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Cough

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Abstract

The etiology of cough can be determined in most cases when considered in terms of duration. Treatment should be tailored to the diagnosis.

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References

  1. Song WJ, Chang YS, Faruqi S, Kim JY, Kang MG, Kim S, Jo EJ, Kim MH, Plevkova J, Park HW, Cho SH, Morice AH. The global epidemiology of chronic cough in adults: a systematic review and meta-analysis. Eur Respir J. 2015;45(5):1479–81.

    Article  Google Scholar 

  2. Irwin RS, Boulet LP, Cloutier MM, Fuller R, Gold PM, Hoffstein V, Ing AJ, McCool FD, O’Byrne P, Poe RH, Prakash UB, Pratter MR, Rubin BK. Managing cough as a defense mechanism and as a symptom. A consensus panel report of the American College of Chest Physicians. Chest. 1998;114(2 Suppl Managing):133S–81S.

    Article  CAS  Google Scholar 

  3. Irwin RS, Baumann MH, Bolser DC, Boulet LP, Braman SS, Brightling CE, Brown KK, Canning BJ, Chang AB, Dicpinigaitis PV, Eccles R, Glomb WB, Goldstein LB, Graham LM, Hargreave FE, Kvale PA, Lewis SZ, McCool FD, McCrory DC, Prakash U, Tarlo SM. Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines. Chest. 2006;129(1 Suppl):1S–23S.

    Article  Google Scholar 

  4. Mello CJ, Irwin RS, Curley FJ. Predictive values of the character, timing, and complications of chronic cough in diagnosing its cause. Arch Intern Med. 1996;156:997–1003.

    Article  CAS  Google Scholar 

  5. Irwin RS, French CL, Chang AB, Altman KW, CHEST Expert Cough Panel. Classification of cough as a symptom in adults and management algorithms: CHEST guideline and expert panel report. Chest. 2018;153(1):196–209.

    Article  Google Scholar 

  6. Moore A, Harnden A, Grant CC, Patel S, Irwin RS, CHEST Expert Cough Panel. Clinically diagnosing pertussis-associated cough in adults and children: CHEST guideline and expert panel report. Chest. 2019;155(1):147–54.

    Article  Google Scholar 

  7. Baraniuk JN, Jamieson MJ. Rhinorrhea, cough and fatigue in patients taking sitagliptin. Allergy Asthma Clin Immunol. 2010;6(1):8.

    Article  CAS  Google Scholar 

  8. Morice AH, McGarvey L, Pavord I, British Thoracic Society Cough Guideline Group. Recommendations for the management of cough in adults. Thorax. 2006;61Suppl 1:i1–24.

    Article  Google Scholar 

  9. Kok C, Kennerson ML, Spring PJ, Ing AJ, Pollard JD, Nicholson GA. A locus for hereditary sensory neuropathy with cough and gastroesophageal reflux on chromosome 3p22-p24. Am J Hum Genet. 2003;73(3):632–7.

    Article  CAS  Google Scholar 

  10. Smith MP, Lown M, Singh S, Ireland B, Hill AT, Linder JA, Irwin RS, CHEST Expert Cough Panel. Acute cough due to acute bronchitis in immunocompetent adult outpatients: CHEST expert panel report. Chest. 2020;157(5):1256–65.

    Article  CAS  Google Scholar 

  11. Uyeki TM, Bernstein HH, Bradley JS, Englund JA, File TM, Fry AM, Gravenstein S, Hayden FG, Harper SA, Hirshon JM, Ison MG, Johnston BL, Knight SL, McGeer A, Riley LE, Wolfe CR, Alexander PE, Pavia AT. Clinical practice guidelines by the Infectious Diseases Society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenza. Clin Infect Dis. 2019;68(6):895–902.

    Article  Google Scholar 

  12. Lim WS, van der Eerden MM, Laing R, Boersma WG, Karalus N, Town GI, Lewis SA, Macfarlane JT. Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study. Thorax. 2003;58(5):377–82.

    Article  CAS  Google Scholar 

  13. Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, Coley CM, Marrie TJ, Kapoor WN. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med. 1997;336(4):243–50.

    Article  CAS  Google Scholar 

  14. Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, et al. Diagnosis and treatment of adults with community-acquired pneumonia. An official clinical practice guideline of the ATS and IDSA. Am J Respir Crit Care Med. 2019;200(7):e45–67.

    Article  Google Scholar 

  15. Wunderink RG, Waterer GW. Clinical practice. Community-acquired pneumonia. N Engl J Med. 2014;370:543.

    Article  CAS  Google Scholar 

  16. Yealy DM, Auble TE, Stone RA, Lave JR, Meehan TP, Graff LG, Fine JM, Obrosky DS, Mor MK, Whittle J, Fine MJ. Effect of increasing the intensity of implementing pneumonia guidelines: a randomized, controlled trial. Ann Intern Med. 2005;143:881–94.

    Article  Google Scholar 

  17. Waterer GW, Wunderink RG. The influence of the severity of community-acquired pneumonia on the usefulness of blood cultures. Respir Med. 2001;95:78–82.

    Article  CAS  Google Scholar 

  18. Metersky ML, Ma A, Bratzler DW, Houck PM. Predicting bacteremia in patients with community-acquired pneumonia. Am J Respir Crit Care Med. 2004;169:342–7.

    Article  Google Scholar 

  19. Wendelboe AM, Van Rie A. Diagnosis of pertussis: a historical review and recent developments. Expert Rev Mol Diagn. 2006;6(6):857–64.

    Article  CAS  Google Scholar 

  20. Kelsall A, Decalmer S, McGuinness K, Woodcock A, Smith JA. Sex differences and predictors of objective cough frequency in chronic cough. Thorax. 2009;64(5):393–8.

    Article  CAS  Google Scholar 

  21. Yeo WW, Foster G, Ramsay LE. Prevalence of persistent cough during long-term enalapril treatment: controlled study versus nifedipine. Q J Med. 1991;80(293):763–70.

    CAS  Google Scholar 

  22. Israili ZH, Hall WD. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy. A review of the literature and pathophysiology. Ann Intern Med. 1992;117(3):234–42.

    Article  CAS  Google Scholar 

  23. Smith JA, Woodcock A. Chronic cough. N Engl J Med. 2016;375:1544–51.

    Article  Google Scholar 

  24. Kastelik JA, Aziz I, Ojoo JC, Thompson RH, Redington AE, Morice AH. Investigation and management of chronic cough using a probability-based algorithm. Eur Respir J. 2005;25(2):235–43.

    Article  CAS  Google Scholar 

  25. https://www.cdc.gov/pertussis/clinical/treatment.html.

  26. Tiwari T, Murphy TV, Moran J, National Immunization Program, and CDC. Recommended antimicrobial agents for the treatment and postexposure prophylaxis of pertussis: 2005 CDC guidelines. MMWR Recomm Rep. 2005;54(RR14):1–16.

    Google Scholar 

  27. Altunaiji S, Kukuruzovic R, Curtis N, Massie J. Antibiotics for whooping cough (pertussis). Cochrane Database Syst Rev. 2007;3:CD004404.

    Google Scholar 

  28. Wang K, Bettiol S, Thompson MJ, Roberts NW, Perera R, Heneghan CJ, Harnden A. Symptomatic treatment of the cough in whooping cough. Cochrane Database Syst Rev. 2014;2014(9):CD003257.

    Google Scholar 

  29. Hayden FG, Osterhaus AD, Treanor JJ, et al. Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza virus infections. GG167 Influenza Study Group. N Engl J Med. 1997;337:874–80.

    Article  CAS  Google Scholar 

  30. Hsu J, Santesso N, Mustafa R, Brozek J, Chen YL, Hopkins JP, Cheung A, Hovhannisyan G, Ivanova L, Flottorp SA, Saeterdal I, Wong AD, Tian J, Uyeki TM, Akl EA, Alonso-Coello P, Smaill F, Schünemann HJ. Antivirals for treatment of influenza: a systematic review and meta-analysis of observational studies. Ann Intern Med. 2012;156(7):512–24.

    Article  Google Scholar 

  31. Bergmann KC, Bauer CP, Overlack A. A placebo-controlled, blind comparison of nedocromil sodium and beclomethasone dipropionate in bronchial asthma. Curr Med Res Opin. 1989;11(8):533–42.

    Article  CAS  Google Scholar 

  32. Di Franco A, Dente FL, Giannini D, Vagaggini B, Conti I, Macchioni P, Scuotri L, Taccola M, Bacci E, Paggiaro PL. Effects of inhaled corticosteroids on cough threshold in patients with bronchial asthma. Pulm Pharmacol Ther. 2001;14(1):35–40.

    Article  Google Scholar 

  33. Dicpinigaitis PV, Dobkin JB, Reichel J. Antitussive effect of the leukotriene receptor antagonist zafirlukast in subjects with cough variant asthma. J Asthma. 2002;39(4):291–7.

    Article  CAS  Google Scholar 

  34. Miwa N, Nagano T, Ohnishi H, Nishiuma T, Takenaka K, Shirotani T, Nakajima T, Dokuni R, Kawa Y, Kobayashi K, Funada Y, Kotani Y, Nishimura Y. An open-label, multi-institutional, randomized study to evaluate the additive effect of a leukotriene receptor antagonist on cough score in patients with cough-variant asthma being treated with inhaled corticosteroids. Kobe J Med Sci. 2018;64(4):E134–9.

    CAS  Google Scholar 

  35. Smith JE, Morjaria JB, Morice AH. Dietary intervention in the treatment of patients with cough and symptoms suggestive of airways reflux as determined by Hull airways Reflux Questionnaire. Cough. 2013;9:27.

    Article  Google Scholar 

  36. Steward DL, Wilson KM, Kelly DH, Patil MS, Schwartzbauer HR, Long JD, Welge JA. Proton pump inhibitor therapy for chronic laryngo-pharyngitis: a randomized placebo control trial. Otolaryngol Head Neck Surg. 2004;131(4):342–50.

    Article  Google Scholar 

  37. Kahrilas PJ, Altman KW, Chang AB, Field SK, Harding SM, Lane AP, Lim K, McGarvey L, Smith J, Irwin RS, CHEST Expert Cough Panel. Chronic cough due to gastroesophageal reflux in adults: CHEST guideline and expert panel report. Chest. 2016;150(6):1341–60.

    Article  Google Scholar 

  38. https://goldcopd.org/2021-gold-reports/.

  39. Malesker MA, Callahan-Lyon P, Madison JM, Ireland B, Irwin RS, CHEST Expert Cough Panel. Chronic cough due to stable chronic bronchitis: CHEST expert panel report. Chest. 2020;158(2):705–18.

    Article  Google Scholar 

  40. Vertigan AE, Theodoros DG, Gibson PG, Winkworth AL. Efficacy of speech pathology management for chronic cough: a randomised placebo controlled trial of treatment efficacy. Thorax. 2006;61(12):1065–9.

    Article  CAS  Google Scholar 

  41. Ryan NM, Birring SS, Gibson PG. Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial. Lancet. 2012;380(9853):1583–9.

    Article  CAS  Google Scholar 

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Correspondence to Israa Soghier .

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Soghier, I., Kinjo, K. (2022). Cough. In: Sydney, E., Weinstein, E., Rucker, L.M. (eds) Handbook of Outpatient Medicine. Springer, Cham. https://doi.org/10.1007/978-3-031-15353-2_11

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  • DOI: https://doi.org/10.1007/978-3-031-15353-2_11

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-15352-5

  • Online ISBN: 978-3-031-15353-2

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