed  Google Scholar 

  58. Silber JH, Williams SV, Krakauer H, Schwartz JS. Hospital and patient characteristics associated with death after surgery: a study of adverse occurrence and failure to rescue. Med Care. 1992;30(7):615–27.

    Article  CAS  PubMed  Google Scholar 

  59. Khan M, Jehan F, Zeeshan M, et al. Failure to rescue after emergency general surgery in geriatric patients: does frailty matter? J Surg Res. 2019;233:397–402. https://doi.org/10.1016/j.jss.2018.08.033. Epub 2018 Sep 17.

    Article  PubMed  Google Scholar 

  60. Fulton JD, Peebles SE, Smith GD, et al. Unrecognized viscus perforation in the elderly. Age Ageing. 1989;18(6):403–6.

    Article  CAS  PubMed  Google Scholar 

  61. Wroblewski M, Mikulowski P, et al. Peritonitis in geriatric inpatients. Age Ageing. 1991;20(2):90–4. https://doi.org/10.1093/ageing/20.2.90.

    Article  CAS  PubMed  Google Scholar 

  62. Elagili F, Stocchi L, Ozuner G, et al. Predictors of postoperative outcomes for patients with diverticular abscess initially treated with percutaneous drainage. Am J Surg. 2015;209(4):703–8. https://doi.org/10.1016/j.amjsurg.2014.05.018. Epub 2014 Jul 23.

    Article  PubMed  Google Scholar 

  63. Buck DL, Vester-Andersen M, Moller MH, et al. Surgical delay is a critical determinant of survival in perforated peptic ulcer. Br J Surg. 2013;100(8):1045–9. https://doi.org/10.1002/bjs.9175.

    Article  CAS  PubMed  Google Scholar 

  64. Lavanchy JL, Holzgang MM, Haltmeier T, et al. Outcomes of emergency abdominal surgery in octogenarians: a single-center analysis. Am J Surg. 2019;218(2):248–54. https://doi.org/10.1016/j.amjsurg.2018.11.023. Epub 2018 Nov 27.

    Article  PubMed  Google Scholar 

  65. Narueponjikarul N, Hwabejire J, Kongwibulwut M, et al. No news is good news? Three-year postdischarge mortality of octogenarian and nonagenarian patients following emergency general surgery. J Trauma Acute Care Surg. 2020;89(1):230–7. https://doi.org/10.1097/TA.0000000000002696.

    Article  CAS  Google Scholar 

  66. Gogna S, Samson D, Choi J, et al. The role of nutritional access in malnourished elderly undergoing major surgery for acute abdomen: a propensity score-matched analysis. Am Surg. 2021;87(8):1252–8. https://doi.org/10.1177/0003134820973719.

    Article  PubMed  Google Scholar 

  67. Krasman ML, Gracie WA, Strasius SR. Biliary tract disease in the aged. Clin Geriatr Med. 1991;7:347–70.

    Article  CAS  PubMed  Google Scholar 

  68. Riall TS, Zhang D, Townsend CM, et al. Failure to perform cholecystectomy for acute cholecystitis in elderly patients is associated with increased morbidity, mortality, and cost. J Am Coll Surg. 2010;210(5):668–79.

    Article  PubMed  PubMed Central  Google Scholar 

  69. Parker LJ, Vukov LF, Wollan PC, et al. Emergency department evaluation of geriatric patients with acute cholecystitis. Acad Emerg Med. 1997;4(1):51–5.

    Article  CAS  PubMed  Google Scholar 

  70. Chang YR, Ahn YJ, Jang JY, et al. Percutaneous cholecystostomy for acute cholecystitis in patients with high comorbidity and re-evaluation of treatment efficacy. Surgery. 2014;155:615–22.

    Article  PubMed  Google Scholar 

  71. Dimou FM, Adhikari D, Mehta H, et al. Outcomes in older patients with grade III cholecystitis and cholecystostomy tube placement: a propensity score analysis. J Am Coll Surg. 2017;224(4):502–511.e1.

    Article  PubMed  PubMed Central  Google Scholar 

  72. Loozen CS, van Ramshorst B, van Santvoort HC, et al. Early cholecystectomy for acute cholecystitis in the elderly population: a systematic review and meta-analysis. Dig Surg. 2017;34(5):371–9.

    Article  PubMed  Google Scholar 

  73. Mayol J, Martinez-Sarmiento J, Tamayo FJ, et al. Complications of laparoscopic cholecystectomy in the ageing patient. Age Ageing. 1997;26:77–81.

    Article  CAS  PubMed  Google Scholar 

  74. Elshaer M, Gravante G, Thomas K, et al. Subtotal cholecystectomy for “difficult gallbladders”: systematic review and meta-analysis. JAMA Surg. 2015;150:159–68.

    Article  PubMed  Google Scholar 

  75. Pisano M, Ceresoli M, Cimbanassi S, et al. 2017 WSES and SICG guidelines on acute calcolous cholecystitis in elderly population. World J Emerg Surg. 2019;14:10.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Martinez JP, Hogan GJ. Mesenteric ischemia. Emerg Med Clin North Am. 2004;22:909–28. https://doi.org/10.1016/j.emc.2004.05.002.

    Article  PubMed  Google Scholar 

  77. Klar E, Rahmanian PB, Bücker A, Hauenstein K, Jauch KW, Luther B. Acute mesenteric ischemia: a vascular emergency. Dtsch Arztebl Int. 2012;109(14):249–56.

    PubMed  PubMed Central  Google Scholar 

  78. Demir ED, Ceyhan GO, Friess H. Beyond lactate: is there a role for serum lactate measurement in diagnosing acute mesenteric ischemia? Dig Surg. 2012;29:226–35.

    Article  CAS  PubMed  Google Scholar 

  79. Kougias P, Lau D, El Sayed HF, et al. Determinants of mortality and treatment outcome following surgical interventions for acute mesenteric ischemia. J Vasc Surg. 2007;46(3):467–74.

    Article  PubMed  Google Scholar 

  80. Wu W, Liu J, Zhou Z, et al. Preoperative risk factors for short-term postoperative mortality of acute mesenteric ischemia after laparotomy: a systematic review and meta-analysis. Emerg Med Int. 2020;2020:1382475.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Akyildiz HY, Sozuer E, Uzer H, et al. The length of necrosis and renal insufficiency predict the outcome of acute mesenteric ischemia. Asian J Surg. 2015;38(1):28–32.

    Article  PubMed  Google Scholar 

Further Reading

  • Joseph B, Pandit V, Zangbar B, et al. Validating trauma-specific frailty index for geriatric trauma patients: a prospective analysis. J Am Coll Surg. 2014;219(1):10–7.

    Article  PubMed  Google Scholar 

  • Latifi R, editor. Surgical decision making in geriatrics. Springer Nature; 2020.

    Google Scholar 

  • Massarweh NN, Legner VJ, Symons RG, et al. Impact of advancing age on abdominal surgical outcomes. Arch Surg. 2009;144:1108–14.

    Article  PubMed  Google Scholar 

  • Narueponjikarul N, Hwabejire J, Kongwibulwut M, et al. No news is good news? Three-year postdischarge mortality of octogenarian and nonagenarian patients following emergency general surgery. J Trauma Acute Care Surg. 2020;89(1):230–7. https://doi.org/10.1097/TA.0000000000002696.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rifat Latifi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Prabhakaran, K., Latifi, R. (2023). Geriatrics: Traumatic and Non-traumatic Surgical Emergencies. In: Coccolini, F., Catena, F. (eds) Textbook of Emergency General Surgery. Springer, Cham. https://doi.org/10.1007/978-3-031-22599-4_23

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-22599-4_23

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-22598-7

  • Online ISBN: 978-3-031-22599-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics