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Sanguinate: History and Clinical Evaluation of a Multimodal HBOCs

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Blood Substitutes and Oxygen Biotherapeutics

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Abstract

Sanguinate is a unique polyethylene glycol modified form of bovine hemoglobin that represents the latest generation of hemoglobin-based oxygen carriers. Its structural characteristics and altered hemoglobin-oxygen binding affinity allow it to bypass obstructions in the microcirculation and effectively deliver oxygen to ischemic tissues. Sanguinate is also able to endogenously deliver carbon monoxide, which has been shown to reduce inflammation, oxidative stress, mitigate ischemia-reperfusion injury, and promote vasodilation. Only results from phase I trials using Sanguinate have been published, although several phase II trials have been completed. While these trials suggest a possible risk of myocardial injury there was little evidence that it was due to Sanguinate. Additional larger studies are needed to better define this relationship. It has been successfully used under emergency circumstances in over 100 patients with severe anemia and impaired oxygen delivery where blood transfusion was contraindicated. The additional therapeutic effects (anti-inflammatory, anti-vasoconstrictive, plasma expansion) may make Sanguinate useful in the treatment of disorders in which blood is ineffective, such as stroke, inflammatory diseases, and sepsis. As such, Sanguinate is more effectively termed a resuscitation fluid than blood substitute.

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Author information

Authors and Affiliations

  1. Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Bryan T. Romito

  2. Departments of Anesthesiology and Pain Management, Neurological Surgery, and Neurology, UT Southwestern Medical Center, Dallas, TX, USA

    Jia W. Romito

  3. Prolong, Inc., South Plainfield, NJ, USA

    Abe Abuchowski

Authors
  1. Bryan T. Romito
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  2. Jia W. Romito
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  3. Abe Abuchowski
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Corresponding author

Correspondence to Bryan T. Romito .

Editor information

Editors and Affiliations

  1. Anesthesiology & Critical Care, University of Pennsylvania, Philadelphia, PA, USA

    Henry Liu

  2. Department of Anesthesiology and Department of Pharmacology, Toxicology, and Neurosciences LSU School of Medicine, Shreveport, LA, USA

    Alan D. Kaye

  3. Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Jonathan S. Jahr

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Romito, B.T., Romito, J.W., Abuchowski, A. (2022). Sanguinate: History and Clinical Evaluation of a Multimodal HBOCs. In: Liu, H., Kaye, A.D., Jahr, J.S. (eds) Blood Substitutes and Oxygen Biotherapeutics. Springer, Cham. https://doi.org/10.1007/978-3-030-95975-3_33

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  • DOI: https://doi.org/10.1007/978-3-030-95975-3_33

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-95974-6

  • Online ISBN: 978-3-030-95975-3

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