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Bioresponsive Nanomaterials for CNS Disease

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Engineering Biomaterials for Neural Applications

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Abstract

Diseases of the central nervous system (CNS) affect millions of people worldwide and disease burden is increasing with an aging population. Yet, there are few medicines available to diagnose and treat neurological disorders and progress on developing new medicines has been limited. One major challenge is the narrow therapeutic window of payloads that act in the CNS – significant transport barriers restrict bioavailability yet the CNS is sensitive to toxicity. Bioresponsive nanomaterials can be engineered to activate based on context and encode sophisticated functions. Contexts that activate bioresponsive nanomaterials can be specific to the temporal and spatial dynamics of healthy and pathological biological processes, and thus offer approaches to increase efficacy of payloads while mitigating off-target effects. In this chapter, environment cues specific to CNS diseases or within subcellular compartments will be discussed and examples of bioresponsive nanomaterials that have been engineered to respond to these cues will be presented.

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Authors and Affiliations

  1. Department of Bioengineering, University of California, San Diego, CA, USA

    Julia A. Kudryashev, Marianne I. Madias & Ester J. Kwon

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  1. Julia A. Kudryashev
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  2. Marianne I. Madias
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  3. Ester J. Kwon
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Correspondence to Ester J. Kwon .

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  1. Department of Chemical Engineering, University of Washington, Seattle, WA, USA

    Elizabeth Nance

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Kudryashev, J.A., Madias, M.I., Kwon, E.J. (2022). Bioresponsive Nanomaterials for CNS Disease. In: Nance, E. (eds) Engineering Biomaterials for Neural Applications. Springer, Cham. https://doi.org/10.1007/978-3-031-11409-0_5

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