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Host Immune Response to Dental Implants

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Dental Implants and Oral Microbiome Dysbiosis

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Abstract

Biocompatibility and biostability are the key properties of dental implants in the “oral environment,” in order to optimize their performance before or after functional loading. Uneventful host defense to dental implant insertion starts with a more favorable immune response that promotes wound healing around the jawbone and soft mucosal tissue. The growth of a biofilm on the surface of an implant is an igniting factor of the inflammatory response of the surrounding peri-implant tissues. At an initial stage, peri-implant mucositis is established, whereas the spread of inflammation towards the supportive bone leads to peri-implantitis. The molecular content of peri-implant crevicular fluid (PICF) offers a medium for “measurable biological indicators” of peri-implant diseases and potentially new targets for the immunomodulatory treatment of peri-implant diseases.

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References

  1. Williams DF. Specifications for innovative, enabling biomaterials based on the principles of biocompatibility mechanisms. Front Bioeng Biotechnol. 2019;7:255.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Williams D. Revisiting the definition of biocompatibility. Med Device Technol. 2003;14(8):10–3.

    PubMed  Google Scholar 

  3. Schroeder A, van der Zypen E, Stich H, Sutter F. The reactions of bone, connective tissue, and epithelium to endosteal implants with titanium-sprayed surfaces. J Maxillofac Surg. 1981;9(1):15–25.

    Article  PubMed  Google Scholar 

  4. Bosshardt DD, Salvi GE, Huynh-Ba G, Ivanovski S, Donos N, Lang NP. The role of bone debris in early healing adjacent to hydrophilic and hydrophobic implant surfaces in man. Clin Oral Implants Res. 2011;22(4):357–64.

    Article  PubMed  Google Scholar 

  5. Berglundh T, Abrahamsson I, Lang NP, Lindhe J. De novo alveolar bone formation adjacent to endosseous implants. Clin Oral Implants Res. 2003;14(3):251–62.

    Article  PubMed  Google Scholar 

  6. Eriksson C, Lausmaa J, Nygren H. Interactions between human whole blood and modified TiO2-surfaces: influence of surface topography and oxide thickness on leukocyte adhesion and activation. Biomaterials. 2001;22(14):1987–96.

    Article  PubMed  Google Scholar 

  7. Abrahamsson I, Berglundh T, Linder E, Lang NP, Lindhe J. Early bone formation adjacent to rough and turned endosseous implant surfaces. An experimental study in the dog. Clin Oral Implants Res. 2004;15(4):381–92.

    Article  PubMed  Google Scholar 

  8. Trindade R, Albrektsson T, Wennerberg A. Current concepts for the biological basis of dental implants: foreign body equilibrium and osseointegration dynamics. Oral Maxillofac Surg Clin North Am. 2015;27(2):175–83.

    Article  PubMed  Google Scholar 

  9. Maenpaa J, Soderstrom KO, Salmi T, Ekblad U. Large atypical polyps of the vagina during pregnancy with concomitant human papilloma virus infection. Eur J Obstet Gynecol Reprod Biol. 1988;27(1):65–9.

    Article  PubMed  Google Scholar 

  10. Ivanovski S, Hamlet S, Salvi GE, Huynh-Ba G, Bosshardt DD, Lang NP, et al. Transcriptional profiling of osseointegration in humans. Clin Oral Implants Res. 2011;22(4):373–81.

    Article  PubMed  Google Scholar 

  11. Donos N, Hamlet S, Lang NP, Salvi GE, Huynh-Ba G, Bosshardt DD, et al. Gene expression profile of osseointegration of a hydrophilic compared with a hydrophobic microrough implant surface. Clin Oral Implants Res. 2011;22(4):365–72.

    Article  PubMed  Google Scholar 

  12. Tomasi C, Tessarolo F, Caola I, Piccoli F, Wennstrom JL, Nollo G, et al. Early healing of peri-implant mucosa in man. J Clin Periodontol. 2016;43(10):816–24.

    Article  PubMed  Google Scholar 

  13. Gurkan A, Tekdal GP, Bostanci N, Belibasakis GN. Cytokine, chemokine, and growth factor levels in peri-implant sulcus during wound healing and osseointegration after piezosurgical versus conventional implant site preparation: randomized, controlled, split-mouth trial. J Periodontol. 2019;90(6):616–26.

    Article  PubMed  Google Scholar 

  14. Peker Tekdal G, Bostanci N, Belibasakis GN, Gurkan A. The effect of piezoelectric surgery implant osteotomy on radiological and molecular parameters of peri-implant crestal bone loss: a randomized, controlled, split-mouth trial. Clin Oral Implants Res. 2016;27(5):535–44.

    Article  PubMed  Google Scholar 

  15. Ozturk VO, Emingil G, Bostanci N, Belibasakis GN. Impact of implant-abutment connection on osteoimmunological and microbiological parameters in short implants: a randomized controlled clinical trial. Clin Oral Implants Res. 2017;28(9):e111–e20.

    Article  PubMed  Google Scholar 

  16. Hotchkiss KM, Reddy GB, Hyzy SL, Schwartz Z, Boyan BD, Olivares-Navarrete R. Titanium surface characteristics, including topography and wettability, alter macrophage activation. Acta Biomater. 2016;31:425–34.

    Article  PubMed  Google Scholar 

  17. Alfarsi MA, Hamlet SM, Ivanovski S. The effect of platelet proteins released in response to titanium implant surfaces on macrophage pro-inflammatory cytokine gene expression. Clin Implant Dent Relat Res. 2015;17(6):1036–47.

    Article  PubMed  Google Scholar 

  18. Wang Y, Zhang Y, Sculean A, Bosshardt DD, Miron RJ. Macrophage behavior and interplay with gingival fibroblasts cultured on six commercially available titanium, zirconium, and titanium-zirconium dental implants. Clin Oral Investig. 2019;23(8):3219–27.

    Article  PubMed  Google Scholar 

  19. Hotchkiss KM, Ayad NB, Hyzy SL, Boyan BD, Olivares-Navarrete R. Dental implant surface chemistry and energy alter macrophage activation in vitro. Clin Oral Implants Res. 2017;28(4):414–23.

    Article  PubMed  Google Scholar 

  20. Albrektsson T, Dahlin C, Jemt T, Sennerby L, Turri A, Wennerberg A. Is marginal bone loss around oral implants the result of a provoked foreign body reaction? Clin Implant Dent Relat Res. 2014;16(2):155–65.

    Article  PubMed  Google Scholar 

  21. Trindade R, Albrektsson T, Galli S, Prgomet Z, Tengvall P, Wennerberg A. Osseointegration and foreign body reaction: titanium implants activate the immune system and suppress bone resorption during the first 4 weeks after implantation. Clin Implant Dent Relat Res. 2018;20(1):82–91.

    Article  PubMed  Google Scholar 

  22. Young CW, Lee JS, Le H, Smith RA. Surrogate markers of health after titanium dental implant placement. J Oral Maxillofac Surg. 2004;62(11):1413–7.

    Article  PubMed  Google Scholar 

  23. Thomas P, Iglhaut G, Wollenberg A, Cadosch D, Summer B. Allergy or tolerance: reduced inflammatory cytokine response and concomitant IL-10 production of lymphocytes and monocytes in symptom-free titanium dental implant patients. Biomed Res Int. 2013;2013:539834.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Quabius ES, Ossenkop L, Harder S, Kern M. Dental implants stimulate expression of Interleukin-8 and its receptor in human blood—an in vitro approach. J Biomed Mater Res B Appl Biomater. 2012;100(5):1283–8.

    Article  PubMed  Google Scholar 

  25. Harder S, Quabius ES, Ossenkop L, Mehl C, Kern M. Surface contamination of dental implants assessed by gene expression analysis in a whole-blood in vitro assay: a preliminary study. J Clin Periodontol. 2012;39(10):987–94.

    Article  PubMed  Google Scholar 

  26. Harder S, Quabius ES, Meinke F, Mehl C, Kern M. Changes in proinflammatory gene expression in human whole blood after contact with UV-conditioned implant surfaces. Clin Oral Investig. 2019;23(10):3731–8.

    Article  PubMed  Google Scholar 

  27. Albrektsson T, Buser D, Sennerby L. Crestal bone loss and oral implants. Clin Implant Dent Relat Res. 2012;14(6):783–91.

    Article  PubMed  Google Scholar 

  28. Kotsakis GA, Olmedo DG. Peri-implantitis is not periodontitis: scientific discoveries shed light on microbiome-biomaterial interactions that may determine disease phenotype. Periodontol 2000. 2021;86(1):231–40.

    Article  PubMed  Google Scholar 

  29. Pettersson M, Kelk P, Belibasakis GN, Bylund D, Molin Thoren M, Johansson A. Titanium ions form particles that activate and execute interleukin-1beta release from lipopolysaccharide-primed macrophages. J Periodontal Res. 2017;52(1):21–32.

    Article  PubMed  Google Scholar 

  30. Olmedo D, Fernandez MM, Guglielmotti MB, Cabrini RL. Macrophages related to dental implant failure. Implant Dent. 2003;12(1):75–80.

    Article  PubMed  Google Scholar 

  31. Tatarakis N, Bashutski J, Wang HL, Oh TJ. Early implant bone loss: preventable or inevitable? Implant Dent. 2012;21(5):379–86.

    Article  PubMed  Google Scholar 

  32. Atieh MA, Alsabeeha NHM, Tawse-Smith A, Duncan WJ. Piezoelectric versus conventional implant site preparation: a systematic review and meta-analysis. Clin Implant Dent Relat Res. 2018;20(2):261–70.

    Article  PubMed  Google Scholar 

  33. Capelli M. Surgical, biologic and implant-related factors affecting bone remodeling around implants. Eur J Esthet Dent. 2013 Summer;8(2):279–313. PMID: 23712347.

    Google Scholar 

  34. Berglundh T, Abrahamsson I, Welander M, Lang NP, Lindhe J. Morphogenesis of the peri-implant mucosa: an experimental study in dogs. Clin Oral Implants Res. 2007;18(1):1–8.

    Article  PubMed  Google Scholar 

  35. Tomasi C, Tessarolo F, Caola I, Wennstrom J, Nollo G, Berglundh T. Morphogenesis of peri-implant mucosa revisited: an experimental study in humans. Clin Oral Implants Res. 2014;25(9):997–1003.

    Article  PubMed  Google Scholar 

  36. Araujo MG, Lindhe J. Peri-implant health. J Periodontol. 2018;89(Suppl 1):S249–S56.

    Article  PubMed  Google Scholar 

  37. Berglundh T, Lindhe J, Jonsson K, Ericsson I. The topography of the vascular systems in the periodontal and peri-implant tissues in the dog. J Clin Periodontol. 1994;21(3):189–93.

    Article  PubMed  Google Scholar 

  38. Emecen-Huja P, Eubank TD, Shapiro V, Yildiz V, Tatakis DN, Leblebicioglu B. Peri-implant versus periodontal wound healing. J Clin Periodontol. 2013;40(8):816–24.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Khoury SB, Thomas L, Walters JD, Sheridan JF, Leblebicioglu B. Early wound healing following one-stage dental implant placement with and without antibiotic prophylaxis: a pilot study. J Periodontol. 2008;79(10):1904–12.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Xiong J, Gronthos S, Bartold PM. Role of the epithelial cell rests of Malassez in the development, maintenance and regeneration of periodontal ligament tissues. Periodontol 2000. 2013;63(1):217–33.

    Article  PubMed  Google Scholar 

  41. Eggert FM, Levin L. Biology of teeth and implants: host factors—pathology, regeneration, and the role of stem cells. Quintessence Int. 2018;49(6):497–509.

    PubMed  Google Scholar 

  42. Schou S, Holmstrup P, Reibel J, Juhl M, Hjorting-Hansen E, Kornman KS. Ligature-induced marginal inflammation around osseointegrated implants and ankylosed teeth: stereologic and histologic observations in cynomolgus monkeys (Macaca fascicularis). J Periodontol. 1993;64(6):529–37.

    Article  PubMed  Google Scholar 

  43. Furst MM, Salvi GE, Lang NP, Persson GR. Bacterial colonization immediately after installation on oral titanium implants. Clin Oral Implants Res. 2007;18(4):501–8.

    Article  PubMed  Google Scholar 

  44. Belibasakis GN, Charalampakis G, Bostanci N, Stadlinger B. Peri-implant infections of oral biofilm etiology. Adv Exp Med Biol. 2015;830:69–84.

    Article  PubMed  Google Scholar 

  45. Belibasakis GN. Microbiological and immuno-pathological aspects of peri-implant diseases. Arch Oral Biol. 2014;59(1):66–72.

    Article  PubMed  Google Scholar 

  46. Liljenberg B, Gualini F, Berglundh T, Tonetti M, Lindhe J. Composition of plaque-associated lesions in the gingiva and the peri-implant mucosa in partially edentulous subjects. J Clin Periodontol. 1997;24(2):119–23.

    Article  PubMed  Google Scholar 

  47. Abrahamsson I, Berglundh T, Lindhe J. Soft tissue response to plaque formation at different implant systems. A comparative study in the dog. Clin Oral Implants Res. 1998;9(2):73–9.

    Article  PubMed  Google Scholar 

  48. Salvi GE, Aglietta M, Eick S, Sculean A, Lang NP, Ramseier CA. Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans. Clin Oral Implants Res. 2012;23(2):182–90.

    Article  PubMed  Google Scholar 

  49. Heitz-Mayfield LJA, Salvi GE. Peri-implant mucositis. J Periodontol. 2018;89(Suppl 1):S257–S66.

    Article  PubMed  Google Scholar 

  50. Heitz-Mayfield LJA, Salvi GE. Peri-implant mucositis. J Clin Periodontol. 2018;45(Suppl 20):S237–S45.

    Article  PubMed  Google Scholar 

  51. Dionigi C, Larsson L, Carcuac O, Berglundh T. Cellular expression of DNA damage/repair and reactive oxygen/nitrogen species in human periodontitis and peri-implantitis lesions. J Clin Periodontol. 2020;47(12):1466–75.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Charalampakis G, Abrahamsson I, Carcuac O, Dahlen G, Berglundh T. Microbiota in experimental periodontitis and peri-implantitis in dogs. Clin Oral Implants Res. 2014;25(9):1094–8.

    Article  PubMed  Google Scholar 

  53. Gualini F, Berglundh T. Immunohistochemical characteristics of inflammatory lesions at implants. J Clin Periodontol. 2003;30(1):14–8.

    Article  PubMed  Google Scholar 

  54. Lindhe J, Berglundh T, Ericsson I, Liljenberg B, Marinello C. Experimental breakdown of peri-implant and periodontal tissues. A study in the beagle dog. Clin Oral Implants Res. 1992;3(1):9–16.

    Article  PubMed  Google Scholar 

  55. Carcuac O, Berglundh T. Composition of human peri-implantitis and periodontitis lesions. J Dent Res. 2014;93(11):1083–1088.

    Google Scholar 

  56. Duarte PM, de Mendonca AC, Maximo MB, Santos VR, Bastos MF, Nociti Junior FH. Differential cytokine expressions affect the severity of peri-implant disease. Clin Oral Implants Res. 2009;20(5):514–20.

    Article  PubMed  Google Scholar 

  57. Venza I, Visalli M, Cucinotta M, De Grazia G, Teti D, Venza M. Proinflammatory gene expression at chronic periodontitis and peri-implantitis sites in patients with or without type 2 diabetes. J Periodontol. 2010;81(1):99–108.

    Article  PubMed  Google Scholar 

  58. Liu Y, Liu Q, Li Z, Acharya A, Chen D, Chen Z, et al. Long non-coding RNA and mRNA expression profiles in peri-implantitis vs periodontitis. J Periodontal Res. 2020;55(3):342–53.

    Article  PubMed  Google Scholar 

  59. Belibasakis GN, Reddi D, Bostanci N. Porphyromonas gingivalis induces RANKL in T-cells. Inflammation. 2011;34(2):133–8.

    Article  PubMed  Google Scholar 

  60. Becker ST, Foge M, Beck-Broichsitter BE, Gavrilova O, Bolte H, Rosenstiel P, et al. Induction of periimplantitis in dental implants. J Craniofac Surg. 2013;24(1):e15–8.

    Article  PubMed  Google Scholar 

  61. Zitzmann NU, Berglundh T, Ericsson I, Lindhe J. Spontaneous progression of experimentally induced periimplantitis. J Clin Periodontol. 2004;31(10):845–9.

    Article  PubMed  Google Scholar 

  62. Schwarz F, Herten M, Sager M, Bieling K, Sculean A, Becker J. Comparison of naturally occurring and ligature-induced peri-implantitis bone defects in humans and dogs. Clin Oral Implants Res. 2007;18(2):161–70.

    Article  PubMed  Google Scholar 

  63. Schou S, Holmstrup P, Stoltze K, Hjorting-Hansen E, Fiehn NE, Skovgaard LT. Probing around implants and teeth with healthy or inflamed peri-implant mucosa/gingiva. A histologic comparison in cynomolgus monkeys (Macaca fascicularis). Clin Oral Implants Res. 2002;13(2):113–26.

    Article  PubMed  Google Scholar 

  64. Hiyari S, Wong RL, Yaghsezian A, Naghibi A, Tetradis S, Camargo PM, et al. Ligature-induced peri-implantitis and periodontitis in mice. J Clin Periodontol. 2018;45(1):89–99.

    Article  PubMed  Google Scholar 

  65. Yu X, Hu Y, Freire M, Yu P, Kawai T, Han X. Role of toll-like receptor 2 in inflammation and alveolar bone loss in experimental peri-implantitis versus periodontitis. J Periodontal Res. 2018;53(1):98–106.

    Article  PubMed  Google Scholar 

  66. Hiyari S, Naghibi A, Wong R, Sadreshkevary R, Yi-Ling L, Tetradis S, et al. Susceptibility of different mouse strains to peri-implantitis. J Periodontal Res. 2018;53(1):107–16.

    Article  PubMed  Google Scholar 

  67. Carcuac O, Abrahamsson I, Albouy JP, Linder E, Larsson L, Berglundh T. Experimental periodontitis and peri-implantitis in dogs. Clin Oral Implants Res. 2013;24(4):363–71.

    Article  PubMed  Google Scholar 

  68. Albouy JP, Abrahamsson I, Persson LG, Berglundh T. Spontaneous progression of ligatured induced peri-implantitis at implants with different surface characteristics. An experimental study in dogs II: histological observations. Clin Oral Implants Res. 2009;20(4):366–71.

    Article  PubMed  Google Scholar 

  69. Wong RL, Hiyari S, Yaghsezian A, Davar M, Casarin M, Lin YL, et al. Early intervention of peri-implantitis and periodontitis using a mouse model. J Periodontol. 2018;89(6):669–79.

    Article  PubMed  PubMed Central  Google Scholar 

  70. Deng S, Hu Y, Zhou J, Wang Y, Wang Y, Li S, et al. TLR4 mediates alveolar bone resorption in experimental peri-implantitis through regulation of CD45(+) cell infiltration, RANKL/OPG ratio, and inflammatory cytokine production. J Periodontol. 2020;91(5):671–82.

    Article  PubMed  Google Scholar 

  71. Ding L, Zhang P, Wang X, Kasugai S. A doxycycline-treated hydroxyapatite implant surface attenuates the progression of peri-implantitis: a radiographic and histological study in mice. Clin Implant Dent Relat Res. 2019;21(1):154–9.

    Article  PubMed  Google Scholar 

  72. Almohandes A, Abrahamsson I, Dahlen G, Berglundh T. Effect of biofilm formation on implant abutments with an anti-bacterial coating: a pre-clinical in vivo study. Clin Oral Implants Res. 2021;32(6):756–66.

    Article  PubMed  Google Scholar 

  73. Sanz-Esporrin J, Di Raimondo R, Pla R, Luengo F, Vignoletti F, Nunez J, et al. Experimental peri-implantitis around titanium implants with a chemically modified surface with a monolayer of multi-phosphonate molecules: a preclinical in vivo investigation. Clin Oral Investig. 2021;25(6):3789–800.

    Article  PubMed  Google Scholar 

  74. Serino G, Turri A, Lang NP. Probing at implants with peri-implantitis and its relation to clinical peri-implant bone loss. Clin Oral Implants Res. 2013;24(1):91–5.

    Article  PubMed  Google Scholar 

  75. Lang NP, Wetzel AC, Stich H, Caffesse RG. Histologic probe penetration in healthy and inflamed peri-implant tissues. Clin Oral Implants Res. 1994;5(4):191–201.

    Article  PubMed  Google Scholar 

  76. Lekholm U, Adell R, Lindhe J, Branemark PI, Eriksson B, Rockler B, et al. Marginal tissue reactions at osseointegrated titanium fixtures. (II) A cross-sectional retrospective study. Int J Oral Maxillofac Surg. 1986;15(1):53–61.

    Article  PubMed  Google Scholar 

  77. Bostanci N, Belibasakis GN. Gingival crevicular fluid and its immune mediators in the proteomic era. Periodontol 2000. 2018;76(1):68–84.

    Article  PubMed  Google Scholar 

  78. Adonogianaki E, Mooney J, Wennstrom JL, Lekholm U, Kinane DF. Acute-phase proteins and immunoglobulin G against Porphyromonas gingivalis in peri-implant crevicular fluid: a comparison with gingival crevicular fluid. Clin Oral Implants Res. 1995;6(1):14–23.

    Article  PubMed  Google Scholar 

  79. Kaklamanos EG, Tsalikis L. A review on peri-implant crevicular fluid assays potential in monitoring and predicting peri-implant tissue responses. J Int Acad Periodontol. 2002;4(2):49–59.

    PubMed  Google Scholar 

  80. Golub LM, Raisanen IT, Sorsa T, Preshaw PM. An unexplored pharmacologic/diagnostic strategy for peri-implantitis: a protocol proposal. Diagnostics (Basel). 2020;10(12)

    Google Scholar 

  81. Thierbach R, Maier K, Sorsa T, Mantyla P. Peri-implant sulcus fluid (PISF) matrix metalloproteinase (MMP) -8 levels in peri-implantitis. J Clin Diagn Res. 2016;10(5):ZC34–8.

    PubMed  PubMed Central  Google Scholar 

  82. Esberg A, Isehed C, Holmlund A, Lundberg P. Peri-implant crevicular fluid proteome before and after adjunctive enamel matrix derivative treatment of peri-implantitis. J Clin Periodontol. 2019;46(6):669–77.

    Article  PubMed  Google Scholar 

  83. Guncu GN, Akman AC, Gunday S, Yamalik N, Berker E. Effect of inflammation on cytokine levels and bone remodelling markers in peri-implant sulcus fluid: a preliminary report. Cytokine. 2012;59(2):313–6.

    Article  PubMed  Google Scholar 

  84. Schierano G, Pejrone G, Brusco P, Trombetta A, Martinasso G, Preti G, et al. TNF-alpha TGF-beta2 and IL-1beta levels in gingival and peri-implant crevicular fluid before and after de novo plaque accumulation. J Clin Periodontol. 2008;35(6):532–8.

    Article  PubMed  Google Scholar 

  85. Schincaglia GP, Hong BY, Rosania A, Barasz J, Thompson A, Sobue T, et al. Clinical, immune, and microbiome traits of gingivitis and peri-implant mucositis. J Dent Res. 2017;96(1):47–55.

    Article  PubMed  Google Scholar 

  86. Curtis DA, Kao R, Plesh O, Finzen F, Franz L. Crevicular fluid analysis around two failing dental implants: a clinical report. J Prosthodont. 1997;6(3):210–4.

    Article  PubMed  Google Scholar 

  87. Severino VO, Napimoga MH, de Lima Pereira SA. Expression of IL-6, IL-10, IL-17 and IL-8 in the peri-implant crevicular fluid of patients with peri-implantitis. Arch Oral Biol. 2011;56(8):823–8.

    Article  PubMed  Google Scholar 

  88. Alassy H, Parachuru P, Wolff L. Peri-implantitis diagnosis and prognosis using biomarkers in peri-implant crevicular fluid: a narrative review. Diagnostics (Basel). 2019;9(4)

    Google Scholar 

  89. Wang HL, Garaicoa-Pazmino C, Collins A, Ong HS, Chudri R, Giannobile WV. Protein biomarkers and microbial profiles in peri-implantitis. Clin Oral Implants Res. 2016;27(9):1129–36.

    Article  PubMed  Google Scholar 

  90. Recker EN, Avila-Ortiz G, Fischer CL, Pagan-Rivera K, Brogden KA, Dawson DV, et al. A cross-sectional assessment of biomarker levels around implants versus natural teeth in periodontal maintenance patients. J Periodontol. 2015;86(2):264–72.

    Article  PubMed  Google Scholar 

  91. Bassetti M, Schar D, Wicki B, Eick S, Ramseier CA, Arweiler NB, et al. Anti-infective therapy of peri-implantitis with adjunctive local drug delivery or photodynamic therapy: 12-month outcomes of a randomized controlled clinical trial. Clin Oral Implants Res. 2014;25(3):279–87.

    Article  PubMed  Google Scholar 

  92. de Mendonca AC, Santos VR, Cesar-Neto JB, Duarte PM. Tumor necrosis factor-alpha levels after surgical anti-infective mechanical therapy for peri-implantitis: a 12-month follow-up. J Periodontol. 2009;80(4):693–9.

    Article  PubMed  Google Scholar 

  93. Faot F, Nascimento GG, Bielemann AM, Campao TD, Leite FR, Quirynen M. Can peri-implant crevicular fluid assist in the diagnosis of peri-implantitis? A systematic review and meta-analysis. J Periodontol. 2015;86(5):631–45.

    Article  PubMed  Google Scholar 

  94. Arakawa H, Uehara J, Hara ES, Sonoyama W, Kimura A, Kanyama M, et al. Matrix metalloproteinase-8 is the major potential collagenase in active peri-implantitis. J Prosthodont Res. 2012;56(4):249–55.

    Article  PubMed  Google Scholar 

  95. Strbac GD, Monov G, Cei S, Kandler B, Watzek G, Gruber R. Cathepsin K levels in the crevicular fluid of dental implants: a pilot study. J Clin Periodontol. 2006;33(4):302–8.

    Article  PubMed  Google Scholar 

  96. Yamalik N, Gunday S, Kilinc K, Karabulut E, Berker E, Tozum TF. Analysis of cathepsin-K levels in biologic fluids from healthy or diseased natural teeth and dental implants. Int J Oral Maxillofac Implants. 2011;26(5):991–7.

    PubMed  Google Scholar 

  97. Rakic M, Lekovic V, Nikolic-Jakoba N, Vojvodic D, Petkovic-Curcin A, Sanz M. Bone loss biomarkers associated with peri-implantitis. A cross-sectional study. Clin Oral Implants Res. 2013;24(10):1110–6.

    Article  PubMed  Google Scholar 

  98. Bostanci N, Saygan B, Emingil G, Atilla G, Belibasakis GN. Effect of periodontal treatment on receptor activator of NF-kappaB ligand and osteoprotegerin levels and relative ratio in gingival crevicular fluid. J Clin Periodontol. 2011;38(5):428–33.

    Article  PubMed  Google Scholar 

  99. Reddi D, Bostanci N, Hashim A, Aduse-Opoku J, Curtis MA, Hughes FJ, et al. Porphyromonas gingivalis regulates the RANKL-OPG system in bone marrow stromal cells. Microbes Infect. 2008;10(14–15):1459–68.

    Article  PubMed  Google Scholar 

  100. Rakic M, Struillou X, Petkovic-Curcin A, Matic S, Canullo L, Sanz M, et al. Estimation of bone loss biomarkers as a diagnostic tool for peri-implantitis. J Periodontol. 2014;85(11):1566–74.

    Article  PubMed  Google Scholar 

  101. Yamalik N, Gunday S, Uysal S, Kilinc K, Karabulut E, Tozum TF. Analysis of cathepsin-K activity at tooth and dental implant sites and the potential of this enzyme in reflecting alveolar bone loss. J Periodontol. 2012;83(4):498–505.

    Article  PubMed  Google Scholar 

  102. Lee YH, Wong DT. Saliva: an emerging biofluid for early detection of diseases. Am J Dent. 2009;22(4):241–8.

    PubMed  PubMed Central  Google Scholar 

  103. Castagnola M, Scarano E, Passali GC, Messana I, Cabras T, Iavarone F, et al. Salivary biomarkers and proteomics: future diagnostic and clinical utilities. Acta Otorhinolaryngol Ital. 2017;37(2):94–101.

    Article  PubMed  PubMed Central  Google Scholar 

  104. Abduljabbar T, Al-Sahaly F, Kellesarian SV, Kellesarian TV, Al-Anazi M, Al-Khathami M, et al. Comparison of peri-implant clinical and radiographic inflammatory parameters and whole salivary destructive inflammatory cytokine profile among obese and non-obese men. Cytokine. 2016;88:51–6.

    Article  PubMed  Google Scholar 

  105. Abduljabbar T, Vohra F, Ullah A, Alhamoudi N, Khan J, Javed F. Relationship between self-rated pain and peri-implant clinical, radiographic and whole salivary inflammatory markers among patients with and without peri-implantitis. Clin Implant Dent Relat Res. 2019;21(6):1218–24.

    Article  PubMed  Google Scholar 

  106. Acharya A, Koh ML, Kheur S, Watt RM, Jin L, Mattheos N. Salivary IL-1beta and red complex bacteria as predictors of the inflammatory status in sub-peri-implant niches of subjects with peri-implant mucositis. Clin Oral Implants Res. 2016;27(6):662–7.

    Article  PubMed  Google Scholar 

  107. Algohar A, Alqerban A. Levels of procalcitonin in saliva and peri-implant crevicular fluid in patients with peri-implant diseases and health. Arch Oral Biol. 2020;120:104931.

    Article  PubMed  Google Scholar 

  108. Gomes AM, Douglas-de-Oliveira DW, Ferreira SD, Silva TAD, Cota LOM, Costa FO. Periodontal disease, peri-implant disease and levels of salivary biomarkers IL-1beta, IL-10, RANK, OPG, MMP-2, TGF-beta and TNF-alpha: follow-up over 5 years. J Appl Oral Sci. 2019;27:e20180316.

    Article  PubMed  PubMed Central  Google Scholar 

  109. Lee S, Kim JY, Hwang J, Kim S, Lee JH, Han DH. Investigation of pathogenic genes in peri-implantitis from implant clustering failure patients: a whole-exome sequencing pilot study. PLoS One. 2014;9(6):e99360.

    Article  PubMed  PubMed Central  Google Scholar 

  110. Lira-Junior R, Teixeira MKS, Lourenco EJV, Telles DM, Figueredo CM, Bostrom EA. CSF-1 and IL-34 levels in peri-implant crevicular fluid and saliva from patients having peri-implant diseases. Clin Oral Investig. 2020;24(1):309–15.

    Article  PubMed  Google Scholar 

  111. Ritzer J, Luhmann T, Rode C, Pein-Hackelbusch M, Immohr I, Schedler U, et al. Diagnosing peri-implant disease using the tongue as a 24/7 detector. Nat Commun. 2017;8(1):264.

    Article  PubMed  PubMed Central  Google Scholar 

  112. Tatarakis N, Kinney JS, Inglehart M, Braun TM, Shelburne C, Lang NP, et al. Clinical, microbiological, and salivary biomarker profiles of dental implant patients with type 2 diabetes. Clin Oral Implants Res. 2014;25(7):803–12.

    Article  PubMed  Google Scholar 

  113. Teixeira MKS, Lira-Junior R, Lourenco EJV, Telles DM, Bostrom EA, Figueredo CM, et al. The modulation of the TREM-1/PGLYRP1/MMP-8 axis in peri-implant diseases. Clin Oral Investig. 2020;24(5):1837–44.

    Article  PubMed  Google Scholar 

  114. Kronstrom M, Svensson B, Erickson E, Houston L, Braham P, Persson GR. Humoral immunity host factors in subjects with failing or successful titanium dental implants. J Clin Periodontol. 2000;27(12):875–82.

    Article  PubMed  Google Scholar 

  115. Jansson H, Hamberg K, De Bruyn H, Bratthall G. Clinical consequences of IL-1 genotype on early implant failures in patients under periodontal maintenance. Clin Implant Dent Relat Res. 2005;7(1):51–9.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Section of Periodontology and Oral Health, Division of Oral Diseases, Department of Dental Medicine, Karolinska Institute, Stockholm, Sweden

    Nagihan Bostanci, Angelika Silberiesen & Kai Bao

  2. School of Dentistry, Department of Periodontology, Ege University, Bornova, Turkey

    Ali Gurkan

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  1. Nagihan Bostanci
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  2. Angelika Silberiesen
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  3. Kai Bao
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  4. Ali Gurkan
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Correspondence to Nagihan Bostanci .

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Editors and Affiliations

  1. Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong

    Prasanna Neelakantan

  2. SASTRA University, Thanjavur, Tamil Nadu, India

    Adline Princy Solomon

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Bostanci, N., Silberiesen, A., Bao, K., Gurkan, A. (2022). Host Immune Response to Dental Implants. In: Neelakantan, P., Princy Solomon, A. (eds) Dental Implants and Oral Microbiome Dysbiosis. Springer, Cham. https://doi.org/10.1007/978-3-030-99014-5_3

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