HSP70-HSP90 Chaperone Networking in Protein-Misfolding Disease

Prodromou, Chrisostomos; Aran-Guiu, Xavi; Oberoi, Jasmeen; Perna, Laura; Chapple, J. Paul; van der Spuy, Jacqueline

doi:10.1007/978-3-031-14740-1_13

Chrisostomos Prodromou⁸,
Xavi Aran-Guiu⁹,
Jasmeen Oberoi⁹,
Laura Perna¹⁰,
J. Paul Chapple¹⁰ &
…
Jacqueline van der Spuy¹¹

Part of the book series: Subcellular Biochemistry ((SCBI,volume 101))

1143 Accesses
5 Citations
2 Altmetric

Abstract

Molecular chaperones and their associated co-chaperones are essential in health and disease as they are key facilitators of protein-folding, quality control and function. In particular, the heat-shock protein (HSP) 70 and HSP90 molecular chaperone networks have been associated with neurodegenerative diseases caused by aberrant protein-folding. The pathogenesis of these disorders usually includes the formation of deposits of misfolded, aggregated protein. HSP70 and HSP90, plus their co-chaperones, have been recognised as potent modulators of misfolded protein toxicity, inclusion formation and cell survival in cellular and animal models of neurodegenerative disease. Moreover, these chaperone machines function not only in folding but also in proteasome-mediated degradation of neurodegenerative disease proteins. This chapter gives an overview of the HSP70 and HSP90 chaperones, and their respective regulatory co-chaperones, and explores how the HSP70 and HSP90 chaperone systems form a larger functional network and its relevance to counteracting neurodegenerative disease associated with misfolded proteins and disruption of proteostasis.

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Department of Biochemistry and Biomedicine, University of Sussex, Brighton, UK
Chrisostomos Prodromou
Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK
Xavi Aran-Guiu & Jasmeen Oberoi
Centre for Endocrinology, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK
Laura Perna & J. Paul Chapple
UCL Institute of Ophthalmology, London, UK
Jacqueline van der Spuy

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Chrisostomos Prodromou
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Laura Perna
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Biomedical Biotechnology Research Unit, Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa
Adrienne L. Edkins
Faculty of Health Sciences, Higher Colleges of Technology, Sharjah, United Arab Emirates
Gregory L. Blatch

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Prodromou, C., Aran-Guiu, X., Oberoi, J., Perna, L., Chapple, J.P., van der Spuy, J. (2023). HSP70-HSP90 Chaperone Networking in Protein-Misfolding Disease. In: Edkins, A.L., Blatch, G.L. (eds) The Networking of Chaperones by Co-Chaperones. Subcellular Biochemistry, vol 101. Springer, Cham. https://doi.org/10.1007/978-3-031-14740-1_13

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