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Non-Small Cell Carcinoma

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Abstract

Lung cancer is the leading cause of cancer death in the world, with over two million new cases and over 1.7 million deaths reported in 2018. In the United States alone lung cancer is responsible for more deaths than colon, breast, and prostate cancer combined. Most patients with lung cancer present with advanced disease, and prognosis is poor. Non-small cell lung carcinomas (NSCLC) account for approximately 80% of primary lung cancers. Tobacco use is responsible for 85–90% of cases of lung cancer in countries where smoking is common. Cough is the most common symptom present in patients with lung cancer, occurring in 45–75% of patients. Other common presenting symptoms include weight loss, dyspnea, hemoptysis, and chest pain. NSCLC is staged using the tumor-node-metastasis (TNM) classification system as developed by the International Association for the Study of Lung Cancer, which has undergone periodic revisions based on metadata. The use of immunohistochemical studies and molecular analysis plays an important role in the diagnosis and treatment alternatives.

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Authors and Affiliations

  1. Department of Medicine, Baylor College of Medicine, Houston, TX, USA

    Donald R. Lazarus

  2. Department of Thoracic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Chad D. Strange, Jitesh Ahuja, Girish S. Shroff, Bradley S. Sabloff, Patricia M. de Groot & Mylene T. Truong

  3. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Cesar A. Moran

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    Mylene T. Truong

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    Patricia M. de Groot

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Lazarus, D.R. et al. (2023). Non-Small Cell Carcinoma. In: Moran, C.A., Truong, M.T., de Groot, P.M. (eds) The Thorax. Springer, Cham. https://doi.org/10.1007/978-3-031-21040-2_10

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