Skip to main content

Synthetic Opioids as New Psychoactive Substances (NPS)

  • Chapter
  • First Online:
Opioids

Abstract

The last decade has seen a significant increase in synthetic opioids among the new psychoactive substances (NSP). The first two sections of this chapter review the different opioids pertaining to this group and the main effects of the opioid drugs recently incorporated into the NPS or currently in use. The third section examines the precursor and pre-precursors needed to synthesize opioids and how they are regulated. The fourth section analyzes the role of the public Internet, the darknet, cryptocurrencies, and postal services in NPS trading. Finally, the last section presents some challenges these substances pose to prevention and regulation policies and the strategies proposed to face them.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. United Nations Office on Drugs and Crime (UNODC). The challenge of new psychoactive substances: Global SMART Programme [Internet]. Vienna: UNODC; 2013. Available from: https://www.unodc.org/documents/scientific/NPS_Report.pdf.

    Google Scholar 

  2. United Nations Office on Drugs and Crime. World Drug Report 2022 [Internet]. (United Nations publication. Sales No. E.20.XI.6). Vienna: UNODC; 2020 Jun [cited 2021 Aug 15]. Available from: https://www.unodc.org/res/wdr2022/MS/WDR22_Booklet_4.pdf

  3. United Nations Office on Drugs and Crime (UNODC). New psychoactive substances (NPS) [Internet]. 2020 [cited Aug 29]. Available from: https://www.unodc.org/documents/scientific/NPS-Leaflet_WEB_2020.pdf.

  4. Ujváry I, Christie R, Evans-Brown M, Gallegos A, Jorge R, De Morais J, et al. DARK classics in chemical neuroscience: etonitazene and related benzimidazoles. ACS Chem Neurosci. 2021;12(7):1072–92.

    Article  PubMed  Google Scholar 

  5. Blanckaert P, Balcaen M, Vanhee C, Risseeuw M, Canfyn M, Desmedt B, et al. Analytical characterization of “etonitazepyne,” a new pyrrolidinyl-containing 2-benzylbenzimidazole opioid sold online. Drug Test Anal. 2021;13(9):1627–34.

    Article  CAS  PubMed  Google Scholar 

  6. Frisoni P, Bacchio E, Bilel S, Talarico A, Gaudio RM, Barbieri M, et al. Novel synthetic opioids: the pathologist’s point of view. Brain Sci. 2018;8(9):1–17.

    Article  Google Scholar 

  7. Ventura L, Carvalho F, Dinis-Oliveira RJ. Opioids in the frame of new psychoactive substances network: a complex pharmacological and toxicological issue. Curr Mol Pharmacol. 2018;11(2):97–108.

    Article  CAS  PubMed  Google Scholar 

  8. Lovrecic B, Lovrecic M, Gabrovec B, Carli M, Pacini M, Maremmani AGI, et al. Non-medical use of novel synthetic opioids: a new challenge to public health. Int J Environ Res Public Health. 2019;16(2):1–21.

    Article  Google Scholar 

  9. Weedn VW, Elizabeth Zaney M, McCord B, Lurie I, Baker A. Fentanyl-related substance scheduling as an effective drug control strategy. J Forensic Sci. 2021;66(4):1186–200.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Vandeputte MM, Krotulski AJ, Papsun DM, Logan BK, Stove CP. The rise and fall of isotonitazene and brorphine: two recent stars in the synthetic opioid firmament. J Anal Toxicol [Internet]. 2021. Available from: https://academic.oup.com/jat/advance-article/doi/10.1093/jat/bkab082/6317457.

  11. Vandeputte MM, Van Uytfanghe K, Layle NK, St. Germaine DM, Iula DM, Stove CP. Synthesis, chemical characterization, and μ-opioid receptor activity assessment of the emerging group of “nitazene” 2-benzylbenzimidazole synthetic opioids. ACS Chem Neurosci. 2021;12(7):1241–51.

    Article  CAS  PubMed  Google Scholar 

  12. Karila L, Marillier M, Chaumette B, Nicolas F, Amine B. New synthetic opioids: part of a new addiction landscape. Neurosci Biobehav Rev. 2019;106:133–40.

    Article  CAS  PubMed  Google Scholar 

  13. Verougstraete N, Vandeputte MM, Lyphout C, Cannaert A, Hulpia F, Van Calenbergh S, et al. First report on brorphine: the next opioid on the deadly new psychoactive substance horizon? J Anal Toxicol [Internet]. 2021;44(9):937–46. Available from: https://academic.oup.com/jat/article/44/9/937/5879253.

    Article  Google Scholar 

  14. Krotulski AJ, Papsun DM, Noble C, Kacinko SL, Logan BK. Brorphine—Investigation and quantitation of a new potent synthetic opioid in forensic toxicology casework using liquid chromatography-mass spectrometry. J Forensic Sci. 2021;66(2):664–76.

    Article  CAS  PubMed  Google Scholar 

  15. Beardsley PM, Zhang Y. Synthetic opioids. In: Handbook of experimental pharmacology [Internet]. Cham: Springer; 2018. p. 353–81. Available from: https://link.springer.com/chapter/10.1007/164_2018_149.

    Google Scholar 

  16. Alzghari SK, Amin ZM, Chau S, Fleming SW, Cho K, Fung V. On the horizon: the synthetic opioid U-49900. Cureus [Internet]. 2017;9(9):1–3. Available from: https://pubmed.ncbi.nlm.nih.gov/29152436/.

    Google Scholar 

  17. Fogarty MF, Mohr ALA, Papsun DM, Logan BK. Analysis of the illicit opioid U-48800 and related compounds by LC-MS-MS and case series of fatalities involving U-48800. J Anal Toxicol [Internet]. 2020. Available from: https://academic.oup.com/jat/advance-article/doi/10.1093/jat/bkaa180/6006236.

  18. Boyer EW, Babu KM, Adkins JE, McCurdy CR, Halpern JH. Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth). Addiction. 2008;103(6):1048–50.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Rech MA, Donahey E, Cappiello Dziedzic JM, Oh L, Greenhalgh E. New drugs of abuse. Pharmacotherapy. 2015;35(2):189–97.

    Article  CAS  PubMed  Google Scholar 

  20. Meireles V, Rosado T, Barroso M, Soares S, Gonçalves J, Luís Â, et al. Mitragyna speciosa: clinical, toxicological aspects and analysis in biological and non-biological samples. Medicines (Basel). 2019;6(1):35.

    Article  CAS  Google Scholar 

  21. Stanciu CN, Gnanasegaram SA, Ahmed S, Penders T. Kratom withdrawal: a systematic review with case series. J Psychoactive Drugs [Internet]. 2019;51(1):12–8. Available from: https://doi.org/10.1080/02791072.2018.1562133.

    Article  Google Scholar 

  22. Feng LY, Battulga A, Han E, Chung H, Li JH. New psychoactive substances of natural origin: a brief review. J Food Drug Anal [Internet]. 2017;25(3):461–71. Available from: https://doi.org/10.1016/j.jfda.2017.04.001.

    Article  CAS  Google Scholar 

  23. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Salvia divinorum drug profile [Internet]. Available from: https://www.emcdda.europa.eu/publications/drug-profiles/salvia_en.

  24. International Narcotics Control Board (INCB). Precursors and chemicals frequently used in the illicit manufacture of narcotic drugs and psychotropic substances: report of the International Narcotics Control Board for 2018 on the Implementation of Article 12 of the United Nations Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances of 1988. Vienna: United Nations; 2019.

    Google Scholar 

  25. International Narcotics Control Board (INCB). Report of the International Narcotics Control Board for 2020 [Internet]. Vienna: United Nations; 2021. 142 p. (Report of the International Narcotics Control Board). Available from: https://www.un-ilibrary.org/content/books/9789210056380.

    Book  Google Scholar 

  26. United Nations Office on Drugs and Crime (UNODC). Global Smart Update: fentanyl and its analogues-50 years on [Internet], vol. 17. Vienna: UNODC; 2017. Available from: https://www.unodc.org/unodc/en/scientists/global-smart-update-2017-vol-17.html.

    Google Scholar 

  27. United Nations Office on Drugs and Crime (UNODC). The growing complexity of the opioid crisis. Global Smart Update, vol. 24. Vienna: UNODC; 2020.

    Google Scholar 

  28. International Narcotics Control Board (INCB). Precursors and chemicals frequently used in the illicit manufacture of Narcotic Drugs and Psychotropic Substances: report of the International Narcotics Control Board for 2020 on the Implementation of Article 12 of the United Nations Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances of 1988 [Internet]. Vienna: United Nations; 2021. Available from: https://www.incb.org/incb/en/precursors/technical_reports/2020.html.

  29. International Narcotics Control Board (INCB). Precursor chemical monographs 2020. Vienna: United Nations Office on Drugs and Crime (UNODC); 2020.

    Google Scholar 

  30. United Nations Office on Drugs and Crime (UNODC). World Drug Report 2021 [Internet]. 2021. Available from: https://www.unodc.org/unodc/en/data-and-analysis/wdr2021.html.

  31. Drug Enforcement Administration (DEA). 2020 National drug threat assessment, vol. 3. Johnstown: National Drug Intelligence Center; 2021.

    Google Scholar 

  32. Lohmuller M, Cook N, Pauley L. Lethal exchange: synthetic drug networks in the digital exchange era [Internet]. Washington, DC: Center for Advanced Defense Studies; 2020. Available from: https://www.c4reports.org/lethal-exchange.

    Google Scholar 

  33. Prekupec MP, Mansky PA, Baumann MH. Misuse of novel synthetic opioids: a deadly new trend. J Addict Med. 2017;11(4):256–65.

    Article  PubMed  PubMed Central  Google Scholar 

  34. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) and Europol. Drugs and the darknet. Perspectives for enforcement, research and policy [Internet]. Luxembourg: Europol Joint Publications, Publications Office of the European Union; 2017. Available from: https://www.emcdda.europa.eu/publications/joint-publications/drugs-and-the-darknet_en.

    Google Scholar 

  35. Horton-Eddison M, Di Cristofaro M. Hard interventions and innovation in crypto-drug markets: the escrow example [Internet]. Swansea: Global Drug Policy Observatory; 2017. Available from: http://www.swansea.ac.uk/media/Escrow_PB11_GDPO_AUGUST2017.pdf.

    Google Scholar 

  36. United States Departament of Justice. Fentanyl and related threats. US Atty Bull [Internet]. 2018;66(4):111. Available from: https://www.justice.gov/usao/page/file/1083791/download.

    Google Scholar 

  37. Kruithof K, Aldridge J, Décary-Hétu D, Sim M, Dujso E, Hoorens S. Internet-facilitated drugs trade: an analysis of the size, scope and the role of the Netherlands [Internet]. RAND Corporation Europe; 2016. Available from: https://www.rand.org/pubs/research_reports/RR1607.html.

  38. Global Drug Survey. GDS 2020 [Internet]. 2020. Available from: https://www.globaldrugsurvey.com/gds-2020/.

  39. United States Postal Service. Use of postal service networks to facilitate illicit drug distribution. Report Number SAT-AR-18-002 [Internet]. 2018. Available from: https://www.uspsoig.gov/sites/default/files/document-library-files/2018/SAT-AR-18-002.pdf.

  40. World Customs Organization (WCO). Illicit trade report 2019 [Internet]. 2019. Available from: https://c4ads.org/wco-2019.

  41. Peacock A, Bruno R, Gisev N, Degenhardt L, Hall W, Sedefov R, et al. New psychoactive substances: challenges for drug surveillance, control, and public health responses. Lancet. 2019;394(10209):1668–84.

    Article  PubMed  Google Scholar 

  42. United Nations Office on Drugs and Crime (UNODC). The Global Smart Programme [Internet]. Available from: https://www.unodc.org/unodc/en/scientists/smart-new.html.

  43. Abdulrahim D, Bowden-Jones O. Guidance on the clinical management of acute and chronic harms of club drugs and novel psychoactive substances [Internet]. London: Novel Psychoactive Treatment UK Network (NEPTUNE); 2015. Available from: http://neptune-clinical-guidance.co.uk/wp-content/uploads/2015/03/NEPTUNE-Guidance-March-2015.pdf.

    Google Scholar 

  44. Abdulrahim D, Bowden-Jones O. The misuse of synthetic opioids: harms and clinical management of fentanyl, fentanyl analogues and other novel synthetic opioids. Information for clinicians. London: Novel Psychoactive Treatment UK Network (NEPTUNE); 2018.

    Google Scholar 

  45. Vicknasingam B, Narayanan S, Singh D, Corazza O. Global strategy for new psychoactive substances: an update. Curr Opin Psychiatry. 2020;33(4):295–300.

    Article  PubMed  Google Scholar 

  46. Cruz SL, Granados-Soto V. Opioids and opiates: pharmacology, abuse, and addiction. In: Pfaff DW, Volkow ND, editors. Neurosci 21st century. New York: Springer; 2016. p. 3625–57. https://doi.org/10.1007/978-1-4939-3474-4_156.

    Chapter  Google Scholar 

  47. Tabarra I, Soares S, Rosado T, Gonçalves J, Luís Â, Malaca S, et al. Novel synthetic opioids–toxicological aspects and analysis. Forensic Sci Res. 2019;4(2):111–40.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Peacock A, Gisev N, Memedovic S, Larance B, Brown J, Cairns R, et al. Opioid use and harms associated with a sustained-release tapentadol formulation: a post-marketing surveillance study. Drug Alcohol Depend [Internet]. 2020;206:107697. Available from: https://doi.org/10.1016/j.drugalcdep.2019.107697.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Silvia L. Cruz .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Cruz, S.L., Martín-del-Campo, R. (2022). Synthetic Opioids as New Psychoactive Substances (NPS). In: Cruz, S.L. (eds) Opioids. Springer, Cham. https://doi.org/10.1007/978-3-031-09936-6_16

Download citation

Publish with us

Policies and ethics