Abstract
Very often, the use of cortisone in pleural pathology is based on a few anecdotal cases, while our therapeutic choices should always be guided by the most trustworthy scientific literature. To address the problem of the use of cortisone in a rational way, it is therefore worth taking a look at the authoritative scientific literature, the most important Guidelines and the Cochrane Library. The only study in the literature to evaluate the efficacy of systemic corticosteroids in parapneumonic effusions was carried out in the paediatric field, but the limit of this study is that it does not include complicated pleural effusion and empyema; for the adult patient, there are no clinical studies that demonstrate the usefulness of cortisone. In the Cochrane review, nothing is found in the field of infectious pleural effusion about the use of cortisone. The Cochrane review does not provide evidence to recommend the use of corticosteroids in TB pleurisy. Neither the Nice Guidelines 2016 nor the Index TB 2016 recommends cortisone in TB pleurisy.
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References
Davies HE, Davies RJ, Davies CW, BTS Pleural Disease Guideline Group. Management of pleural infection in adults: British Thoracic Society Pleural Disease Guideline 2010. Thorax. 2010;65(Suppl. 2):ii41–53. https://doi.org/10.1136/thx.2010.137000. PMID: 20696693.
Maskell NA, Batt S, Hedley EL, Davies CW, Gillespie SH, Davies RJ. The bacteriology of pleural infection by genetic and standard methods and its mortality significance. Am J Respir Crit Care Med. 2006;174(7):817–23. https://doi.org/10.1164/rccm.200601-074OC. Epub 2006 Jul 13. PMID: 16840746.
Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, Cooley LA, Dean NC, Fine MJ, Flanders SA, Griffin MR, Metersky ML, Musher DM, Restrepo MI, Whitney CG. Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019;200(7):e45–67. https://doi.org/10.1164/rccm.201908-1581ST. PMID: 31573350; PMCID: PMC6812437.
Stern A, Skalsky K, Avni T, Carrara E, Leibovici L, Paul M. Corticosteroids for pneumonia. Cochrane Database Syst Rev. 2017;12(12):CD007720. https://doi.org/10.1002/14651858.CD007720.pub3. PMID: 29236286; PMCID: PMC6486210.
Tagarro A, Otheo E, Baquero-Artigao F, Navarro ML, Velasco R, Ruiz M, PenÃn M, Moreno D, Rojo P, Madero R, CORTEEC Study Group. Dexamethasone for parapneumonic pleural effusion: a randomized, double-blind, clinical trial. J Pediatr. 2017;185:117–123.e6. https://doi.org/10.1016/j.jpeds.2017.02.043. Epub 2017 Mar 28. PMID: 28363363.
Sundaralingam A, Banka R, Rahman NM. Management of pleural infection. Pulm Ther. 2021;7(1):59–74. https://doi.org/10.1007/s41030-020-00140-7. Epub 2020 Dec 9. PMID: 33296057; PMCID: PMC7724776.
Fitzgerald DB, Waterer GW, Read CA, Fysh ET, Shrestha R, Stanley C, Muruganandan S, Lan NSH, Popowicz ND, Peddle-McIntyre CJ, Rahman NM, Gan SK, Murray K, Lee YCG. Steroid therapy and outcome of parapneumonic pleural effusions (STOPPE): Study protocol for a multicenter, double-blinded, placebo-controlled randomized clinical trial. Medicine (Baltimore). 2019;98(43):e17397. https://doi.org/10.1097/MD.0000000000017397. PMID: 31651842; PMCID: PMC6824804.
Dyrhovden R, Nygaard RM, Patel R, Ulvestad E, Kommedal Ø. The bacterial aetiology of pleural empyema. A descriptive and comparative metagenomic study. Clin Microbiol Infect. 2019;25(8):981–6. https://doi.org/10.1016/j.cmi.2018.11.030. Epub 2018 Dec 21. PMID: 30580031.
Brims F, Popowicz N, Rosenstengel A, Hart J, Yogendran A, Read CA, Lee F, Shrestha R, Franke A, Lewis JR, Kay I, Waterer G, Lee YCG. Bacteriology and clinical outcomes of patients with culture-positive pleural infection in Western Australia: a 6-year analysis. Respirology. 2019;24(2):171–8. https://doi.org/10.1111/resp.13395. Epub 2018 Sep 6. PMID: 30187976.
Stavrou A, Challoumas D, Dimitrakakis G. Archibald Cochrane (1909-1988): the father of evidence-based medicine. Interact Cardiovasc Thorac Surg. 2014;18(1):121–4. https://doi.org/10.1093/icvts/ivt451. Epub 2013 Oct 18. PMID: 24140816; PMCID: PMC3867052.
Crowley P, Chalmers I, Keirse MJ. The effects of corticosteroid administration before preterm delivery: an overview of the evidence from controlled trials. Br J Obstet Gynaecol. 1990;97(1):11–25. https://doi.org/10.1111/j.1471-0528.1990.tb01711.x. PMID: 2137711.
McGoldrick E, Stewart F, Parker R, Dalziel SR. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev. 2020;(12):CD004454. https://doi.org/10.1002/14651858.CD004454.pub4.
Engel ME, Matchaba PT, Volmink J. Corticosteroids for tuberculous pleurisy. Cochrane Database Syst Rev. 2007;(4):CD001876. https://doi.org/10.1002/14651858.CD001876.pub2. Update in: Cochrane Database Syst Rev. 2017;3: CD001876. PMID: 17943759.
Ryan H, Yoo J, Darsini P. Corticosteroids for tuberculous pleurisy. Cochrane Database Syst Rev. 2017;3(3):CD001876. https://doi.org/10.1002/14651858.CD001876.pub3. PMID: 28290161; PMCID: PMC5461868.
Hoppe LE, Kettle R, Eisenhut M, Abubakar I, Guideline Development Group. Tuberculosis--diagnosis, management, prevention, and control: summary of updated NICE guidance. BMJ. 2016;352:h6747. https://doi.org/10.1136/bmj.h6747. PMID: 26762607.
Sharma SK, Ryan H, Khaparde S, Sachdeva KS, Singh AD, Mohan A, Sarin R, Paramasivan CN, Kumar P, Nischal N, Khatiwada S, Garner P, Tharyan P. Index-TB guidelines: guidelines on extrapulmonary tuberculosis for India. Indian J Med Res. 2017;145(4):448–63. https://doi.org/10.4103/ijmr.IJMR_1950_16. PMID: 28862176; PMCID: PMC5663158.
Ketata W, Rekik WK, Ayadi H, Kammoun S. Les tuberculoses extrapulmonaires [Extrapulmonary tuberculosis]. Rev Pneumol Clin. 2015;71(2–3):83–92. doi: https://doi.org/10.1016/j.pneumo.2014.04.001. French. Epub 2014 Aug 15. PMID: 25131362.
Light RW, Lee YC, editors. Textbook of pleural diseases. 3rd ed. Boca Raton, FL: CRC Press; 2016.
Matchaba PT, Volmink J. Steroids for treating tuberculous pleurisy. Cochrane Database Syst Rev. 2000;(2): CD001876. doi: https://doi.org/10.1002/14651858.CD001876. Update in: Cochrane Database Syst Rev. 2007;(4): CD001876. PMID: 10796669.
Light RW. Update on tuberculous pleural effusion. Respirology. 2010;15(3):451–8. https://doi.org/10.1111/j.1440-1843.2010.01723.x. Epub 2010 Mar 21. PMID: 20345583.
Porcel JM. Tuberculous pleural effusion. Lung. 2009;187(5):263–70. https://doi.org/10.1007/s00408-009-9165-3. Epub 2009 Aug 13. PMID: 19672657.
Lee CH, Wang WJ, Lan RS, Tsai YH, Chiang YC. Corticosteroids in the treatment of tuberculous pleurisy. A double-blind, placebo-controlled, randomized study. Chest. 1988;94(6):1256–9. https://doi.org/10.1378/chest.94.6.1256. PMID: 3056661.
Galarza I, Cañete C, Granados A, Estopà R, Manresa F. Randomised trial of corticosteroids in the treatment of tuberculous pleurisy. Thorax. 1995;50(12):1305–7. https://doi.org/10.1136/thx.50.12.1305. PMID: 8553306; PMCID: PMC1021356.
Wyser C, Walzl G, Smedema JP, Swart F, van Schalkwyk EM, van de Wal BW. Corticosteroids in the treatment of tuberculous pleurisy. A double-blind, placebo-controlled, randomized study. Chest. 1996;110(2):333–8. https://doi.org/10.1378/chest.110.2.333. PMID: 8697829.
Cohen M, Sahn SA. Resolution of pleural effusions. Chest. 2001;119(5):1547–62. https://doi.org/10.1378/chest.119.5.1547. PMID: 11348966.
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Casalini, A.G. (2023). Use of Cortisone in Pleural Pathology. In: Casalini, A.G. (eds) Practical Manual of Pleural Pathology. Springer, Cham. https://doi.org/10.1007/978-3-031-20312-1_19
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