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Exercise and Muscle Glycogen Metabolism

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Exercise Metabolism

Part of the book series: Physiology in Health and Disease ((PIHD))

Abstract

Muscle glycogen is an important fuel source for contracting skeletal muscle, and it is well documented that exercise performance is impaired when the muscle’s stores of glycogen are exhausted. The role of carbohydrate (CHO) availability on exercise performance has been known for more than a century, while the specific role of muscle glycogen for muscle function has been known for half a century. Nonetheless, the precise cellular and molecular mechanisms by which glycogen availability regulates cell function and contractile-induced fatigue are unresolved. Alterations of pre-exercise muscle glycogen reserves by dietary and exercise manipulations or modifying the degree of dependency on endogenous glycogen during exercise have collectively established a close relationship between muscle glycogen and the resistance to fatigue. It is also apparent that glycogen availability regulates rates of muscle glycogenolysis and resynthesis, muscle glucose uptake, key steps in excitation-contraction coupling, and exercise-induced cell signaling regulating training adaptation. The present review provides both a historical and contemporary overview of the effects of exercise on muscle glycogen metabolism, addressing factors affecting glycogen use during exercise as well as the evolving concepts of how glycogen and glycolysis are integrated with cell function, skeletal muscle fatigue, and training adaptation.

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Authors and Affiliations

  1. Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark

    Niels Ørtenblad & Joachim Nielsen

  2. Research Institute for Sport and Exercise Sciences, School of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK

    James P. Morton & José L. Areta

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  1. Niels Ørtenblad
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  2. Joachim Nielsen
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  4. José L. Areta
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Correspondence to Niels Ørtenblad .

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  1. Victoria University, Melbourne, VIC, Australia

    Glenn McConell

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Ørtenblad, N., Nielsen, J., Morton, J.P., Areta, J.L. (2022). Exercise and Muscle Glycogen Metabolism. In: McConell, G. (eds) Exercise Metabolism. Physiology in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-94305-9_5

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